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List of works by Yoshiyuki Kubo

ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms

scientific article

Amino acid residues involved in the substrate specificity of TauT/SLC6A6 for taurine and γ-aminobutyric acid

scientific article published in January 2014

Application of membrane permeability evaluated in in vitro analyses to estimate blood-retinal barrier permeability.

scientific article published on 25 April 2012

Asymmetric intestinal first-pass metabolism causes minimal oral bioavailability of midazolam in cynomolgus monkey

scientific article

Blood-to-brain influx transport of nicotine at the rat blood-brain barrier: involvement of a pyrilamine-sensitive organic cation transport process.

scientific article published on 7 December 2012

Blood-to-retina transport of riboflavin via RFVTs at the inner blood-retinal barrier

scientific article published on 8 October 2016

Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter.

scientific article

Carnitine/organic cation transporter OCTN2 (Slc22a5) is responsible for renal secretion of cephaloridine in mice

scientific article published on 12 February 2009

Carrier-Mediated Transport of Nicotine Across the Inner Blood-Retinal Barrier: Involvement of a Novel Organic Cation Transporter Driven by an Outward H(+) Gradient

scientific article

Carrier-mediated Transport of Cationic Drugs across the Blood-Tissue Barrier

scientific article

Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700.

scientific article published on February 2006

Cationic polyrotaxanes effectively inhibit uptake via carnitine/organic cationic transporters without cytotoxicity.

scientific article

Characterization of the transdermal transport of flurbiprofen and indomethacin.

scientific article published on 27 December 2005

Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: involvement of organic anion transporting polypeptide (OATP)-B.

scientific article published on 14 November 2006

Cloning of rat ABCA7 and its preferential expression in platelets

scientific journal article

Cysteine-scanning mutagenesis around transmembrane segments 1 and 11 and their flanking loop regions of Tn10-encoded metal-Tetracycline/H+ antiporter

scientific article published on 01 June 2000

Direct evidence for efficient transport and minimal metabolism of L-cephalexin by oligopeptide transporter 1 in budded baculovirus fraction.

scientific article

Excitatory Amino Acid Transporter 1-Mediated L-Glutamate Transport at the Inner Blood-Retinal Barrier: Possible Role in L-Glutamate Elimination from the Retina

scientific article

Function and regulation of taurine transport in Müller cells under osmotic stress.

scientific article

Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver

scientific article published on 2 July 2010

Functional expression of nicotine influx transporter in A549 human alveolar epithelial cells.

scientific article published on 9 December 2015

Functional expression of stereoselective metabolism of cephalexin by exogenous transfection of oligopeptide transporter PEPT1.

scientific article published in December 2006

Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.

scientific article

Histamine elimination from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4).

scientific article published on 08 August 2016

Impact of Cationic Amino Acid Transporter 1 on Blood-Retinal Barrier Transport of L-Ornithine

scientific article published on September 2015

Impact of SLC6A Transporters in Physiological Taurine Transport at the Blood-Retinal Barrier and in the Liver.

scientific article published on January 2016

In Vitro Study of L-Glutamate and L-Glutamine Transport in Retinal Pericytes: Involvement of Excitatory Amino Acid Transporter 1 and Alanine-Serine-Cysteine Transporter 2

scientific article published on 01 January 2015

Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig.

scientific article published on 27 September 2017

Investigation of Receptor-Mediated Cyanocobalamin (Vitamin B12) Transport across the Inner Blood–Retinal Barrier Using Fluorescence-Labeled Cyanocobalamin

scientific article published on 17 July 2018

Investigation of the role of oligopeptide transporter PEPT1 and sodium/glucose cotransporter SGLT1 in intestinal absorption of their substrates using small GTP-binding protein Rab8-null mice

scientific article

Involvement of a Novel Organic Cation Transporter in Verapamil Transport Across the Inner Blood-Retinal Barrier ⬇️

