List of works by Hans K. Hasselbalch

A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis

scientific article

A der(18)t(9;18)(p13;p11) and a der(9;18)(p10;q10) in polycythemia vera associated with a hyperproliferative phenotype in transformation to postpolycythemic myelofibrosis.

scientific article published in January 2007

A distinct subtype of idiopathic myelofibrosis with bone marrow features mimicking hairy cell leukemia: evidence of an autoimmune pathogenesis

scientific article published on 01 June 1987

A highly sensitive quantitative real-time PCR assay for determination of mutant JAK2 exon 12 allele burden

scientific article

A nationwide population-based cross-sectional survey of health-related quality of life in patients with myeloproliferative neoplasms in Denmark (MPNhealthSurvey): survey design and characteristics of respondents and nonrespondents

scientific article published on 02 March 2017

A new internet-based tool for reporting and analysing patient-reported outcomes and the feasibility of repeated data collection from patients with myeloproliferative neoplasms

scientific article

A novel immunohistochemical sequential multi-labelling and erasing technique enables epitope characterization of bone marrow pericytes in primary myelofibrosis

scientific article published on 17 January 2012

A phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia.

scientific article published on 11 June 2013

A phase II study of vorinostat (MK-0683) in patients with primary myelofibrosis and post-polycythemia vera myelofibrosis

scientific article published on January 2014

A phase II trial of pegylated interferon alpha-2b therapy for polycythemia vera and essential thrombocythemia: feasibility, clinical and biologic effects, and impact on quality of life.

scientific article published in June 2006

A phase III randomized trial comparing glucocorticoid monotherapy versus glucocorticoid and rituximab in patients with autoimmune haemolytic anaemia.

scientific article published on 24 August 2013

A possible role for STI571 in the treatment of idiopathic myelofibrosis

scientific article

A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate

scientific article published on 27 June 2016

A retrospective analysis of the impact of treatments and blood counts on survival and the risk of vascular events during the course of polycythaemia vera.

scientific article published on 5 May 2017

A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis?

scientific article published on 9 August 2013

A unified definition of clinical resistance and intolerance to hydroxycarbamide in polycythaemia vera and primary myelofibrosis: results of a European LeukemiaNet (ELN) consensus process

scientific article published on 23 November 2009

A unified definition of clinical resistance/intolerance to hydroxyurea in essential thrombocythemia: results of a consensus process by an international working group.

scientific article published on 16 November 2006

Aberrations of chromosome 6 in 193 newly diagnosed untreated cases of chronic lymphocytic leukemia

scientific article published on 01 May 1991

Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes

scientific article published on 18 September 2013

Acute leukemia and myelodysplasia in patients with a Philadelphia chromosome negative chronic myeloproliferative disorder treated with hydroxyurea alone or with hydroxyurea after busulphan

scientific article published in September 2003

Age-Related Macular Degeneration in Patients With Chronic Myeloproliferative Neoplasms

scientific article

Alcohol intolerance in the hypereosinophilic syndrome

scientific article published on 01 February 1988

Anagrelide treatment in 52 patients with chronic myeloproliferative diseases

scientific article published in October 2004

Anemia is present years before myelodysplastic syndrome diagnosis: Results from the pre-diagnostic period.

scientific article published on 6 April 2017

Angiogenesis in pulmonary hypertension with myelofibrosis

scientific article published on 06 May 2008

Antecedent cardiovascular disease and autoimmunity in Philadelphia-negative chronic myeloproliferative neoplasms.

scientific article published on 2 December 2015

Association of the blood eosinophil count with hematological malignancies and mortality

scientific article published on 16 January 2015

B lymphocyte depletion with the monoclonal antibody rituximab in Graves' disease: a controlled pilot study

scientific article published on 06 February 2007

B-cell depletion with rituximab in the treatment of autoimmune diseases. Graves' ophthalmopathy the latest addition to an expanding family

scientific article published on July 2007

B-cell depletion with rituximab-a targeted therapy for Graves' disease and autoimmune thyroiditis

scientific article published on 01 July 2003

B-cell frequencies and immunoregulatory phenotypes in myeloproliferative neoplasms: Influence of ruxolitinib, interferon-α2, or combination treatment

scientific article published on 18 August 2019

Bone marrow histomorphology and JAK2 mutation status in essential thrombocythemia

scientific article published on 01 November 2007

Characterization of blood donors with high haemoglobin concentration

scientific article published on 15 August 2012

Chronic inflammation and autoimmunity as risk factors for the development of chronic myelomonocytic leukemia?

