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List of works by Manuel Medarde

A fast and simple GC MS method for lignan profiling in Anthriscus sylvestris and biosynthetically related Plant species

scientific article published in December 2001

A new family of quinoline and quinoxaline analogues of combretastatins.

scientific article

Anti-HIV activity of some synthetic lignanolides and intermediates.

scientific article published in September 2004

Antihypertensive activity of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylate enantiomers

scientific article published on 01 February 2000

Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target

scientific article published on 25 October 2018

Biosynthesis of podophyllotoxin in Linum album cell cultures.

scientific article

Conformationally restricted macrocyclic analogues of combretastatins

scientific article published on 4 September 2007

Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization

scientific article published on 26 April 2008

Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes

scientific article published in January 2000

Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins.

scientific article published on 20 March 2013

Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins

scientific article

Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins.

scientific article

Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.

scientific article published on January 2005

Heterolignanolides: antitumor activity of furyl-, thienyl-, and pyridyl analogs of lignanolides

scientific article published on 01 May 1995

Inhibition of the intestinal absorption of bile acids using cationic derivatives: mechanism and repercussions.

scientific article published on 20 October 2006

Inotropic activity of hydroindene amidinohydrazones.

scientific article

Intrinsically fluorescent cytotoxic cisplatin analogues as DNA marker molecules.

scientific article

Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds

scientific article published on 9 July 2009

Leishmanicidal activity of combretastatin analogues and heteroanalogues

scientific article published on 01 September 1999

N-substituted pyrrolinones from enamines and α-dicarbonyls

Naphthalene analogues of lignans

scientific article

Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.

scientific article

New naphthylcombretastatins. Modifications on the ethylene bridge.

scientific article

New para–para Stilbenophanes: Synthesis by McMurry Coupling, Conformational Analysis and Inhibition of Tubulin Polymerisation ⬇️

scientific article published on February 23, 2011

Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases

scientific article published on 28 December 2006

Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake.

scientific article published on 19 January 2007

Open analogues of arcyriaflavin A. Synthesis through Diels-Alder reaction between maleimides and 1-aryl-3-tert-butyldimethylsiloxy-1, 3-butadienes

scientific article published on 01 June 2000

Physiological characteristics of allo-cholic acid

scientific article

Pyridine Based Antitumour Compounds Acting at the Colchicine Site.

scientific article published on January 2016

Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines.

scientific article published on 30 November 2006

Sesquiterpene Lactones from Leucanthemopsis pectinata

scientific article published on 01 April 1988

Structural characterization, kinetic studies, and in vitro biological activity of new cis-diamminebis-cholylglycinate(O,O') Pt(II) and cis-diamminebis-ursodeoxycholate(O,O') Pt(II) complexes.

scientific article

Synthesis and Characterization of the New Cytostatic Complexcis-Diammineplatinum(II)−Chlorocholylglycinate

scientific article published on 01 July 1997

Synthesis and biological activity of bromolignans and cyclolignans

scientific article published on 01 July 1993

Synthesis and biological activity of naphthalene analogues of phenstatins: naphthylphenstatins

scientific article published on 30 March 2007

Synthesis and cytotoxic activities of analogues of thuriferic acid

scientific article published in February 2002

Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues.

scientific article

Synthesis and inotropic activity of hydroindene derivatives

scientific article published on 01 December 1999

Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins

scientific article published on 01 August 1999

Synthesis of Enantiopure 2,3,8,8a- Tetrahydro-7H-oxazolo[3,2-a]pyridine Derivatives†

scientific article published on 01 March 1996

Synthesis, antitumoral and antiviral evaluation of halo- and demethyl-yatein derivatives

scientific article published on 01 September 1995

Trypanosoma cruzi: Inhibition of Parasite Growth and Respiration by Oxazolo(thiazolo)pyridine Derivatives and Its Relationship to Redox Potential and Lipophilicity

scientific article published on 01 September 2001

p,p-Dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin inhibition

scientific article

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