List of works - Stephen J. Tucker

A BEST example of channel structure annotation by molecular simulation.

scientific article published on 20 March 2017

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.

scientific article published on February 2016

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura

scientific article

A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates

scientific article published on 24 June 2019

A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel

scientific article

A lower X-gate in TASK channels traps inhibitors within the vestibule

scientific article published on 29 April 2020

A novel KCNA1 mutation identified in an Italian family affected by episodic ataxia type 1

scientific article

A novel method for measurement of submembrane ATP concentration

scientific article published in September 2000

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels ⬇️

scientific article published on 01 February 2019

A touching case of channel regulation: the ATP-sensitive K+ channel

scientific article

Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits.

scientific article published on August 1997

Altered functional properties of a missense variant in the TRESK K+ channel (KCNK18) associated with migraine and intellectual disability

scientific article published on 12 May 2020

Assignment of KATP-1, the cardiac ATP-sensitive potassium channel gene (KCNJ5), to human chromosome 11q24

scientific article

Asymmetric mechanosensitivity in a eukaryotic ion channel.

scientific article published on 18 September 2017

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

scientific article published on 24 March 2017

Cloning and functional characterization of a superfamily of microbial inwardly rectifying potassium channels

scientific article published on 04 April 2006

Conformational changes during the gating of a potassium channel revealed by structural mass spectrometry

scientific article

Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties

scientific article

Control of KirBac3.1 Potassium Channel Gating at the Interface between Cytoplasmic Domains

scientific article

Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing

scientific article published in September 2007

Correction: Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy

scientific article published on 21 July 2016

Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport

scientific article

Cystic fibrosis transmembrane conductance regulator-dependent up-regulation of Kir1.1 (ROMK) renal K+ channels by the epithelial sodium channel

scientific article

De novo point mutations in patients diagnosed with ataxic cerebral palsy.

scientific article

Direct Photoaffinity Labeling of the Kir6.2 Subunit of the ATP-sensitive K+Channel by 8-Azido-ATP

scientific article published in Journal of Biological Chemistry

Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide

scientific article published in June 2000

Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel

scientific article published on 18 July 2017

Electric Field Induced Wetting of a Hydrophobic Gate in a Model Nanopore Based on the 5-HT 3 Receptor Channel

Electric Field Induced Wetting of a Hydrophobic Gate in a Model Nanopore Based on the 5-HT3 Receptor Channel

scientific article published on 16 July 2020

Electronic Polarizability Tunes the Function of the Human Bestrophin 1 Cl − Channel

Functional analysis of missense variants in the TRESK (KCNK18) K channel

scientific article

Functional characterisation of missense variations in the Kir4.1 potassium channel (KCNJ10) associated with seizure susceptibility.

scientific article

Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains

scientific article

Genetic Inactivation of Kcnj16 Identifies Kir5.1 as an Important Determinant of Neuronal PCO2/pH Sensitivity ⬇️

scientific article published on November 3, 2010

Heteromeric channel formation and Ca(2+)-free media reduce the toxic effect of the weaver Kir 3.2 allele.

scientific article published in July 1996

How highly charged anionic lipids bind and regulate ion channels

scientific article

Hydrophobic gating in ion channels

scientific article

In vitro reconstitution of eukaryotic ion channels using droplet interface bilayers

scientific article published on 27 May 2011

Induced Polarization in MD Simulations of the 5HT3 Receptor Channel

scientific article published on 26 April 2020

Influence of Electronic Polarization on the Binding of Anions to a Chloride-Pumping Rhodopsin

Influence of effective polarization on ion and water interactions within a biomimetic nanopore

Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel

scientific article

Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels

scientific article published on 07 February 2014

Inhibitory interactions between two inward rectifier K+ channel subunits mediated by the transmembrane domains

scientific article published in March 1996

Insights into the structural nature of the transition state in the Kir channel gating pathway

scientific article

Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel

scientific article

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.

scientific article published in January 1999

Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor

scientific article published in July 1999

Inward rectification in KATP channels: a pH switch in the pore.

scientific article

Ion Mobility Mass Spectrometry of Two Tetrameric Membrane Protein Complexes Reveals Compact Structures and Differences in Stability and Packing

article

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

scientific article published in March 2015

Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis

scientific journal article

Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels

scientific article published on 24 June 2005

Mechanism of ATP-sensitive K Channel Inhibition by Sulfhydryl Modification ⬇️

scientific article published on September 1, 1998

MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.

scientific article published on June 1998

Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channels

scientific article

Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.

scientific article

Molecular determinants of KATP channel inhibition by ATP.

scientific article

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study

scientific article published on 28 February 2007

Molecular simulation studies of hydrophobic gating in nanopores and ion channels

scientific article published on April 2015

Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.

scientific article published in November 2001

NEM modification prevents high-affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor, SUR1

scientific article published on 01 September 1999

Non-equivalent cooperation between the two nucleotide-binding folds of P-glycoprotein

scientific article published on 01 August 1998

Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels

scientific article

Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene

scientific article

PIP 2 and PIP as Determinants for ATP Inhibition of K ATP Channels ⬇️

scientific article published on November 6, 1998

Peptide backbone mutagenesis of putative gating hinges in a potassium ion channel

scientific article published in July 2008

Publisher Correction: Structure and assembly of calcium homeostasis modulator proteins

scientific article published on 01 March 2020

Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome.

scientific article

Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16).

scientific article

Role of receptor protein tyrosine phosphatase alpha (RPTPalpha) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels

scientific article published in December 2000

Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel

scientific article published on 05 December 2019

Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.

scientific article

State-dependent network connectivity determines gating in a K+ channel

scientific article

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1

scientific article

Structural basis for proton coupled cystine transport by cystinosin

Structure and assembly of calcium homeostasis modulator proteins

scientific article published on 27 January 2020

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating

scientific article

The effects of stretch activation on ionic selectivity of the TREK-2 K2P K+ channel.