scientific article published on 16 February 2016

Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?

scientific article

Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms

scientific article published on 4 February 2014

Chronic myeloproliferative neoplasms and subsequent cancer risk: a Danish population-based cohort study

scientific article published on 28 October 2011

Circulating YKL-40 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state

scientific article published on 25 April 2014

Circulating YKL-40 in patients with essential thrombocythemia and polycythemia vera treated with the novel histone deacetylase inhibitor vorinostat

scientific article published in July 2014

Circulating hyaluronan in the myelofibrosis/osteomyelosclerosis syndrome and other myeloproliferative disorders

scientific article published in January 1991

Collagen metabolism and enzymes of the urokinase plasminogen activator system in chronic myeloproliferative disorders: correlation between plasma-soluble urokinase plasminogen activator receptor and serum markers for collagen metabolism.

scientific article

Combination therapy with interferon and JAK1-2 inhibitor is feasible: Proof of concept with rapid reduction in JAK2V617F-allele burden in polycythemia vera

scientific article published on August 2014

Corrigendum to "Combination therapy with interferon and JAK1-2 inhibitor is feasible. Proof of concept with rapid reduction in JAK2V617F-allele burden in Polycythemia Vera" [Leuk. Res. Rep. 3 (2) (2014) 73-75].

scientific article published on 15 May 2015

Data-driven analysis of JAK2V617F kinetics during interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms

scientific article published on 28 January 2020

Demonstrated Benefit of Continuous Interferon-Alpha-2b Therapy in Hairy Cell Leukemia. A Two-Year Follow-Up

scientific article published on 01 January 1991

Diagnosis, pathogenesis and treatment of the myeloproliferative disorders essential thrombocythemia, polycythemia vera and essential megakaryocytic granulocytic metaplasia and myelofibrosis.

scientific article

Differential Dynamics of CALR Mutant Allele Burden in Myeloproliferative Neoplasms during Interferon Alfa Treatment

scientific article

Discordance between the cortisol response to insulin-hypoglycemia and 30-minute ACTH stimulation test in chronic alcoholic men.

scientific article published in August 1987

Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence.

scientific article published on 31 July 2008

Effect of thrombopoietin-receptor agonists on circulating cytokine and chemokine levels in patients with primary immune thrombocytopenia (ITP).

scientific article

Elevated plasma levels of TIMP-1 correlate with plasma suPAR/uPA in patients with chronic myeloproliferative disorders

scientific article published on 01 November 2003

Elevated soluble urokinase plasminogen activator receptor in plasma from patients with idiopathic myelofibrosis or polycythaemia vera

scientific article published in July 2002

Eosinophilia in routine blood samples and the subsequent risk of hematological malignancies and death

scientific article published in August 2013

Eosinophilia in routine blood samples as a biomarker for solid tumor development - A study based on the Copenhagen Primary Care Differential Count (CopDiff) Database.

scientific article published on 10 March 2014

Epigenetic changes in myelofibrosis: Distinct methylation changes in the myeloid compartments and in cases with ASXL1 mutations

scientific article published on 28 July 2017

Expansion of circulating CD56bright natural killer cells in patients with JAK2-positive chronic myeloproliferative neoplasms during treatment with interferon-α.

scientific article published on 24 September 2014

Extreme neutrophil granulocytosis in a patient with anaplastic large cell lymphoma of T-cell lineage.

scientific article

FLT3-mediated p38-MAPK activation participates in the control of megakaryopoiesis in primary myelofibrosis.

