List of works by Joaquín M Espinosa

A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX.

scientific article published on 13 January 2012

A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response.

scientific article

A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation.

scientific article published on 16 May 2013

A new synthesis of 6-oxopyrimidinium-4-olates. Theoretical study of the regioselective cycloaddition of arylisocyanates with A 1,3-thiazolium-4-olate system

A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint

scientific article published in June 2009

A signature for success.

scientific article published on 16 June 2015

ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.

scientific article

ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels

scientific article

Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands

scientific article published on 25 April 2018

An early ancestor in the evolution of splicing: a Trypanosoma cruzi serine-arginine-rich protein (TcSR) is functional in cis-splicing

scientific article

Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover.

scientific article published in March 2018

Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels

scientific article

BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death

scientific article

Back to bases: how a nucleotide biosynthetic enzyme controls p53 activation

scientific article published on February 2014

CBX3 regulates efficient RNA processing genome-wide

scientific article

CDK8 Kinase Activity Promotes Glycolysis.

scientific article published in November 2017

CDK8 is a positive regulator of transcriptional elongation within the serum response network

scientific article

CDK8: a positive regulator of transcription

scientific article

Control of Trypanosoma cruzi epimastigote motility through the nitric oxide pathway

scientific article published on 01 March 1997

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

scientific article

Differential regulation of p53 target genes: it's (core promoter) elementary.

scientific article

Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes

scientific article

Down Syndrome and COVID-19: A Perfect Storm?

scientific article published on 01 May 2020

Down Syndrome patients with COVID-19 pneumonia: a high-risk category for unfavourable outcome

scientific article published on 30 November 2020

Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism

scientific article

ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1

scientific article published on 17 September 2013

Exosomal biomarkers in Down syndrome and Alzheimer's disease

scientific article published on 4 September 2017

Factors from Trypanosoma cruzi interacting with AP-1 sequences.

scientific article

Further understanding the connection between Alzheimer's disease and Down syndrome

scientific article published on 16 June 2020

Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding.

scientific article

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program

scientific article

Get back TFIIF, don't let me Gdown1.

scientific article

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms.

scientific article

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia

scientific article

Histone H2B ubiquitination: the cancer connection

scientific article published on October 2008

How does ΔNp63α drive cancer?

scientific article published in February 2013

Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells

scientific article

Identification of Salmonella serovars isolated from live molluscan shellfish and their significance in the marine environment

scientific article published in February 2003

Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity

scientific article published on 13 September 2017

Inhibition of telomerase recruitment and cancer cell death

scientific article

JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

scientific article published on 01 November 2020

JAK1 inhibition blocks lethal sterile immune responses: implications for COVID-19 therapy

scientific article published on 09 April 2020

Janus kinase inhibition in Down syndrome: 2 cases of therapeutic benefit for alopecia areata

Lessons on transcriptional control from the serum response network

scientific article

Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome

scientific article published on 01 November 2019

Mechanisms of transcriptional regulation by p53.

scientific article published on 10 November 2017

Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination

scientific article published on 06 August 2019

Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response

scientific article published on 02 March 2021

Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation

scientific article

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.

scientific article published on September 2016

NPM and BRG1 Mediate Transcriptional Resistance to Retinoic Acid in Acute Promyelocytic Leukemia

scientific article published on 15 March 2016

Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30

scientific article published on 01 March 2020

On the Origin of lncRNAs: Missing Link Found

scientific article published in August 2017

RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes.

scientific article

Red blood cell metabolism in Down syndrome: hints on metabolic derangements in aging

scientific article published on 21 December 2017

Revisiting lncRNAs: How Do You Know Yours Is Not an eRNA?

scientific article published in April 2016

Role of the host restriction factor APOBEC3 on papillomavirus evolution

scientific article published on January 2015

SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program

scientific article published on 03 January 2019

Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing

scientific article published on October 2005

Seroconversion stages COVID19 into distinct pathophysiological states

scientific article published on 07 December 2020

Stimulus-specific transcriptional regulation within the p53 network

scientific article published on 13 August 2007

The Crusade against Mutant p53: Does the COMPASS Point to the Holy Grail?

scientific article published in October 2015

The NSL Chromatin-Modifying Complex Subunit KANSL2 Regulates Cancer Stem-like Properties in Glioblastoma That Contribute to Tumorigenesis.

scientific article published on 12 July 2016

The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p.

scientific article

The TIP60 Complex Is a Conserved Coactivator of HIF1A

scientific article published on 15 June 2016

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

scientific journal article

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator

scientific article

The impact of post-transcriptional regulation in the p53 network

scientific article published on 14 December 2012

The meaning of pausing ⬇️

scientific article published on November 24, 2010

The p53 circuit board

scientific article

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

scientific article published on 2 January 2017

Therapeutic targeting of transcriptional cyclin-dependent kinases

scientific article published on 09 November 2018

Transcriptional CDKs in the spotlight

scientific article published on 01 April 2019

Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions

scientific article published on 05 September 2019

Transcriptional control by enhancers: working remotely for improved performance

scientific article published on 01 February 2020

Transcriptional regulation by hypoxia inducible factors

scientific article published on 07 October 2013

Trisomy 21 Represses Cilia Formation and Function

scientific article published on 09 August 2018

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

scientific article published on 18 October 2019

Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation.

scientific article published in November 2017

Trisomy 21 consistently activates the interferon response.

scientific article published on 29 July 2016

Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity

scientific article published on 07 November 2019

Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases

scientific article published in 2003

Trypanosoma cruzi poly-zinc finger protein: a novel DNA/RNA-binding CCHC-zinc finger protein.

scientific article

Tumor suppression by p53: is apoptosis important or not?

scientific article published in May 2013

Tumoural soft tissue calcification in Down syndrome: association with heterozygous germline SAMD9 mutation and hyperactive type I interferon signaling

scientific article published on 28 June 2020

Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment

scientific article published on 15 August 2018

p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer

scientific article published on 10 March 2015

p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage ⬇️

scientific article published on October 1, 2003

ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas

ΔNp63α represses anti-proliferative genes via H2A.Z deposition.

scientific article

ΔNp63α utilizes multiple mechanisms to repress transcription in squamous cell carcinoma cells.

scientific article published on 16 January 2013

Paulina is supported by:

About Paulina

Help