List of works by Jose de Leon

A brief measure of high nicotine dependence for busy clinicians and large epidemiological surveys

scientific article published in March 2005

A case report with ziprasidone-induced catatonic symptoms

scientific article published in January 2007

A clinical study of the association of antipsychotics with hyperlipidemia.

scientific article published on 8 March 2007

A comparison of polydipsia prevalence among chronic psychiatric patients using three measurement approaches.

scientific article published in December 1997

A comprehensive review of swallowing difficulties and dysphagia associated with antipsychotics in adults

scientific article published on 08 February 2019

A comprehensive review of the clinical utility of and a combined analysis of the clozapine/norclozapine ratio in therapeutic drug monitoring for adult patients

scientific article published on 31 May 2019

A gender-specific association between the serotonin transporter gene and suicide attempts

scientific article

A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors

scientific article

A pilot genetic study of the continuum between compulsivity and impulsivity in females: the serotonin transporter promoter polymorphism

scientific article

A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers

scientific article

A pilot study on a gene-hormone interaction in female suicide attempts

scientific article

A post-DSM-III wake-up call to European psychiatry

scientific article published on 12 September 2013

A simple high performance liquid chromatographic method for the quantification of total cotinine, total 3'-hydroxycotinine and caffeine in the plasma of smokers

scientific article published on 01 August 2000

A study of bedside screening procedures for cognitive deficits in chronic psychiatric inpatients

scientific article published in September 1996

A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting paliperidone

scientific article published on 04 December 2018

A systematic review and combined analysis of therapeutic drug monitoring studies for oral paliperidone

scientific article published on 18 June 2018

ADGRL3 (LPHN3) variants predict substance use disorder

scientific article published on 29 January 2019

Adverse drug reactions and their fatal outcomes in clozapine patients in VigiBase: Comparing the top four reporting countries (US, UK, Canada and Australia)

scientific article published in 2023

Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers

scientific article published in August 2003

Age at onset in bipolar I disorder: two may be better than three subgroups.

scientific article published in March 2009

AmpliChip CYP450 test: personalized medicine has arrived in psychiatry.

scientific article

An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasma

scientific article published on 01 July 2007

An empirical analysis of latent structures underlying schizophrenic symptoms: a four-syndrome model

scientific article published on December 1994

An exploratory study of the relationship between diverse life events and specific personality disorders in a sample of suicide attempters

scientific article

An investigation of theα1A-adrenergic receptor gene and antipsychotic-induced side-effects

article

Antipsychotic medication exposure, clozapine, and pneumonia: results from a self-controlled study

scientific article published on 25 December 2019

Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients.

scientific article published on 21 June 2009

Association between smoking and alcohol use in the general population: stable and unstable odds ratios across two years in two different countries

scientific article published in May 2007

Association between the T102C polymorphism of the serotonin-2A receptor gene and schizophrenia

article

Association between the menses and suicide attempts: a replication study

scientific article

Association study of serotonergic gene variants with antipsychotic-induced adverse reactions

scientific article published in December 2009

Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts

scientific article

Beyond the "hype" on the association between metabolic syndrome and atypical antipsychotics: the confounding effects of cohort, typical antipsychotics, severe mental illness, comedications, and comorbid substance use.

scientific article published on April 2008

Beyond the corrupting influence of pharmaceutical companies on antidepressant meta-analyses (Letter commenting on: J Clin Epidemiol. 70, 2016, 155-163).

scientific article published on 14 March 2016

CYP2D6 genetic variation in healthy adults and psychiatric African-American subjects: implications for clinical practice and genetic testing

scientific article published on 21 March 2006

CYP2D6 genotyping for psychiatric patients treated with risperidone: considerations for cost-effectiveness studies

scientific article published in April 2009

CYP2D6 pharmacogenetics and risperidone: reflections after 25 years of research

scientific article published on 15 October 2020

Can the Holmes-Rahe Social Readjustment Rating Scale (SRRS) be used as a suicide risk scale? An exploratory study

scientific article published in January 2012

Catatonia Secondary to Sudden Clozapine Withdrawal: A Case with Three Repeated Episodes and a Literature Review

scientific article published on 15 March 2017

Clinical determinants of fever in clozapine users and implications for treatment management: A narrative review

scientific article published on 01 August 2019

Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19.

