List of works by Ming-Daw Tsai

A DNA polymerase with specificity for five base pairs

scientific article published on February 2001

A calorimetric study of the thermotropic behavior of pure sphingomyelin diastereomers

scientific article published on 01 August 1987

A low-barrier hydrogen bond between histidine of secreted phospholipase A2 and a transition state analog inhibitor

scientific article

A novel calcium-dependent bacterial phosphatidylinositol-specific phospholipase C displaying unprecedented magnitudes of thio effect, inverse thio effect, and stereoselectivity

scientific article published on 01 January 2003

A novel expression vector for high-level synthesis and secretion of foreign proteins in Escherichia coli: overproduction of bovine pancreatic phospholipase A2.

scientific article published in September 1990

A small, high-copy-number vector suitable for both in vitro and in vivo gene expression

scientific article published on 01 December 1994

A unified kinetic mechanism applicable to multiple DNA polymerases.

scientific article published on 10 April 2007

A unique flavin mononucleotide-linked primary alcohol oxidase for glycopeptide A40926 maturation

scientific article published on 13 October 2007

AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633

scientific article published on 8 January 2009

Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells

scientific article published on 29 January 2016

Amino acid substitutions of MagA in Klebsiella pneumoniae affect the biosynthesis of the capsular polysaccharide

scientific article

An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4

scientific article published on 01 November 2003

Ankyrin repeat: a unique motif mediating protein-protein interactions.

scientific article

Applicability of the phosphorus-31 (oxygen-17) nuclear magnetic resonance method in the study of enzyme mechanism involving phosphorus

scientific article published on 01 July 1980

Application of Brønsted-type LFER in the study of the phospholipase C mechanism

scientific article published in March 2003

Are D- and L-chiro-phosphoinositides substrates of phosphatidylinositol-specific phospholipase C?

scientific article

Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA.

scientific article published on 10 November 2016

Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA

scientific article published on 13 December 2018

Binding proteins on synaptic membranes for certain phospholipases A2 with presynaptic toxicity.

scientific article published on January 1996

Binding proteins on synaptic membranes for crotoxin and taipoxin, two phospholipases A2 with neurotoxicity

scientific article published on 01 April 1995

Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms

scientific article

Catalytic Mechanism of DNA Polymerases - Two Metal Ions or Three?

scientific article published on 20 December 2018

Cationic residues 53 and 56 control the anion-induced interfacial k*cat activation of pancreatic phospholipase A2

scientific article published on 01 June 1998

Chiral Methyl Groups ⬇️

scientific article published on January 1, 1979

Conformation-reactivity relationship for pyridoxal Schiff's bases. Rates of racemization and alpha-hydrogen exchange of the pyridoxal Schiff's bases of amino acids

scientific article published in August 1978

Conformational analysis of pyridoxal Schiff's bases. Nuclear magnetic resonance studies of the conformations about the C4-C4', Calpha-Cbeta, and N-Calpha bonds of the pyridoxal Schiff's bases of amino acids

scientific article published on 01 August 1978

Contribution of the reverse rate of the conformational step to polymerase beta fidelity

scientific article published in April 2009

Contributions of conserved TPLH tetrapeptides to the conformational stability of ankyrin repeat proteins.

scientific article

Contributions of residues of pancreatic phospholipase A2 to interfacial binding, catalysis, and activation

scientific article published on 01 April 1999

Conversion of bovine pancreatic phospholipase A2 at a single site into a competitor of neurotoxic phospholipases A2 by site-directed mutagenesis.

