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List of works by Robert C. Burghardt

17 beta-Estradiol-mediated growth inhibition of MDA-MB-468 cells stably transfected with the estrogen receptor: cell cycle effects

scientific article published on 01 September 1997

A comparison of two methods for fractionating complex mixtures in preparation for toxicity analysis.

scientific article

A fetal whole ovarian culture model for the evaluation of CrVI-induced developmental toxicity during germ cell nest breakdown.

scientific article

A study of 2,4,6-trinitrotoluene inhibition of benzo[a]pyrene uptake and activation in a microbial mutagenicity assay

scientific article

Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways

scientific article

Adsorption of Salmonella enteritidis by cetylpyridinium-exchanged montmorillonite clays

scientific article

Adverse organogenesis and predisposed long-term metabolic syndrome from prenatal exposure to fine particulate matter

scientific article published on 28 May 2019

Alteration of oxytocin-induced calcium oscillations in clone 9 cells by toxin exposure

scientific article published on October 1996

Analysis of Pb2+ entry into cultured astroglia

scientific article

Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer

scientific article published on 6 January 2005

Aquaporins in the female reproductive system of mammals

scientific article published on January 2015

Arginine decarboxylase and agmatinase: an alternative pathway for de novo biosynthesis of polyamines for development of mammalian conceptuses

scientific article published on 25 April 2014

Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase

scientific article published on 3 April 2008

Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut adult rat liver and kidney slices

scientific article published on 01 October 1998

Bovine nuclear transfer embryo development using cells derived from a cloned fetus.

scientific article published in July 2001

Caprine uterine and placental osteopontin expression is distinct among epitheliochorial implanting species

scientific article published in February 2005

Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae

scientific article published on 27 January 2010

Cell-to-cell communication competence in simian virus 40-transfected rat ovarian cells is reduced following tumor selection

scientific article

Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells

scientific article published on August 2002

Chromatin structure in the unicellular algae Olisthodiscus luteus, Crypthecodinium cohnii and Peridiniun balticum

scientific article published on 01 January 1980

Chromium VI - Induced developmental toxicity of placenta is mediated through spatiotemporal dysregulation of cell survival and apoptotic proteins.

scientific article

Chromium-VI arrests cell cycle and decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-inhibitors.

scientific article

Cloning of GJA1 (connexin43) and its expression in canine ovarian follicles throughout the estrous cycle

scientific article published on 3 June 2006

Comparative aspects of implantation.

scientific article published on 05 June 2009

Conceptus signals for establishment and maintenance of pregnancy.

scientific article

Concomitant alterations of desmosomes, adhesiveness, and diffusion through gap junction channels in a rat ovarian transformation model system

scientific article published on July 1993

Confocal fluorescence microscopy studies of a fluorophore-labeled dirhodium compound: visualizing metal-metal bonded molecules in lung cancer (A549) cells

scientific article

Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function

scientific article

Cyclic AMP induces rapid increases in gap junction permeability and changes in the cellular distribution of connexin43

scientific article published on 01 December 1995

Development and characterization of immortalized ovine endometrial cell lines.

scientific article published on November 1999

Developmental toxicity and structure-activity relationships of chlorophenols using human embryonic palatal mesenchymal cells.

scientific article published in June 1995

Dietary supplementation with 0.8% L-arginine between days 0 and 25 of gestation reduces litter size in gilts

scientific article published on 14 April 2010

Dietary supplementation with L-arginine between days 14 and 25 of gestation enhances embryonic development and survival in gilts

scientific article

Disruption of cadherin/catenin expression, localization, and interactions during HgCl2-induced nephrotoxicity

scientific article published on 14 April 2004

Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells

scientific article

Edaravone mitigates hexavalent chromium-induced oxidative stress and depletion of antioxidant enzymes while estrogen restores antioxidant enzymes in the rat ovary in F1 offspring

scientific article published on 7 May 2014

Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.

scientific article published on 29 March 2006

Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells

scientific article

Effects of long-term progesterone exposure on porcine uterine gene expression: progesterone alone does not induce secreted phosphoprotein 1 (osteopontin) in glandular epithelium

scientific article published on 12 August 2010

Effects of long-term progesterone on developmental and functional aspects of porcine uterine epithelia and vasculature: progesterone alone does not support development of uterine glands comparable to that of pregnancy

scientific article published on 15 July 2010

Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells.

scientific article published on 2 February 2007

Effects of the estrous cycle and early pregnancy on uterine expression of Mx protein in sheep (Ovis aries).