scientific article

Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents

scientific article

Frequent occurrence of anticardiolipin antibodies, Factor V Leiden mutation, and perturbed endothelial function in chronic myeloproliferative disorders

scientific article published in March 2002

High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis

scientific article published on 05 April 2011

High prevalence of arterial thrombosis in JAK2 mutated essential thrombocythaemia: independence of the V617F allele burden

scientific article published in April 2008

High rate of abnormal blood values and vascular complications before diagnosis of myeloproliferative neoplasms.

scientific article published on 8 April 2015

Hydroxycarbamide: a user's guide for chronic myeloproliferative disorders.

scientific article

Hypercalcemia in idiopathic myelofibrosis: modulation of calcium and collagen homeostasis by 1,25-dihydroxyvitamin D3

scientific article published on 01 March 1992

Hypothalamic-pituitary and thyroid function in chronic alcoholics with neurological complications

scientific article published in June 1990

Hypothesis: a possible role for interferon in the treatment of idiopathic myelofibrosis

scientific article published on December 1988

Idiopathic myelofibrosis--an update with particular reference to clinical aspects and prognosis

scientific article published on January 1993

Imatinib mesylate in idiopathic and postpolycythemic myelofibrosis

scientific article published in December 2003

Incidence, clinical features and outcome of essential thrombocythaemia in a well defined geographical area

scientific article published in August 2000

Increase in circulating CD4+CD25+Foxp3+ T cells in patients with Philadelphia-negative chronic myeloproliferative neoplasms during treatment with IFN-

scientific article published on 27 June 2011

Increased circulating platelet-leukocyte aggregates in myeloproliferative disorders is correlated to previous thrombosis, platelet activation and platelet count

scientific article

Increased gene expression of histone deacetylases in patients with Philadelphia-negative chronic myeloproliferative neoplasms

scientific article published on August 2011

Increased iron stores prolong the QT interval - a general population study including 20 261 individuals and meta-analysis of thalassaemia major.

scientific article published on 8 April 2016

Increased platelet activation and abnormal membrane glycoprotein content and redistribution in myeloproliferative disorders

scientific article published on 01 July 2000

Interferon alfa in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms

scientific article published on 16 May 2011

Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis

scientific article published in February 2013

Interferon in myelofibrosis

scientific article published on 01 February 1988

Interferon in polycythemia vera and related neoplasms. Can it become the treatment of choice without a randomized trial?

scientific article published on 21 May 2015

Interferon-α induces marked alterations in circulating regulatory T cells, NK cell subsets, and dendritic cells in patients with JAK2V617F-positive essential thrombocythemia and polycythemia vera.

scientific article

Is thrombocytosis a valid indicator of advanced stage and high mortality of gynecological cancer?

scientific article published on 22 September 2015

Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms

scientific article published on 15 December 2011

Limited efficacy of hydroxyurea in lowering of the JAK2 V617F allele burden

scientific article published in February 2009

Long term molecular responses in a cohort of Danish patients with essential thrombocythemia, polycythemia vera and myelofibrosis treated with recombinant interferon alpha

scientific article published in July 2013

MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort.

scientific article

MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives

scientific article

Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development

scientific article published on 31 August 2017

Mediators of Inflammation in Myeloproliferative Neoplasms: State of the Art.

scientific article published on 23 November 2015

Minimal residual disease after long-term interferon-alpha2 treatment: a report on hematological, molecular and histomorphological response patterns in 10 patients with essential thrombocythemia and polycythemia vera

scientific article published on 8 May 2015

Minimal residual disease and normalization of the bone marrow after long-term treatment with alpha-interferon2b in polycythemia vera. A report on molecular response patterns in seven patients in sustained complete hematological remission

article

Minimal residual disease or cure in MPNs? Rationales and perspectives on combination therapy with interferon-alpha2 and ruxolitinib.

