List of works - Ouathek Ouerfelli

A Self-Assembling and DisAssembling (SADA) bispecific antibody (BsAb) platform for curative 2-step pre-targeted radioimmunotherapy

scientific article published on 21 September 2020

A peptidomimetic siRNA transfection reagent for highly effective gene silencing.

scientific article published on 17 May 2006

A protecting group-free synthesis of deazathiamine: a step toward inhibitor design

scientific article published on 16 September 2010

ARN-509: a novel antiandrogen for prostate cancer treatment

scientific article

Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase

scientific journal article

Affinity of monoclonal antibodies for Globo-series glycans

scientific article published on 14 July 2014

Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays

scientific article

Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation

scientific article

Confirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims.

scientific article

DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1

scientific article

Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer

scientific article published on 14 September 2009

Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells

scientific article

Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.

scientific article

Evaluation of glycodendron and synthetically modified dextran clearing agents for multistep targeting of radioisotopes for molecular imaging and radioimmunotherapy.

scientific article

From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine

scientific article

High-throughput identification of inhibitors of human mitochondrial peptide deformylase.

scientific article

Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1.

scientific article

Inhibition of human peptide deformylase disrupts mitochondrial function

scientific article

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling

scientific article

Loss of BAP1 function leads to EZH2-dependent transformation

scientific article published on 5 October 2015

Mechanistic details of the actinobacterial lyase-catalyzed degradation reaction of 2-hydroxyisobutyryl-CoA

scientific article published on 22 December 2021

N-acetylgalactosamino dendrons as clearing agents to enhance liver targeting of model antibody-fusion protein

scientific article

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

scientific article

Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors

scientific article

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

scientific article published on 01 February 2019

Pilot study of a heptavalent vaccine-keyhole limpet hemocyanin conjugate plus QS21 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer

scientific article

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors

scientific article

Radiosynthesis of [(131)I]IAZGP via nucleophilic substitution and its biological evaluation as a hypoxia marker - is specific activity a factor influencing hypoxia-mapping ability of a hypoxia marker?

scientific article

Radiosynthesis of the tumor hypoxia marker [18F]TFMISO via O-[18F]trifluoroethylation reveals a striking difference between trifluoroethyl tosylate and iodide in regiochemical reactivity toward oxygen nucleophiles

scientific article

Sequence characteristics of functional siRNAs

scientific article published in June 2005

Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells

scientific article published on 22 January 2015

Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target

scientific article

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines

scientific article

Synthesis and evaluation of geldanamycin-testosterone hybrids

scientific article published on 01 June 2000

Synthesis of novel PET tracer 124I-trametinib for MAPK/ERK kinase distribution and resistance monitoring

scientific article published on 22 May 2020

Targeting Germline and Tumor Associated Nucleotide Excision Repair Defects in Cancer

scientific article published on 16 November 2020

List of works by Ouathek Ouerfelli

A Self-Assembling and DisAssembling (SADA) bispecific antibody (BsAb) platform for curative 2-step pre-targeted radioimmunotherapy

A peptidomimetic siRNA transfection reagent for highly effective gene silencing.

A protecting group-free synthesis of deazathiamine: a step toward inhibitor design

ARN-509: a novel antiandrogen for prostate cancer treatment

Activity-based metabolomic profiling of enzymatic function: identification of Rv1248c as a mycobacterial 2-hydroxy-3-oxoadipate synthase

Affinity of monoclonal antibodies for Globo-series glycans

Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays

Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation

Confirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims.

DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1

Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer

Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells

Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.

Evaluation of glycodendron and synthetically modified dextran clearing agents for multistep targeting of radioisotopes for molecular imaging and radioimmunotherapy.

From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine

High-throughput identification of inhibitors of human mitochondrial peptide deformylase.

Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1.

Inhibition of human peptide deformylase disrupts mitochondrial function

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling

Loss of BAP1 function leads to EZH2-dependent transformation

Mechanistic details of the actinobacterial lyase-catalyzed degradation reaction of 2-hydroxyisobutyryl-CoA

N-acetylgalactosamino dendrons as clearing agents to enhance liver targeting of model antibody-fusion protein

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

Pilot study of a heptavalent vaccine-keyhole limpet hemocyanin conjugate plus QS21 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors

Radiosynthesis of [(131)I]IAZGP via nucleophilic substitution and its biological evaluation as a hypoxia marker - is specific activity a factor influencing hypoxia-mapping ability of a hypoxia marker?

Radiosynthesis of the tumor hypoxia marker [18F]TFMISO via O-[18F]trifluoroethylation reveals a striking difference between trifluoroethyl tosylate and iodide in regiochemical reactivity toward oxygen nucleophiles

Sequence characteristics of functional siRNAs

Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells

Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines

Synthesis and evaluation of geldanamycin-testosterone hybrids

Synthesis of novel PET tracer 124I-trametinib for MAPK/ERK kinase distribution and resistance monitoring

Targeting Germline and Tumor Associated Nucleotide Excision Repair Defects in Cancer