List of works - Tirso Pons

A common structural scaffold in CTD phosphatases that supports distinct catalytic mechanisms.

scientific article published on 10 September 2013

A novel sea anemone peptide that inhibits acid-sensing ion channels

scientific article published on 10 June 2013

Akirins in sea lice: first steps towards a deeper understanding

scientific article published on 10 July 2013

Association Between Germline Mutations in BRF1, a Subunit of the RNA Polymerase III Transcription Complex, and Hereditary Colorectal Cancer.

scientific article

Beta-propellers: associated functions and their role in human diseases.

scientific article

Characterization and comparative 3D modeling of CmPI-II, a novel 'non-classical' Kazal-type inhibitor from the marine snail Cenchritis muricatus (Mollusca).

scientific article published in November 2007

Cloning and sequence analysis of the gene encoding invertase (INV1) from the yeast Candida utilis

scientific article published in September 1998

Comparison of algorithms for the detection of cancer drivers at subgene resolution

scientific article published on 17 July 2017

Computational biology in Cuba: an opportunity to promote science in a developing country

scientific article

Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design

scientific article

Crystal structure of levansucrase from the Gram-negative bacterium Gluconacetobacter diazotrophicus

scientific article

Effect of divalent cations on the porcine kidney cortex membrane-bound form of dipeptidyl peptidase IV

scientific article published on 17 November 2010

Effect of zinc and calcium ions on the rat kidney membrane-bound form of dipeptidyl peptidase IV.

scientific article

Elucidating the molecular basis of MSH2-deficient tumors by combined germline and somatic analysis.

scientific article published on 2 June 2017

Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans

scientific article published on 24 November 2018

Exome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of anti-angiogenic therapies.

scientific article published on 27 March 2018

FlgM anti-sigma factors: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships

scientific article published on 4 May 2006

Functional analysis of archaeal MBF1 by complementation studies in yeast

scientific article

Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking

scientific article published on 05 September 2019

Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair.

scientific article

Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis

scientific article published on 15 February 2018

Germline variation in O6-methylguanine-DNA methyltransferase (MGMT) as cause of hereditary colorectal cancer

scientific article published on 21 January 2019

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis

article

Homology modeling, model and software evaluation: three related resources ⬇️

scientific article published on January 1, 1998

Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels

scientific article published on 21 June 2021

In silico studies of potential phosphoresidues in the human nucleophosmin/B23: its kinases and related biological processes

scientific article published on 01 July 2012

KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily

scientific article

MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation/non-compaction and are associated with Ménétrier-like gastropathy

scientific article published on 23 December 2016

Molecular cloning of an alpha-glucosidase-like gene from Penicillium minioluteum and structure prediction of its gene product.

scientific article

NMR structure and dynamics of Q4D059, a kinetoplastid-specific and conserved protein from Trypanosoma cruzi

scientific article

New aspects concerning to the characterization and the relationship with the immune response in vivo of the spiny lobster Panulirus argus nitric oxide synthase.

scientific article

New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket.

scientific article published on 22 July 2010

New parameterization approaches of the LIE method to improve free energy calculations of PlmII-Inhibitors complexes

scientific article published on November 2010

POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance

scientific article

PhcrTx2, a New Crab-Paralyzing Peptide Toxin from the Sea Anemone Phymanthus crucifer.

scientific article published on 7 February 2018

Physico-chemical studies of molecular interactions between non-ionic surfactants and bovine serum albumin

scientific article published on 4 September 2009

Predicting Protein Relationships to Human Pathways through a Relational Learning Approach Based on Simple Sequence Features

scientific article published on July 2014

Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations.

scientific article published in November 2008

Predicting functional residues of the Solanum lycopersicum aspartic protease inhibitor (SLAPI) by combining sequence and structural analysis with molecular docking

scientific article published on 20 November 2011

Prediction of a common beta-propeller catalytic domain for fructosyltransferases of different origin and substrate specificity

scientific article published on November 2000

Role of MDH2 pathogenic variant in pheochromocytoma and paraganglioma patients

scientific article published on 16 July 2018

Somatic Embryonic FGFR2 Mutations in Keratinocytic Epidermal Nevi.

scientific article

Structural model for family 32 of glycosyl-hydrolase enzymes

scientific article published on 01 November 1998

Structural model of Dex protein from Penicillium minioluteum and its implications in the mechanism of catalysis

scientific article published in June 1998

Structure of the recombinant BPTI/Kunitz-type inhibitorrShPI-1A from the marine invertebrateStichodactyla helianthus

scientific article

Structure-PPi: a module for the annotation of cancer-related single-nucleotide variants at protein-protein interfaces

scientific article

Structures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: Could the aspartic protease inhibition have evolved from a canonical serine protease-binding loop?

scientific article

The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels

scientific article published on 13 April 2016

The cattle tick antigen, Bm95, expressed in Pichia pastoris contains short chains of N- and O-glycans

scientific article published on 01 December 2004

Three acidic residues are at the active site of a beta-propeller architecture in glycoside hydrolase families 32, 43, 62, and 68.

scientific article published in February 2004

Towards a detailed atlas of protein–protein interactions ⬇️

scientific article published on July 26, 2013

Two aspartate residues at the putative p10 subunit of a type II metacaspase from Nicotiana tabacum L. may contribute to the substrate-binding pocket.

scientific article published in January 2014

Unraveling the binding mechanism of polyoxyethylene sorbitan esters with bovine serum albumin: a novel theoretical model based on molecular dynamic simulations.

scientific article

Validation of a mutant of the pore-forming toxin sticholysin-I for the construction of proteinase-activated immunotoxins.

scientific article published on 4 February 2011

wKinMut-2: Identification and Interpretation of Pathogenic Variants in Human Protein Kinases.

scientific article published on 7 October 2015

List of works by Tirso Pons

A common structural scaffold in CTD phosphatases that supports distinct catalytic mechanisms.