scientific article published on 12 April 2017

Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms

scientific article published on 7 September 2010

Molecular profiling as a novel tool to predict response to interferon-α2 in MPNs: The proof of concept in early myelofibrosis

scientific article published on 18 May 2017

Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: identification of deregulated genes of significance for inflammation and immune surveillance

scientific article published on 09 August 2012

Myeloproliferative blood cancers as a human neuroinflammation model for development of Alzheimer's disease: evidences and perspectives

scientific article published on 23 August 2020

Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both

scientific article published on 8 February 2016

Myeloproliferative neoplasms in five multiple sclerosis patients

scientific article published on 31 July 2013

Neo-antigen specific memory T-cell responses in healthy individuals

scientific article published on 19 April 2019

Non-invasive imaging of retinal blood flow in myeloproliferative neoplasms

scientific article published on 29 September 2016

On the pathogenesis of angiogenesis in idiopathic myelofibrosis

scientific article published on 01 February 1990

Optimal therapy for polycythemia vera and essential thrombocythemia: Preferred use of interferon therapy based on phase 2 trials

scientific article

Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?

scientific article published on 07 February 2012

Perspectives on interferon-alpha in the treatment of Polycythemia vera and related Myeloproliferative neoplasms: minimal residual disease and cure?

scientific article published on 10 September 2018

Perspectives on the impact of JAK-inhibitor therapy upon inflammation-mediated comorbidities in myelofibrosis and related neoplasms.

scientific article published on 13 February 2014

Perspectives on the increased risk of second cancer in patients with essential thrombocythemia, polycythemia vera and myelofibrosis.

scientific article published in February 2015

Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet.

scientific article published on 04 January 2011

Prevalence and clinical significance of neutropenia discovered in routine complete blood cell counts: a longitudinal study

scientific article published on 21 January 2016

Prevalence and phenotypes of JAK2 V617F and calreticulin mutations in a Danish general population

scientific article published on 19 June 2019

Quantitative assessment of the JAK2 V617F allele burden: equivalent levels in peripheral blood and bone marrow

scientific article published on 12 July 2007

Response criteria for essential thrombocythemia and polycythemia vera: result of a European LeukemiaNet consensus conference.

scientific article published on 10 March 2009

Response criteria for myelofibrosis with myeloid metaplasia: results of an initiative of the European Myelofibrosis Network (EUMNET).

scientific article published on 30 June 2005

Risk of lymphoma and solid cancer among patients with rheumatoid arthritis in a primary care setting

scientific article

Rituximab and dexamethasone vs dexamethasone monotherapy in newly diagnosed patients with primary immune thrombocytopenia

scientific article

Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura

scientific article

Ruxolitinib is manageable in patients with myelofibrosis and severe thrombocytopenia: a report on 12 Danish patients.

scientific article

SU6668 in idiopathic myelofibrosis--a rational therapeutic approach targeting several tyrosine kinases of importance for the myeloproliferation and the development of bone marrow fibrosis and angiogenesis

scientific article published in August 2003

Safety and efficacy of combination therapy of interferon-α2 and ruxolitinib in polycythemia vera and myelofibrosis

scientific article published on 22 June 2018

Second malignancies in hydroxyurea and interferon-treated Philadelphia-negative myeloproliferative neoplasms.

scientific article published on 29 July 2016

Serum hyaluronan is increased in malignant lymphoma.

scientific article

Serum laminin P1 in idiopathic myelofibrosis and related diseases

scientific article published on 01 August 1994

Serum markers for type IV collagen and type III procollagen in the myelofibrosis-osteomyelosclerosis syndrome and other chronic myeloproliferative disorders

scientific article published on 01 October 1986

Smoking and philadelphia-negative chronic myeloproliferative neoplasms

scientific article published on 18 September 2015

Smoking as a contributing factor for development of polycythemia vera and related neoplasms

scientific article published on 09 September 2015

Smoking is associated with increased risk of myeloproliferative neoplasms: A general population-based cohort study

article

Smoking, blood cells and myeloproliferative neoplasms: meta-analysis and Mendelian randomization of 2·3 million people

scientific article published on 25 December 2019

Sorted peripheral blood cells identify CALR mutations in B- and T-lymphocytes

scientific article published on 09 August 2017

Spontaneous T-cell responses against Arginase-1 in the chronic myeloproliferative neoplasms relative to disease stage and type of driver mutation

scientific article published on 23 July 2018

Statins in the treatment of polycythaemia vera and allied disorders: an antithrombotic and cytoreductive potential?

