List of works - Thomas Kietzmann

A ferro-heme protein senses oxygen levels, which modulate the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures

scientific article published on 01 September 1993

Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes

scientific article published in July 2002

Antioxidant responses and cellular adjustments to oxidative stress

scientific article

Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.

scientific article published on January 1997

Cell type-dependent regulation of the hypoxia-responsive plasminogen activator inhibitor-1 gene by upstream stimulatory factor-2

scientific article published on 05 December 2005

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

scientific article published on 26 October 2017

Corrigendum: Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer

scientific article published on 5 April 2016

Cross-talk between the signals hypoxia and glucose at the glucose response element of the L-type pyruvate kinase gene

scientific journal article

Deficiency of manganese superoxide dismutase in hepatocytes disrupts zonated gene expression in mouse liver

scientific journal article

Differential transcriptional regulation of hypoxia-inducible factor-1α by arsenite under normoxia and hypoxia: involvement of Nrf2

scientific article

Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease

scientific article published on March 2011

Enhanced plasminogen activator inhibitor-1 expression in transgenic mice with hepatocyte-specific overexpression of superoxide dismutase or glutathione peroxidase

scientific article published in August 2004

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

scientific article published on 18 May 2017

Expression of hypoxia-inducible factor-1 in the cochlea of newborn rats

scientific article published in September 2003

Expression patterns of erythropoietin and its receptor in the developing midbrain

scientific article published on 10 February 2004

FOXO4 induces human plasminogen activator inhibitor-1 gene expression via an indirect mechanism by modulating HIF-1alpha and CREB levels

scientific article published on 01 August 2010

GSK3β-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2.

scientific article

Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner

scientific article published on 26 February 2007

HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus

scientific article published on 25 February 2008

Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes

scientific article

Hypoxia and hypoxia-inducible factor modulated gene expression in brain: involvement in neuroprotection and cell death.

scientific article

Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells

scientific article

Hypoxia-Inducible Factor Prolyl 4-Hydroxylases and Metabolism

scientific article published on 01 November 2018

Hypoxia-Inducible Factors: Post-translational Crosstalk of Signaling Pathways ⬇️

scientific article published on January 1, 2010

Hypoxia-induced cell death and changes in hypoxia-inducible factor-1 activity in PC12 cells upon exposure to nerve growth factor

scientific article

Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling

scientific article

Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer.

scientific article published on 27 December 2016

Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes

article by Thomas Kietzmann et al published 12 September 2002 in Blood

Identification of an oxygen-responsive element in the 5'-flanking sequence of the rat cytosolic phosphoenolpyruvate carboxykinase-1 gene, modulating its glucagon-dependent activation

scientific article published on May 1999

Increased levels of the HER1 adaptor protein Rukl/CIN85 contribute to breast cancer malignancy.

scientific article published on 12 July 2012

Induction of plasminogen activator inhibitor I gene expression by intracellular calcium via hypoxia-inducible factor-1.

scientific article published on 24 August 2004

Influence of ischemia/hypoxia on the HIF-1 activity and expression of hypoxia-dependent genes in the cochlea of the newborn rat

scientific journal article

Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2.

scientific article published on June 2009

Inhibition of phorbol ester-dependent peroxiredoxin I gene activation by lipopolysaccharide via phosphorylation of RelA/p65 at serine 276 in monocytes.

scientific article published on 17 November 2007

Intracellular redox compartments: mechanisms and significances

scientific article published on 01 August 2010

JAK2 and Endothelial Function: New Options for Anti-Thrombotic Therapies

scientific article published on 13 August 2018

Manganese superoxide dismutase in carcinogenesis: friend or foe?

scientific article

Metabolic zonation of the liver: The oxygen gradient revisited.

scientific article published on 17 January 2017

Metabolic, hormonal and environmental regulation of plasminogen activator inhibitor-1 (PAI-1) expression: lessons from the liver

scientific article published on 01 December 2008

Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis

scientific article

Modulation by oxygen of zonal gene expression in liver studied in primary rat hepatocyte cultures

scientific article published on 01 July 1997

Modulation of glucokinase expression by hypoxia-inducible factor 1 and upstream stimulatory factor 2 in primary rat hepatocytes

scientific article

Modulation of hemopexin gene expression by physiological oxygen tensions in primary rat hepatocyte cultures

scientific article published in August 1995

Modulation of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures. Evidence for a heme protein as oxygen sensor

scientific article published on October 1992

Myocardial infarction in elderly patients: How to assess their bleeding risk?

scientific article published on 30 July 2015

NOX2 and NOX4 mediate proliferative response in endothelial cells.

scientific article published on September 2006

Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription.

scientific article published on 8 May 2017

Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus

scientific journal article

Obesity and inflammation: reduced cytokine expression due to resveratrol in a human in vitro model of inflamed adipose tissue

scientific article

Opposite expression of the antioxidant heme oxygenase-1 in primary cells and tumor cells: regulation by interaction of USF-2 and Fra-1.

scientific article

Oxygen-dependent regulation of hepatic glucose metabolism

scientific article published in January 2004

PAI-1 modulates cell migration in a LRP1-dependent manner via β-catenin and ERK1/2.

