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List of works by Ana Perez-Castillo

15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest.

scientific article

15-deoxy-Delta-12,14-prostaglandin J2 induces programmed cell death of breast cancer cells by a pleiotropic mechanism

scientific article

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

scientific article published on 14 July 2015

5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.

scientific article published on 3 February 2012

Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats.

scientific article published in December 2009

CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease

scientific article published on 19 October 2017

CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury

scientific article published in April 2008

CCAAT/enhancer binding protein β directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor.

scientific article

CCAAT/enhancer-binding protein beta plays a regulatory role in differentiation and apoptosis of neuroblastoma cells

scientific journal article

Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ.

scientific article published on 21 October 2016

Control by thyroid hormone of NGFI-A gene expression in lung: regulation of NGFI-A promoter activity

scientific article published in June 1998

Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders

scientific article published on 17 January 2014

Decreased CCAAT/enhancer binding protein β expression inhibits the growth of glioblastoma cells

scientific article published on 23 December 2010

Developmental hypothyroidism increases the expression of kainate receptors in the hippocampus and the sensitivity to kainic acid-induced seizures in the rat.

scientific article published on 21 April 2010

Developmentally-induced hypothyroidism alters the expression of Egr-1 and Arc genes and the sensitivity to cannabinoid agonists in the hippocampus. Possible implications for memory and learning.

scientific article

Differential effect of thyroid hormone on NGFI-A gene expression in developing rat brain.

scientific article published in August 1994

Effect of perinatal hypothyroidism on the developmental regulation of rat pituitary growth hormone and thyrotropin genes

scientific article published in October 1995

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

scientific article published on 16 March 2012

Effects of neonatal hypothyroidism on rat brain gene expression

scientific article published in February 1991

Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line

scientific article published in August 2003

Evidence of glucagon biosynthesis involving protein intermediates in rat salivary glands

scientific article published in October 1984

Familial reciprocal translocation t(1;4)(q31;p15) traced through five generations

scientific article published in 1985

Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.

scientific article

Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease

scientific article

Hypothyroidism decreases the biogenesis in free mitochondria and neuronal oxygen consumption in the cerebral cortex of developing rats.

scientific article published on 23 April 2009

Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism

scientific article published on 24 January 2008

Infertility associated with two accessory bisatellited chromosomes

scientific article published in June 1986

Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8

scientific article

Interaction of Dietary Carbohydrate and Glucagon in Regulation of Rat Hepatic Messenger Ribonucleic Acid S14 Expression: Role of Circadian Factors and 3′,5′-Cyclic Adenosine Monophosphate

scientific article published in September 1987

Is a gene for microcephaly located on chromosome 1?

scientific article published on January 1984

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress

scientific article published on 5 October 2012

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors

scientific article published on 8 October 2014

Multiple regulation of S14 gene expression during brown fat differentiation

scientific article published in August 1993

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

scientific article published on 11 December 2014

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

scientific article published on 28 September 2020

NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders

scientific article

Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids.

scientific article

Neuronal mitochondrial morphology and transmembrane potential are severely altered by hypothyroidism during rat brain development.

scientific article published in September 1997

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

scientific article

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

scientific article published on 25 May 2016

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

scientific article published on 01 December 2019

New insights into the effects of extra nucleolus organizer regions

scientific article published in January 1986

New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease

scientific article

New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.

scientific article published on 12 July 2016

Normal level of thyroglobulin messenger ribonucleic acid in a human congenital goiter with thyroglobulin deficiency

scientific article published on October 1986

Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.

scientific article

PDE7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis

scientific article

Peroxisome proliferator-activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo

scientific article published on 01 February 2011

Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease

scientific article published on 09 May 2017

Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson's Disease

scientific article published on 31 August 2019

Phosphodiesterase 7 inhibition induces dopaminergic neurogenesis in hemiparkinsonian rats.

scientific article published on 29 April 2015

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease

scientific article (publication date: 24 February 2011)

Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo

scientific article published on 19 August 2016

Regulation by Thyroid Hormone and Retinoic Acid of the CCAAT/Enhancer Binding Protein α and β Genes during Liver Development

scientific article published in May 1997

Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation

scientific article

Role of C/EBPβ transcription factor in adult hippocampal neurogenesis

scientific article

Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.

scientific article published on 13 October 2014

Subtly Modulating Glycogen Synthase Kinase 3 β: Allosteric Inhibitor Development and Their Potential for the Treatment of Chronic Diseases

scientific article published on 26 May 2017

Synthesis and release of glucagon by human salivary glands

scientific article published in August 1980

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

scientific article

The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice.

scientific article published on 22 December 2016

The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro

scientific article

The early ontogenesis of thyroid hormone receptor in the rat fetus

scientific article published in December 1985

The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action

scientific article published on 16 January 2005

The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells.

scientific article

Thyroid hormone controls the expression of insulin-like growth factor I receptor gene at different levels in lung and heart of developing and adult rats

scientific article published on 01 March 1997

Thyroid hormone regulates Galphai1 gene expression in the rat cerebellar cortex during post-natal development.

scientific article published in January 2005

Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats.

scientific article

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