scientific article

Successful treatment of anemia in idiopathic myelofibrosis with recombinant human erythropoietin

scientific article

Survival after a blood alcohol of 1127 mg/dl

scientific article published on 01 August 1981

Survival of patients with chronic myeloproliferative neoplasms and new primary cancers: a population-based cohort study

scientific article published on 11 June 2015

Sustained major molecular response on interferon alpha-2b in two patients with polycythemia vera.

scientific article published on 15 May 2008

Sustained remission of platelet counts following monoclonal anti-CD20 antibody therapy in two cases of idiopathic autoimmune thrombocytopenia and neutropenia.

scientific article

The CALR exon 9 mutations are shared neoantigens in patients with CALR mutant chronic myeloproliferative neoplasms

scientific article published on 18 August 2016

The Copenhagen Primary Care Differential Count (CopDiff) database

scientific article

The Danish National Chronic Myeloid Neoplasia Registry

scientific article

The JAK2 V617F allele burden in essential thrombocythemia, polycythemia vera and primary myelofibrosis--impact on disease phenotype

scientific article published on 23 October 2007

The JAK2 V617F mutation involves B- and T-lymphocyte lineages in a subgroup of patients with Philadelphia-chromosome negative chronic myeloproliferative disorders

scientific article published on 01 March 2007

The JAK2V617F allele burden and STAT3- and STAT5 phosphorylation in myeloproliferative neoplasms: early prefibrotic myelofibrosis compared with essential thrombocythemia, polycythemia vera and myelofibrosis

scientific article published on 17 April 2011

The Role of Reactive Oxygen Species in Myelofibrosis and Related Neoplasms

scientific article

The V617F and exon 9 mutations are shared immunogenic neoantigens in hematological malignancy

scientific article published on 02 August 2017

The impact of interferon-alpha2 on HLA genes in patients with polycythemia vera and related neoplasms

scientific article published on 02 December 2016

The platelet-cancer loop in myeloproliferative cancer. Is thrombocythemia an enhancer of cancer invasiveness and metastasis in essential thrombocythemia, polycythemia vera and myelofibrosis?

scientific article published on 22 July 2014

The rationale for B lymphocyte depletion in Graves' disease. Monoclonal anti-CD20 antibody therapy as a novel treatment option.

scientific article

The red blood cell count and the erythrocyte sedimentation rate in the diagnosis of polycythaemia vera

scientific article published on 22 November 2019

The role of cytokines in the initiation and progression of myelofibrosis.

scientific article published on 13 February 2013

Thrombopoietin-receptor agonists in haematological disorders: the Danish experience

scientific article

Transcriptional profiling of whole blood identifies a unique 5-gene signature for myelofibrosis and imminent myelofibrosis transformation

scientific article published on 13 January 2014

Treatment-resistant severe, active Graves' ophthalmopathy successfully treated with B lymphocyte depletion

scientific article published on 01 July 2006

Urinary free cortisol during pregnancy

scientific article published on 01 January 1984

V617F mutation in JAK2 is associated with poorer survival in idiopathic myelofibrosis

scientific article published on 17 November 2005

WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect--the Danish experience

scientific article published on 22 July 2015

Whole blood assay for NK activity in splenectomized and non-splenectomized hairy cell leukemia patients during IFN-α-2b treatment

scientific article published on 01 January 1989

Whole blood transcriptional profiling reveals deregulation of oxidative and antioxidative defence genes in myelofibrosis and related neoplasms. Potential implications of downregulation of Nrf2 for genomic instability and disease progression

scientific article

Whole blood transcriptional profiling reveals significant down-regulation of human leukocyte antigen class I and II genes in essential thrombocythemia, polycythemia vera and myelofibrosis

scientific article published on 15 May 2013

Whole-blood transcriptional profiling of interferon-inducible genes identifies highly upregulated IFI27 in primary myelofibrosis

scientific article published on 01 July 2011

Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome

scientific article published on 19 October 2015

World Health Organization-defined classification of myeloproliferative neoplasms: morphological reproducibility and clinical correlations--the Danish experience

scientific article

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