scientific article published on February 1995

Crystal structure of the Y52F/Y73F double mutant of phospholipase A2: increased hydrophobic interactions of the phenyl groups compensate for the disrupted hydrogen bonds of the tyrosines

scientific article published on December 1992

DNA polymerase beta: analysis of the contributions of tyrosine-271 and asparagine-279 to substrate specificity and fidelity of DNA replication by pre-steady-state kinetics

scientific article published on April 1997

DNA polymerase beta: contributions of template-positioning and dNTP triphosphate-binding residues to catalysis and fidelity

scientific article published on 01 December 2000

DNA polymerase beta: effects of gapped DNA substrates on dNTP specificity, fidelity, processivity and conformational changes

scientific article published on April 1998

DNA polymerase beta: multiple conformational changes in the mechanism of catalysis

scientific article published on 01 September 1997

DNA polymerase beta: pre-steady-state kinetic analyses of dATP alpha S stereoselectivity and alteration of the stereoselectivity by various metal ions and by site-directed mutagenesis

scientific article published in July 2001

DNA polymerase beta: pre-steady-state kinetic analysis and roles of arginine-283 in catalysis and fidelity.

scientific article

Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade

scientific article

Direct binding of the N-terminus of HTLV-1 tax oncoprotein to cyclin-dependent kinase 4 is a dominant path to stimulate the kinase activity

scientific article published in June 2003

Disrupting the Conserved Salt Bridge in the Trimerization of Influenza A Nucleoprotein

scientific article published on 17 December 2019

Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.

scientific article published on 22 August 2007

Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation

scientific article published on 12 June 2003

Does the magnesium(II) ion interact with the alpha-phosphate of adenosine triphosphate? An investigation by oxygen-17 nuclear magnetic resonance

scientific article published on 01 March 1982

E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors

scientific article

Engineering a catalytic metal binding site into a calcium-independent phosphatidylinositol-specific phospholipase C leads to enhanced stereoselectivity

scientific article published in March 2003

Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A.

scientific article published in May 2003

FHA domain-ligand interactions: importance of integrating chemical and biological approaches

scientific article

FHA: a signal transduction domain with diverse specificity and function

scientific article published on 01 July 2002

Fha interaction with phosphothreonine of TssL activates type VI secretion in Agrobacterium tumefaciens

scientific article (publication date: March 2014)

Frequent p16INK4A/CDKN2A alterations in chemically induced Syrian golden hamster pancreatic tumors

scientific article published on 6 November 2003

Functions of some capsular polysaccharide biosynthetic genes in Klebsiella pneumoniae NTUH K-2044.

scientific article

Gene library synthesis by structure-based combinatorial protein engineering.

scientific article

Glycopeptide Biosynthesis: Dbv21/Orf2* fromdbv/tcpGene Clusters AreN-Ac-Glm Teicoplanin Pseudoaglycone Deacetylases and Orf15 fromcepGene Cluster Is a Glc-1-P Thymidyltransferase

article

How DNA polymerases catalyze DNA replication, repair, and mutation.

scientific article

How a low-fidelity DNA polymerase chooses non-Watson-Crick from Watson-Crick incorporation

scientific article

Human DNA Polymerase μ Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions

scientific article published on 17 May 2019

Human DNA ligase IV and the ligase IV/XRCC4 complex: analysis of nick ligation fidelity.

scientific article published on 04 April 2007

Human p16gamma, a novel transcriptional variant of p16(INK4A), coexpresses with p16(INK4A) in cancer cells and inhibits cell-cycle progression.

scientific article published on 7 May 2007

Identification of histone demethylases in Saccharomyces cerevisiae.

scientific article

Identification of in vivo phosphorylation sites and their functional significance in the sodium iodide symporter.

scientific article

Identification of potential binding sites for the FHA domain of human Chk2 by in vitro binding studies.

scientific article

Immunogenicity and conformational properties of an N-linked glycosylated peptide epitope of human T-lymphotropic virus type 1 (HTLV-I).

scientific article published in January 1995

Interaction of monodisperse anionic amphiphiles with the i-face of secreted phospholipase A2.

scientific article published in May 2003

Interfacial catalysis by phospholipase A2: the rate-limiting step for enzymatic turnover

scientific article

Interfacial enzymology: the secreted phospholipase A(2)-paradigm.