scientific article

PHD1 regulates p53-mediated colorectal cancer chemoresistance.

scientific article published on 19 August 2015

Periportal localization of glucagon receptor mRNA in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures

scientific article published in January 1998

Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver

scientific journal article

Perivenous localization of insulin receptor protein in rat liver, and regulation of its expression by glucose and oxygen in hepatocyte cultures

scientific article published on June 2000

Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway

scientific article published on 5 September 2003

Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1alpha mediated transcription

scientific article published on 15 July 2010

Physiological oxygen tensions modulate expression of the mdr1b multidrug-resistance gene in primary rat hepatocyte cultures

scientific article published on September 2000

Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer

scientific article

Reactive oxygen species and fibrosis: further evidence of a significant liaison

scientific article

Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression.

scientific article

Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

scientific article

Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences

scientific article

Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells

scientific article published on March 2004

Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes

scientific article published on 06 February 2006

Regulation of the gluconeogenic phosphoenolpyruvate carboxykinase and glycolytic aldolase A gene expression by O2 in rat hepatocyte cultures. Involvement of hydrogen peroxide as mediator in the response to O2

scientific article published on 01 June 1996

Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide

scientific article published on 20 August 2001

Resveratrol suppresses PAI-1 gene expression in a human in vitro model of inflamed adipose tissue

scientific article published on 02 June 2013

Resveratrol: beneficial or not? Opposite effects of resveratrol on hypoxia-dependent PAI-1 expression in tumour and primary cells

scientific article published on 27 August 2015

Role of NF-kappaB and p38 MAP kinase signaling pathways in the lipopolysaccharide-dependent activation of heme oxygenase-1 gene expression

scientific article published on October 2004

Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem

scientific article published in December 2001

Serum-free, long-term cultures of human hepatocytes: maintenance of cell morphology, transcription factors, and liver-specific functions

scientific article published on 01 March 2000

Signaling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements.

scientific article

Subcellular localization of rat Abca5, a rat ATP-binding-cassette transporter expressed in Leydig cells, and characterization of its splice variant apparently encoding a half-transporter

scientific journal article

Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors.

scientific article published on January 2007

The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential.

scientific article

The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2

scientific article published on 29 May 2019

The adaptor protein Ruk/CIN85 activates plasminogen activator inhibitor-1 (PAI-1) expression via hypoxia-inducible factor-1alpha.

scientific article published on 9 March 2010

The air that we breeze: From 'Noble' discoveries of a general oxygen-sensing principle to its clinical use

scientific article published on 02 December 2019

The epigenetic landscape related to reactive oxygen species formation in the cardiovascular system

scientific article published on 23 March 2017

The hypoxia-inducible factor (HIF) pathway as a target for prevention and treatment of clinical manifestations

scientific article published on 01 January 2009

The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.

scientific article published on February 2017

The nuclear fraction of protein kinase CK2 binds to the upstream stimulatory factors (USFs) in the absence of DNA.

scientific article published on 11 November 2015

The transcription factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/protein kinase B pathway

scientific article published on 10 November 2003

The upstream stimulatory factor USF1 is regulated by protein kinase CK2 phosphorylation.

scientific article published on 4 September 2014

The upstream stimulatory factor-2a inhibits plasminogen activator inhibitor-1 gene expression by binding to a promoter element adjacent to the hypoxia-inducible factor-1 binding site

scientific article published on 01 May 2001

Thrombin activates the p21-activated kinase in pulmonary artery smooth muscle cells. Role in tissue factor expression

scientific article published on 01 June 2005

Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes

scientific article published on 18 July 2017

Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes

scientific article published on 11 March 2003

Transcriptional regulation of plasminogen activator inhibitor-1 expression by insulin-like growth factor-1 via MAP kinases and hypoxia-inducible factor-1 in HepG2 cells

scientific article published on 01 June 2005

Transcriptional regulation of serine/threonine kinase-15 (STK15) expression by hypoxia and HIF-1.

scientific article

Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish

scientific article

USP28 Deficiency Promotes Breast and Liver Carcinogenesis as well as Tumor Angiogenesis in a HIF-independent Manner

scientific article published on 15 March 2018

Upregulation of heme oxygenase-1 gene by turpentine oil-induced localized inflammation: involvement of interleukin-6.

scientific article published in March 2005

Urokinase is a negative modulator of Egf-dependent proliferation and motility in the two breast cancer cell lines MCF-7 and MDA-MB-231.

scientific article

Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6.

scientific article published on 26 December 2007

List of works by Thomas Kietzmann

A ferro-heme protein senses oxygen levels, which modulate the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures

Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes

Antioxidant responses and cellular adjustments to oxidative stress

Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2.

