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List of works by Ingo Ott

5-Alkynyl-2'-deoxyuridines: chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cells

scientific article published on February 2007

A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.

scientific article published on 25 September 2014

A chemical-biological evaluation of rhodium(I) N-heterocyclic carbene complexes as prospective anticancer drugs.

scientific article published on 15 November 2013

A comparative chemical-biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand

scientific article published in May 2013

A gold(I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor.

scientific article published in February 2009

A gold(i) biscarbene complex with improved activity as a TrxR inhibitor and cytotoxic drug: comparative studies with different gold metallodrugs

scientific article published on 01 March 2019

A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.

scientific article published on 23 June 2016

A ruthenocene-PNA bioconjugate--synthesis, characterization, cytotoxicity, and AAS-detected cellular uptake.

scientific article

AAS, XRF, and MS Methods in Chemical Biology of Metal Complexes

Alkynyl gold(I) phosphane complexes: Evaluation of structure-activity-relationships for the phosphane ligands, effects on key signaling proteins and preliminary in-vivo studies with a nanoformulated complex.

scientific article published on 30 December 2015

Analysis of the mechanism of action of potent antibacterial hetero-tri-organometallic compounds: a structurally new class of antibiotics

scientific article published on 26 April 2013

Anticancer and Antibacterial Activity Studies of Gold(I)-Alkynyl Chromones.

scientific article published on 30 October 2015

Antiglioma activity of GoPI-sugar, a novel gold(I)-phosphole inhibitor: chemical synthesis, mechanistic studies, and effectiveness in vivo

scientific article published on 16 January 2014

Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes

scientific article published on 28 January 2011

Antitumor-active cobalt-alkyne complexes derived from acetylsalicylic acid: studies on the mode of drug action

scientific article (publication date: 27 January 2005)

Atomic absorption spectrometric determination of the iridium content in tumor cells exposed to an iridium metallodrug

scientific article published on 4 March 2008

Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties

scientific article published on 17 November 2010

Biscarbene gold(i) complexes: structure-activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability

scientific article published on 27 June 2017

Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition, and interactions with proteins

scientific article published on 23 December 2012

Cellular Selectivity and Biological Impact of Cytotoxic Rhodium(III) and Iridium(III) Complexes Containing Methyl‐Substituted Phenanthroline Ligands ⬇️

scientific article published on February 17, 2011

Cellular Uptake Quantification of Metalated Peptide and Peptide Nucleic Acid Bioconjugates by Atomic Absorption Spectroscopy

scientific article published on 01 January 2008

Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation

scientific article published on 17 August 2009

Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes.

scientific article published on 6 January 2016

Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species.

scientific article

Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.

scientific article

Cyclometallated Au(iii) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies

scientific article published on 01 November 2018

Cytotoxic gold(I) N-heterocyclic carbene complexes with phosphane ligands as potent enzyme inhibitors

scientific article published on 26 March 2014

Cytotoxic rhodium(III) and iridium(III) polypyridyl complexes: structure-activity relationships, antileukemic activity, and apoptosis induction.

scientific article

Cytotoxicity and cellular impact of dinuclear organoiridium DNA intercalators and nucleases with long rigid bridging ligands ⬇️

scientific article published on March 14, 2012

DNA Intercalating RuIIPolypyridyl Complexes as Effective Photosensitizers in Photodynamic Therapy

scientific article published on 11 September 2014

Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.

scientific article published on September 2014

Development of a method for the quantification of the molar gold concentration in tumour cells exposed to gold-containing drugs

scientific article published in May 2007

Development of cobalt(3,4-diarylsalen) complexes as tumor therapeutics

scientific article

Dinuclear organoiridium(III) mono- and bis-intercalators with rigid bridging ligands: synthesis, cytotoxicity and DNA binding.

scientific article

Effects of Metal Salophene and Saldach Complexes on Lymphoma and Leukemia Cells ⬇️

scientific article published on January 14, 2011

Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules

scientific article published on 14 November 2012

Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid – Synthesis, electrochemistry and biological activity ⬇️

scientific article published on September 23, 2012

Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs.

scientific article published on 20 October 2016

Fluorescence properties and antiproliferative effects of mono-, bis-, and tris- thiophenylnaphthalimides: results of a comparative pilot study.

scientific article

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction

scientific article published on 25 June 2018

From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents

scientific article published on 08 November 2018

From catalysts to bioactive organometallics: do Grubbs catalysts trigger biological effects?

scientific article

Gold Organometallics with Biological Properties

Gold(I) N-heterocyclic carbene complexes with naphthalimide ligands as combined thioredoxin reductase inhibitors and DNA intercalators

scientific article published on 6 May 2014

Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram-Positive Directed Antibacterial Effects.

scientific article

Gold(I) thiotetrazolates as thioredoxin reductase inhibitors and antiproliferative agents

scientific article

Gold(i) complexes of water-soluble diphos-type ligands: Synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition ⬇️

scientific article published on August 9, 2011

Highly Electrophilic, Catalytically Active and Redox-Responsive Cobaltoceniumyl and Ferrocenyl Triazolylidene Coinage Metal Complexes.

