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List of works by Juan Carlos Lacal

18F-choline images murine atherosclerotic plaques ex vivo

scientific article published on 15 December 2005

A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells

scientific article

A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomas

scientific article

A new family of choline kinase inhibitors with antiproliferative and antitumor activity derived from natural products

scientific article

Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition.

scientific article

Activation of phospholipase D by ras proteins is independent of protein kinase C.

scientific article published on June 1996

Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors

scientific article published on 01 March 1999

Acylphosphatase synergizes with progesterone during maturation of Xenopus laevis oocytes

scientific article published in August 1993

Agonist-induced phosphorylation of an immunologically ras-related protein in human erythroleukemia cells

scientific article published in June 1989

Anticancer research: a few hints for discovery of new targets

scientific article published on 01 April 2004

Antiplasmodial activity and mechanism of action of RSM-932A, a promising synergistic inhibitor of Plasmodium falciparum choline kinase

scientific article published on 16 September 2013

Approaches for the study of cancer: towards the integration of genomics, proteomics and metabolomics

scientific article published on September 1, 2011

Bad patients meet good drugs

scientific article published on 01 April 2006

Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability

scientific article published on August 2002

Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors.

scientific article published on 14 January 2016

Choline kinase alpha depletion selectively kills tumoral cells.

scientific article

Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy.

scientific article

Choline kinase inhibition in rheumatoid arthritis

scientific article

Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action.

scientific article published on October 2004

Choline kinase inhibitory effect and antiproliferative activity of new 1,1',1"-(benzene-1,3,5-triylmethylene)tris[4-[(disubstituted)amino]pyridinium] tribromides

scientific article published on January 2003

Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis.

scientific article published on July 2005

Clinical and Translational Oncology accepted in SciSearch and journal citation reports

scientific article published on 01 December 2008

Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts.

scientific article

Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment

scientific article

Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study.

scientific article published on October 2007

FESEO and Clinical & Translational Oncology: a brief historical perspective

scientific article published in November 2008

Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation.

scientific article published on January 1995

How molecular biology can improve clinical management: the MammaPrint experience

scientific article published in April 2007

Human urine proteomics: building a list of human urine cancer biomarkers.

scientific article published on June 2011

Identification of rho as a substrate for botulinum toxin C3-catalyzed ADP-ribosylation

scientific article published on 01 April 1989

Influence of the linker in bispyridium compounds on the inhibition of human choline kinase

scientific article

Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.

scientific article published on July 2001

Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells.

scientific article published on December 2003

Involvement of human choline kinase alpha and beta in carcinogenesis: a different role in lipid metabolism and biological functions

scientific article

It is about time that Spain launches a National Cancer Act?

scientific article published on 01 December 2006

LUMO energy of model compounds of bispyridinium compounds as an index for the inhibition of choline kinase

scientific article

Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils.

scientific article

Loss of mouse fibroblast cell response to phorbol esters restored by microinjected protein kinase C.

scientific article

Micro-injection of recombinant lysyl oxidase blocks oncogenic p21-Ha-Ras and progesterone effects on Xenopus laevis oocyte maturation

scientific article published in December 1997

Microinjection of acylphosphatase blocks Xenopus laevis oocytes maturation induced by ras-p21.

scientific article published in July 1993

Modulation of phospholipase D by hexadecylphosphorylcholine: a putative novel mechanism for its antitumoral activity

scientific article published on March 2001

Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases

scientific article published on 01 May 1998

New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties.

scientific article published on March 2004

Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models

scientific article published in January 2006

Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites.

scientific article published on March 2007

Permeabilization of cells during animal virus infection ⬇️

scientific article published on January 1, 1983

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma

scientific article published on 03 February 2016

Phosphorylation of ras oncogene product by protein kinase C

scientific article published on 01 June 1987

Preclinical characterization of RSM-932A, a novel anticancer drug targeting the human choline kinase alpha, an enzyme involved in increased lipid metabolism of cancer cells.

scientific article

Protein chimerism: Novel source of protein diversity in humans adds complexity to bottom-up proteomics

scientific article published on 12 December 2012

QSAR-derived choline kinase inhibitors: how rational can antiproliferative drug design be?

scientific article

Quantitative structure-activity relationships for a series of symmetrical bisquaternary anticancer compounds

scientific article

ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences

scientific article published on July 2003

Ras p21 proteins with high or low GTPase activity can efficiently transform NIH/3T3 cells

scientific article published on February 1986

Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells

scientific article

Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid‐dependent signaling ⬇️

scientific article published on June 23, 1997

Rho GTPase expression in tumourigenesis: evidence for a significant link

scientific article

Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation

scientific article

Rho GTPases: potential candidates for anticancer therapy

scientific article published on April 2004

STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA

scientific article

Screening for new compounds with antiherpes activity.

scientific article published on October 1984

Sensitization of (colon) cancer cells to death receptor related therapies: a report from the FP6-ONCODEATH research consortium

scientific article published on May 2012

Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway.

scientific article published on August 1997

Symmetrical bis-quinolinium compounds: new human choline kinase inhibitors with antiproliferative activity against the HT-29 cell line.

scientific article

TWIST1 overexpression is associated with nodal invasion and male sex in primary colorectal cancer.

scientific article published on 11 November 2008

The Ras family of GTPases in cancer cell invasion.

scientific article

The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.

scientific article

Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility.

scientific article published on 30 July 2013

Wortmannin, an inhibitor of phosphatidyl‐inositol 3‐kinase, induces oocyte maturation through a MPF‐MAPK‐dependent pathway ⬇️

scientific article published on January 30, 1998

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