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List of works by Donald M O'Rourke

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

scientific article published in July 2017

Actinomycotic brain infection: registered diffusion, perfusion MR imaging and MR spectroscopy

scientific article

Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells

scientific article published on 24 October 2009

Anticancer effects of fenretinide in human medulloblastoma

scientific article published in January 2006

Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MR Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma

scientific article published on 19 June 2019

Arterial spin-labeling and MR spectroscopy in the differentiation of gliomas.

scientific article published on 24 September 2007

Assignment Confidence in Localization of the Hand Motor Cortex: Comparison of Structural Imaging With Functional MRI.

scientific article

Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy

scientific article published on 13 February 2017

Automated tumor volumetry using computer-aided image segmentation

scientific article

Clinically silent somatotroph adenomas are common.

scientific article

Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells

scientific article

Diagnostic utility of diffusion tensor imaging in differentiating glioblastomas from brain metastases

scientific article published on 6 February 2014

Differentiation between glioblastomas and solitary brain metastases using diffusion tensor imaging.

scientific article published on 07 October 2008

Differentiation between glioblastomas, solitary brain metastases, and primary cerebral lymphomas using diffusion tensor and dynamic susceptibility contrast-enhanced MR imaging.

scientific article

Differentiation between oligodendroglioma genotypes using dynamic susceptibility contrast perfusion-weighted imaging and proton MR spectroscopy.

scientific article

Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells

scientific article

Domain-specific Interactions between the p185neuand Epidermal Growth Factor Receptor Kinases Determine Differential Signaling Outcomes

scientific article published on 01 January 1999

Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B.

scientific article published on 24 November 2002

Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development.

scientific article

Experimental traumatic brain injury modulates the survival, migration, and terminal phenotype of transplanted epidermal growth factor receptor-activated neural stem cells.

scientific article

Expression of oncogenic epidermal growth factor receptor family kinases induces paclitaxel resistance and alters beta-tubulin isotype expression

scientific article published on June 2000

Factors associated with increased survival after surgical resection of glioblastoma in octogenarians

scientific article published on 15 May 2015

Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity

scientific article

Go, no-go decision making for phase 3 clinical trials: ACT IV revisited - Authors' reply

scientific article published in December 2017

Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla

scientific article

Histopathology-validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo-progression in glioblastoma

scientific article published on 04 March 2020

IDH mutation impairs histone demethylation and results in a block to cell differentiation

scientific article (publication date: 15 February 2012)

Identification of a 140 kDa protein of rat presynaptic terminal membranes encompassing the active zones

scientific article published on 01 November 1995

Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques.

scientific article published on 16 July 2015

In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ-Index.

scientific article published on 20 April 2017

In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature.

scientific article published on 30 March 2018

Intraaxial brain masses: MR imaging-based diagnostic strategy--initial experience.

scientific article

Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases.

scientific article

Isoform-level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes.

scientific article published on 06 February 2014

Magnetic resonance perfusion-weighted imaging defines angiogenic subtypes of oligodendroglioma according to 1p19q and EGFR status

scientific article published on 9 April 2009

Neural stem cell biology may be well suited for improving brain tumor therapies.

scientific article

Novel risk scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases

scientific article

Pattern analysis of dynamic susceptibility contrast-enhanced MR imaging demonstrates peritumoral tissue heterogeneity

scientific article

Population-based MRI atlases of spatial distribution are specific to patient and tumor characteristics in glioblastoma.

scientific article published on 12 March 2016

Posttreatment recurrence of malignant brain neoplasm: accuracy of relative cerebral blood volume fraction in discriminating low from high malignant histologic volume fraction

scientific article

Prediction of oligodendroglial tumor subtype and grade using perfusion weighted magnetic resonance imaging.

scientific article

Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics

scientific article published on January 2017

Prognostic Value of Dynamic Susceptibility Contrast-Enhanced and Diffusion-Weighted MR Imaging in Patients with Glioblastomas.

scientific article published on 2 April 2015

Proton magnetic resonance spectroscopy in differentiating glioblastomas from primary cerebral lymphomas and brain metastases.

scientific article published on November 2010

Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1.

scientific article

Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo.

scientific article published in February 2000

Receptor tyrosine kinase signaling in gliomagenesis: pathobiology and therapeutic approaches.

scientific article published on July 2003

Relationship of p215BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells

scientific article published on June 1997

Resident training in neurosurgical oncology: results of the survey of North American training programs by the AANS/CNS Section on Tumors

scientific article published in May 2006

Reversion of the ErbB malignant phenotype and the DNA damage response.

scientific article published on 27 September 2012

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

scientific article published on 22 August 2017

Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors.

scientific article

Role of proton magnetic resonance spectroscopy in differentiating oligodendrogliomas from astrocytomas.

scientific article published in January 2010

SHP-2-dependent mitogen-activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival

scientific article

SIRPalpha1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration.

scientific article

Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.

scientific article published on September 2004

Sprouty2 Drives Drug Resistance and Proliferation in Glioblastoma.

scientific article

Sustained mitogen-activated protein kinase activation is induced by transforming erbB receptor complexes

scientific article published on October 1999

The ability of protein tyrosine phosphatase SHP-1 to suppress NFkappaB can be inhibited by dominant negative mutant of SIRPalpha.

scientific article published in March 2004

The application of 5-bromodeoxyuridine in the management of CNS tumors

scientific article published on January 1994

The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells.

scientific article published on 08 May 2009

The role of distinct p185neu extracellular subdomains for dimerization with the epidermal growth factor (EGF) receptor and EGF-mediated signaling.

scholarly article

The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors

scientific article

Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains.

scientific article

Transcriptional regulation of signal regulatory protein alpha1 inhibitory receptors by epidermal growth factor receptor signaling

scientific article published on September 2004

Treatment of steroid refractory, Gamma Knife related radiation necrosis with bevacizumab: Case report and review of the literature ⬇️

scientific article published on September 8, 2011

Use of magnetic perfusion-weighted imaging to determine epidermal growth factor receptor variant III expression in glioblastoma ⬇️

scientific article published on April 4, 2012

Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma

scientific article published on 01 February 2020

c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

scientific article published on 4 April 2016

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