scientific article

Clinically Significant Drug-Drug Interactions with Agents for Attention-Deficit/Hyperactivity Disorder

scientific article published on 01 December 2019

Clinically relevant drug interactions between newer antidepressants and oral anticoagulants

scientific article published on 10 December 2019

Clozapine is strongly associated with the risk of pneumonia and inflammation

scientific article published on 16 April 2020

Clozapine levels after clozapine discontinuation

scientific article published on 01 April 1996

Clozapine treatment of polydipsia: a prolactin connection?

scientific article published on June 1, 1992

Clozapine ultrarapid metabolism during weak induction probably exists but requires careful diagnosis. A literature review, five new cases and a proposed definition

scientific article published in 2023

Comparison of the Heavy Smoking Index and of the Fagerstrom Test for Nicotine Dependence in a sample of 749 cigarette smokers

scientific article published in August 2005

Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships

scientific article published in April 2003

Cytochrome P450 2D6 and antidepressant toxicity and response: what is the evidence?

scientific article

Datapoints: Smoking and smoking cessation among persons with severe mental illnesses.

scientific article published in April 2006

Delusion of parasitosis or chronic tactile hallucinosis: hypothesis about their brain physiopathology

scientific article published on January 1, 1992

Development and validation of the Patient's Health Belief Questionnaire on Psychiatric Treatment

scientific article published on 10 April 2019

Diagnostic stability and evolution of bipolar disorder in clinical practice: a prospective cohort study.

scientific article published in June 2007

Dimensions of suicidal behavior according to patient reports.

scientific article published in August 2003

Do atypical antipsychotic drugs reduce the risk of ischemic heart disease and mortality? Possible role of 5-HT2A receptor blockade

scientific article published on 6 January 2010

Does clozapine decrease smoking?

scientific article published in June 2005

Dose and safety concerns of clozapine: Worldwide package inserts need revisions

scientific article published on 08 January 2020

Eosinophilic pleural effusion associated with the addition of sodium valproate.

scientific article published in June 2009

Erratum to: “Schizophrenia and tobacco smoking in a Spanish psychiatric hospital” [Schizophr. Res. 58 (2002) 323–327]

article

Estimating the effects of co-medications on plasma olanzapine concentrations by using a mixed model

scientific article published on 7 May 2008

Estimating the size of the effects of co-medications on plasma clozapine concentrations using a model that controls for clozapine doses and confounding variables.

scientific article published in May 2008

Evidence-based medicine versus personalized medicine: are they enemies?

scientific article published on 01 April 2012

Exploring brief measures of nicotine dependence for epidemiological surveys

scientific article published in October 2003

Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels.

scientific article

Exploring low clozapine C/D ratios, inverted clozapine-norclozapine ratios and undetectable concentrations as measures of non-adherence in clozapine patients

scientific article published in 2023

Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness.

scientific article

Fagerstrom test for nicotine dependence vs heavy smoking index in a general population survey.

scientific article

First episode in bipolar disorder: misdiagnosis and psychotic symptoms

scientific article published on 01 July 1998

Formal thought disorder in schizophrenia: a factor analytic study

scientific article published on March 1, 1992

From the serotonin model of suicide to a mental pain model of suicide

scientific article

Genetics of schizophrenia and smoking: an approach to studying their comorbidity based on epidemiological findings

scientific article

Guidelines for the use of clozapine in individuals with developmental disabilities.

