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List of works by Stuart M Pitson

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

scientific article published on 27 September 2016

3D-printed microplate inserts for long term high-resolution imaging of live brain organoids

scientific article published on 01 April 2021

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis.

scientific article published on December 2015

A Proinflammatory Role for Proteolytically Cleaved Annexin A1 in Neutrophil Transendothelial Migration ⬇️

scientific article published on August 2, 2010

A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1 ⬇️

scientific article published on November 11, 2010

A point mutant of human sphingosine kinase 1 with increased catalytic activity

scientific article published in December 2001

A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties

scientific article published on March 2015

Action patterns and mapping of the substrate-binding regions of endo-(1 → 5)-α-l-arabinanases from Aspergillus niger and Aspergillus aculeatus ⬇️

scientific article published on September 5, 1997

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation ⬇️

scientific article published on October 15, 2003

An Improved Isoform-Selective Assay for Sphingosine Kinase 1 Activity.

scientific article published on 25 May 2017

An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes

scientific article published in August 2004

An oncogenic role for sphingosine kinase 2.

scientific article published on 30 August 2016

An oncogenic role of sphingosine kinase

scientific article

Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3' AU-rich mRNA destabilizing elements

scientific article published in August 2008

CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1

scientific article

CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1.

scientific article published on 20 July 2017

Cellular signalling by sphingosine kinase and sphingosine 1-phosphate.

scientific article published on August 2006

Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells.

scientific article published on 23 February 2009

Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720.

scientific article published on 20 January 2016

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

scientific article published on 27 June 2017

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

scientific article published on 30 August 2017

Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma

scientific article published in 2019

Deactivation of sphingosine kinase 1 by protein phosphatase 2A.

scientific article published on 13 October 2008

Dengue Virus Infection of Primary Endothelial Cells Induces Innate Immune Responses, Changes in Endothelial Cells Function and Is Restricted by Interferon-Stimulated Responses

scientific article published on 22 April 2015

Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs.

scientific article

Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics.

scientific article

Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD.

scientific article

Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1.

scientific article published on 25 November 2013

Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response.

scientific article

Enhancing ER stress in myeloma

scientific article published on 30 July 2017

Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells

scientific article published on 4 August 2005

Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity.

scientific article published on 29 January 2016

Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease.

scientific article

Extracellular and intracellular sphingosine-1-phosphate distinctly regulates exocytosis in chromaffin cells

scientific article published on 08 May 2019

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

scientific article

From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).

scientific article published on 18 January 2016

Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors.

scientific article published in May 2009

Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia

scientific article published on 12 May 2022

Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis ⬇️

scientific article published on September 13, 2010

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

scientific article

Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia.

scientific article

In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection

scientific article published on 14 March 2019

Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.

scientific article published on 23 May 2012

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

scientific article

Inhibitors of the sphingosine kinase pathway as potential therapeutics.

scientific article published on June 2010

Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways

scientific article

Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection.

scientific article published on 21 July 2017

Isoform-selective assays for sphingosine kinase activity

scientific article published in January 2012

Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1

scientific article published on 01 November 2019

Local Sphingosine Kinase 1 Activity Improves Islet Transplantation.

scientific article

Meeting report: Barossa 2005--Signaling Networks

scientific article published on 28 February 2006

Modification of the tumour microenvironment via exosomal shedding of sphingosine 1-phosphate receptor 2 by breast cancer cells

scientific article published on 24 July 2018

Molecular targets of FTY720 (fingolimod).

scientific article published on December 2012

Noncellulolytic fungal beta-glucanases: their physiology and regulation

scientific article published on March 1993

Novel therapies for multiple myeloma

scientific article published on 01 August 2017

Over-expression of sphingosine kinase-1 enhances a progenitor phenotype in human endothelial cells

scientific article published on 01 October 2011

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

scientific article

Post-translational regulation of sphingosine kinases.

scientific article published on 16 July 2012

Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD).

