List of works - Diane P. Hanger

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies.

scientific article published on 7 May 2018

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

scientific article published on 03 January 2019

A role for tau at the synapse in Alzheimer's disease pathogenesis.

scientific article published on 25 September 2013

ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.

scientific article published on 14 July 2016

Advances in tau-based drug discovery.

scientific article

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

scientific article published on December 1994

Anti-inflammatory impact of minocycline in a mouse model of tauopathy.

scientific article published on 12 October 2010

Astrocytes and neuroinflammation in Alzheimer's disease.

scientific article published in October 2014

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.

scientific article

Autopsy-confirmed familial early-onset Alzheimer disease caused by the l153V presenilin 1 mutation

scientific article published in June 2001

Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.

scientific article

Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy

Chicken synucleins: cloning and expression in the developing embryo.

scientific article

Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

scientific article

Considerations for future tau-targeted therapeutics: can they deliver?

scientific article published on 29 October 2019

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease

scientific article published on 18 May 2016

Differential involvement and heterogeneous phosphorylation of tau isoforms in progressive supranuclear palsy

scientific article published in February 2004

Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats.

scientific article published in June 2008

Dynamic association of tau with neuronal membranes is regulated by phosphorylation

scientific article

Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology.

scientific article published in March 1992

Fluconazole and testosterone: in vivo and in vitro studies.

scientific article

Functional Implications of Glycogen Synthase Kinase‐3‐Mediated Tau Phosphorylation ⬇️

scientific article published on July 11, 2011

Functional implications of the association of tau with the plasma membrane.

scientific article published on August 2010

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase

scientific article published in November 1992

Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein.

scientific article published on 20 July 2017

Induction of neuronal death by α-synuclein

article by Anirban R. Saha et al published August 2000 in European Journal of Neuroscience

Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's disease

scientific article

Intracellular and extracellular roles for tau in neurodegenerative disease.

scientific article published on January 2014

Isolation of detergent resistant microdomains from cultured neurons: detergent dependent alterations in protein composition

scientific article

Key issues in the acquisition and analysis of qualitative and quantitative mass spectrometry data for peptide-centric proteomic experiments

scientific article

Kinase activities increase during the development of tauopathy in htau mice.

scientific article published in October 2007

Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease

scientific article

Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures.

scientific article published on 16 March 2017

Membrane-bound β-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism

article by Ritchie Williamson et al published May 2008 in FASEB Journal

Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding

scientific article published on 21 April 2009

Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease.

scientific article

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.

scientific article published on 7 December 2015

Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β.

scientific article published on 15 January 2014

Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells

scientific article published on 01 May 1995

Molecular motors implicated in the axonal transport of tau and alpha-synuclein

scientific article

NUB1 modulation of GSK3β reduces tau aggregation

scientific article published on 10 September 2012

Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos.

scientific article published in March 1996

Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis

scientific article

O2-05-07

P1-405

P1-468: Amyloid oligomers mobilize fyn kinase to lipid rafts

P2-132: Potential toxicity of tau cleavage products in progressive supranuclear palsy

article

P3-291

P3-309

P3-310

P3-315

P3-342: Amyloid-mediated NCX3 cleavage by calpain is an early and toxic event

article

PHF-tau from Alzheimer's brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3 beta

scientific article published in August 1994

Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

scientific article published in March 2004

Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies

scientific article published on June 2003

Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome

scientific article published in November 1996

Phosphorylation of Tau by Cyclic-AMP-Dependent Protein Kinase

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.

scientific article published on 29 May 2008

Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases

scientific article

Phosphorylation-dependent association of tau with the neuronal membrane

Physiological release of endogenous tau is stimulated by neuronal activity.

