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List of works by Paul G. Thomas

A Cell for the Ages: Human γδ T Cells across the Lifespan

scientific article published on 24 November 2020

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus

scientific article (publication date: 2015)

A Modular Cytokine Analysis Method Reveals Novel Associations With Clinical Phenotypes and Identifies Sets of Co-signaling Cytokines Across Influenza Natural Infection Cohorts and Healthy Controls

scientific article published on 18 June 2019

A comprehensive collection of systems biology data characterizing the host response to viral infection.

scientific article

A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness.

scientific article

A multi-valent vaccine approach that elicits broad immunity within an influenza subtype.

scientific article published on 07 January 2009

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens

scientific article (publication date: August 2016)

An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses

scholarly article

Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function.

scientific article published on 09 January 2016

Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier

scientific article published on 29 April 2020

Bach2 Negatively Regulates T Follicular Helper Cell Differentiation and Is Critical for CD4+ T Cell Memory

scientific article published on 10 April 2019

Balancing Immune Protection and Immune Pathology by CD8(+) T-Cell Responses to Influenza Infection

scientific article

Bohemian T cell receptors: sketching the repertoires of unconventional lymphocytes

scientific article published on 01 July 2018

Cell-Intrinsic Barriers of T Cell-Based Immunotherapy

scientific article published on 4 November 2016

Cell-mediated protection in influenza infection.

scientific article

Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model

scientific article

Characterizing Emerging Canine H3 Influenza Viruses

scientific article published on 14 April 2020

Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence ⬇️

scientific article published on December 17, 2010

Chronic helminth infections impair pneumococcal vaccine responses

scientific article published on 13 August 2014

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease.

scientific article published on 26 February 2018

Clonally related CD8+ T cells responsible for rapid population of both diffuse nasal-associated lymphoid tissue and lung after respiratory virus infection

scientific article

Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels

scientific article published on 25 January 2013

Consequences of immunodominant epitope deletion for minor influenza virus-specific CD8+-T-cell responses

scientific article

Constrained evolution drives limited influenza diversity

scientific article

Contemporary seasonal influenza A (H1N1) virus infection primes for a more robust response to split inactivated pandemic influenza A (H1N1) Virus vaccination in ferrets

scientific article

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

scientific article

Cytokine Profiles of Severe Influenza Virus-Related Complications in Children

scientific article published on 6 November 2017

Cytomegalovirus infection enhances the immune response to influenza.

scientific article

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

scientific article

Dangerous for ferrets: lethal for humans? ⬇️

scientific article published on February 20, 2012

Data from CAR T-cell Design-dependent Remodeling of the Brain Tumor Immune Microenvironment Modulates Tumor-associated Macrophages and Anti-glioma Activity

De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation

scientific article

Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

scientific article published on 15 August 2016

Defining the risk of SARS-CoV-2 variants on immune protection

scientific article published on 31 March 2022

Dendritic cells activated by an anti-inflammatory agent induce CD4(+) T helper type 2 responses without impairing CD8(+) memory and effector cytotoxic T-lymphocyte responses

scientific article published on 16 November 2009

Depletion of Alveolar Macrophages during Influenza Infection Facilitates Bacterial Superinfections ⬇️

scientific article published on June 26, 2013

Detection of antibodies against Turkey astrovirus in humans

scientific article

Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.

scientific article published on 13 March 2013

Differential host response, rather than early viral replication efficiency, correlates with pathogenicity caused by influenza viruses

scientific article

Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8+ T Cell Differentiation

scientific article published in December 2014

Distinct epigenetic signatures delineate transcriptional programs during virus-specific CD8(+) T cell differentiation

scientific article published on 6 November 2014

Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm

scientific article published on 13 November 2020

Diverse heterologous primary infections radically alter immunodominance hierarchies and clinical outcomes following H7N9 influenza challenge in mice

scientific article

Ecological analysis of antigen-specific CTL repertoires defines the relationship between naïve and immune T-cell populations ⬇️

scientific article (publication date: 29 January 2013)

Enhanced Susceptibility of Ago1/3 Double-Null Mice to Influenza A Virus Infection.

scientific article published in August 2012

Enhanced susceptibility of Ago1/3 double-null mice to influenza A virus infection.