scientific article

Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activation

scientific article

Investigation of the conformational states of Wzz and the Wzz.O-antigen complex under near-physiological conditions.

scientific article published on 27 September 2007

Involvement of the Arg-Asp-His catalytic triad in enzymatic cleavage of the phosphodiester bond

scientific article published in May 2001

Is the binding of magnesium (II) to calmodulin significant? An investigation by magnesium-25 nuclear magnetic resonance

scientific article published on 01 June 1987

JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells

scientific article

Kinetic Isotope Effects and Stereochemical Studies on a Ribonuclease Model: Hydrolysis Reactions of Uridine 3'-Nitrophenyl Phosphate

scientific article published on 01 June 2000

Kinetic mechanism of active site assembly and chemical catalysis of DNA polymerase β

scientific article published on 19 October 2011

Ligand-protein interactions via nuclear magnetic resonance of quadrupolar nuclei.

scientific article published in January 1989

Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease

scientific article

Manipulating phosphorus stereospecificity of adenylate kinase by site-directed mutagenesis

scientific article published on 01 January 1995

Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.

scientific article

Mechanism of adenylate kinase. 1H, 13C, and 15N NMR assignments, secondary structures, and substrate binding sites

scientific article published on 01 November 1993

Mechanism of adenylate kinase. Demonstration of a functional relationship between aspartate 93 and Mg2+ by site-directed mutagenesis and proton, phosphorus-31, and magnesium-25 NMR.

scientific article

Mechanism of adenylate kinase. Does adenosine 5'-triphosphate bind to the adenosine 5'-monophosphate site?

scientific article published on 01 October 1987

Mechanism of adenylate kinase. Histidine-36 is not directly involved in catalysis, but protects cysteine-25 and stabilizes the tertiary structure

scientific article published on 01 July 1988

Mechanism of adenylate kinase. Is there a relationship between local substrate dynamics, local binding energy, and the catalytic mechanism?

scientific article published on 01 November 1989

Mechanism of adenylate kinase. Structural and functional demonstration of arginine-138 as a key catalytic residue that cannot be replaced by lysine

scientific article published on 01 July 1990

Mechanism of adenylate kinase. Structural and functional roles of the conserved arginine-97 and arginine-132.

scientific article

Mechanism of adenylate kinase. The conserved aspartates 140 and 141 are important for transition state stabilization instead of substrate-induced conformational changes.

scientific article published on March 1994

Mechanism of adenylate kinase. What can be learned from a mutant enzyme with minor perturbation in kinetic parameters?

scientific article published on 01 June 1993

Mechanism of phosphatidylinositol-specific phospholipase C: a unified view of the mechanism of catalysis

scientific article published on 01 March 1998

Mechanism of phosphatidylinositol-specific phospholipase C: origin of unusually high nonbridging thio effects

scientific article published in May 2001

Mismatched and matched dNTP incorporation by DNA polymerase beta proceed via analogous kinetic pathways

scientific article published on 22 August 2008

Molecular basis of the essential s phase function of the rad53 checkpoint kinase

scientific article published on 10 June 2013

Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus

scientific article

PHRF1 promotes genome integrity by modulating non-homologous end-joining.

scientific article

Pancreatic phospholipase A(2): new views on old issues.

scientific article

Phosphatidylinositol-specific phospholipase C: kinetic and stereochemical evidence for an interaction between arginine-69 and the phosphate group of phosphatidylinositol.

scientific article

Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation.

scientific article published on 31 August 2017

Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface

scientific article

Phospholipase A2 engineering. Probing the structural and functional roles of N-terminal residues with site-directed mutagenesis, X-ray, and NMR.

scientific article published on June 1995

Phospholipase A2 engineering. Structural and functional roles of highly conserved active site residues tyrosine-52 and tyrosine-73 ⬇️

scientific article published on July 21, 1992

Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-99

scientific article

Phospholipase A2 engineering. The roles of disulfide bonds in structure, conformational stability, and catalytic function.

