List of works - Lona Louring Christrup

A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain

scientific article

A Pharmacokinetic-Pharmacodynamic Model of Morphine Exposure and Subsequent Morphine Consumption in Postoperative Pain

scientific article published on 11 January 2016

A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model

scientific article published on 04 April 2006

A cortical source localization analysis of resting EEG data after remifentanil infusion.

scientific article

A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia

scientific article published on December 2010

A physiologically-based recirculatory meta-model for nasal fentanyl in man.

scientific article published on 19 August 2012

A review of morphine and morphine-6-glucuronide's pharmacokinetic-pharmacodynamic relationships in experimental and clinical pain

scientific article published on 07 April 2015

Altered cortical causality after remifentanil administration in healthy volunteers: a novel approach for pharmaco-EEG.

scientific article published on January 2014

Altered frequency distribution in the electroencephalogram is correlated to the analgesic effect of remifentanil

scientific article published on 21 October 2014

Association Between Genetic Polymorphisms and Pain Sensitivity in Patients with Hip Osteoarthritis

scientific article published on 20 October 2017

Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review

scientific article published on 09 September 2014

Association between Gene Polymorphisms and Pain Sensitivity Assessed in a Multi-Modal Multi-Tissue Human Experimental Model - An Explorative Study

article

Barriers to cancer pain management in Danish and Lithuanian patients treated in pain and palliative care units

scientific article published on 21 August 2012

Blood-brain distribution of morphine-6-glucuronide in sheep.

scientific article

Changing M3G/M6G ratios and pharmacodynamics in a cancer patient during long-term morphine treatment

scientific article published in February 2002

Chronic abdominal pain and persistent opioid use after bariatric surgery

scientific article published on 22 November 2019

Cortical and spinal assessment - a comparative study using encephalography and the nociceptive withdrawal reflex.

scientific article published on 29 October 2016

Creatinine-Based Renal Function Estimates and Dosage of Postoperative Pain Management for Elderly Acute Hip Fracture Patients

article

Danish pain specialists' rationales behind the choice of fentanyl transdermal patches and oral transmucosal systems--a delphi study

scientific article published on 29 September 2009

Definition, diagnosis and treatment strategies for opioid-induced bowel dysfunction-Recommendations of the Nordic Working Group

scientific article published on 4 February 2016

Differences between opioids: pharmacological, experimental, clinical and economical perspectives

scientific article

Differential effect of opioids in patients with chronic pancreatitis: an experimental pain study

scientific article published on March 2007

Disruption of cortical connectivity during remifentanil administration is associated with cognitive impairment but not with analgesia

scientific article published in January 2015

Does mutual compensation of the cognitive effects induced by pain and opioids exist? An experimental study

scientific article

Effect of intraoral and subcutaneous morphine on dyspnea at rest in terminal patients with primary lung cancer or lung metastases

scientific article published in July 2013

Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug

scientific article published on 5 January 2005

Exploratory survey study of long-term users of nicotine replacement therapy in Danish consumers

scientific article published on 19 January 2015

Genetic Influences of OPRM1 ,OPRD1 and COMT on Morphine Analgesia in a Multi-Modal, Multi-Tissue Human Experimental Pain Model

scientific article published on 14 March 2017

Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study

scientific article published in April 2014

Healthcare professionals' agreement on clinical relevance of drug-related problems among elderly patients

scientific article

Modelling concentration–analgesia relationships for morphine to evaluate experimental pain models

article by Eva Sverrisdóttir et al published 23 January 2015 in European Journal of Pharmaceutical Sciences

Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study

scientific article published on 9 January 2013

Neuropsychological assessment of chronic non-malignant pain patients treated in a multidisciplinary pain centre

scientific article published on 5 November 2004

Objective markers of the analgesic response to morphine in experimental pain research

scientific article published on 07 February 2015

Objective methods for the assessment of the spinal and supraspinal effects of opioids

scientific article

Offset Analgesia and The Impact of Treatment with Oxycodone and Venlafaxine: A Placebo-Controlled, Randomized Trial in Healthy Volunteers

scientific article published on 31 July 2018

Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists

scientific article published in September 1998

Pain characteristics and management of inpatients admitted to a comprehensive cancer centre: a cross-sectional study

scientific article published on 22 January 2013

Pain, sedation and morphine metabolism in cancer patients during long-term treatment with sustained-release morphine

scientific article published in March 2002

Patient-related barriers to cancer pain management: a systematic exploratory review

scientific article

Patients' evaluation of shape, size and colour of solid dosage forms

scientific article published in October 2001

Pharmacodynamic modelling of placebo and buprenorphine effects on event-related potentials in experimental pain.

