List of works - John H. McVey

450 million years of hemostasis.

scientific article

A Tyr346-->Cys substitution in the interdomain acidic region a1 of factor VIII in an individual with factor VIII:C assay discrepancy

scientific article

A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.

scientific article

AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.

scientific article published on December 2011

Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop

scientific article published on 23 January 2007

Adenovirus serotype 5 hexon mediates liver gene transfer

scientific article published in February 2008

An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease

scientific article published on April 1990

Analysis of the consequences of premature termination codons within factor VIII coding sequences.

scientific article published in January 2003

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

scientific article

Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex

scientific article (publication date: June 2003)

Characterization of a recent retroposon insertion on mouse chromosome 2 and localization of the cognate parental gene to chromosome 11.

scientific article published on February 1998

Coagulation factor VII Gln100 --> Arg. Amino acid substitution at the epidermal growth factor 2-protease domain interface results in severely reduced tissue factor binding and procoagulant function

scientific article published on 01 April 1998

Codon optimization of human factor VIII cDNAs leads to high-level expression

scientific article published in November 2010

Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.

scientific article published in December 2004

Detection and characterisation of two missense mutations at a cleavage site in the factor VIII light chain

scientific article published in February 1991

Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p.

scientific article

Domains of invasion organelle proteins from apicomplexan parasites are homologous with the Apple domains of blood coagulation factor XI and plasma pre-kallikrein and are members of the PAN module superfamily

scientific article published on 01 May 2001

Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer

scientific article published on 22 October 2008

Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions.

scientific article published on 15 November 2007

Enhanced effect of inhibition of thrombin on endothelium in murine endotoxaemia: specific inhibition of thrombocytopenia

scientific article

Expression of human tissue factor pathway inhibitor on vascular smooth muscle cells inhibits secretion of macrophage migration inhibitory factor and attenuates atherosclerosis in ApoE-/- mice

scientific article published on 12 February 2015

Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells

scientific article published in September 2008

FVIIa gene delivery: potential treatment for hemophilia?

scientific article

Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C.

scientific article

Factor VIII gene analysis in Japanese CRM‐positive and CRM‐reduced haemophilia A patients by single‐strand conformation polymorphism ⬇️

scientific article published on September 1, 1997

Factor VIIShinjo: a dysfunctional factor VII variant homozygous for the substitution Gln for Arg at position 79

scientific article published on 01 May 1995

Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts.

scientific article

Factor seven‐activating protease: does it do what it says on the tin? ⬇️

scientific article published on 01 May 2012

Fibrocytes mediate intimal hyperplasia post-vascular injury and are regulated by two tissue factor-dependent mechanisms

scientific article published on 01 May 2013

Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis

scientific article published on 24 December 2003

Generation of a polyclonal rabbit anti-mouse tissue factor antibody by nucleic acid immunisation

scientific article published on 01 January 2005

Haemophilia A diagnosis by analysis of a hypervariable dinucleotide repeat within the factor VIII gene

scientific article

High-level production of human blood coagulation factors VII and XI using a new mammalian expression vector.

scientific article

Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins

article

Hyperactive piggyBac transposons for sustained and robust liver-targeted gene therapy

scientific article

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

scientific article published on 08 May 2009

Identification of two novel mutations in non‐Jewish factor XI deficiency ⬇️

scientific article published on August 1, 1995

In utero administration of Ad5 and AAV pseudotypes to the fetal brain leads to efficient, widespread and long-term gene expression.

scientific article

Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors

scientific article

Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.

scientific article published on 24 January 2007

Inhibition of Thrombin Receptor Signaling on α-Smooth Muscle Actin + CD34 + Progenitors Leads to Repair After Murine Immune Vascular Injury

article

Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium

scientific article

Interferon-gamma modulates prolactin and tissue factor expression in differentiating human endometrial stromal cells

scientific article

Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo

scientific article published on 6 February 2015

Molecular Analysis in Factor XI Deficiency

scientific article published on 01 January 1999

Molecular cloning of laminin

scientific article published on 01 January 1987

Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting

scientific article published on February 2009

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

scientific article published on 20 June 2006

Nomenclature of genetic variants in hemostasis

scientific article published in April 2011

O tissue factor, where art thou? ⬇️

scientific article published on 01 August 2010

Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins

scientific article published on 27 June 2006

Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.

scientific article published on 7 July 2008

Regenerative repair after endoluminal injury in mice with specific antagonism of protease activated receptors on CD34+ vascular progenitors

scientific article published on 11 February 2008

Regulated endothelial cell expression of novel anticoagulants: a strategy for the prevention and therapy of intravascular thrombosis

scientific article published on 01 August 2000

Regulated inhibition of coagulation by porcine endothelial cells expressing P-selectin-tagged hirudin and tissue factor pathway inhibitor fusion proteins

scientific article published in September 1999

Stable recombinant expression and characterization of the two haemophilic factor VIII variants C329S (CRM(-)) and G1948D (CRM(r)).

scientific article published in June 2001

Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.

scientific article

Temporal expression of alternatively spliced forms of tissue factor pathway inhibitor in mice.