Cell type-dependent regulation of the hypoxia-responsive plasminogen activator inhibitor-1 gene by upstream stimulatory factor-2

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

Corrigendum: Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer

Cross-talk between the signals hypoxia and glucose at the glucose response element of the L-type pyruvate kinase gene

Deficiency of manganese superoxide dismutase in hepatocytes disrupts zonated gene expression in mouse liver

Differential transcriptional regulation of hypoxia-inducible factor-1α by arsenite under normoxia and hypoxia: involvement of Nrf2

Early determinants of pulmonary vascular remodeling in animal models of complex congenital heart disease

Enhanced plasminogen activator inhibitor-1 expression in transgenic mice with hepatocyte-specific overexpression of superoxide dismutase or glutathione peroxidase

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Expression of hypoxia-inducible factor-1 in the cochlea of newborn rats

Expression patterns of erythropoietin and its receptor in the developing midbrain

FOXO4 induces human plasminogen activator inhibitor-1 gene expression via an indirect mechanism by modulating HIF-1alpha and CREB levels

GSK3β-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2.

Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner

HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus

Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes

Hypoxia and hypoxia-inducible factor modulated gene expression in brain: involvement in neuroprotection and cell death.

Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells

Hypoxia-Inducible Factor Prolyl 4-Hydroxylases and Metabolism

Hypoxia-Inducible Factors: Post-translational Crosstalk of Signaling Pathways ⬇️

Hypoxia-induced cell death and changes in hypoxia-inducible factor-1 activity in PC12 cells upon exposure to nerve growth factor

Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling

Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer.

Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes

Identification of an oxygen-responsive element in the 5'-flanking sequence of the rat cytosolic phosphoenolpyruvate carboxykinase-1 gene, modulating its glucagon-dependent activation

Increased levels of the HER1 adaptor protein Rukl/CIN85 contribute to breast cancer malignancy.

Induction of plasminogen activator inhibitor I gene expression by intracellular calcium via hypoxia-inducible factor-1.

Influence of ischemia/hypoxia on the HIF-1 activity and expression of hypoxia-dependent genes in the cochlea of the newborn rat

Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2.

Inhibition of phorbol ester-dependent peroxiredoxin I gene activation by lipopolysaccharide via phosphorylation of RelA/p65 at serine 276 in monocytes.

Intracellular redox compartments: mechanisms and significances

JAK2 and Endothelial Function: New Options for Anti-Thrombotic Therapies

Manganese superoxide dismutase in carcinogenesis: friend or foe?

Metabolic zonation of the liver: The oxygen gradient revisited.

Metabolic, hormonal and environmental regulation of plasminogen activator inhibitor-1 (PAI-1) expression: lessons from the liver

Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis

Modulation by oxygen of zonal gene expression in liver studied in primary rat hepatocyte cultures

Modulation of glucokinase expression by hypoxia-inducible factor 1 and upstream stimulatory factor 2 in primary rat hepatocytes

Modulation of hemopexin gene expression by physiological oxygen tensions in primary rat hepatocyte cultures

Modulation of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene by oxygen in rat hepatocyte cultures. Evidence for a heme protein as oxygen sensor

Myocardial infarction in elderly patients: How to assess their bleeding risk?

NOX2 and NOX4 mediate proliferative response in endothelial cells.

Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription.

Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus

Obesity and inflammation: reduced cytokine expression due to resveratrol in a human in vitro model of inflamed adipose tissue

Opposite expression of the antioxidant heme oxygenase-1 in primary cells and tumor cells: regulation by interaction of USF-2 and Fra-1.

Oxygen-dependent regulation of hepatic glucose metabolism

PAI-1 modulates cell migration in a LRP1-dependent manner via β-catenin and ERK1/2.

PHD1 regulates p53-mediated colorectal cancer chemoresistance.

Periportal localization of glucagon receptor mRNA in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures

Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver

Perivenous localization of insulin receptor protein in rat liver, and regulation of its expression by glucose and oxygen in hepatocyte cultures

Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway

Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1alpha mediated transcription

Physiological oxygen tensions modulate expression of the mdr1b multidrug-resistance gene in primary rat hepatocyte cultures

Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer

Reactive oxygen species and fibrosis: further evidence of a significant liaison

Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression.

Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences

Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells

Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes

Regulation of the gluconeogenic phosphoenolpyruvate carboxykinase and glycolytic aldolase A gene expression by O2 in rat hepatocyte cultures. Involvement of hydrogen peroxide as mediator in the response to O2

Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide

Resveratrol suppresses PAI-1 gene expression in a human in vitro model of inflamed adipose tissue

Resveratrol: beneficial or not? Opposite effects of resveratrol on hypoxia-dependent PAI-1 expression in tumour and primary cells

Role of NF-kappaB and p38 MAP kinase signaling pathways in the lipopolysaccharide-dependent activation of heme oxygenase-1 gene expression

Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem

Serum-free, long-term cultures of human hepatocytes: maintenance of cell morphology, transcription factors, and liver-specific functions

Signaling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements.

Subcellular localization of rat Abca5, a rat ATP-binding-cassette transporter expressed in Leydig cells, and characterization of its splice variant apparently encoding a half-transporter

Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors.

The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential.

The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2

The adaptor protein Ruk/CIN85 activates plasminogen activator inhibitor-1 (PAI-1) expression via hypoxia-inducible factor-1alpha.