scientific article published on 17 March 2014

Pharmacokinetic-Pharmacodynamic Modelling of the Analgesic and Antihyperalgesic Effects of Morphine after Intravenous Infusion in Human Volunteers

scientific article published on 17 March 2014

Pharmacokinetic-pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model.

scientific article published in May 2008

Pharmacokinetic-pharmacodynamic relationships of cognitive and psychomotor effects of intravenous buprenorphine infusion in human volunteers

scientific article published in July 2008

Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models.

scientific article published on 8 December 2010

Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery.

scientific article

Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers

scientific article published on 31 May 2007

Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, double-dummy, two-way, crossover study.

scientific article

Pharmacological consequences of long-term morphine treatment in patients with cancer and chronic non-malignant pain

scientific article published in June 2004

Population pharmacokinetic-pharmacodynamic modelling of liquid and controlled-release formulations of oxycodone in healthy volunteers

scientific article published on 28 October 2019

Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers

scientific article published on 16 September 2007

Population pharmacokinetics of morphine and morphine-6-glucuronide following rectal administration--a dose escalation study

scientific article published on 5 December 2014

Psychological and behavioural predictors of pain management outcomes in patients with cancer

scientific article published on December 2010

Quality of life and symptoms in patients with malignant diseases admitted to a comprehensive cancer centre.

scientific article

Rationales behind the choice of administration form with fentanyl: Delphi survey among Danish general practitioners ⬇️

scientific article published on July 1, 2010

Relationships among morphine metabolism, pain and side effects during long-term treatment: an update.

scientific article

Renal function and symptoms/adverse effects in opioid-treated patients with cancer

scientific article published on 5 May 2015

Repeated Time-to-event Analysis of Consecutive Analgesic Events in Postoperative Pain

scientific article published on 23 October 2015

Role of active metabolites in the use of opioids

scientific article

Short-term oxycodone treatment does not affect electrogenic ion transport in isolated mucosa from the human rectosigmoid colon

scientific article published on 26 November 2015

Steady-State Kinetics and Dynamics of Morphine in Cancer Patients

article

Stereoselective pharmacokinetics of methadone in chronic pain patients

scientific article published on June 1996

Switching from high doses of pure μ-opioid agonists to transdermal buprenorphine in patients with cancer: a feasibility study

scientific article

Symptoms and side effects in chronic non-cancer pain patients: clinical implications and development of new assessment tools

scientific article published on 29 May 2015

Symptoms and side effects in chronic non-cancer pain: patient report vs. systematic assessment

scientific article

The Danish version of the Medication Adherence Report Scale: preliminary validation in cancer pain patients

scientific article published on 8 October 2008

The effects of morphine and methylnaltrexone on gastrointestinal pain in healthy male participants

scientific article published on 22 March 2015

The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy: a randomized controlled trial.

scientific article published in January 2010

Translational pain research: evaluating analgesic effect in experimental visceral pain models.

scientific article published on January 2009

List of works by Lona Louring Christrup

A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain

A Pharmacokinetic-Pharmacodynamic Model of Morphine Exposure and Subsequent Morphine Consumption in Postoperative Pain

A comparative study of oxycodone and morphine in a multi-modal, tissue-differentiated experimental pain model

A cortical source localization analysis of resting EEG data after remifentanil infusion.

A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia

A physiologically-based recirculatory meta-model for nasal fentanyl in man.

A review of morphine and morphine-6-glucuronide's pharmacokinetic-pharmacodynamic relationships in experimental and clinical pain

Altered cortical causality after remifentanil administration in healthy volunteers: a novel approach for pharmaco-EEG.

Altered frequency distribution in the electroencephalogram is correlated to the analgesic effect of remifentanil

Association Between Genetic Polymorphisms and Pain Sensitivity in Patients with Hip Osteoarthritis

Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review

Association between Gene Polymorphisms and Pain Sensitivity Assessed in a Multi-Modal Multi-Tissue Human Experimental Model - An Explorative Study

Association between Gene Polymorphisms and Pain Sensitivity Assessed in a Multi-Modal Multi-Tissue Human Experimental Model - An Explorative Study

Barriers to cancer pain management in Danish and Lithuanian patients treated in pain and palliative care units

Blood-brain distribution of morphine-6-glucuronide in sheep.

Changing M3G/M6G ratios and pharmacodynamics in a cancer patient during long-term morphine treatment

Chronic abdominal pain and persistent opioid use after bariatric surgery

Cortical and spinal assessment - a comparative study using encephalography and the nociceptive withdrawal reflex.