scientific article

Haloperidol half-life after chronic dosing

scientific article published in December 2004

High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity

scientific article published in June 2005

Highlights of drug package inserts and the website DailyMed: the need for further improvement in package inserts to help busy prescribers

scientific article published on 01 June 2011

Horror Vacui: Emptiness Might Distinguish between Major Suicide Repeaters and Nonmajor Suicide Repeaters: A Pilot Study

scientific article

How safe are psychiatric medications after a voluntary overdose?

scientific article published in December 2002

How should research productivity be assessed in early career psychiatric researchers? research funding versus scientific productivity

scientific article published in September 2009

Individualizing drug dosage by using a random intercept linear model.

scientific article published in April 2007

Initiation of daily smoking and nicotine dependence in schizophrenia and mood disorders

scientific article published in July 2002

Interaction of sertraline with clozapine

scientific article published on 01 April 1997

Interactions between antiepileptics and second-generation antipsychotics.

scientific article published on 15 February 2012

Is psychiatry scientific? A letter to a 21st century psychiatry resident

scientific article

Is there a future for CYP1A2 pharmacogenetics in the optimal dosing of clozapine?

scientific article published on 20 April 2020

Lack of association between plasma apolipoprotein E and suicide attempts

scientific article published in April 2004

Lack of association between polymorphic variations in the alpha 3 subunit GABA receptor gene (GABRA3) and suicide attempts

scientific article published in March 2004

Lack of association between testosterone and suicide attempts

scientific article published on 30 December 2010

Lack of association between the serotonin transporter promoter gene polymorphism and impulsivity or aggressive behavior among suicide attempters and healthy volunteers

scientific article

Low plasma cholesterol levels in suicidal males: a gender- and body mass index-matched case-control study of suicide attempters and nonattempters.

scientific article published on 15 February 2007

Low serum cholesterol may be associated with suicide attempt history

scientific article published on 21 October 2008

Lower gastrointestinal bleeding and paroxetine use: two case reports

scientific article published in March 2012

Measuring individual benefits of psychiatric treatment using longitudinal binary outcomes: Application to antipsychotic benefits in non-cannabis and cannabis users

scientific article published on 08 June 2020

Metabolic drug interactions with newer antipsychotics: a comparative review.

scientific article published on January 2007

Negative symptoms, defect state and Huber's basic symptoms: A comparison of the concepts ⬇️

scientific article published on January 1, 1991

Neuroleptic-induced catatonia: neuroleptic malignant syndrome?

scientific article published on January 1990

Neurological frontal signs and neuropsychological deficits in schizophrenic patients

scientific article published on 01 May 1996

New insights on the consequences of biotransformation processes on the distribution and pharmacodynamic profiles of some neuropsychotropic drugs.

scientific article published on 13 September 2011

Nicotine dependence and symptoms in schizophrenia: naturalistic study of complex interactions

scientific article published in March 2005

Nicotine exposure can be detected in cerebrospinal fluid of active and passive smokers

scientific article published on 15 October 2008

No association between the Ser9Gly polymorphism of the dopamine D3 receptor gene and schizophrenia in a Spanish sample

article

Nucleotide variation in central nervous system genes among male suicide attempters

scientific article

Oral tardive dyskinesia: validation of a measuring device using digital image processing.

scientific article

Osteoporosis and schizophrenia: can we limit known risk factors?

scientific article published on 01 July 1995

Pathophysiology and clinical trials have limitations in some areas of medicine: focus on psychiatry (letter commenting: J Clin Epidemiol. 2014;67(4):361-363.).

scientific article published on 22 January 2016

Paying attention to pharmacokinetic and pharmacodynamic mechanisms to progress in the area of anticholinergic use in geriatric patients.

scientific article published on September 2011

Periodic Catatonia Marked by Hypercortisolemia and Exacerbated by the Menses: A Case Report and Literature Review

scientific article published on 04 July 2018

Personality disorders and health problems distinguish suicide attempters from completers in a direct comparison

scientific article published on 13 July 2013

Personalizing dosing of risperidone, paliperidone and clozapine using therapeutic drug monitoring and pharmacogenetics

scientific article published on 28 May 2019

Pharmacogenetic testing in psychiatry: a review of features and clinical realities.

