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List of works by Michael C. Heinrich

"Pediatric-type" gastrointestinal stromal tumors in adults: distinctive histology predicts genotype and clinical behavior

scientific article published in April 2011

A comprehensive target selectivity survey of the BCR-ABL kinase inhibitor INNO-406 by kinase profiling and chemical proteomics in chronic myeloid leukemia cells

scientific article published on 5 November 2009

A molecular portrait of gastrointestinal stromal tumors: an integrative analysis of gene expression profiling and high-resolution genomic copy number

scientific article published on 14 June 2010

A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia

scientific article

A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors

scientific article

A phase II trial of imatinib mesylate in merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology Group study (S0331)

scientific article

A precision therapy against cancers driven by KIT/PDGFRA mutations.

scientific article published in November 2017

A single nucleotide polymorphism in the coding region of ABL and its effects on sensitivity to imatinib

scientific article

Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas.

scientific article published in June 2010

Activating alleles of JAK3 in acute megakaryoblastic leukemia

scientific article published on July 2006

Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation.

scientific article published on 21 June 2005

Allele-specific polymerase chain reaction for the imatinib-resistant KIT D816V and D816F mutations in mastocytosis and acute myelogenous leukemia.

scientific article published on November 2006

An activating KRAS mutation in imatinib-resistant chronic myeloid leukemia

scientific article published on 29 May 2008

BRAF in papillary thyroid carcinoma of ovary (struma ovarii)

scientific article published on 01 September 2007

Basic fibroblast growth factor and epidermal growth factor downmodulate the growth of hematopoietic cells in long-term stromal cultures

scientific article published on November 1995

Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations.

scientific article

Biology of gastrointestinal stromal tumors.

scientific article published in September 2004

Cancer: Oncogenes in context

scientific article published on October 2010

Case series of chronic myeloid leukemia patients who maintained deep molecular response (DMR) with very low-dose ponatinib: experience in discontinuing low-dose ponatinib and treatment-free remission (TFR) outcomes

scientific article published on 26 May 2020

Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KIT D816V.

scientific article

Clinical management of gastrointestinal stromal tumors: before and after STI-571.

scientific article

Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases

scientific article published in February 2008

Clonal evolution of resistance to imatinib in patients with metastatic gastrointestinal stromal tumors

scientific article published on 01 September 2007

Co-transduction of cDNAs for c-kit and steel factor into single CD34+ cord blood cells further enhances the growth of erythroid and multipotential progenitors

scientific article published on 01 December 2000

Combination therapy for KIT-mutant mast cells: targeting constitutive NFAT and KIT activity.

scientific article published on 24 September 2014

Combined Abl inhibitor therapy for minimizing drug resistance in chronic myeloid leukemia: Src/Abl inhibitors are compatible with imatinib

scientific article

Combining Highly Multiplexed PCR with Semiconductor-Based Sequencing for Rapid Cancer Genotyping ⬇️

scientific article published on December 27, 2012

Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants

scientific article published on 19 September 2019

Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours

scientific article published on 22 February 2019

Correction: Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours

scientific article published on 01 July 2019

Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial

scientific article published on 15 January 2016

Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncol

scientific article published on 27 October 2008

Correlation of minimal residual disease cell frequency with molecular genotype in patients with acute myeloid leukemia

scientific article published on 27 November 2008

Crenolanib Inhibits the Drug-Resistant PDGFRA D842V Mutation Associated with Imatinib-Resistant Gastrointestinal Stromal Tumors ⬇️

scientific article published on June 27, 2012

Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance

scientific article

Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies

scientific article published in January 2006

Defining the Impact of Adjuvant Therapy in Molecularly Defined Subsets of Gastrointestinal Stromal Tumor : From Lumping to Splitting

scientific article published on 23 March 2017

Dermatofibrosarcoma protuberans: a partial response to imatinib therapy

scientific article published on 01 March 2006

Detection of ABL kinase domain mutations with denaturing high-performance liquid chromatography

scientific article published in April 2004

Differences in the prevalence of PTPN11 mutations in FAB M5 paediatric acute myeloid leukaemia

scientific article

Differential expression of neural markers in KIT and PDGFRA wild-type gastrointestinal stromal tumours.

scientific article published in December 2011

Does tumor mutational status correlate with clinical response to imatinib?

scientific article published on 01 November 2006

Dose-escalation study of a second-generation non-ansamycin HSP90 inhibitor, onalespib (AT13387), in combination with imatinib in patients with metastatic gastrointestinal stromal tumour.

scientific article published on 5 May 2016

Ectodermally derived steel/stem cell factor functions non-cell autonomously during primitive erythropoiesis in Xenopus

scientific article published on 15 December 2005

Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis

scientific article published on 8 July 2004

Efficacy and Safety of Regorafenib in Patients With Metastatic and/or Unresectable GI Stromal Tumor After Failure of Imatinib and Sunitinib: A Multicenter Phase II Trial ⬇️

scientific article published on May 21, 2012

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

scientific article (publication date: 15 August 2002)

Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial

scientific article

Epidemiology of GIST

scientific article published on 01 October 2005

Expression of KIT and epidermal growth factor receptor in chemotherapy refractory non-seminomatous germ-cell tumors.

scientific article

Extragastrointestinal stromal tumors presenting as vulvovaginal/rectovaginal septal masses: a diagnostic pitfall

scientific article published on 01 July 2006

FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248).

scientific article published on 14 September 2006

Familial Gastrointestinal Stromal Tumor Syndrome: Phenotypic and Molecular Features in a Kindred

scientific article published on 01 April 2005

Fine-needle aspiration biopsy diagnosis of gastrointestinal stromal tumors using morphology, immunocytochemistry, and mutational analysis of c-kit

scientific article published on 01 August 2001

Frequencies of KIT and PDGFRA mutations in the MolecGIST prospective population-based study differ from those of advanced GISTs

scientific article published on 28 September 2011

Gastric GI stromal tumors (GISTs): the role of surgery in the era of targeted therapy.

scientific article

Gastrointestinal stromal tumors

scientific article published on 01 December 2001

Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles

scientific article

Gastrointestinal stromal tumors of the esophagus: a clinicopathologic and molecular analysis of 27 cases.

scientific article published on 23 June 2017

Gastrointestinal stromal tumors: molecular markers and genetic subtypes.

scientific article

Gastrointestinal stromal tumour.

scientific article published on May 2007

Gastrointestinal stromal tumours: origin and molecular oncology.

scientific article

Genetic profiling to determine risk of relapse-free survival in high-risk localized prostate cancer.

scientific article

Genotyping and immunohistochemistry of gastrointestinal stromal tumors: An update.

scientific article published on 07 February 2015

Heterogeneity of kinase inhibitor resistance mechanisms in GIST

scientific article published on September 2008

High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib

scientific article published in January 2004

High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast

scientific article

High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

scientific article published on 5 February 2008

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

scientific article published on 15 December 2008

Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

scientific article published in December 2007

Imatinib targeting of KIT-mutant oncoprotein in melanoma.

scientific article

Imatinib treatment of metastatic GIST: don't stop (believing) ⬇️

scientific article published on September 21, 2010

Immunohistochemical and molecular markers in breast phyllodes tumors

scientific article published in March 2011

In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants

scientific article published on June 2005

In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit.

scientific article published on 3 March 2005

Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies

scientific article

Insulin-like growth factor 1 receptor expression in wild-type GISTs: a potential novel therapeutic target.

scientific article published in December 2009

Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST).

scientific article

Intrigue: Phase III study of ripretinib versus sunitinib in advanced gastrointestinal stromal tumor after imatinib

scientific article published on 22 November 2019

KIT gene mutations and copy number in melanoma subtypes

scientific article

KIT-Dependent and KIT-Independent Genomic Heterogeneity of Resistance in Gastrointestinal Stromal Tumors - TORC1/2 Inhibition as Salvage Strategy

scientific article published on 15 July 2019

KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications

scientific article

KRAS and KIT Gatekeeper Mutations Confer Polyclonal Primary Imatinib Resistance in GI Stromal Tumors: Relevance of Concomitant Phosphatidylinositol 3-Kinase/AKT Dysregulation

scientific article

Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells

scientific article

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

scientific article

LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma

scientific article published on 21 September 2018

Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study

scientific article published on 02 December 2019

Long-term follow-up results of the multicenter phase II trial of regorafenib in patients with metastatic and/or unresectable GI stromal tumor after failure of standard tyrosine kinase inhibitor therapy

scientific article published on July 2016

Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT.

scientific article

Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study

scientific article published on 17 July 2012

MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation.

scientific article published on 08 March 2017

MET receptor sequence variants R970C and T992I lack transforming capacity

scientific article

Major response to imatinib mesylate in KIT-mutated melanoma.

scientific article

Metastatic intravagal paraganglioma. Case report and review of the literature

article published in 1985

MicroRNA expression signature of human sarcomas

scientific article published on 8 October 2007

Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225.

scientific article

Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.

scientific article

Molecular determinants of response to matuzumab in combination with paclitaxel for patients with advanced non-small cell lung cancer

scientific article published on 10 March 2009

Molecular pathobiology of gastrointestinal stromal sarcomas.

scientific article published on January 2008

Molecular target modulation, imaging, and clinical evaluation of gastrointestinal stromal tumor patients treated with sunitinib malate after imatinib failure.

scientific article

Multiplex high-throughput gene mutation analysis in acute myeloid leukemia.

scientific article published in June 2012

Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry

scientific article

Multiplex mutation screening by mass spectrometry in gastrointestinal stromal tumours.

