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List of works by Michelle L Halls

A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

scientific article published on 12 September 2012

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

scientific article published on 28 January 2021

Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu.

scientific article published on February 2012

Comparison of Signaling Pathways Activated by the Relaxin Family Peptide Receptors, RXFP1 and RXFP2, Using Reporter Genes

scientific article published on 27 June 2006

Constitutive formation of an RXFP1‐signalosome: a novel paradigm in GPCR function and regulation ⬇️

scientific article published on March 1, 2012

Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling

scientific article published on 10 April 2012

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

scientific article published on 16 June 2020

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

scientific article published on 30 October 2017

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

scientific article

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner

scientific article published on 6 April 2015

Identification of Binding Sites with Differing Affinity and Potency for Relaxin Analogues on LGR7 and LGR8 Receptors

scientific article published in May 2005

Interaction with Caveolin-1 Modulates G Protein Coupling of Mouse β3-Adrenoceptor ⬇️

scientific article published on April 25, 2012

International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.

scientific article

Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation

scientific article published on April 2009

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks

scientific article published on 12 September 2019

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

scientific article published on 31 March 2020

Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).

scientific article

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

scientific article published on 17 July 2018

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

scientific article published on May 2017

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

article published in the Proceedings of the National Academy of Sciences of the United States of America

RXFP1 couples to the Galpha-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail.

scientific article published on April 2009

Regulation by Ca2+-Signaling Pathways of Adenylyl Cyclases ⬇️

scientific article published on January 1, 2011

Relaxin activates multiple cAMP signaling pathway profiles in different target cells

scientific article

Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.

scientific article

Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms

scientific article

Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways

scientific article

Relaxin family peptide receptors--from orphans to therapeutic targets.

scientific article published on 06 June 2008

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

scientific journal article

Roles of the receptor, the ligand, and the cell in the signal transduction pathways utilized by the relaxin family peptide receptors 1-3.

scientific article published on April 2009

Signal switching after stimulation of LGR7 receptors by human relaxin 2

scientific article

Signaling pathways of the LGR7 and LGR8 receptors determined by reporter genes

scientific article published on May 2005

Signalling in response to sub-picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity

scientific article published on 05 April 2019

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex

scientific article

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells

scientific article

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