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List of works by Lena Alexopoulou

A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity

scientific article published on 17 April 2007

A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling

scientific article published on 01 October 1997

A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity

scientific article published on 21 May 2012

Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3.

scientific article published in July 2004

Arthritogenic properties of double-stranded (viral) RNA.

scientific article published in May 2004

Brucella abortus induces Irgm3 and Irga6 expression via type-I IFN by a MyD88-dependent pathway, without the requirement of TLR2, TLR4, TLR5 and TLR9.

scientific article published on 9 September 2009

Brucella control of dendritic cell maturation is dependent on the TIR-containing protein Btp1.

scientific article

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

scientific article published on 08 July 2013

Complementation of Lymphotoxin α Knockout Mice with Tumor Necrosis Factor–expressing Transgenes Rectifies Defective Splenic Structure and Function ⬇️

scientific article published on August 17, 1998

Contribution of TLR7 and TLR9 signaling to the susceptibility of MyD88-deficient mice to myocarditis

scientific article published on 01 June 2010

Contribution of microbial-associated molecules in innate mucosal responses.

scientific article

Cutting edge: Priming of NK cells by IL-18.

scientific article published on August 2008

Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection

scientific article published on February 2006

Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia

scientific article published on 9 June 2006

Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis.

scientific article

Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice.

scientific article published on April 1996

Does Toll-like receptor 3 play a biological role in virus infections?

scientific article published in May 2004

Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways

scientific journal article

Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules

scientific article published in September 2004

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

scientific journal article

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis

article

Inflammatory regulation by TLR3 in acute hepatitis

scientific article published on 26 August 2009

Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.

scientific article

Innate immunity and apoptosis in IBD.

scientific article published on February 2004

Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.

scientific article

Investigating TLR signaling responses in murine dendritic cells upon bacterial infection

article

Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice

scientific article published on June 2009

Lupus Autoimmunity and Metabolic Parameters Are Exacerbated Upon High Fat Diet-Induced Obesity Due to TLR7 Signaling

scientific article published on 04 September 2019

Microglia recognize double-stranded RNA via TLR3.

scientific article published in March 2006

Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila

scientific article published on 8 September 2008

Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum

scientific article

Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro

scientific article published on 2 November 2010

Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

scientific article

Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis

scientific article

PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation

scientific article

Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice

scientific article published on 01 July 1997

Protective role of membrane tumour necrosis factor in the host's resistance to mycobacterial infection

scientific article published on 09 June 2008

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

scientific article (publication date: 18 October 2001)

Recognition of single-stranded RNA viruses by Toll-like receptor 7

scientific article

Resurrection of endogenous retroviruses in antibody-deficient mice

scientific article

Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines.

scientific article published on 04 December 2008

Role of Toll-like receptor 13 in innate immune recognition of group B streptococci

scientific article

Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells

scientific article published on 12 January 2010

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.

scientific article published on 11 April 2017

TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses

scientific article published in December 2004

TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA

scientific article published on 16 July 2010

TLR3 deletion limits mortality and disease severity due to Phlebovirus infection.

scientific article published on November 2006

TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules

scientific article

TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice

scientific article published on 21 October 2016

TLR8 deficiency leads to autoimmunity in mice

scientific article

TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice

scientific article published on 13 January 2014

TNF-alpha transgenic and knockout models of CNS inflammation and degeneration

scientific article published on February 1997

The Role of Toll-Like Receptors 3 and 9 in the Development of Autoimmune Diabetes in NOD Mice

article

The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity

scientific article

The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling

scientific article published on 7 September 2016

Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals

scientific article

Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury

scientific article published on 25 August 2006

Toll-like receptor 3 promotes cross-priming to virus-infected cells.

scientific article

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

scientific article

Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis.

scientific article

Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity

scientific article published in October 2006

Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoclastogenesis

scientific article published on September 2000

Tumour necrosis factors in immune regulation: everything that's interesting is...new!

scientific article published on October 1996

Type I interferon induction is detrimental during infection with the Whipple's disease bacterium, Tropheryma whipplei

scientific article

Unexpected protective role for Toll-like receptor 3 in the arterial wall

scientific article

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

scientific article published on 16 November 2003

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.

scientific article

[Toll-like receptor 8: the awkward TLR]

scientific article published on 27 January 2012

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