A novel sea anemone peptide that inhibits acid-sensing ion channels

Akirins in sea lice: first steps towards a deeper understanding

Association Between Germline Mutations in BRF1, a Subunit of the RNA Polymerase III Transcription Complex, and Hereditary Colorectal Cancer.

Beta-propellers: associated functions and their role in human diseases.

Characterization and comparative 3D modeling of CmPI-II, a novel 'non-classical' Kazal-type inhibitor from the marine snail Cenchritis muricatus (Mollusca).

Cloning and sequence analysis of the gene encoding invertase (INV1) from the yeast Candida utilis

Comparison of algorithms for the detection of cancer drivers at subgene resolution

Computational biology in Cuba: an opportunity to promote science in a developing country

Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design

Crystal structure of levansucrase from the Gram-negative bacterium Gluconacetobacter diazotrophicus

Effect of divalent cations on the porcine kidney cortex membrane-bound form of dipeptidyl peptidase IV

Effect of zinc and calcium ions on the rat kidney membrane-bound form of dipeptidyl peptidase IV.

Elucidating the molecular basis of MSH2-deficient tumors by combined germline and somatic analysis.

Evidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans

Exome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of anti-angiogenic therapies.

FlgM anti-sigma factors: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships

Functional analysis of archaeal MBF1 by complementation studies in yeast

Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking

Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair.

Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis

Germline variation in O6-methylguanine-DNA methyltransferase (MGMT) as cause of hereditary colorectal cancer

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis

Homology modeling, model and software evaluation: three related resources ⬇️

Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels

In silico studies of potential phosphoresidues in the human nucleophosmin/B23: its kinases and related biological processes

KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily

MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation/non-compaction and are associated with Ménétrier-like gastropathy

Molecular cloning of an alpha-glucosidase-like gene from Penicillium minioluteum and structure prediction of its gene product.

NMR structure and dynamics of Q4D059, a kinetoplastid-specific and conserved protein from Trypanosoma cruzi

New aspects concerning to the characterization and the relationship with the immune response in vivo of the spiny lobster Panulirus argus nitric oxide synthase.

New members of the brachyurins family in lobster include a trypsin-like enzyme with amino acid substitutions in the substrate-binding pocket.

New parameterization approaches of the LIE method to improve free energy calculations of PlmII-Inhibitors complexes

POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance

PhcrTx2, a New Crab-Paralyzing Peptide Toxin from the Sea Anemone Phymanthus crucifer.

Physico-chemical studies of molecular interactions between non-ionic surfactants and bovine serum albumin

Predicting Protein Relationships to Human Pathways through a Relational Learning Approach Based on Simple Sequence Features

Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations.

Predicting functional residues of the Solanum lycopersicum aspartic protease inhibitor (SLAPI) by combining sequence and structural analysis with molecular docking

Prediction of a common beta-propeller catalytic domain for fructosyltransferases of different origin and substrate specificity

Role of MDH2 pathogenic variant in pheochromocytoma and paraganglioma patients

Somatic Embryonic FGFR2 Mutations in Keratinocytic Epidermal Nevi.

Structural model for family 32 of glycosyl-hydrolase enzymes

Structural model of Dex protein from Penicillium minioluteum and its implications in the mechanism of catalysis

Structure of the recombinant BPTI/Kunitz-type inhibitorrShPI-1A from the marine invertebrateStichodactyla helianthus

Structure-PPi: a module for the annotation of cancer-related single-nucleotide variants at protein-protein interfaces

Structures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: Could the aspartic protease inhibition have evolved from a canonical serine protease-binding loop?

The Kunitz-Type Protein ShPI-1 Inhibits Serine Proteases and Voltage-Gated Potassium Channels

The cattle tick antigen, Bm95, expressed in Pichia pastoris contains short chains of N- and O-glycans

Three acidic residues are at the active site of a beta-propeller architecture in glycoside hydrolase families 32, 43, 62, and 68.

Towards a detailed atlas of protein–protein interactions ⬇️

Two aspartate residues at the putative p10 subunit of a type II metacaspase from Nicotiana tabacum L. may contribute to the substrate-binding pocket.

Unraveling the binding mechanism of polyoxyethylene sorbitan esters with bovine serum albumin: a novel theoretical model based on molecular dynamic simulations.

Validation of a mutant of the pore-forming toxin sticholysin-I for the construction of proteinase-activated immunotoxins.

wKinMut-2: Identification and Interpretation of Pathogenic Variants in Human Protein Kinases.