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List of works by Adrian Robert Krainer

A Broad Set of Chromatin Factors Influences Splicing

scientific article

A generalizable pre-clinical research approach for orphan disease therapy

scientific article published on 15 June 2012

A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma

scientific article published on 15 February 2018

A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes

scientific article published on January 2001

A mutation in a rare type of intron in a sodium-channel gene results in aberrant splicing and causes myotonia

scientific article

A new path to oncogene-induced senescence: At the crossroads of splicing and translation ⬇️

scientific article published on April 22, 2013

A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B

scientific article

A positive modifier of spinal muscular atrophy in the SMN2 gene

scientific article

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins)

scientific article

A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm ⬇️

scientific article published on January 1, 1998

A splicing component adapted to gene silencing

scientific article published in March 2009

A splicing-independent function of SF2/ASF in microRNA processing

scientific article

A-44G transition in SMN2 intron 6 protects patients with spinal muscular atrophy

scientific article published on 28 April 2017

Aberrant 5' splice sites in human disease genes: mutation pattern, nucleotide structure and comparison of computational tools that predict their utilization

scientific article published on 18 June 2007

Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis

scientific article

Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway

scientific article published on 11 October 2010

Alternative splicing of the adenylyl cyclase stimulatory G-protein G alpha(s) is regulated by SF2/ASF and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and involves the use of an unusual TG 3'-splice Site

scientific article

Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1

scientific article

An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites

scientific article published on 19 December 2004

An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor

scientific article published in January 2002

An increased specificity score matrix for the prediction of SF2/ASF-specific exonic splicing enhancers

scientific article

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

scientific article

Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice

scientific article published on 27 March 2008

Antisense oligonucleotide-directed inhibition of nonsense-mediated mRNA decay

scientific article published on 14 December 2015

Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB.

scientific article

Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice.

scientific article

Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy

scientific article

Antisense-based therapy for the treatment of spinal muscular atrophy

scientific article

Antisense-mediated exon inclusion

scientific article

Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF

scientific article

BRCA2 T2722R is a deleterious allele that causes exon skipping

scientific article published on 19 July 2002

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

scientific article published on 14 November 2017

CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function

scientific article published on August 2015

Characterization of a SR protein from Trypanosoma brucei with homology to RNA-binding cis-splicing proteins

scientific article published in July 1999

Comprehensive splice-site analysis using comparative genomics

scientific article

Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65)

scientific article

Cooperative-binding and splicing-repressive properties of hnRNP A1.

scientific article

Correction of disease-associated exon skipping by synthetic exon-specific activators

scientific article published in February 2003

Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1.

scientific article

Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs

scientific article

Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein

scientific article

Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA

scientific article

Crystallization and preliminary X-ray diffraction studies of UP1, the two-RRM domain of hnRNP A1.

scientific article

Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch

scientific article

Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2.

scientific article published on September 2008

Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing

scientific article

Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor

Determinants of the inherent strength of human 5' splice sites

scientific article

Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP

scientific article

Differential connectivity of splicing activators and repressors to the human spliceosome.

scientific article published on 6 June 2015

Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss

scientific article

Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1.

scientific article published on 4 March 2002

Disruption of exonic splicing enhancer elements is the principal cause of exon skipping associated with seven nonsense or missense alleles of NF1.

scientific article published in December 2004

Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors

scientific article

Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1.

scientific article published in September 1998

Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes

scientific article

Downregulation of Survivin contributes to cell-cycle arrest during postnatal cardiac development in a severe spinal muscular atrophy mouse model

scientific article

Dual-specificity splice sites function alternatively as 5' and 3' splice sites

scholarly article

ESEfinder: A web resource to identify exonic splicing enhancers

scientific article (publication date: July 2003)

Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer

scientific article

Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon

scientific article

Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing

scientific article published on September 1999

Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing

scientific article

Evolutionary impact of limited splicing fidelity in mammalian genes

scientific article published on 24 August 2007

Exon Identity Established through Differential Antagonism between Exonic Splicing Silencer-Bound hnRNP A1 and Enhancer-Bound SR Proteins

scientific article (publication date: December 2001)

Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons

scientific article

Exonic splicing enhancer motif recognized by human SC35 under splicing conditions

scientific article

Extensive in silico analysis of NF1 splicing defects uncovers determinants for splicing outcome upon 5' splice-site disruption

scientific article published in June 2007

Features of 5'-splice-site efficiency derived from disease-causing mutations and comparative genomics

scientific article published on 21 November 2007

Functional expression of cloned human splicing factor SF2: homology to rna-binding proteins, U1 70K, and drosophila splicing regulators ⬇️

scientific article published on July 26, 1991

Functional significance of a deep intronic mutation in the ATM gene and evidence for an alternative exon 28a.

