List of works - James B Konopka

A Candida albicans temperature-sensitive cdc12-6 mutant identifies roles for septins in selection of sites of germ tube formation and hyphal morphogenesis

scientific article

A microdomain formed by the extracellular ends of the transmembrane domains promotes activation of the G protein-coupled alpha-factor receptor

scientific article

A photostable green fluorescent protein variant for analysis of protein localization in Candida albicans

scientific article

Accessibility of cysteine residues substituted into the cytoplasmic regions of the alpha-factor receptor identifies the intracellular residues that are available for G protein interaction.

scientific article published on 6 December 2006

Activation of the abl oncogene in murine and human leukemias.

scientific article

An N-acetylglucosamine transporter required for arbuscular mycorrhizal symbioses in rice and maize.

scientific article published on 26 May 2017

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.

scientific article

Aromatic residues at the extracellular ends of transmembrane domains 5 and 6 promote ligand activation of the G protein-coupled alpha-factor receptor

scientific article published in January 2003

BAR domain proteins Rvs161 and Rvs167 contribute to Candida albicans endocytosis, morphogenesis, and virulence

scientific article published on 13 July 2009

Candida albicans rvs161Δ and rvs167Δ Endocytosis Mutants Are Defective in Invasion into the Oral Cavity ⬇️

scientific article published on 12 November 2019

Candida albicans septin mutants are defective for invasive growth and virulence ⬇️

scientific article

Candida here, and Candida there, and Candida everywhere!

scientific article published on 01 June 2008

Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth

scientific article

Clathrin- and Arp2/3-independent endocytosis in the fungal pathogen Candida albicans

scientific article published on 27 August 2013

Combining mutations in the incoming and outgoing pheromone signal pathways causes a synergistic mating defect in Saccharomyces cerevisiae

scientific article published on 01 June 1999

Comparison of class A and D G protein-coupled receptors: common features in structure and activation

scientific article

DEP-domain-mediated regulation of GPCR signaling responses.

scientific article

Distinct roles of cell wall biogenesis in yeast morphogenesis as revealed by multivariate analysis of high-dimensional morphometric data

scientific article

Eisosomes promote the ability of Sur7 to regulate plasma membrane organization in Candida albicans

scientific article published on 23 March 2016

Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids".

scientific article published on 13 March 2018

Expression of a translocated c-abl gene in hybrids of mouse fibroblasts and chronic myelogenous leukaemia cells.

scientific article

Flavodoxin-Like Proteins Protect Candida albicans from Oxidative Stress and Promote Virulence.

scientific article published on September 2015

Functional assays for mammalian G-protein-coupled receptors in yeast

scientific article published in January 2002

Functional expression of mammalian receptors and membrane channels in different cells

scientific article published on 3 February 2007

Fungal membrane organization: the eisosome concept.

scientific article published on 18 June 2014

Genetic Analysis of Family Transcription Factors in Using New CRISPR-Cas9 Approaches

scientific article published on 21 November 2018

Hyphal growth in Candida albicans does not require induction of hyphal-specific gene expression

scientific article

Identification of GIG1, a GlcNAc-induced gene in Candida albicans needed for normal sensitivity to the chitin synthase inhibitor nikkomycin Z.

scientific article

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

scientific article published on 23 June 2015

Identification of amino acids at two dimer interface regions of the alpha-factor receptor (Ste2).

scientific article published in August 2009

Identification of an N-acetylglucosamine transporter that mediates hyphal induction in Candida albicans.

scientific article published on 27 December 2006

Identification of residues that contribute to receptor activation through the analysis of compensatory mutations in the G protein-coupled alpha-factor receptor

scientific article published in February 2005

Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans

scientific article published on 16 August 2021

Interaction between transmembrane domains five and six of the alpha -factor receptor

scientific article published on 01 August 2000

Iqg1p links spatial and secretion landmarks to polarity and cytokinesis

scientific article

Lipid raft polarization contributes to hyphal growth in Candida albicans

scientific article

MCC/Eisosomes Regulate Cell Wall Synthesis and Stress Responses in Fungi

scientific article published on 3 November 2017

Membrane Compartment Occupied by Can1 (MCC) and Eisosome Subdomains of the Fungal Plasma Membrane.

scientific article published on December 2011

Modulating Host Signaling Pathways to Promote Resistance to Infection by Candida albicans

scientific article published on 21 November 2017

Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.

scientific article published on June 1996

Mutational analysis of the role of N-glycosylation in alpha-factor receptor function

scientific article published on 01 August 2001

N-Acetylglucosamine Metabolism Promotes Survival of Candida albicans in the Phagosome

scientific article published on 6 September 2017

N-acetylglucosamine (GlcNAc) functions in cell signaling

scientific article published on January 2012

N-acetylglucosamine (GlcNAc) induction of hyphal morphogenesis and transcriptional responses in Candida albicans are not dependent on its metabolism

scientific article

N-acetylglucosamine (GlcNAc) triggers a rapid, temperature-responsive morphogenetic program in thermally dimorphic fungi.