scientific article published on 20 October 2015

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells

scientific article published on 25 February 2016

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival

scientific article

Proteolytic inactivation of an extracellular (1-->3)-beta-glucanase from the fungus Acremonium persicinum is associated with growth at neutral or alkaline medium pH

scientific article published on 01 December 1996

Purification and characterization of an extracellular (1 --> 6)-beta-glucanase from the filamentous fungus Acremonium persicinum

scientific article published on June 1996

Purification and characterization of an extracellular beta-glucosidase from the filamentous fungus Acremonium persicinum and its probable role in beta-glucan degradation

scientific article published on 01 August 1997

Purification and characterization of three extracellular (1-->3)-beta-D-glucan glucohydrolases from the filamentous fungus Acremonium persicinum

scientific article published on June 1995

Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.

scientific article published on 7 February 2012

Recent advances in the development of sphingosine kinase inhibitors

scientific article published on 10 June 2016

Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type-2 RNA.

scientific article published on 12 August 2013

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease

scientific article published on 27 January 2014

Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses.

scientific article published on 5 November 2015

Regulation of sphingosine kinase and sphingolipid signaling.

scientific article published on October 2010

Regulation of stem cell pluripotency and neural differentiation by lysophospholipids

scientific article published on 30 September 2009

Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.

scientific article

Resistance to proteasome inhibitors and other targeted therapies in myeloma.

scientific article published on 20 April 2018

Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity

scientific article published on 6 November 2017

Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology

scientific article published on 06 September 2018

Roles, regulation and inhibitors of sphingosine kinase 2.

scientific article published on 07 June 2013

Science amongst the vines. Meeting on signalling systems.

scientific article published on 11 April 2008

Sphingolipids and the unfolded protein response

scientific article published on 05 June 2019

Sphingolipids--who's controlling who in disease?

scientific article published on 04 August 2015

Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis.

scientific article published on 18 May 2015

Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function.

scientific article published on 18 April 2010

Sphingosine kinase 1 in viral infections ⬇️

scientific article published on May 28, 2012

Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway

scientific article

Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress.

scientific article published on 14 April 2017

Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression.

scientific article

Sphingosine kinase 2-deficiency mediated changes in spinal pain processing.

scientific article published on 3 August 2015

Sphingosine kinase localization in the control of sphingolipid metabolism ⬇️

scientific article published on November 12, 2010

Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation

scientific article published on 24 December 2008

Sphingosine kinase transmits estrogen signaling in human breast cancer cells.

scientific article published on 24 July 2003

Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens

scientific article published on 20 October 2010

Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine

scientific article published on 07 June 2019

Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice

scientific article published on 02 November 2011

Stem cell regulation by lysophospholipids.

scientific article published on 05 September 2007

Stereochemical Course of Hydrolysis Catalysed by α-l-Rhamnosyl and α-d-Galacturonosyl Hydrolases fromAspergillus aculeatus ⬇️

scientific article published on January 26, 1998

Stereochemical course of hydrolysis catalyzed by arabinofuranosyl hydrolases

scientific article published in November 1996

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

scientific article published on 23 December 2015

Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies

scientific article published on 28 June 2018

Targeting sphingosine kinase 1 in acute myeloid leukemia: translation to clinic

scientific article published on 01 June 2017

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

scientific article published on 12 December 2016

Targeting the Sphingolipid System as a Therapeutic Direction for Glioblastoma

scientific article published on 01 January 2020

The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1.

scientific article

The GM-CSF receptor family: mechanism of activation and implications for disease

scientific article published on 18 January 2012

The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity

scientific article published on 09 October 2018

The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells ⬇️

scientific article published on October 6, 2010

The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells.

scientific article published on 23 February 2009

The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1α protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6

scientific article published on 27 July 2010

The phosphorylation motif at serine 225 governs the localization and function of sphingosine kinase 1 in resistance arteries.

scientific article published on 3 September 2009

The sphingolipid rheostat: a potential target for improving pancreatic islet survival and function.

scientific article published on December 2011

Topical Application of Fingolimod Perturbs Cutaneous Inflammation.

scientific article published on 21 March 2016

Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1

scientific article

Tumour necrosis factor alpha (TNF- ) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF- to activate nuclear factor B and reduced sphingosine kinase-1 activity

scientific article published on 09 December 2010

Validation of commercially available sphingosine kinase 2 antibodies for use in immunoblotting, immunoprecipitation and immunofluorescence

scientific article published on 6 December 2016

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