scientific article

Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway.

scientific article

General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection

scientific article published on December 1992

HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism

scientific article published on 06 March 2014

HIV-1 transcription is regulated by splicing factor SRSF1.

scientific article published on December 2014

Higher-order epistasis and phenotypic prediction

scientific article published in 2022

Human Immunodeficiency Virus Type 1 hnRNP A/B-Dependent Exonic Splicing Silencer ESSV Antagonizes Binding of U2AF65 to Viral Polypyrimidine Tracts ⬇️

scientific article published on December 1, 2003

Human p32: a coactivator for Epstein-Barr virus nuclear antigen-1-mediated transcriptional activation and possible role in viral latent cycle DNA replication

scientific article

Identification of synaptic targets of Drosophila pumilio

scientific article

Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly

scientific article

Intrinsic differences between authentic and cryptic 5' splice sites

scientific article published on November 2003

Involvement of SR proteins in mRNA surveillance

scientific article published on 01 November 2004

Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition

scientific article

Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing

scientific article

Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides

scientific article

Manipulation of alternative splicing by a newly developed inhibitor of Clks

scientific article (publication date: 4 June 2004)

Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1.

scientific article published in May 2018

Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing

scientific article published on March 1994

Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2.

scientific article published on 19 December 2011

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

scientific article published on May 1993

Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models

scientific article

Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing

scientific article published on December 1989

NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry

scientific article (publication date: 18 August 2000)

Nuclear export and retention signals in the RS domain of SR proteins

scientific article

OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds.

scientific article published on 9 April 2013

Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC.

scientific article published on February 2012

Pathological impact of SMN2 mis-splicing in adult SMA mice

scientific article

Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF.

scientific article published on September 1993

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

scientific article

Pharmacology of a central nervous system delivered 2'-O-methoxyethyl-modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates

scientific article

Pick one, but be quick: 5' splice sites and the problems of too many choices

scientific article published on January 2013

Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors

scientific article published on April 1996

Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing

scientific article published on 01 January 1999

Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing

scientific article

Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP.

scientific article published on December 1998

RCC1 and nuclear organization

scientific article

RNA landscape of evolution for optimal exon and intron discrimination

scholarly article

RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins

scientific article

RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease

scientific article published on 18 December 2014

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

scientific article

Recognition of atypical 5' splice sites by shifted base-pairing to U1 snRNA.

scientific article published on 25 January 2009

Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2

scientific article (publication date: 24 January 1992)

Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock

scientific article

Rescue of gene-expression changes in an induced mouse model of spinal muscular atrophy by an antisense oligonucleotide that promotes inclusion of SMN2 exon 7.

scientific article published on 31 January 2015

Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity

scientific article

S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1.

scientific article published on 27 December 2012

SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control

scientific article

SMN deficiency in severe models of spinal muscular atrophy causes widespread intron retention and DNA damage

scientific article published on 07 March 2017

SR proteins function in coupling RNAP II transcription to pre-mRNA splicing.

scientific article

SRSF1-Regulated Alternative Splicing in Breast Cancer

scientific article

Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer

scientific article published on 18 January 2007

Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1.

scientific article

Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo

scientific article

Short/branched-chain acyl-CoA dehydrogenase deficiency due to an IVS3+3A>G mutation that causes exon skipping

scientific article

SpliceTrap: a method to quantify alternative splicing under single cellular conditions

scientific article

Splicing factor SRSF6 promotes hyperplasia of sensitized skin

scientific article

Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs.

scientific article published in June 1997

Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components

scientific article

Splicing therapeutics in SMN2 and APOB.

scientific article published on April 2009

Splicing-factor alterations in cancers

scientific article published on September 2016

Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence

scientific article published on 7 March 2013

Splicing: still so much to learn

scientific article published on April 2015

Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements

scientific article

Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing

scientific article

TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals

scientific article

Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy

scientific article

The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation

scientific article

The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins.

scientific article

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

scientific article

The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites.

scientific article

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

scientific article

The spliceosome, a potential Achilles heel of MYC-driven tumors

scientific article published on 22 October 2015

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

scientific article published on 15 January 2012

The splicing-factor oncoprotein SF2/ASF activates mTORC1.

scholarly article

The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)

scientific article

The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40.

scientific article

The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor

scientific article

Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing

scientific article published on February 1992

Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing

scientific article (publication date: 12 April 2002)

U1-mediated exon definition interactions between AT-AC and GT-AG introns

scientific article

Where in the cell is the minor spliceosome?

scholarly article

Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides

scientific article published on May 2012

atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes

scientific article

hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing ⬇️

scientific article published on July 1999

hnRNP A1 associates with telomere ends and stimulates telomerase activity

scientific article

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