scientific article published on December 2008

Pharmacogenomics: the promise of personalized medicine for CNS disorders.

scientific article published on 17 September 2008

Pharmacokinetic drug interaction studies must consider pharmacological heterogeneity, use of repeated dosing, and translation into a message understandable to practicing clinicians

scientific article published on 01 June 2009

Pharmacokinetic drug-drug interactions between olanzapine and valproate need to be better studied.

scientific article published on July 2010

Planning for the optimal design of studies to personalize antipsychotic prescriptions in the post-CATIE era: the clinical and pharmacoepidemiological data suggest that pursuing the pharmacogenetics of metabolic syndrome complications (hypertension,

scientific article published on 06 July 2007

Plasma clozapine concentration coefficients of variation in a long-term study

scientific article published in January 2005

Plasma cotinine, 3'-hydroxycotinine, and their glucuronides in white and black smokers

scientific article published in April 2003

Polydipsia and schizophrenia in a psychiatric hospital: a replication study

scientific article published in October 2002

Polydipsia and water intoxication in a long-term psychiatric hospital

scientific article published on July 1996

Polydipsia and water intoxication in psychiatric patients: a review of the epidemiological literature

scientific article published on March 1994

Polydipsia--a study in a long-term psychiatric unit.

scientific article

Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness

scientific article

Positive and negative symptoms in schizophrenia: where are the data?

scientific article published on 01 March 1992

Positive versus negative schizophrenia and basic symptoms

scientific article published on 01 May 1992

Possible individual and gender differences in the small increases in plasma prolactin levels seen during clozapine treatment.

scientific article published in October 2004

Possible interaction between warfarin and quetiapine

scientific article published on 01 August 1999

Postmortem clozapine levels

scientific article

Practical guidelines for the use of new generation antipsychotic drugs (except clozapine) in adult individuals with intellectual disabilities.

scientific article published on 11 December 2008

Premenstrual symptoms and luteal suicide attempts

scientific article published in October 2004

Probable association between ziprasidone and worsening hypertension

scientific article published in September 2006

Psychopharmacology: atypical antipsychotic dosing: the effect of co-medication with anticonvulsants.

scientific article published in February 2004

Psychosis and smoking cessation: difficulties in quitting associated with sex and substance abuse.

scientific article published in September 2011

Psychosocial stressors may be strongly associated with suicide attempts

QTc interval in a sample of long-term schizophrenia inpatients.

scientific article published in January 2010

Quantitative determination of risperidone, paliperidone and olanzapine in human serum by liquid chromatography-tandem mass spectrometry coupled with on-line solid-phase extraction

scientific article published on 26 April 2018

Relaxin polymorphisms associated with metabolic disturbance in patients treated with antipsychotics.

scientific article published on 21 June 2011

Repetitive behaviors in schizophrenia: a single disturbance or discrete symptoms?

scientific article published on May 1996

Reply to the Multifaceted Aspects of Suicide Behavior by Tondo

scientific article published on 28 January 2016

Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer.

scientific article published on 24 April 2006

Reviving Research on Medication Attitudes for Improving Pharmacotherapy: Focusing on Adherence

scientific article published on 10 February 2017

Risperidone half-life in a patient taking paroxetine -- a case report

scientific article published in September 2005

Schizophrenia and tobacco smoking in a Spanish psychiatric hospital.

scientific article published in December 2002

Schizophrenia and tobacco smoking in a Spanish psychiatric hospital.

scientific article published in April 2003

Schizophrenic syndromes associated with treatment response

scientific article published in January 1994

Self-Report for Measuring and Predicting Medication Adherence: Experts' Experience in Predicting Adherence in Stable Psychiatric Outpatients and in Pharmacokinetics

scientific article published on 09 October 2020

Serious respiratory infections can increase clozapine levels and contribute to side effects: a case report

scientific article published on September 2003

Serum IgG antibodies against the NR1 subunit of the NMDA receptor not detected in schizophrenia.