scientific article published on 15 February 2013

Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease

scientific article published on 12 April 2013

Quantitation of glycogen synthase kinase-3 sensitive proteins in neuronal membrane rafts

scientific article

Quantitative analysis of tau isoform transcripts in sporadic tauopathies

scientific article published on 29 March 2005

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

scientific article published on 9 October 2015

Roles of tau protein in health and disease

scientific article

Synaptic Localisation of Tau

scientific article published on 01 January 2019

Tau cleavage and tau aggregation in neurodegenerative disease

scientific article published on August 2010

Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 in the amyloid precursor protein

scientific article published in October 1992

Tau phosphorylation affects its axonal transport and degradation

scientific article published on 17 April 2013

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

scientific article published on 24 February 2009

Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease.

scientific article published on July 1997

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

scientific article published on 12 June 2016

The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy.

scientific article published on 18 January 2017

The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies

scientific article published in November 2002

The importance of tau phosphorylation for neurodegenerative diseases

scientific article published on July 2013

The microtubule-associated protein tau is also phosphorylated on tyrosine

scientific article published on January 2009

The microtubule-associated protein tau is phosphorylated by Syk

scientific article

The ultrastructural distribution of alpha-synuclein-like protein in normal mouse brain

scientific article published in April 2004

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

scientific article published on July 2005

Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau.

scientific article published on 7 July 2011

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain

scientific article published on 31 March 2016

α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production

scientific article

List of works by Diane P. Hanger

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies.

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

A role for tau at the synapse in Alzheimer's disease pathogenesis.

ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.

Advances in tau-based drug discovery.

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

Anti-inflammatory impact of minocycline in a mouse model of tauopathy.

Astrocytes and neuroinflammation in Alzheimer's disease.

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.

Autopsy-confirmed familial early-onset Alzheimer disease caused by the l153V presenilin 1 mutation

Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.

Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy

Chicken synucleins: cloning and expression in the developing embryo.

Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

Considerations for future tau-targeted therapeutics: can they deliver?

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease

Differential involvement and heterogeneous phosphorylation of tau isoforms in progressive supranuclear palsy

Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats.

Dynamic association of tau with neuronal membranes is regulated by phosphorylation

Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology.

Fluconazole and testosterone: in vivo and in vitro studies.

Functional Implications of Glycogen Synthase Kinase‐3‐Mediated Tau Phosphorylation ⬇️

Functional implications of the association of tau with the plasma membrane.

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase

Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein.

Induction of neuronal death by α-synuclein

Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's disease

Intracellular and extracellular roles for tau in neurodegenerative disease.

Isolation of detergent resistant microdomains from cultured neurons: detergent dependent alterations in protein composition

Key issues in the acquisition and analysis of qualitative and quantitative mass spectrometry data for peptide-centric proteomic experiments

Kinase activities increase during the development of tauopathy in htau mice.

Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease

Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures.

Membrane-bound β-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism

Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding

Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease.

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.

Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β.

Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells

Molecular motors implicated in the axonal transport of tau and alpha-synuclein

NUB1 modulation of GSK3β reduces tau aggregation

Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos.

Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis

O2-05-07

P1-405

P1-468: Amyloid oligomers mobilize fyn kinase to lipid rafts

P2-132: Potential toxicity of tau cleavage products in progressive supranuclear palsy

P3-291

P3-309

P3-310

P3-315

P3-342: Amyloid-mediated NCX3 cleavage by calpain is an early and toxic event

PHF-tau from Alzheimer's brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3 beta

Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies

Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome

Phosphorylation of Tau by Cyclic-AMP-Dependent Protein Kinase

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.

Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases

Phosphorylation-dependent association of tau with the neuronal membrane

Physiological release of endogenous tau is stimulated by neuronal activity.

Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease

Quantitation of glycogen synthase kinase-3 sensitive proteins in neuronal membrane rafts

Quantitative analysis of tau isoform transcripts in sporadic tauopathies

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

Roles of tau protein in health and disease

Synaptic Localisation of Tau

Tau cleavage and tau aggregation in neurodegenerative disease

Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 in the amyloid precursor protein

Tau phosphorylation affects its axonal transport and degradation

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease.

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy.

The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies

The importance of tau phosphorylation for neurodegenerative diseases

The microtubule-associated protein tau is also phosphorylated on tyrosine

The microtubule-associated protein tau is phosphorylated by Syk