scientific article

Phospholipase A2 engineering. The structural and functional roles of aromaticity and hydrophobicity in the conserved phenylalanine-22 and phenylalanine-106 aromatic sandwich

scientific article published on 01 November 1992

Phospholipase A2 engineering. X-ray structural and functional evidence for the interaction of lysine-56 with substrates ⬇️

scientific article published on December 24, 1991

Phospholipase A2 engineering: design, synthesis, and expression of a gene for bovine (pro)phospholipase A2.

scientific article published on July 1989

Phospholipase stereospecificity at phosphorus

scientific article published on 01 January 1991

Phospholipids chiral at phosphorus. Absolute configuration of chiral thiophospholipids and stereospecificity of phospholipase D.

scientific article published on April 1984

Phospholipids chiral at phosphorus. Characterization of the sub-gel phase of thiophosphatidylcholines by use of X-ray diffraction, phosphorus-31 nuclear magnetic resonance, and Fourier transform infrared spectroscopy

scientific article published on 01 June 1988

Phospholipids chiral at phosphorus. Dramatic effects of phosphorus chirality on the deuterium NMR properties of the choline head group of phospholipids in the liquid crystalline phase

scientific article published on 01 December 1990

Phospholipids chiral at phosphorus. Preparation and spectral properties of chiral thiophospholipids

scientific article published on 01 May 1983

Phospholipids chiral at phosphorus. Stereochemical mechanism for the formation of inositol 1-phosphate catalyzed by phosphatidylinositol-specific phospholipase C.

scientific article

Phospholipids chiral at phosphorus. Stereochemical mechanism of reactions catalyzed by phosphatidylinositide-specific phospholipase C from Bacillus cereus and guinea pig uterus.

scientific article

Phospholipids chiral at phosphorus. Steric course of the reactions catalyzed by phosphatidylserine synthase from Escherichia coli and yeast

scientific article published on 01 June 1987

Phospholipids chiral at phosphorus. Synthesis and stereospecificity of phosphorothioate analogues of platelet-activating factor

scientific article published on 01 June 1988

Phospholipids chiral at phosphorus. Synthesis of chiral phosphatidylcholine and stereochemistry of phospholipase D

scientific article published on 01 April 1984

Phospholipids chiral at phosphorus: Fourier-transform infrared study on the gel-liquid crystalline transition of chiral thiophosphatidylcholine

scientific article published on 01 June 1986

Phosphorylation of NuSAP by Cdk1 regulates its interaction with microtubules in mitosis.

scientific article published in December 2011

Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes

scientific article

Protein Arginine Methyltransferase 8: Tetrameric Structure and Protein Substrate Specificity

scientific article

Protein kinase A-mediated serine 35 phosphorylation dissociates histone H1.4 from mitotic chromosome

scientific article

Quantitative Analysis of Yeast Checkpoint Protein Kinase Activity by Combined Mass Spectrometry Enzyme Assays.

scientific article published on 2 November 2016

Regioselective deacetylation based on teicoplanin-complexed Orf2* crystal structures

scientific article

SUMOylation of Blimp-1 is critical for plasma cell differentiation

scientific article

Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67.

scientific article

Solution structure of a viral DNA polymerase X and evidence for a mutagenic function

scientific article

Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship.

scientific article published in September 2004

Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck

scientific article published on 01 January 2001

Splase: a new class IIS zinc-finger restriction endonuclease with specificity for Sp1 binding sites.

