List of works - Nicola Margiotta

A Molecular Tool for Measuring the Electron-Acceptor Ability of Ligands from Crystallographic Data

A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO).

scientific article published on July 2013

Antiviral properties and cytotoxic activity of platinum(II) complexes with 1,10-phenanthrolines and acyclovir or penciclovir

scientific article published on August 2004

Bisphosphonate complexation and calcium doping in silica xerogels as a combined strategy for local and controlled release of active platinum antitumor compounds

article

Cationic intermediates in oxidative addition reactions of Cl2 to [PtCl2(cis-1,4-DACH)]

article

Cisplatin, Oxaliplatin, and Kiteplatin Subcellular Effects Compared in a Plant Model.

scientific article published on 31 January 2017

Computational evidence for structural consequences of kiteplatin damage on DNA.

scientific article

Conformer distribution in (cis-1,4-DACH)bis(guanosine-5'-phosphate)platinum(II) adducts: a reliable model for DNA adducts of antitumoral cisplatin

scientific article

Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring Pt II chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand.

scientific article published on February 2010

Cytotoxicity-boosting of kiteplatin by Pt(IV) prodrugs with axial benzoate ligands.

scientific article published on 18 December 2015

DNA fragment conformations in adducts with Kiteplatin

article

Dinuclear Pt(II)-bisphosphonate complexes: a scaffold for multinuclear or different oxidation state platinum drugs

scientific article

Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands

scientific article published on 01 May 2018

Encapsulation of lipophilic kiteplatin Pt(iv) prodrugs in PLGA-PEG micelles.

scientific article

Influence of Carrier Ligand NH Hydrogen Bonding to the O6 and Phosphate Group of Guanine Nucleotides in Platinum Complexes with a Single Guanine Ligand

scientific article published on 01 February 2000

Influence of steric and electronic factors in the stabilization of five-coordinate ethylene complexes of platinum(II): X-ray crystal structure of [PtCl2(2,9-dimethyl-1,10-phenanthroline-5,6-dione)]

article published in 2004

Insights into the role of the lead/surfactant ratio in the formation and passivation of cesium lead bromide perovskite nanocrystals

scientific article published on 01 January 2020

Metallo-drugs in the treatment of malignant pleural mesothelioma

Monofunctional platinum(II) complexes with potent tumor cell growth inhibitory activity: the effect of a hydrogen-bond donor/acceptor N-heterocyclic ligand.

scientific article published on 2 May 2014

Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions

scientific article published on 14 July 2018

NMR investigation of the spontaneous thermal- and/or photoinduced reduction of trans dihydroxido Pt(IV) derivatives.

scientific article

Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates

scientific article published on 10 November 2011

Novel Kiteplatin Pyrophosphate Derivatives with Improved Efficacy

scientific article

Novel therapeutic agents for bone resorption. Part 1. Synthesis and protonation thermodynamics of poly(amido-amine)s containing bis-phosphonate residues

scientific article published on 01 December 2006

Platinum(II) complexes with antitumoral/antiviral aromatic heterocycles: effect of glutathione upon in vitro cell growth inhibition

scientific article

Platinum(II) complexes with bioactive carrier ligands having high affinity for the translocator protein.

scientific article published on July 2010

Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance

scientific article published on 27 March 2020

Platinum-based antitumor drugs containing enantiomerically pure alpha-trifluoromethyl alanine as ligand.

scientific article

Platinum-bisphosphonate complexes have proven to be inactive chemotherapeutics targeted for malignant mesothelioma because of inappropriate hydrolysis

scientific article published on 30 December 2010

Platinum-loaded, selenium-doped hydroxyapatite nanoparticles selectively reduce proliferation of prostate and breast cancer cells co-cultured in the presence of stem cells

scientific article published on 01 April 2020

Preclinical evaluation of platinum-loaded hydroxyapatite nanoparticles in an embryonic zebrafish xenograft model

scientific article published on 19 June 2020

Quantitative imaging of platinum-based antitumor complexes in bone tissue samples using LA-ICP-MS

scientific article published on 19 April 2019

Reactivity of kiteplatin with S-donor biomolecules and nucleotides

scientific article published on 01 September 2014

Revisiting [PtCl₂(cis-1,4-DACH)]: an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal cancer.

scientific article

Silica xerogels and hydroxyapatite nanocrystals for the local delivery of platinum–bisphosphonate complexes in the treatment of bone tumors: A mini-review ⬇️

scientific article published on June 15, 2012

Sterically hindered complexes of platinum(II) with planar heterocyclic nitrogen donors. A novel complex with 1-methyl-cytosine has a spectrum of activity different from cisplatin and is able of overcoming acquired cisplatin resistance

scientific article published on 3 August 2006

Structure and dynamics of a platinum(II) aminophosphine complex and its nucleobase adducts

Synthesis and characterization of a platinum(II) complex tethered to a ligand of the peripheral benzodiazepine receptor

scientific article published on 8 February 2007

Synthesis, Characterization, and Cytotoxicity of the First Oxaliplatin Pt(IV) Derivative Having a TSPO Ligand in the Axial Position.

scientific article published on 25 June 2016

Synthesis, Characterization, and in Vitro Evaluation of a New TSPO-Selective Bifunctional Chelate Ligand

scientific article published on 30 March 2014

Synthesis, characterization, and cytotoxicity of dinuclear platinum-bisphosphonate complexes to be used as prodrugs in the local treatment of bone tumours

scientific article

Synthesis, characterization, and in vitro evaluation of new coordination complexes of platinum(II) and rhenium(I) with a ligand targeting the translocator protein (TSPO).

scientific article

Targeting of radioactive platinum-bisphosphonate anticancer drugs to bone of high metabolic activity

scientific article published on 03 April 2020

Thermodynamic and mechanistic insights into translesion DNA synthesis catalyzed by Y-family DNA polymerase across a bulky double-base lesion of an antitumor platinum drug.

scientific article

List of works by Nicola Margiotta

A Molecular Tool for Measuring the Electron-Acceptor Ability of Ligands from Crystallographic Data

A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO).

