Search filters

List of works by Paul R. Carlier

3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae

scientific article

Access to "Friedel-Crafts-restricted" tert-alkyl aromatics by activation/methylation of tertiary benzylic alcohols.

scientific article published on 16 March 2012

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity

scientific article

Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant

scientific article published on 10 December 2014

Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers

scientific article published on 20 October 2006

Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box.

scientific article

Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050.

scientific article

Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)

scientific article

Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae

scientific article published on 16 September 2012

Axial-selective H/D exchange of glycine-derived 1H-benzo[e][1,4]diazepin-2(3H)-ones: kinetic and computational studies of enantiomerization

scientific article published on October 2010

Biological Studies and Target Engagement of the 2-C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1R,3S)-MMV008138 and Analogs.

scientific article published on 26 October 2017

Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade.

scientific article

Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.

scientific article published on 25 May 2011

Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats

scientific article published in March 2000

Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine

scientific article published on 01 September 2000

Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae

scientific article published in October 2016

Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae

scientific article published on 9 March 2015

Catalytic asymmetric synthesis of protected tryptophan regioisomers

scientific article published in August 2002

Complete mapping of the stereochemical course of retentive deprotonation/alkylation of 1H-benzo[e][1,4]diazepin-2(3H)-ones.

scientific article published in December 2009

Complexes of Alkylene-Linked Tacrine Dimers withTorpedo californicaAcetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge

scientific article published on 01 September 2006

Computational studies of ion-pair separation of benzylic organolithium compounds in THF: importance of explicit and implicit solvation

scientific article published in February 2010

Configurational stability of chiral lithiated cyclopropylnitriles: a density functional study

scientific article published in May 2003

Corrigendum to 'Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor' [Neurosci. Lett. 288 (2000) 95–98]

scientific article published on 01 August 2000

Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase

scientific article published on 01 August 2005

Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies

scientific article

Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study.

scientific article published on 24 November 2008

Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease.

scientific article

Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase

scientific article

Discovery of non-zwitterionic GABA(A) receptor full agonists and a superagonist.

scientific article

Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities

scientific article published on 01 November 1999

Effect of 2,6-disubstituted aryl groups on acyclic conformation: preference for an antiperiplanar orientation of the geminal and vicinal hydrogens

scientific article

Effects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine Acetylcholinesterase

scientific article published on July 2013

Enantioselective deprotonative ring contraction of N1-methyl-N4-Boc-benzo[e][1,4]diazepine-2,5-diones

scientific article published on 23 September 2014

Enantioselective synthesis of "quaternary" 1,4-benzodiazepin-2-one scaffolds via memory of chirality

scientific article published in September 2003

Enantioselective synthesis of diversely substituted quaternary 1,4-benzodiazepin-2-ones and 1,4-benzodiazepine-2,5-diones

scientific article

Enzyme biosensor for studying therapeutics of Alzheimer's disease.

scientific article

Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis

scientific article published in February 1999

Experimental and computational studies of ring inversion of 1,4-benzodiazepin-2-ones: implications for memory of chirality transformations

scientific article

Heterodimeric Tacrine-Based Acetylcholinesterase Inhibitors: Investigating Ligand−Peripheral Site Interactions

scientific article published on 01 October 1999

Highly enantioselective synthesis of rigid, quaternary 1,4-benzodiazepine-2,5-diones derived from proline

scientific article published in November 2005

Immobilized enzymes as catalytically-active tools for nanofabrication

scientific article published in October 2002

Incremental solvation precedes ion-pair separation in enantiomerization of a cyano-stabilized Grignard reagent.

scientific article published on 21 September 2011

Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue

scientific article

Inhibitor profile of bis(n)-tacrines and N-methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi

scientific article published on July 2013

Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates.

scientific article published on 28 April 2019

Mosquitocidal carbamates with low toxicity to agricultural pests: an advantageous property for insecticide resistance management

scientific article

Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets

scientific article published on 16 September 2011

Neurotoxicology of bis(n)-tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase.

scientific article published on 5 June 2013

Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors

scientific article published on 14 February 2005

Parallel inhibition of amino acid efflux and growth of erythrocytic Plasmodium falciparum by mefloquine and non-piperidine analogs: Implication for the mechanism of antimalarial action

scientific article published on 3 August 2016

Pd-catalyzed amination as an alternative to nucleophilic aromatic substitution for the synthesis of N-alkyltacrines and analogues.

scientific article

Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors

scientific article published on 01 August 1999

Preventing H2O2-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone

scientific article published on 09 February 2011

Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected].

scientific article published in July 2000

Protonated 2-methyl-1,2-epoxypropane: a challenging problem for density functional theory

scientific article

Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using 1H-1H coupling constants

scientific article published on 24 June 2019

Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase

scientific article

Regioselective synthesis of aniline-derived 1,3- and Ci-symmetric 1,4-diols from trans-1,4-cyclohexadiene dioxide

scientific article published in February 2010

Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.

scientific article published in March 2002

Select small core structure carbamates exhibit high contact toxicity to "carbamate-resistant" strain malaria mosquitoes, Anopheles gambiae (Akron).

scientific article

Stereochemical inversion of a cyano-stabilized grignard reagent: remarkable effects of the ethereal solvent structure and concentration.

scientific article published on 13 September 2013

Structural genomics for drug design against the pathogen Coxiella burnetii

scientific article

The first enantioenriched metalated nitrile possessing macroscopic configurational stability

scientific article published on 10 March 2007

The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine

scientific article published on 4 September 2007

Threading the needle: mimicking natural toroidal catalysts

scientific article

Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae

scientific article published on 4 May 2008

Toxicology of potassium channel-directed compounds in mosquitoes

scientific article published in June 2016

Paulina is supported by:

About Paulina

Help