scientific article

N-acetylglucosamine Regulates Virulence Properties in Microbial Pathogens

scientific article (publication date: July 2015)

Novel roles for GlcNAc in cell signaling

scientific article

Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic Candida albicans Infection

scientific article published on 17 April 2018

Plasma Membrane MCC/Eisosome Domains Promote Stress Resistance in Fungi

scientific article published on 16 September 2020

Plasma membrane architecture protects Candida albicans from killing by copper

scientific article published on 11 January 2019

Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans

scientific article published on 27 February 2016

Protection from systemic Candida albicans infection by inactivation of the Sts phosphatases

scientific article

Raft-like membrane domains in pathogenic microorganisms.

scientific article published on 11 April 2015

Recognition of yeast by murine macrophages requires mannan but not glucan

scientific article

Regulation of Hyphal Growth and N-Acetylglucosamine Catabolism by Two Transcription Factors in Candida albicans.

scientific article

S. cerevisiae alpha pheromone receptors activate a novel signal transduction pathway for mating partner discrimination

scientific article published on 01 October 1991

SUMO modification of septin-interacting proteins in Candida albicans

scientific article published on 23 July 2004

Saccharomyces cerevisiae Afr1 protein is a protein phosphatase 1/Glc7-targeting subunit that regulates the septin cytoskeleton during mating.

scientific article

Scanning mutagenesis of regions in the Galpha protein Gpa1 that are predicted to interact with yeast mating pheromone receptors

scientific article published on 24 September 2007

Septin function in Candida albicans morphogenesis.

scientific article

Septin function in yeast model systems and pathogenic fungi.

scientific article

Sterol-rich plasma membrane domains in fungi.

scientific article published on 16 March 2007

Strategies for isolating constitutively active and dominant-negative pheromone receptor mutants in yeast

scientific article published on January 2010

Successful expression of a functional yeast G-protein-coupled receptor (Ste2) in mammalian cells.

scientific article published on April 2005

Sur7 promotes plasma membrane organization and is needed for resistance to stressful conditions and to the invasive growth and virulence of Candida albicans. ⬇️

scientific article published on 27 December 2011

The C-terminus of the S. cerevisiae alpha-pheromone receptor mediates an adaptive response to pheromone

scientific article published on 01 August 1988

The Candida albicans Sur7 protein is needed for proper synthesis of the fibrillar component of the cell wall that confers strength.

scientific article

The MARVEL domain protein Nce102 regulates actin organization and invasive growth of Candida albicans ⬇️

scientific article

The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicans

scientific article

The Sur7 protein resides in punctate membrane subdomains and mediates spatial regulation of cell wall synthesis in Candida albicans

scientific article published on January 2009

The cytoplasmic end of transmembrane domain 3 regulates the activity of the Saccharomyces cerevisiae G-protein-coupled alpha-factor receptor

scientific article

The mitochondrial protein Mcu1 plays important roles in carbon source utilization, filamentation, and virulence in Candida albicans

scientific article published on 24 January 2015

The pheromone signal pathway in Saccharomyces cerevisiae

scientific article published on August 1, 1992

Two New S-Phase-Specific Genes from Saccharomyces cerevisiae ⬇️

scientific article published on September 15, 1997

cAMP-independent signal pathways stimulate hyphal morphogenesis in Candida albicans

scientific article

List of works by James B Konopka

A Candida albicans temperature-sensitive cdc12-6 mutant identifies roles for septins in selection of sites of germ tube formation and hyphal morphogenesis

A microdomain formed by the extracellular ends of the transmembrane domains promotes activation of the G protein-coupled alpha-factor receptor

A photostable green fluorescent protein variant for analysis of protein localization in Candida albicans

Accessibility of cysteine residues substituted into the cytoplasmic regions of the alpha-factor receptor identifies the intracellular residues that are available for G protein interaction.

Activation of the abl oncogene in murine and human leukemias.

An N-acetylglucosamine transporter required for arbuscular mycorrhizal symbioses in rice and maize.

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.

Aromatic residues at the extracellular ends of transmembrane domains 5 and 6 promote ligand activation of the G protein-coupled alpha-factor receptor

BAR domain proteins Rvs161 and Rvs167 contribute to Candida albicans endocytosis, morphogenesis, and virulence

Candida albicans rvs161Δ and rvs167Δ Endocytosis Mutants Are Defective in Invasion into the Oral Cavity ⬇️

Candida albicans septin mutants are defective for invasive growth and virulence ⬇️

Candida here, and Candida there, and Candida everywhere!

Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth

Clathrin- and Arp2/3-independent endocytosis in the fungal pathogen Candida albicans

Combining mutations in the incoming and outgoing pheromone signal pathways causes a synergistic mating defect in Saccharomyces cerevisiae

Comparison of class A and D G protein-coupled receptors: common features in structure and activation

DEP-domain-mediated regulation of GPCR signaling responses.