scientific article published on November 22, 2012

Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart

scientific article published in January 2008

Involvement of carrier-mediated transport in the retinal uptake of clonidine at the inner blood-retinal barrier

scientific article published on 26 September 2014

Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol

scientific article

Involvement of multidrug resistance-associated protein 1 in intestinal toxicity of methotrexate

scientific article published on 14 March 2009

Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics

scientific article

Involvement of organic anion transport system in transdermal absorption of flurbiprofen

scientific article published on 25 August 2007

Involvement of the H+/organic cation antiporter in nicotine transport in rat liver

scientific article published on 28 October 2014

Involvement of the carrier-mediated process in the retina-to-blood transport of spermine at the inner blood-retinal barrier.

scientific article published on 14 May 2014

L-type fatty acid binding protein transgenic mouse as a novel tool to explore cytotoxicity to renal proximal tubules

scientific article published in January 2008

Lysosomal Trapping Is Present in Retinal Capillary Endothelial Cells: Insight into Its Influence on Cationic Drug Transport at the Inner Blood-Retinal Barrier.

scientific article published on January 2016

Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells.

scientific article

Mutation in an adaptor protein PDZK1 affects transport activity of organic cation transporter OCTNs and oligopeptide transporter PEPT2.

scientific article

Na+/H+ exchanger 3 affects transport property of H+/oligopeptide transporter 1.

scientific article published in December 2005

Organic anion-transporting polypeptide 1a4-mediated heterogeneous distribution of sulforhodamine-101 in rat hepatic lobules

scientific article published on 11 April 2019

Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse.

scientific article

P-glycoprotein (Abcb1) is involved in absorptive drug transport in skin

scientific article published on 12 August 2008

PDZK1 regulates organic anion transporting polypeptide Oatp1a in mouse small intestine.

scientific article published on 12 November 2010

PDZK1 regulates two intestinal solute carriers (Slc15a1 and Slc22a5) in mice.

scientific article

Pharmacokinetics of guanidinosuccinic acid in rat blood and cerebrospinal fluid

scientific article published on 13 August 2013

Propranolol transport across the inner blood-retinal barrier: potential involvement of a novel organic cation transporter.

scientific article published on 9 April 2013

Proximity of periplasmic loops in the metal-Tetracycline/H(+) antiporter of Escherichia coli observed on site-directed chemical cross-linking.

scientific article

Quantitative Determination of Luminal and Abluminal Membrane Distributions of Transporters in Porcine Brain Capillaries by Plasma Membrane Fractionation and Quantitative Targeted Proteomics

scientific article published on 20 February 2015

Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects.

scientific article published on 10 May 2011

Retina-to-Blood Transport of 1-Methyl-4-Phenylpyridinium Involves Carrier-Mediated Process at the Blood-Retinal Barrier

scientific article published on 25 April 2017

Role of l-Type Amino Acid Transporter 1 at the Inner Blood-Retinal Barrier in the Blood-to-Retina Transport of Gabapentin

scientific article published on 02 May 2018

Species difference in intestinal absorption mechanism of etoposide and digoxin between cynomolgus monkey and rat.

scientific article published on 15 July 2008

The Rab8 GTPase regulates apical protein localization in intestinal cells

scientific article published on 27 June 2007

Transporter-mediated L-glutamate elimination from cerebrospinal fluid: possible involvement of excitatory amino acid transporters expressed in ependymal cells and choroid plexus epithelial cells

scientific article

Transporter-mediated prostaglandin E₂ elimination across the rat blood-brain barrier and its attenuation by the activation of N-methyl-D-aspartate receptors

scientific article published on 08 April 2014

Up-regulation of l-Type Amino Acid Transporter 1 (LAT1) in Cultured Rat Retinal Capillary Endothelial Cells in Response to Glucose Deprivation ⬇️

scientific article published on December 20, 2011

Β-alanine and l-histidine transport across the inner blood-retinal barrier: potential involvement in L-carnosine supply

scientific article

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