scientific article published on 19 July 2017

The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation

scientific article published in October 1997

The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.

scientific article published in November 1999

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

scientific article (publication date: 8 May 1997)

Water Nanoconfined in a Hydrophobic Pore: MD Simulations and Water Models

Water Nanoconfined in a Hydrophobic Pore: Molecular Dynamics Simulations of Transmembrane Protein 175 and the Influence of Water Models

scientific article published on 16 November 2021

Water and hydrophobic gates in ion channels and nanopores

scientific article published on 01 September 2018

pH dependence of the inwardly rectifying potassium channel, Kir5.1, and localization in renal tubular epithelia

scientific article published in June 2000

List of works by Stephen J. Tucker

A BEST example of channel structure annotation by molecular simulation.

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.

A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura

A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates

A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel

A lower X-gate in TASK channels traps inhibitors within the vestibule

A novel KCNA1 mutation identified in an Italian family affected by episodic ataxia type 1

A novel method for measurement of submembrane ATP concentration

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels ⬇️

A touching case of channel regulation: the ATP-sensitive K+ channel

Activation and inhibition of K-ATP currents by guanine nucleotides is mediated by different channel subunits.

Altered functional properties of a missense variant in the TRESK K+ channel (KCNK18) associated with migraine and intellectual disability

Assignment of KATP-1, the cardiac ATP-sensitive potassium channel gene (KCNJ5), to human chromosome 11q24

Asymmetric mechanosensitivity in a eukaryotic ion channel.

Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

Cloning and functional characterization of a superfamily of microbial inwardly rectifying potassium channels

Conformational changes during the gating of a potassium channel revealed by structural mass spectrometry

Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties

Control of KirBac3.1 Potassium Channel Gating at the Interface between Cytoplasmic Domains

Control of pH and PIP2 gating in heteromeric Kir4.1/Kir5.1 channels by H-Bonding at the helix-bundle crossing

Correction: Dominant-Negative Effect of a Missense Variant in the TASK-2 (KCNK5) K+ Channel Associated with Balkan Endemic Nephropathy

Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport

Cystic fibrosis transmembrane conductance regulator-dependent up-regulation of Kir1.1 (ROMK) renal K+ channels by the epithelial sodium channel

De novo point mutations in patients diagnosed with ataxic cerebral palsy.

Direct Photoaffinity Labeling of the Kir6.2 Subunit of the ATP-sensitive K+Channel by 8-Azido-ATP

Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide

Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel

Electric Field Induced Wetting of a Hydrophobic Gate in a Model Nanopore Based on the 5-HT 3 Receptor Channel

Electric Field Induced Wetting of a Hydrophobic Gate in a Model Nanopore Based on the 5-HT3 Receptor Channel

Electronic Polarizability Tunes the Function of the Human Bestrophin 1 Cl − Channel

Functional analysis of missense variants in the TRESK (KCNK18) K channel

Functional characterisation of missense variations in the Kir4.1 potassium channel (KCNJ10) associated with seizure susceptibility.

Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains

Genetic Inactivation of Kcnj16 Identifies Kir5.1 as an Important Determinant of Neuronal PCO2/pH Sensitivity ⬇️

Heteromeric channel formation and Ca(2+)-free media reduce the toxic effect of the weaver Kir 3.2 allele.

How highly charged anionic lipids bind and regulate ion channels

Hydrophobic gating in ion channels

In vitro reconstitution of eukaryotic ion channels using droplet interface bilayers

Induced Polarization in MD Simulations of the 5HT3 Receptor Channel

Influence of Electronic Polarization on the Binding of Anions to a Chloride-Pumping Rhodopsin

Influence of effective polarization on ion and water interactions within a biomimetic nanopore

Influence of effective polarization on ion and water interactions within a biomimetic nanopore

Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel

Influence of the N terminus on the biophysical properties and pharmacology of TREK1 potassium channels

Inhibitory interactions between two inward rectifier K+ channel subunits mediated by the transmembrane domains

Insights into the structural nature of the transition state in the Kir channel gating pathway

Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.

Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor

Inward rectification in KATP channels: a pH switch in the pore.

Ion Mobility Mass Spectrometry of Two Tetrameric Membrane Protein Complexes Reveals Compact Structures and Differences in Stability and Packing

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis

Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels

Mechanism of ATP-sensitive K Channel Inhibition by Sulfhydryl Modification ⬇️

MgATP activates the beta cell KATP channel by interaction with its SUR1 subunit.

Modular Design of the Selectivity Filter Pore Loop in a Novel Family of Prokaryotic 'Inward Rectifier' (NirBac) channels

Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.

Molecular determinants of KATP channel inhibition by ATP.

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study

Molecular simulation studies of hydrophobic gating in nanopores and ion channels

Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.

NEM modification prevents high-affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor, SUR1

Non-equivalent cooperation between the two nucleotide-binding folds of P-glycoprotein

Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels

Novel phenotype associated with a mutation in the KCNA1(Kv1.1) gene

PIP 2 and PIP as Determinants for ATP Inhibition of K ATP Channels ⬇️

Peptide backbone mutagenesis of putative gating hinges in a potassium ion channel

Publisher Correction: Structure and assembly of calcium homeostasis modulator proteins

Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome.

Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16).

Role of receptor protein tyrosine phosphatase alpha (RPTPalpha) and tyrosine phosphorylation in the serotonergic inhibition of voltage-dependent potassium channels

Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel

Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel.

State-dependent network connectivity determines gating in a K+ channel

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1

Structural basis for proton coupled cystine transport by cystinosin

Structure and assembly of calcium homeostasis modulator proteins