scientific article

Serum antimuscarinic activity during clozapine treatment

scientific article published in August 2003

Severity of personality disorders and suicide attempt.

scientific article published on 10 November 2008

Short self-reported sleep duration and suicidal behavior: a cross-sectional study

scientific article published on 5 May 2011

Short- and long-term effects on prolactin of risperidone and olanzapine treatments in children and adolescents.

scientific article

Skepticism and pharmacophobia toward medication may negatively impact adherence to psychiatric medications: a comparison among outpatient samples recruited in Spain, Argentina, and Venezuela.

scientific article published on 20 February 2018

Smoking initiation and schizophrenia: a replication study in a Spanish sample.

scientific article published on 7 January 2005

Smoking is associated with schizophrenia, but not with mood disorders, within a population with low smoking rates: a matched case-control study in Bucaramanga, Colombia

scientific article published on 23 February 2006

Subjective effects and the main reason for smoking in outpatients with schizophrenia: a case-control study

scientific article published on 5 December 2006

Suicidal behavior in schizophrenia and depression: a comparison

scientific article published on 01 June 2005

Suicide attempts among women during low estradiol/low progesterone states

scientific article published on 25 September 2009

Suicide attempts and impulsivity

scientific article published on 19 November 2004

The French attempt to include the bouffée délirante in the DSM-V during 2006: a recollection in the year 2050.

scientific article

The association between schizophrenia and smoking: unexplained by either the illness or the prodromal period.

scientific article published on 22 July 2008

The association of clozapine and haematological malignancies needs to be replicated by other studies and more importantly by analyses of subsamples from VigiBase

scientific article published on 06 May 2020

The crucial role of the therapeutic window in understanding the clinical relevance of the poor versus the ultrarapid metabolizer phenotypes in subjects taking drugs metabolized by CYP2D6 or CYP2C19

scientific article published on 01 June 2007

The effect of atypical versus typical antipsychotics on tardive dyskinesia: a naturalistic study.

scientific article published on 5 December 2006

The future (or lack of future) of personalized prescription in psychiatry.

scientific article published on 17 October 2008

The lions of Granada Maristan

scientific article published in February 2013

The mathematics of drug dose individualization should be built with random-effects linear models.

scientific article published in April 2013

Tobacco smoking behaviors in bipolar disorder: a comparison of the general population, schizophrenia, and major depression

scientific article

Total cotinine in plasma: a stable biomarker for exposure to tobacco smoke

scientific article published in October 2002

Toxicity of dipyridyl compounds and related compounds.

scientific article

Treatment of polydipsia and hyponatremia in psychiatric patients. Can clozapine be a new option?

scientific article published on 01 April 1995

Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of Intramuscular Antipsychotics

scientific article published on 15 August 2016

Two case reports of oral ulcers with lamotrigine several weeks after oxcarbazepine withdrawal.

scientific article published in May 2007

Two cases of high serum clozapine concentrations occurring during inflammation in Chinese patients

scientific article published in January 2018

Using structural equations to test for a direct effect of some antipsychotics on triglyceride levels in drug-naïve first-episode psychosis patients.

scientific article published on 2 July 2011

Using therapeutic drug monitoring to personalize clozapine dosing in Asians

scientific article published on 02 March 2020

Valproic acid toxicity associated with low dose of aspirin and low total valproic acid levels: a case report

scientific article published in October 2009

Variables associated with familial suicide attempts in a sample of suicide attempters

scientific article published on 7 June 2007

Variables associated with high olanzapine dosing in a state hospital.

scientific article published in August 2004

Variables associated with hospitalization decisions by emergency psychiatrists after a patient's suicide attempt

scientific article

Weight gain during a double-blind multidosage clozapine study

scientific article published in February 2007

Worldwide impact of economic cycles on suicide trends over 3 decades: differences according to level of development. A mixed effect model study.

scientific article

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