scientific article

Embryo production and possible species preservation by nuclear transfer of somatic cells isolated from bovine semen.

scientific article

Energy transfer cassettes in silica nanoparticles target intracellular organelles.

scientific article published on 31 March 2011

Enhanced focal adhesion assembly reflects increased mechanosensation and mechanotransduction at maternal-conceptus interface and uterine wall during ovine pregnancy

scientific article

Enhancement of melphalan toxicity by octanol in ovarian adenocarcinoma cell lines: effects of altered cell-cell communication, glutathione levels, and plasma membrane fluidity

scientific article published on 01 April 1995

Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1.

scientific article published on 05 January 2001

Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex

scientific article published in August 2002

Evaluation of culture systems for attachment and proliferation of epithelial cells cultured from ovine semen.

scientific article published on 24 November 2008

Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures

scientific article published in April 2001

Exosomes, endogenous retroviruses and toll-like receptors: pregnancy recognition in ewes.

scientific article published on 19 December 2014

Expression of progesterone receptor in the porcine uterus and placenta throughout gestation: correlation with expression of uteroferrin and osteopontin

scientific article published on 15 July 2016

Expression of the interferon tau inducible ubiquitin cross-reactive protein in the ovine uterus

scientific article published on 01 July 1999

FIA/MS analysis of temporally ozonated benzo[a]pyrene and pyrene and their reaction products: inhibition of gap junction-mediated intercellular communication.

scientific article

Fructose Synthesis and Transport at the Uterine-Placental Interface of Pigs: Cell-Specific Localization of SLC2A5, SLC2A8, and Components of the Polyol Pathway.

scientific article published on 17 August 2016

Functional effects of transforming growth factor beta on adhesive properties of porcine trophectoderm

scientific article published on 16 June 2005

Functional role of arginine during the peri-implantation period of pregnancy. I. Consequences of loss of function of arginine transporter SLC7A1 mRNA in ovine conceptus trophectoderm

scientific article published on 13 March 2014

Functional role of arginine during the peri-implantation period of pregnancy. II. Consequences of loss of function of nitric oxide synthase NOS3 mRNA in ovine conceptus trophectoderm

scientific article published on 24 July 2014

Functional roles of arginine during the peri-implantation period of pregnancy. III. Arginine stimulates proliferation and interferon tau production by ovine trophectoderm cells via nitric oxide and polyamine-TSC2-MTOR signaling pathways.

scientific article

Galectin 15 (LGALS15) functions in trophectoderm migration and attachment

scientific article published on 21 September 2007

Galectin 15 (LGALS15): a gene uniquely expressed in the uteri of sheep and goats that functions in trophoblast attachment

scientific article published on 12 September 2007

Galectin-15 in ovine uteroplacental tissues

scientific article published on 01 August 2005

Gap junction amplification in rat ovarian granulosa cells. I. A direct response to follicle-stimulating hormone

scientific article published on 01 November 1982

HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer.

scientific article

High passage T47D human breast cancer cells: altered endocrine and 2,3,7,8-tetrachlorodibenzo-p-dioxin responsiveness

scientific article published on January 1994

Histone-like protein and chromatin structure in the wall-less dinoflagellate Gymnodinium nelsoni

scientific article published on 01 January 1982

Hormonal modulation of gap junctions in rat ovarian follicles

scientific article published on 01 January 1981

Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells

scientific article published on July 2004

Hypoxia induces proteasome-dependent degradation of estrogen receptor alpha in ZR-75 breast cancer cells

scientific article

ITGAV (alpha v integrins) bind SPP1 (osteopontin) to support trophoblast cell adhesion.

scientific article published in March 2017

Identification of appropriate reference genes for qPCR analyses of placental expression of SLC7A3 and induction of SLC5A1 in porcine endometrium.

scientific article published on 4 February 2017

Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in CrVI-induced adverse effects on germ cell nest breakdown and follicle development in rats

scientific article

Immunohistochemical Examination of Trophoblast Syncytialization during Early Placentation in Sheep

scientific article published on 13 September 2019

Immunosuppressant inhibition of P-glycoprotein function is independent of drug-induced suppression of peptide-prolyl isomerase and calcineurin activity.

scientific article

Impacts of amino acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine production

scientific article published on 23 October 2009

Impacts of arginine nutrition on embryonic and fetal development in mammals.

scientific article published on 04 June 2013

Implantation and Establishment of Pregnancy in the Pig.