Distinct roles of cell wall biogenesis in yeast morphogenesis as revealed by multivariate analysis of high-dimensional morphometric data

Eisosomes promote the ability of Sur7 to regulate plasma membrane organization in Candida albicans

Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids".

Expression of a translocated c-abl gene in hybrids of mouse fibroblasts and chronic myelogenous leukaemia cells.

Flavodoxin-Like Proteins Protect Candida albicans from Oxidative Stress and Promote Virulence.

Functional assays for mammalian G-protein-coupled receptors in yeast

Functional expression of mammalian receptors and membrane channels in different cells

Fungal membrane organization: the eisosome concept.

Genetic Analysis of Family Transcription Factors in Using New CRISPR-Cas9 Approaches

Hyphal growth in Candida albicans does not require induction of hyphal-specific gene expression

Identification of GIG1, a GlcNAc-induced gene in Candida albicans needed for normal sensitivity to the chitin synthase inhibitor nikkomycin Z.

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

Identification of amino acids at two dimer interface regions of the alpha-factor receptor (Ste2).

Identification of an N-acetylglucosamine transporter that mediates hyphal induction in Candida albicans.

Identification of residues that contribute to receptor activation through the analysis of compensatory mutations in the G protein-coupled alpha-factor receptor

Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans

Interaction between transmembrane domains five and six of the alpha -factor receptor

Iqg1p links spatial and secretion landmarks to polarity and cytokinesis

Lipid raft polarization contributes to hyphal growth in Candida albicans

MCC/Eisosomes Regulate Cell Wall Synthesis and Stress Responses in Fungi

Membrane Compartment Occupied by Can1 (MCC) and Eisosome Subdomains of the Fungal Plasma Membrane.

Modulating Host Signaling Pathways to Promote Resistance to Infection by Candida albicans

Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.

Mutational analysis of the role of N-glycosylation in alpha-factor receptor function

N-Acetylglucosamine Metabolism Promotes Survival of Candida albicans in the Phagosome

N-acetylglucosamine (GlcNAc) functions in cell signaling

N-acetylglucosamine (GlcNAc) induction of hyphal morphogenesis and transcriptional responses in Candida albicans are not dependent on its metabolism

N-acetylglucosamine (GlcNAc) triggers a rapid, temperature-responsive morphogenetic program in thermally dimorphic fungi.

N-acetylglucosamine Regulates Virulence Properties in Microbial Pathogens

Novel roles for GlcNAc in cell signaling

Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic Candida albicans Infection

Plasma Membrane MCC/Eisosome Domains Promote Stress Resistance in Fungi

Plasma membrane architecture protects Candida albicans from killing by copper

Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans

Protection from systemic Candida albicans infection by inactivation of the Sts phosphatases

Raft-like membrane domains in pathogenic microorganisms.

Recognition of yeast by murine macrophages requires mannan but not glucan

Regulation of Hyphal Growth and N-Acetylglucosamine Catabolism by Two Transcription Factors in Candida albicans.

S. cerevisiae alpha pheromone receptors activate a novel signal transduction pathway for mating partner discrimination

SUMO modification of septin-interacting proteins in Candida albicans

Saccharomyces cerevisiae Afr1 protein is a protein phosphatase 1/Glc7-targeting subunit that regulates the septin cytoskeleton during mating.

Scanning mutagenesis of regions in the Galpha protein Gpa1 that are predicted to interact with yeast mating pheromone receptors

Septin function in Candida albicans morphogenesis.

Septin function in yeast model systems and pathogenic fungi.

Sterol-rich plasma membrane domains in fungi.

Strategies for isolating constitutively active and dominant-negative pheromone receptor mutants in yeast

Successful expression of a functional yeast G-protein-coupled receptor (Ste2) in mammalian cells.

Sur7 promotes plasma membrane organization and is needed for resistance to stressful conditions and to the invasive growth and virulence of Candida albicans. ⬇️

The C-terminus of the S. cerevisiae alpha-pheromone receptor mediates an adaptive response to pheromone

The Candida albicans Sur7 protein is needed for proper synthesis of the fibrillar component of the cell wall that confers strength.

The MARVEL domain protein Nce102 regulates actin organization and invasive growth of Candida albicans ⬇️

The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicans

The Sur7 protein resides in punctate membrane subdomains and mediates spatial regulation of cell wall synthesis in Candida albicans

The cytoplasmic end of transmembrane domain 3 regulates the activity of the Saccharomyces cerevisiae G-protein-coupled alpha-factor receptor

The mitochondrial protein Mcu1 plays important roles in carbon source utilization, filamentation, and virulence in Candida albicans

The pheromone signal pathway in Saccharomyces cerevisiae

Two New S-Phase-Specific Genes from Saccharomyces cerevisiae ⬇️

cAMP-independent signal pathways stimulate hyphal morphogenesis in Candida albicans