scientific article published on 24 April 2009

The EAHAD Blood Coagulation Factor VII Variant Database

scientific article published on 25 April 2020

The European Association for Haemophilia and Allied Disorders (EAHAD) Coagulation Factor Variant Databases: Important resources for haemostasis clinicians and researchers

scientific article published on 13 March 2020

The chromatin structure of the mouse beta-2-microglobulin locus

scientific article

The influence of blood on in vivo adenovirus bio-distribution and transduction.

scientific article published on 15 May 2007

The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes.

scholarly article

The role of the tissue factor pathway in haemostasis and beyond

scientific article

Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant

scientific article published on 20 February 2013

Tissue factor pathway

scientific article published on September 1994

Two novel mutations in severe factor VII deficiency

scientific article

Your bleeding heart: lessons from low tissue factor expression in mice.

scientific article

List of works by John H. McVey

450 million years of hemostasis.

A Tyr346-->Cys substitution in the interdomain acidic region a1 of factor VIII in an individual with factor VIII:C assay discrepancy

A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.

AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage.

Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop

Adenovirus serotype 5 hexon mediates liver gene transfer

An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease

Analysis of the consequences of premature termination codons within factor VIII coding sequences.

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex

Characterization of a recent retroposon insertion on mouse chromosome 2 and localization of the cognate parental gene to chromosome 11.

Coagulation factor VII Gln100 --> Arg. Amino acid substitution at the epidermal growth factor 2-protease domain interface results in severely reduced tissue factor binding and procoagulant function

Codon optimization of human factor VIII cDNAs leads to high-level expression

Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.

Detection and characterisation of two missense mutations at a cleavage site in the factor VIII light chain

Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p.

Domains of invasion organelle proteins from apicomplexan parasites are homologous with the Apple domains of blood coagulation factor XI and plasma pre-kallikrein and are members of the PAN module superfamily

Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer

Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions.

Enhanced effect of inhibition of thrombin on endothelium in murine endotoxaemia: specific inhibition of thrombocytopenia

Expression of human tissue factor pathway inhibitor on vascular smooth muscle cells inhibits secretion of macrophage migration inhibitory factor and attenuates atherosclerosis in ApoE-/- mice

Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells

FVIIa gene delivery: potential treatment for hemophilia?

Factor V I359T: a novel mutation associated with thrombosis and resistance to activated protein C.

Factor VIII gene analysis in Japanese CRM‐positive and CRM‐reduced haemophilia A patients by single‐strand conformation polymorphism ⬇️

Factor VIIShinjo: a dysfunctional factor VII variant homozygous for the substitution Gln for Arg at position 79

Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts.

Factor seven‐activating protease: does it do what it says on the tin? ⬇️

Fibrocytes mediate intimal hyperplasia post-vascular injury and are regulated by two tissue factor-dependent mechanisms

Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis

Generation of a polyclonal rabbit anti-mouse tissue factor antibody by nucleic acid immunisation

Haemophilia A diagnosis by analysis of a hypervariable dinucleotide repeat within the factor VIII gene

High-level production of human blood coagulation factors VII and XI using a new mammalian expression vector.

Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins

Hyperactive piggyBac transposons for sustained and robust liver-targeted gene therapy

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

Identification of two novel mutations in non‐Jewish factor XI deficiency ⬇️

In utero administration of Ad5 and AAV pseudotypes to the fetal brain leads to efficient, widespread and long-term gene expression.

Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors

Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.

Inhibition of Thrombin Receptor Signaling on α-Smooth Muscle Actin + CD34 + Progenitors Leads to Repair After Murine Immune Vascular Injury

Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium

Interferon-gamma modulates prolactin and tissue factor expression in differentiating human endometrial stromal cells

Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo

Molecular Analysis in Factor XI Deficiency

Molecular cloning of laminin

Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

Nomenclature of genetic variants in hemostasis

O tissue factor, where art thou? ⬇️

Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins

Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.

Regenerative repair after endoluminal injury in mice with specific antagonism of protease activated receptors on CD34+ vascular progenitors

Regulated endothelial cell expression of novel anticoagulants: a strategy for the prevention and therapy of intravascular thrombosis

Regulated inhibition of coagulation by porcine endothelial cells expressing P-selectin-tagged hirudin and tissue factor pathway inhibitor fusion proteins

Stable recombinant expression and characterization of the two haemophilic factor VIII variants C329S (CRM(-)) and G1948D (CRM(r)).

Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.

Temporal expression of alternatively spliced forms of tissue factor pathway inhibitor in mice.

The EAHAD Blood Coagulation Factor VII Variant Database

The European Association for Haemophilia and Allied Disorders (EAHAD) Coagulation Factor Variant Databases: Important resources for haemostasis clinicians and researchers

The chromatin structure of the mouse beta-2-microglobulin locus

The influence of blood on in vivo adenovirus bio-distribution and transduction.

The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes.

The role of the tissue factor pathway in haemostasis and beyond

Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant

Tissue factor pathway

Two novel mutations in severe factor VII deficiency

Your bleeding heart: lessons from low tissue factor expression in mice.