scientific article published on January 2015

Implantation mechanisms: insights from the sheep.

scientific article

Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells

scientific article published on December 1998

Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans

scientific article published on 22 August 2008

Insulin-like growth factor II activates phosphatidylinositol 3-kinase-protooncogenic protein kinase 1 and mitogen-activated protein kinase cell Signaling pathways, and stimulates migration of ovine trophectoderm cells

scientific article published on 13 March 2008

Insulin-like growth factor binding protein-1 in the ruminant uterus: potential endometrial marker and regulator of conceptus elongation.

scientific article published on 4 June 2009

Integrin activation in bovine placentomes and in caruncular epithelial cells isolated from pregnant cows

scientific article published on 16 April 2008

Integrins and extracellular matrix proteins at the maternal-fetal interface in domestic animals.

scientific article

Intercellular junctions and exocytosis in the vas deferens of Ascaris

scientific article published on 01 May 1980

Interferon stimulated gene 15 conjugates to endometrial cytosolic proteins and is expressed at the uterine-placental interface throughout pregnancy in sheep

scientific article published on 4 November 2004

Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells

scientific article

Intracellular imaging of organelles with new water-soluble benzophenoxazine dyes.

scientific article published on 3 March 2010

Ischemia-induced cleavage of cadherins in NRK cells is not sufficient for beta-catenin transcriptional activity

scientific article published in October 2007

Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14).

scientific article

Ischemia-induced cleavage of cadherins in NRK cells: evidence for a role of metalloproteinases

scientific article

Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats

scientific journal article

Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens.

scientific article published on 23 February 2008

Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2.

scientific article

MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells

scientific article

Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents

scientific article

Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin

scientific article published on May 1997

Mechanisms for the establishment and maintenance of pregnancy: Synergies from scientific collaborations.

scientific article published on 16 February 2018

Mechanistic mammalian target of rapamycin (MTOR) cell signaling: effects of select nutrients and secreted phosphoprotein 1 on development of mammalian conceptuses.

scientific article published on September 2011

Membrane fusion during spermiogenesis in Ascaris

scientific article published on 01 February 1978

Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis.

scientific article

Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells.

scientific article published on 4 May 2006

Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line

scientific article (publication date: 15 May 2011)

Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines

scientific article (publication date: February 2009)

Nck deficiency is associated with delayed breast carcinoma progression and reduced metastasis

scientific article

Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds

scientific article published on January 2003

Non-covalent delivery of proteins into mammalian cells

scientific article published on 30 October 2008

Novel pathways for implantation and establishment and maintenance of pregnancy in mammals.

scientific article

Organelle-selective energy transfer: a fluorescent indicator of intracellular environment

scientific article

Osteopontin expression in uterine stroma indicates a decidualization-like differentiation during ovine pregnancy

scientific article published on 27 December 2002

Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy

scientific article published on 08 January 2003

Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep.

scientific article

Overexpression of MMP-7 Increases Collagen 1A2 in the Aging Kidney

scientific article published on October 2013

Ovine osteopontin: II. Osteopontin and alpha(v)beta(3) integrin expression in the uterus and conceptus during the periimplantation period

scientific article published on 01 October 1999

Patulin-induced cellular toxicity: a vital fluorescence study

scientific article published on February 1992

Phenotypic profiles of cultured glomerular cells following repeated cycles of hydrocarbon injury

scientific article published on 01 April 2000

Pig conceptuses increase uterine interferon-regulatory factor 1 (IRF1), but restrict expression to stroma through estrogen-induced IRF2 in luminal epithelium

scientific article published on 02 May 2007

Pregnancy recognition and conceptus implantation in domestic ruminants: roles of progesterone, interferons and endogenous retroviruses.

scientific article published on January 2007

Prenatal exposure to chromium induces early reproductive senescence by increasing germ cell apoptosis and advancing germ cell cyst breakdown in the F1 offspring

scientific article published on 12 February 2014

Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility.

scientific article

Progesterone and placentation increase secreted phosphoprotein one (SPP1 or osteopontin) in uterine glands and stroma for histotrophic and hematotrophic support of ovine pregnancy

scientific article published on 30 July 2008

Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney

scientific article published on 24 October 2007

Rb localization and phosphorylation kinetics correlate with the cellular phenotype of cultured breast adenocarcinoma cells

scientific article published on 01 April 2002

Reduced cell-cell communication between mitotic and nonmitotic coupled cells

scientific article published on January 1992

Regulation of expression of fibroblast growth factor 7 in the pig uterus by progesterone and estradiol

scientific article published on 28 March 2007

Resveratrol protects the ovary against chromium-toxicity by enhancing endogenous antioxidant enzymes and inhibiting metabolic clearance of estradiol.