Antiviral properties and cytotoxic activity of platinum(II) complexes with 1,10-phenanthrolines and acyclovir or penciclovir

Bisphosphonate complexation and calcium doping in silica xerogels as a combined strategy for local and controlled release of active platinum antitumor compounds

Cationic intermediates in oxidative addition reactions of Cl2 to [PtCl2(cis-1,4-DACH)]

Cisplatin, Oxaliplatin, and Kiteplatin Subcellular Effects Compared in a Plant Model.

Computational evidence for structural consequences of kiteplatin damage on DNA.

Conformer distribution in (cis-1,4-DACH)bis(guanosine-5'-phosphate)platinum(II) adducts: a reliable model for DNA adducts of antitumoral cisplatin

Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring Pt II chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand.

Cytotoxicity-boosting of kiteplatin by Pt(IV) prodrugs with axial benzoate ligands.

DNA fragment conformations in adducts with Kiteplatin

Dinuclear Pt(II)-bisphosphonate complexes: a scaffold for multinuclear or different oxidation state platinum drugs

Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands

Encapsulation of lipophilic kiteplatin Pt(iv) prodrugs in PLGA-PEG micelles.

Influence of Carrier Ligand NH Hydrogen Bonding to the O6 and Phosphate Group of Guanine Nucleotides in Platinum Complexes with a Single Guanine Ligand

Influence of steric and electronic factors in the stabilization of five-coordinate ethylene complexes of platinum(II): X-ray crystal structure of [PtCl2(2,9-dimethyl-1,10-phenanthroline-5,6-dione)]

Insights into the role of the lead/surfactant ratio in the formation and passivation of cesium lead bromide perovskite nanocrystals

Metallo-drugs in the treatment of malignant pleural mesothelioma

Monofunctional platinum(II) complexes with potent tumor cell growth inhibitory activity: the effect of a hydrogen-bond donor/acceptor N-heterocyclic ligand.

Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions

NMR investigation of the spontaneous thermal- and/or photoinduced reduction of trans dihydroxido Pt(IV) derivatives.

Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates

Novel Kiteplatin Pyrophosphate Derivatives with Improved Efficacy

Novel therapeutic agents for bone resorption. Part 1. Synthesis and protonation thermodynamics of poly(amido-amine)s containing bis-phosphonate residues

Platinum(II) complexes with antitumoral/antiviral aromatic heterocycles: effect of glutathione upon in vitro cell growth inhibition

Platinum(II) complexes with bioactive carrier ligands having high affinity for the translocator protein.

Platinum(IV) Complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance

Platinum-based antitumor drugs containing enantiomerically pure alpha-trifluoromethyl alanine as ligand.

Platinum-bisphosphonate complexes have proven to be inactive chemotherapeutics targeted for malignant mesothelioma because of inappropriate hydrolysis

Platinum-loaded, selenium-doped hydroxyapatite nanoparticles selectively reduce proliferation of prostate and breast cancer cells co-cultured in the presence of stem cells

Preclinical evaluation of platinum-loaded hydroxyapatite nanoparticles in an embryonic zebrafish xenograft model

Quantitative imaging of platinum-based antitumor complexes in bone tissue samples using LA-ICP-MS

Reactivity of kiteplatin with S-donor biomolecules and nucleotides

Revisiting [PtCl₂(cis-1,4-DACH)]: an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal cancer.

Silica xerogels and hydroxyapatite nanocrystals for the local delivery of platinum–bisphosphonate complexes in the treatment of bone tumors: A mini-review ⬇️

Sterically hindered complexes of platinum(II) with planar heterocyclic nitrogen donors. A novel complex with 1-methyl-cytosine has a spectrum of activity different from cisplatin and is able of overcoming acquired cisplatin resistance

Structure and dynamics of a platinum(II) aminophosphine complex and its nucleobase adducts

Synthesis and characterization of a platinum(II) complex tethered to a ligand of the peripheral benzodiazepine receptor

Synthesis, Characterization, and Cytotoxicity of the First Oxaliplatin Pt(IV) Derivative Having a TSPO Ligand in the Axial Position.

Synthesis, Characterization, and in Vitro Evaluation of a New TSPO-Selective Bifunctional Chelate Ligand

Synthesis, characterization, and cytotoxicity of dinuclear platinum-bisphosphonate complexes to be used as prodrugs in the local treatment of bone tumours

Synthesis, characterization, and in vitro evaluation of new coordination complexes of platinum(II) and rhenium(I) with a ligand targeting the translocator protein (TSPO).

Targeting of radioactive platinum-bisphosphonate anticancer drugs to bone of high metabolic activity

Thermodynamic and mechanistic insights into translesion DNA synthesis catalyzed by Y-family DNA polymerase across a bulky double-base lesion of an antitumor platinum drug.