Creatinine-Based Renal Function Estimates and Dosage of Postoperative Pain Management for Elderly Acute Hip Fracture Patients

Danish pain specialists' rationales behind the choice of fentanyl transdermal patches and oral transmucosal systems--a delphi study

Definition, diagnosis and treatment strategies for opioid-induced bowel dysfunction-Recommendations of the Nordic Working Group

Differences between opioids: pharmacological, experimental, clinical and economical perspectives

Differential effect of opioids in patients with chronic pancreatitis: an experimental pain study

Disruption of cortical connectivity during remifentanil administration is associated with cognitive impairment but not with analgesia

Does mutual compensation of the cognitive effects induced by pain and opioids exist? An experimental study

Effect of intraoral and subcutaneous morphine on dyspnea at rest in terminal patients with primary lung cancer or lung metastases

Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug

Exploratory survey study of long-term users of nicotine replacement therapy in Danish consumers

Genetic Influences of OPRM1 ,OPRD1 and COMT on Morphine Analgesia in a Multi-Modal, Multi-Tissue Human Experimental Pain Model

Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study

Healthcare professionals' agreement on clinical relevance of drug-related problems among elderly patients

Modelling concentration–analgesia relationships for morphine to evaluate experimental pain models

Morphine- and buprenorphine-induced analgesia and antihyperalgesia in a human inflammatory pain model: a double-blind, randomized, placebo-controlled, five-arm crossover study

Neuropsychological assessment of chronic non-malignant pain patients treated in a multidisciplinary pain centre

Objective markers of the analgesic response to morphine in experimental pain research

Objective methods for the assessment of the spinal and supraspinal effects of opioids

Offset Analgesia and The Impact of Treatment with Oxycodone and Venlafaxine: A Placebo-Controlled, Randomized Trial in Healthy Volunteers

Opioid analgesics as noncompetitive N-methyl-D-aspartate (NMDA) antagonists

Pain characteristics and management of inpatients admitted to a comprehensive cancer centre: a cross-sectional study

Pain, sedation and morphine metabolism in cancer patients during long-term treatment with sustained-release morphine

Patient-related barriers to cancer pain management: a systematic exploratory review

Patients' evaluation of shape, size and colour of solid dosage forms

Pharmacodynamic modelling of placebo and buprenorphine effects on event-related potentials in experimental pain.

Pharmacokinetic-Pharmacodynamic Modelling of the Analgesic and Antihyperalgesic Effects of Morphine after Intravenous Infusion in Human Volunteers

Pharmacokinetic-pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model.

Pharmacokinetic-pharmacodynamic relationships of cognitive and psychomotor effects of intravenous buprenorphine infusion in human volunteers

Pharmacokinetic/pharmacodynamic relationships of transdermal buprenorphine and fentanyl in experimental human pain models.

Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery.

Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers

Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: a randomized, double-blind, double-dummy, two-way, crossover study.

Pharmacological consequences of long-term morphine treatment in patients with cancer and chronic non-malignant pain

Population pharmacokinetic-pharmacodynamic modelling of liquid and controlled-release formulations of oxycodone in healthy volunteers

Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers

Population pharmacokinetics of morphine and morphine-6-glucuronide following rectal administration--a dose escalation study

Psychological and behavioural predictors of pain management outcomes in patients with cancer

Quality of life and symptoms in patients with malignant diseases admitted to a comprehensive cancer centre.

Rationales behind the choice of administration form with fentanyl: Delphi survey among Danish general practitioners ⬇️

Relationships among morphine metabolism, pain and side effects during long-term treatment: an update.

Renal function and symptoms/adverse effects in opioid-treated patients with cancer

Repeated Time-to-event Analysis of Consecutive Analgesic Events in Postoperative Pain

Role of active metabolites in the use of opioids

Short-term oxycodone treatment does not affect electrogenic ion transport in isolated mucosa from the human rectosigmoid colon

Steady-State Kinetics and Dynamics of Morphine in Cancer Patients

Stereoselective pharmacokinetics of methadone in chronic pain patients

Switching from high doses of pure μ-opioid agonists to transdermal buprenorphine in patients with cancer: a feasibility study

Symptoms and side effects in chronic non-cancer pain patients: clinical implications and development of new assessment tools

Symptoms and side effects in chronic non-cancer pain: patient report vs. systematic assessment

The Danish version of the Medication Adherence Report Scale: preliminary validation in cancer pain patients

The effects of morphine and methylnaltrexone on gastrointestinal pain in healthy male participants

The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy: a randomized controlled trial.

Translational pain research: evaluating analgesic effect in experimental visceral pain models.