scientific article

Mutations of the BCR-ABL-kinase domain occur in a minority of patients with stable complete cytogenetic response to imatinib.

scientific article published on 25 January 2007

Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach.

scientific article

Neurofibromatosis type 1-associated wild-type gastrointestinal stromal tumor treated with anti-IGF-1R monoclonal antibody.

scientific article

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia.

scientific article

Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract

scientific article published on 17 May 2014

PDGFRA Antibody for Soft Tissue Sarcoma

scientific article published in February 2017

PDGFRA activating mutations in gastrointestinal stromal tumors.

scientific article

PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib

scientific article

Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial.

scientific article

Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors

scientific article published on 01 October 2007

Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics

scientific article published on 10 August 2006

Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition

scientific article published on 18 February 2015

Phase II study of imatinib mesylate in chemotherapy refractory germ cell tumors expressing KIT.

scientific article published in February 2006

Phase II trial of neoadjuvant/adjuvant imatinib mesylate for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumors: long-term follow-up results of Radiation Therapy Oncology Group 0132.

scientific article published on 28 December 2011

Phase II, open-label study evaluating the activity of imatinib in treating life-threatening malignancies known to be associated with imatinib-sensitive tyrosine kinases

scientific article published in May 2008

Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033.

scientific article

Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma

scientific article

Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes

scientific article published on 7 February 2006

Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.

scientific article

Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML.

scientific article

Primary adenoid cystic carcinoma of the lung: absence of KIT mutations

scientific article published on 01 December 2007

Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor

scientific article

Primary extragastrointestinal stromal tumor of the pleura: report of a unique case with genetic confirmation

scientific article published in June 2010

Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs).

scientific article

Pure red cell aplasia associated with parvovirus B19 infection occurring late after allogeneic bone marrow transplantation

scientific article published in March 2004

Quadruple wild-type (WT) GIST: defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways

scientific article published on 28 August 2014

Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms ⬇️

scientific article published on March 7, 2013

RNAi screen for rapid therapeutic target identification in leukemia patients

scholarly article

RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia

scientific article

RNAi-induced down-regulation of FLT3 expression in AML cell lines increases sensitivity to MLN518.

scientific article

Rare expression of KIT and absence of KIT mutations in high grade renal cell carcinoma.

scientific article published in January 2006

Rates of deep molecular response by digital and conventional PCR with frontline nilotinib in newly diagnosed chronic myeloid leukemia: a landmark analysis

scientific article published on 26 March 2019

Regorafenib Induces Rapid and Reversible Changes in Plasma Nitric Oxide and Endothelin-1 ⬇️

scientific article published on July 12, 2012

Regorafenib for treatment of advanced gastrointestinal stromal tumors.

scientific article published on 10 January 2014

Resistance to Tyrosine Kinase Inhibitors in Gastrointestinal Stromal Tumors.

scientific article published on December 2009

Resistance to avapritinib in PDGFRA-driven GIST is caused by secondary mutations in the PDGFRA kinase domain

scientific article published on 24 September 2020

Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants

scientific article published on 01 May 2019

S0502: A SWOG Phase III Randomized Study of Imatinib, With or Without Bevacizumab, in Patients With Untreated Metastatic or Unresectable Gastrointestinal Stromal Tumors

scientific article

SDHA loss-of-function mutations in KIT-PDGFRA wild-type gastrointestinal stromal tumors identified by massively parallel sequencing

scientific article

SDHC methylation in gastrointestinal stromal tumors (GIST): a case report

scientific article published on 28 September 2015

STI571: a paradigm of new agents for cancer therapeutics

scientific article

SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo

scientific article published on 16 January 2003

SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase

scientific article published in October 2002

Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970.

scientific article published on 10 August 2004

Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib

scientific article published on 8 January 2004

Sorafenib inhibits many kinase mutations associated with drug-resistant gastrointestinal stromal tumors.

scientific article published on 4 June 2012

Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases

scientific article published on 30 June 2018

Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib.

scientific article

Survey of activated FLT3 signaling in leukemia

scientific article

Survival in advanced GIST has improved over time and correlates with increased access to post-imatinib tyrosine kinase inhibitors: results from Life Raft Group Registry

scientific article published on 02 April 2019

Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells

scientific article published on 10 August 2004

The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

scientific article

The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific

scientific article (publication date: 19 July 2002)

The gene expression profile of extraskeletal myxoid chondrosarcoma.

scientific article published in August 2005

The multitargeted receptor tyrosine kinase inhibitor linifanib (ABT-869) induces apoptosis through an Akt and glycogen synthase kinase 3β-dependent pathway.

scientific article

Translational insights into gastrointestinal stromal tumor and current clinical advances

scientific article published on 01 October 2018

Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit.

scientific article published on May 2003

Using molecular diagnostic testing to personalize the treatment of patients with gastrointestinal stromal tumors.

scientific article published on 20 March 2017

Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors

scientific article

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