scientific article published on 27 April 2016

Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells

scientific article published on 01 September 2004

Ruthenium(II)-Polypyridyl Compounds with π-Extended Nitrogen Donor Ligands Induce Apoptosis in Human Lung Adenocarcinoma (A549) Cells by Triggering Caspase-3/7 Pathway

scientific article published on 21 September 2018

Salmonella enterica serovar Typhimurium-induced internalization and IL-8 expression in HeLa cells does not have a direct relationship with intracellular Ca(2+) levels

scientific article published on 18 May 2009

Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alpha v beta 6 on porcine trophectoderm cells and integrin alpha v beta 3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration.

scientific article

Secreted phosphoprotein 1 (osteopontin) is expressed by stromal macrophages in cyclic and pregnant endometrium of mice, but is induced by estrogen in luminal epithelium during conceptus attachment for implantation

scientific article published on 01 December 2006

Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells

scientific article published on 10 April 2010

Select nutrients in the ovine uterine lumen. IX. Differential effects of arginine, leucine, glutamine, and glucose on interferon tau, ornithine decarboxylase, and nitric oxide synthase in the ovine conceptus.

scientific article published on 3 February 2011

Select nutrients in the ovine uterine lumen. VII. Effects of arginine, leucine, glutamine, and glucose on trophectoderm cell signaling, proliferation, and migration.

scientific article published on 15 September 2010

Select nutrients in the ovine uterine lumen. VIII. Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines.

scientific article published on 15 September 2010

Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms

scientific article

Spatial and temporal analyses of integrin and Muc-1 expression in porcine uterine epithelium and trophectoderm in vitro

scientific article published on February 1997

Spatial and temporal analyses of integrin and Muc-1 expression in porcine uterine epithelium and trophectoderm in vivo

scientific article published in November 1996

Stanniocalcin 1 is a luminal epithelial marker for implantation in pigs regulated by progesterone and estradiol

scientific article

Steroid regulation of cell specific secreted phosphoprotein 1 (osteopontin) expression in the pregnant porcine uterus

scientific article published on 24 August 2005

Structural equation modeling highlights the potential of Kim-1 as a biomarker for chronic kidney disease

scientific article published on 20 January 2012

Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells

scientific article published on 01 December 1997

Technical note: Isolation and characterization of ovine brown adipocyte precursor cells.

scientific article published on May 2015

Technical note: Isolation and characterization of porcine mammary epithelial cells

scientific article published on November 2015

The IGF system in the neonatal ovine uterus

scientific article

The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes

scientific article

The influence of estrogen on hepatobiliary osteopontin (SPP1) expression in a female rodent model of alcoholic steatohepatitis.

scientific article published on 22 April 2009

The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep.

scientific article

The temporal expression of osteopontin (SPP-1) in the rodent model of alcoholic steatohepatitis: a potential biomarker

scientific article published on 01 January 2006

Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone

scientific article published on 03 May 2007

Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.

scientific article published on 30 April 2009

Transforming growth factor beta (TGFB) signaling is activated during porcine implantation: proposed role for latency-associated peptide interactions with integrins at the conceptus-maternal interface.

scientific article

Triennial Growth Symposium: important roles for L-glutamine in swine nutrition and production

scientific article published on 17 December 2010

Using quantitative structure-activity relationships (QSAR) to predict toxic endpoints for polycyclic aromatic hydrocarbons (PAH).

scientific article

Uterine Histotroph and Conceptus Development. II. Arginine and Secreted Phosphoprotein 1 Cooperatively Stimulate Migration and Adhesion of Ovine Trophectoderm Cells via Focal Adhesion-MTORC2 Mediated Cytoskeleton Reorganization.

scientific article published on 10 August 2016

Uterine biology in pigs and sheep

scientific article

Uterine histotroph and conceptus development. I. cooperative effects of arginine and secreted phosphoprotein 1 on proliferation of ovine trophectoderm cells via activation of the PDK1-Akt/PKB-TSC2-MTORC1 signaling cascade

scientific article

Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model.

scientific article

Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins

scientific article

WNTs in the ovine uterus: potential regulation of periimplantation ovine conceptus development.

scientific article published on 12 April 2007

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