scientific article

Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells.

scientific article published on 21 April 2011

Historical and biochemical aspects of a seventeenth century gold-based aurum vitae recipe

scientific article published on 19 April 2014

Insights on the mechanism of thioredoxin reductase inhibition by gold N-heterocyclic carbene compounds using the synthetic linear selenocysteine containing C-terminal peptide hTrxR(488-499): an ESI-MS investigation

scientific article

Investigations on the effects of cobalt-alkyne complexes on leukemia and lymphoma cells: cytotoxicity and cellular uptake

scientific article published in March 2004

Labile Pd-sulphur and Pt-sulphur bonds in organometallic palladium and platinum complexes [(COD)M(alkyl)(S-ligand)]n+-A speciation study.

scientific article published on 4 June 2016

Luminescent alkynyl-gold(I) coumarin derivatives and their biological activity

scientific article published on March 2014

Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents.

scientific article published on 20 December 2016

Metal complexes as protein kinase inhibitors.

scientific article

Metal complexes with 2-acetylpyridine-N(4)-orthochlorophenylthiosemicarbazone: cytotoxicity and effect on the enzymatic activity of thioredoxin reductase and glutathione reductase

scientific article published on 17 July 2014

Metallo-nucleosides: synthesis and biological evaluation of hexacarbonyl dicobalt 5-alkynyl-2'-deoxyuridines.

scientific article published on 26 November 2007

Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid ⬇️

scientific article published on December 11, 2012

Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors.

scientific article published on 23 April 2018

N-Heterocyclic carbene metal complexes in medicinal chemistry

scientific article published on 7 December 2012

Naphthalimide gold(I) phosphine complexes as anticancer metallodrugs.

scientific article

New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide

scientific article

On the biological properties of alkynyl phosphine gold(I) complexes.

scientific article published on 29 July 2012

Organometallic anticancer compounds

scientific article

Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells

scientific article

Phosphine-bridged dinuclear gold(I) alkynyl complexes: Thioredoxin reductase inhibition and cytotoxicity

Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex

scientific article published on 8 February 2008

Potent Inhibition of Thioredoxin Reductase by the Rh Derivatives of Anticancer M(arene/Cp*)(NHC)Cl2 Complexes

scientific article published on 19 February 2020

Preclinical and clinical studies on the use of platinum complexes for breast cancer treatment.

scientific article published on January 2007

Protease-activatable organometal-Peptide bioconjugates with enhanced cytotoxicity on cancer cells

scientific article published in July 2010

Special qualities of inorganic cytostatics. Medicinal chemistry of platinum complexes

scientific article published in January 2006

Stability, protein binding and thiol interaction studies on [2-acetoxy-(2-propynyl)benzoate]hexacarbonyldicobalt

scientific article published in April 2005

Structure-activity relationships and DNA binding properties of apoptosis inducing cytotoxic rhodium(III) polypyridyl complexes containing the cyclic thioether [9]aneS(3).

scientific article

Substituted pyridazino[3,4-b][1,5]benzoxazepin-5(6H)ones as multidrug-resistance modulating agents

scientific article

Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging, and phototoxic effects in cultured tumor cells.

scientific article

Surfactant protein B labelled with [99mTc(CO)3(H2O)3]+ retains biological activity in vitro

scientific article published on 01 April 2001

Synthesis and Biological Activities of Transition Metal Complexes Based on Acetylsalicylic Acid as Neo-Anticancer Agents ⬇️

scientific article published on October 14, 2010

Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes

scientific article published on 17 January 2018

Synthesis and biological activities of novel dexibuprofen tetraacetylriboflavin conjugates.

scientific article published on 2 November 2006

Synthesis and biological evaluation of chromium bioorganometallics based on the antibiotic platensimycin lead structure

scientific article published on November 2009

Synthesis, cellular uptake and structure-activity relationships for potent cytotoxic trichloridoiridium(III) polypyridyl complexes.

scientific article

Synthesis, structure and cytotoxicity of cyclic (alkyl)(amino) carbene and acyclic carbene complexes of group 11 metals.

scientific article

The antioxidant 2,6-di-tert-butylphenol moiety attenuates the pro-oxidant properties of the auranofin analogue

scientific article

The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.

scientific article published on 19 September 2014

Total reflection X-ray fluorescence spectrometry as a tool for the quantification of gold and platinum metallodrugs: determination of recovery rates and precision in the ppb concentration range

scientific article published on 25 July 2012

Tuning the electronic properties of dppz-ligands and their palladium(II) complexes.

scientific article published on 25 March 2010

[Cyclopentadienyl]metalcarbonyl complexes of acetylsalicylic acid as neo-anticancer agents.

scientific article published on 18 August 2010

[N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties

scientific article

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