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List of works by Ulrik Gether

A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter

scientific article published on January 2013

A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain.

scientific article published in August 2011

A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function.

scientific article

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins

scientific article

A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity

scientific article published on 19 August 2015

A randomized trial of the effect of escitalopram versus placebo on cognitive function in healthy first-degree relatives of patients with depression

scientific article published on October 2011

A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation.

scientific article

A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT.

scientific article published on 21 August 2012

AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons ⬇️

scientific article published on August 12, 2013

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

scientific article

Adaptive aspects of impulsivity and interactions with effects of catecholaminergic agents in the 5-choice serial reaction time task: implications for ADHD

scientific article published on 09 June 2021

Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling.

scientific article

Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation

scientific article published on May 2015

Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites

scientific article published on 14 April 2007

Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.

scientific article published on May 2015

Amphipathic motifs in BAR domains are essential for membrane curvature sensing

scientific article

An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1

scientific article published on 01 May 2018

An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population

scientific article

An intracellular interaction network regulates conformational transitions in the dopamine transporter.

scientific article published on 21 April 2008

An unsuspected role for organic cation transporter 3 in the actions of amphetamine

scientific article published on 06 April 2018

Antidepressants at work

journal article; published in Nature on 2016-04-06

Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake.

scientific article published on 21 September 2017

Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression

scientific article published in April 2012

Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors

scientific article published on 16 May 2019

BAR domains, amphipathic helices and membrane-anchored proteins use the same mechanism to sense membrane curvature.

scientific article published on 31 January 2010

Binding epitopes for peptide and non-peptide ligands on the NK1 (substance P) receptor ⬇️

scientific article published on July 2, 1993

Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter

scientific article published on 2 November 2000

Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes

scientific article published on 3 October 2011

Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport.

scientific article published in August 2006

Calmodulin kinase II regulates amphetamine-induced reverse transport in dopamine and serotonin transporters

scientific article published on 17 September 2012

Cat pancreatic eicosapeptide and its biosynthetic intermediate. Conservation of a monobasic processing site

scientific article published on November 1986

Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor

scientific article published on 01 January 1999

Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research.

scientific article

Chemogenetic Targeting of Dorsomedial Direct-pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice

scientific article published on 19 January 2019

Chimeric NK1 (substance P)/NK3 (neurokinin B) receptors. Identification of domains determining the binding specificity of tachykinin agonists

scientific article published in April 1993

Clinical utility of Standardised Assessment of Personality - Abbreviated Scale (SAPAS) among patients with first episode depression

scientific article published on 26 June 2010

Comparison of peptidyl-glycine alpha-amidation activity in medullary thyroid carcinoma cells, pheochromocytomas, and serum

scientific article published on 01 August 1991

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290

scientific article published on 29 July 2016

Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1.

scientific article published on October 2002

Conformational dynamics of the human serotonin transporter during substrate and drug binding

scientific article published on 11 April 2019

Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.

scientific article published on December 1993

Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.

scientific article

Copy number variations in affective disorders and meta-analysis

scientific article published in December 2011

Correlation between genetic and geographic structure in Europe

scientific article

David versus Goliath

scientific article published on 22 April 2010

De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder

scientific article

Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site

scientific article published in December 1999

Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites

scientific article published in April 2001

Delineation of an endogenous zinc-binding site in the human dopamine transporter

scientific article

Differences between early and late onset adult depression

scientific article

Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling ⬇️

scientific article published on February 27, 1998

Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist.

scientific article published in March 1993

Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini.

scientific article published on 19 January 2016

Differential effects of chemogenetic inhibition of dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task

scientific article published on 06 December 2018

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

scientific article (publication date: 24 January 2017)

Do stressful life events predict medical treatment outcome in first episode of depression?

scientific article published on 05 February 2009

Does bereavement-related first episode depression differ from other kinds of first depressions?

scientific article published on 20 August 2009

Drosophila melanogaster: a novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter gene.

scientific article published in December 2013

Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2.

scientific article

Effect of chronic escitalopram versus placebo on personality traits in healthy first-degree relatives of patients with depression: a randomized trial

scientific article (publication date: 2012)

Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial

scientific article published on 11 January 2016

Effects of guanine, inosine, and xanthine nucleotides on beta(2)-adrenergic receptor/G(s) interactions: evidence for multiple receptor conformations

scientific article published on August 1999

Efficient amidation of C-peptide deleted NPY precursors by non-endocrine cells is affected by the presence of Lys-Arg at the C-terminus.

scientific article published on February 1993

Elucidating conformational changes in the gamma-aminobutyric acid transporter-1.

scientific article published on 10 April 2009

Engineered Zn(2+) switches in the gamma-aminobutyric acid (GABA) transporter-1. Differential effects on GABA uptake and currents

scientific article published on 29 August 2001

Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients--a randomized placebo-controlled trial

scientific article (publication date: 2011)

Evidence for a common molecular mode of action for chemically distinct nonpeptide antagonists at the neurokinin-1 (substance P) receptor

scientific article published on 01 March 1994

Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter

scientific article published on 28 May 2003

Examination of ligand-induced conformational changes in the beta 2-adrenergic receptor by fluorescence spectroscopy.

scientific article published on January 1998

Examination of ligand-induced conformational changes in the beta2 adrenergic receptor

scientific article published on 01 January 1998

Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-gsalpha fusion protein

scientific article

Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes

scientific article published in November 1995

Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations.

scientific article published on June 2001

G protein-coupled receptor pharmacology-The next generation

scientific article published on 13 July 2019

G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization

scientific article published on 04 June 2019

G protein-coupled receptors. II. Mechanism of agonist activation

scientific article published in July 1998

Gender differences among patients with a single depressive episode

scientific article published on 27 February 2010

Genome-Wide Association Study of Genetic Variants in LPS-Stimulated IL-6, IL-8, IL-10, IL-1ra and TNF-α Cytokine Response in a Danish Cohort

scientific article

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

scientific article published on March 2013

Glycine transporter dimers: evidence for occurrence in the plasma membrane

scientific article published on 5 February 2008

High-performance liquid chromatography of phenylthiocarbamyl derivatives of amino acids and side-chain derivatized amino acids

scientific article published on 01 March 1987

How curved membranes recruit amphipathic helices and protein anchoring motifs

scientific article published on 13 September 2009

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

scientific article

Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2.

scientific article published on 17 August 2005

Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.

scientific article published on 3 November 2003

In vivo amphetamine action is contingent on αCaMKII

scientific article

Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout

scientific article published on 26 August 2019

Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol

scientific article published on 10 August 2018

Interaction between genetic polymorphisms and stressful life events in first episode depression

scientific article

Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1.

scientific article

Introducing tetraCys motifs at two different sites results in a functional dopamine transporter

scientific article published in March 2009

Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer

scientific article published on 18 April 2017

Ligand stabilization of the beta 2 adrenergic receptor: effect of DTT on receptor conformation monitored by circular dichroism and fluorescence spectroscopy

scientific article published in November 1996

Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons.

scientific article published in May 2018

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

scientific article

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

scientific article published on 13 April 2015

Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets

scientific article published on 03 January 2019

Membrane localization is critical for activation of the PICK1 BAR domain

scientific article published on 8 May 2008

Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching.

scientific article published on 22 August 2007

Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.

scientific article published on 24 July 2013

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

scientific article

Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges

scientific article published on 01 April 2019

Molecular determinants for the complex binding specificity of the PDZ domain in PICK1

scientific journal article

Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6.

scientific article published on July 1999

Mutations along transmembrane segment II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding.

scientific article published on November 1994

N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization.

scientific article published on 2 December 2002

Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

scientific article published on 20 March 2018

Neurotransmitter transporters: molecular function of important drug targets

scientific article (publication date: July 2006)

No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: a randomised trial

scientific article

No interactions between genetic polymorphisms and stressful life events on outcome of antidepressant treatment

scientific article published in May 2010

Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram.

scientific article

Novel tripod amphiphiles for membrane protein analysis

scientific article published on 02 October 2013

Optogenetics brings hidden neural mechanisms into the light and could become a future therapy ⬇️

scientific article published on August 2015

PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance

scientific article (publication date: 2013)

PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system.

scientific article

PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis.

scientific article published in May 2018

Passive water and urea permeability of a human Na(+)-glutamate cotransporter expressed in Xenopus oocytes

scientific article published in August 2002

Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization.

scientific article published on June 2006

Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons.

scientific article

PreproVIP-derived peptides in tissue and plasma from patients with VIP-producing tumours

scientific article published on 01 April 1991

Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice.

scientific article published on 25 July 2016

Probing dopamine transporter structure and function by Zn2+-site engineering ⬇️

scientific article published on October 31, 2003

Processing or inactivation of antimicrobial peptides

scientific article published in Nature

Protein Interacting with C Kinase 1 (PICK1) Reduces Reinsertion Rates of Interaction Partners Sorted to Rab11-dependent Slow Recycling Pathway ⬇️

scientific article published on February 2, 2012

Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.

scientific article

Purification and fluorescent labeling of the human serotonin transporter.

scientific article

Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors

scientific article

Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram v

scientific article

Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling.

scientific article

Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges.

scientific article published on 18 January 2010

Regulation of dopamine transporter trafficking by intracellular amphetamine

scientific article published on 09 May 2006

Reply to Wilkinson et al.: Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling

scientific article published on January 2014

Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1.

scientific article published on 22 May 2003

Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter

scientific article published in December 2005

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.

scientific article published on 6 January 2012

Serotonin-induced down-regulation of cell surface serotonin transporter

scientific article

Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345 [corrected]

scientific article published on 01 September 1994

Stable expression of high affinity NK1 (substance P) and NK2 (neurokinin A) receptors but low affinity NK3 (neurokinin B) receptors in transfected CHO cells

scientific article (publication date: 27 January 1992)

Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter ⬇️

scientific article published on September 24, 2012

Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy.

scientific article published on October 2003

Structural basis for activation of G-protein-coupled receptors

scientific article

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

scientific article published on January 1997

Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

scientific article published on 01 December 2000

Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering

scientific article published on 11 June 2015

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter

scientific article published on 23 December 2015

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

scientific article

Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

scientific article published on 12 July 2017

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

scientific article

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT.

scientific article

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

scientific article published on 29 September 2017

Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions.

scientific article published on August 2004

Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux

scientific article

Tachykinin non-peptide antagonists: binding domain and molecular mode of action.

scientific article published on February 1995

Tandem facial amphiphiles for membrane protein stabilization

scientific article

The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells.

scientific article published on August 2014

The Environment Shapes the Inner Vestibule of LeuT.

scientific article

The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway

scientific article published on 9 March 2017

The Influence of Comorbid Personality Disorder and Neuroticism on Treatment Outcome in First Episode Depression

scientific article published on 06 April 2010

The N terminus of monoamine transporters is a lever required for the action of amphetamines

scientific article

The binding sites for benztropines and dopamine in the dopamine transporter overlap.

scientific article published on 06 September 2010

The effect of escitalopram versus placebo on perceived stress and salivary cortisol in healthy first-degree relatives of patients with depression-A randomised trial.

scientific article published on 14 June 2012

The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

scientific article published in February 2000

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

scientific article published on 20 March 2020

The monoamine neurotransmitter transporters: structure, conformational changes and molecular gating.

scientific article

The role of zinc ions in reverse transport mediated by monoamine transporters.

scientific article

The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride

scientific article

The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation

scientific article

The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors

scientific article published on February 1994

Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task.

scientific article published on 9 January 2017

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter.

scientific article published on 28 September 2016

Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.

scientific article

Tyrosylation and purification of peptides for radioiodination

scientific article published on 01 August 1988

Use of fluorescence spectroscopy to study conformational changes in the β2-adrenoceptor

scientific article published on January 1, 2002

Validity of the diagnosis of a single depressive episode in a case register

scientific article published on 12 February 2009

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

scientific article published on 21 February 2020

Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase

scientific article published on January 1990

Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter

scientific article published on 9 September 2004

Zn(2+) site engineering at the oligomeric interface of the dopamine transporter.

scientific article

Zn2+ modulation of neurotransmitter transporters.

scientific article published in January 2006

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