scientific article published on 8 February 2012

Eosinophils Promote Antiviral Immunity in Mice Infected with Influenza A Virus

scientific article

Epitope-specific TCR  repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

scientific article

Establishment of memory CD8+ T cells with live attenuated influenza virus across different vaccination doses

scientific article published on 2 November 2016

Evaluation of IFITM3 rs12252 Association With Severe Pediatric Influenza Infection

scientific article published in 2017

Exogenous remodeling of lung resident macrophages protects against infectious consequences of bone marrow-suppressive chemotherapy

scientific article published on 26 September 2016

Exuberant fibroblast activity compromises lung function via ADAMTS4

scientific article published on 28 October 2020

Functional implications of T cell receptor diversity

scientific article published on 11 June 2009

Gamma delta T cell reconstitution is associated with fewer infections and improved event-free survival after hematopoietic stem cell transplantation for pediatric leukemia.

scientific article

HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity

scientific article published on September 2017

Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice

scientific article published on 19 January 2016

Helminth infections predispose mice to pneumococcal pneumonia but not to other pneumonic pathogens

scientific article published on 21 June 2014

Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses

scientific article published in March 2007

Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells

scientific article

Hitting the Target: How T Cells Detect and Eliminate Tumors

scientific article published in January 2018

Host detection and the stealthy phenotype in influenza virus infection.

scientific article published on January 2015

Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

scientific article published on 18 February 2019

Human H7N9 and H5N1 influenza viruses differ in induction of cytokines and tissue tropism.

scientific article

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses

scientific article published on 27 January 2020

Identifying T Cell Receptors from High-Throughput Sequencing: Dealing with Promiscuity in TCRα and TCRβ Pairing

scientific article

Immune biasing by helminth glycans.

scientific article published on January 2004

Immunity to avian influenza A viruses.

scientific article published on April 2009

Immunity to influenza. Preventing infection and regulating disease

scientific article published in February 2015

Immunity to seasonal and pandemic influenza A viruses

scientific article

Implementing hospital-based surveillance for severe acute respiratory infections caused by influenza and other respiratory pathogens in New Zealand

scientific article

Influenza and the challenge for immunology

scientific article

Influenza epitope-specific CD8+ T cell avidity, but not cytokine polyfunctionality, can be determined by TCRβ clonotype

scientific article

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles.

scientific article published on 8 January 2018

Interrogating the relationship between naïve and immune antiviral T cell repertoires

scientific article published on 10 July 2013

Intranasal influenza infection of mice and methods to evaluate progression and outcome

scientific article published on January 2013

Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

scientific article published on 30 December 2019

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.

scientific article published on August 2016

Lipid composition of viral envelope of three strains of influenza virus - not all viruses are created equal.

scientific article published on 24 June 2015

Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation

scientific article published on July 2013

Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

scientific article published on 29 October 2021

MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates

scientific article

Maintenance of the EBV-specific CD8+ TCRαβ repertoire in immunosuppressed lung transplant recipients

scientific article published on 10 August 2016

Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism

scientific article published in December 2003

Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.

scientific article

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells

scientific article published on 01 July 2018

Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses

scientific article published on 31 March 2016

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination

scientific article

Mucosal immune responses predict clinical outcomes during influenza infection independently of age and viral load.

scientific article published on February 2014

NFkappaB negatively regulates interferon-induced gene expression and anti-influenza activity.

scientific article published on 03 March 2006

Neonatal CD8 T-cell hierarchy is distinct from adults and is influenced by intrinsic T cell properties in respiratory syncytial virus infected mice

scientific article published on December 2011

Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1-Dependent Myeloid Cells

scientific article published on 23 July 2021

New Approaches in Immunotherapy

scientific article published in Science

New advances in CMV and immunosenescence

scientific article

New fronts emerge in the influenza cytokine storm

scientific article published on 29 May 2017

Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death.

scientific article

Non-random lymphocyte distribution among virus-infected cells of the respiratory tract.

scientific article published on December 2013

Nucleotide oligomerization and binding domain 2-dependent dendritic cell activation is necessary for innate immunity and optimal CD8+ T Cell responses to influenza A virus infection

scientific article

Oseltamivir Prophylaxis Reduces Inflammation and Facilitates Establishment of Cross-Strain Protective T Cell Memory to Influenza Viruses

scientific article

Overlapping Peptides Elicit Distinct CD8+ T Cell Responses following Influenza A Virus Infection

scientific article published on 31 August 2020

Paired TCRαβ analysis of virus-specific CD8(+) T cells exposes diversity in a previously defined 'narrow' repertoire

scientific article

Paired analysis of TCRα and TCRβ chains at the single-cell level in mice

scientific article

Parasite-secreted products regulate the host response to larval Taenia crassiceps

article

Pause on avian flu transmission research

scientific article published on January 2012

Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses

scientific article published on 01 June 2019

Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challenge

scientific article

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

scientific article

Protective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

scientific article

Protective memory responses are modulated by priming events prior to challenge.