scientific article

Stereochemical course of the transmethylation catalyzed by catechol O-methyltransferase

scientific article published on 01 October 1980

Stereochemistry and mechanism of reactions catalyzed by indolyl-3-alkane alpha-hydroxylase

scientific article published on July 1979

Stereochemistry and mechanism of reactions catalyzed by tryptophan synthetase and its beta2 subunit

scientific article published on 01 August 1978

Stereochemistry and mechanism of reactions catalyzed by tryptophanase Escherichia coli

scientific article

Stereochemistry of the beta-cyanoalanine synthetase and S-alkylcysteine lyase reactions

scientific article published on 01 October 1978

Stereochemistry of the hydrolysis of adenosine 5'-thiophosphate catalyzed by venom 5'-nucleotidase ⬇️

scientific article published on November 11, 1980

Structural analysis of phospholipase A2 from functional perspective. 1. Functionally relevant solution structure and roles of the hydrogen-bonding network

scientific article

Structural analysis of phospholipase A2 from functional perspective. 2. Characterization of a molten globule-like state induced by site-specific mutagenesis.

scientific article published in March 1999

Structure and function of 2:1 DNA polymerase.DNA complexes.

scientific article published on August 2008

Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: absence of the conserved structural water

scientific article published on November 1994

Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase

scientific article

Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions

scientific article

Structure of the bifunctional cryptochrome aCRY from Chlamydomonas reinhardtii.

scientific article

Structure of the complex of bovine pancreatic phospholipase A2 with a transition-state analogue

scientific article

TIFA as a crucial mediator for NLRP3 inflammasome.

scientific article published on 13 December 2016

TagF-mediated repression of bacterial type VI secretion systems involves a direct interaction with the cytoplasmic protein Fha.

scientific article published on 29 March 2018

Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions

scientific article published on 16 December 2019

The catalytic role of aspartate in a short strong hydrogen bond of the Asp274-His32 catalytic dyad in phosphatidylinositol-specific phospholipase C can be substituted by a chloride ion.

scientific article

The ligand specificity of yeast Rad53 FHA domains at the +3 position is determined by nonconserved residues.

scientific article published in April 2004

The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner

scientific article

The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation

scientific article published on 17 March 2016

Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.

scientific article published on 20 June 2019

Toward the mechanism of phosphoinositide-specific phospholipases C.

scientific article published on February 1994

Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C)

scientific article

Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A

scientific article

Tumor suppressor INK4: quantitative structure-function analyses of p18INK4C as an inhibitor of cyclin-dependent kinase 4

scientific article published on 01 February 2000

Twist and turn: a revised structural view on the unpaired bubble of class II CPD photolyase in complex with damaged DNA

scientific article published on 08 August 2018

Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response

scientific article

Ultrafast water dynamics at the interface of the polymerase-DNA binding complex

scientific article

Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses

scientific article

Use of 2-aminopurine and tryptophan fluorescence as probes in kinetic analyses of DNA polymerase beta

scientific article published in September 2002

Use of 31P(18O), 31P(17O), and 17O NMR methods to study enzyme mechanisms involving phosphorus

scientific article published on 01 January 1982

Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase

scientific article published on 02 April 2019

Use of damaged DNA and dNTP substrates by the error-prone DNA polymerase X from African swine fever virus.

scientific article published on 3 March 2007

Use of phosphorus-31 nuclear magnetic resonance to distinguish bridge and nonbridge oxygens of oxygen-17-enriched nucleoside triphosphates. Stereochemistry of acetate activation by acetyl coenzyme A synthetase ⬇️

scientific article published on April 17, 1979

Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo

scientific article

Use of short-chain cyclopentano-phosphatidylcholines to probe the mode of activation of phospholipase A2 from bovine pancreas and bee venom

scientific article published on 01 September 1988

Visualizing the DNA repair process by a photolyase at atomic resolution

scientific article published on 30 November 2023

X-ray structure of the R69D phosphatidylinositol-specific phospholipase C enzyme: insight into the role of calcium and surrounding amino acids in active site geometry and catalysis

scientific article published in August 2005

alpha-Helical burst on the folding pathway of FHA domains from Rad53 and Ki67.

scientific article

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