scientific article

Publisher Correction: Exuberant fibroblast activity compromises lung function via ADAMTS4

scientific article published on 18 November 2020

Quantifiable predictive features define epitope-specific T cell receptor repertoires

scientific article published on 21 June 2017

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

scientific article published on 28 June 2019

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.

scientific article published on 15 June 2016

Rapid cloning, expression, and functional characterization of paired αβ and γδ T-cell receptor chains from single-cell analysis.

scientific article published on 27 January 2016

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

scientific article published on 24 March 2013

Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8⁺ T cells

scientific article published on 13 May 2015

Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection

scientific article published on 13 January 2014

Respiratory Mucosal Proteome Quantification in Human Influenza Infections

scientific article

Respiratory epithelial cells in innate immunity to influenza virus infection

scientific article published on 17 September 2010

Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A.

scientific article published on 22 January 2014

Retinol binding protein and vitamin D associations with serum antibody isotypes, serum influenza virus-specific neutralizing activities and airway cytokine profiles

scientific article published on October 2015

Rules to 'prime' by.

scientific article published on January 2009

SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans

scientific article published on 17 July 2017

Screening monoclonal antibodies for cross-reactivity in the ferret model of influenza infection

scientific article published on 28 April 2008

Seasonal influenza vaccination is the strongest correlate of cross-reactive antibody responses in migratory bird handlers.

scientific article

Severe Influenza Is Characterized by Prolonged Immune Activation: Results From the SHIVERS Cohort Study

scholarly article

Simulation modelling for immunologists

scientific article published on 05 December 2019

Single-Cell Analysis of T-Cell Receptor αβ Repertoire

scientific article published in January 2015

Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing

scientific article

Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structure-based design of head-only fusion glycoprotein immunogens for respiratory syncytial virus

scientific article

Surveillance states

scientific article published in April 2017

T Cell receptor clonotype influences epitope hierarchy in the CD8+ T cell response to respiratory syncytial virus infection.

scientific article

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.

scientific article published on 3 November 2011

T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection

scientific article published on April 2012

T<sub>RH</sub> cells, helpers making an impact in their local community

scientific article published on 01 January 2021

TCR meta-clonotypes for biomarker discovery with tcrdist3: quantification of public, HLA-restricted TCR biomarkers of SARS-CoV-2 infection

scientific article published on 26 December 2020

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection.

scientific article

Targeted Immunosuppression Distinguishes COVID-19 from Influenza in Moderate and Severe Disease

scientific article published on 30 May 2020

Targeting Metabolic Reprogramming by Influenza Infection for Therapeutic Intervention

scientific article published on May 2017

Targeting phospholipase D in cancer, infection and neurodegenerative disorders

scientific article published on 17 February 2017

Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models

scientific article published on 17 November 2021

Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses

scientific article published on August 2008

The Role of Extracellular Histones in Influenza Virus Pathogenesis

scientific article published on 26 October 2017

The TNF Superfamily Molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection

scientific article published on 7 March 2018

The human side of influenza ⬇️

scientific article published on February 23, 2012

The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1

scientific article

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.

scientific article

The neoepitope landscape in pediatric cancers.

scientific article published on 31 August 2017

The two faces of heterologous immunity: protection or immunopathology

scientific article

Towards integrating extracellular matrix and immunological pathways.

scientific article published on 18 March 2017

Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine

scientific article

Transcription factor ZNF148 is a negative regulator of human muscle differentiation

scientific article published on 15 August 2017

Transmission studies resume for avian flu.

scientific article

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

scientific article

Twelve-Month Longitudinal Serology in SARS-CoV-2 Naïve and Experienced Vaccine Recipients and Unvaccinated COVID-19-Infected Individuals

scientific article published on 20 May 2022

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.

scientific article published on 16 February 2018

Understanding the drivers of MHC restriction of T cell receptors

scientific article published on 01 July 2018

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

scientific article published on September 2017

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

scientific article

Vascular Permeability Drives Susceptibility to Influenza Infection in a Murine Model of Sickle Cell Disease

scientific article published on 03 March 2017

Virus-specific CD8+ T cells in the liver: armed and ready to kill

scientific article published in March 2007

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