List of works - Karelle Leroy

A neuronal aging pattern unique to humans and common chimpanzees

scientific article

Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model

scientific article published on February 2011

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits

scientific article

Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model

scientific article published on 5 April 2017

Analysis of Peripapillary Intrachoroidal Cavitation and Myopic Peripapillary Distortions in Polar Regions by Optical Coherence Tomography

scientific article published in 2022

Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells

scientific article

Cell surface targeting of VPAC1 receptors: evidence for implication of a quality control system and the proteasome

scientific article published on 8 April 2008

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

scientific article

Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice

scientific article published on 23 November 2012

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

scientific journal article

Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model

scientific article published on August 2010

Developmental expression and localization of glycogen synthase kinase-3beta in rat brain

scientific article published in June 1999

Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice

scientific article

Epigenetic control of aquaporin 1 expression by the amyloid precursor protein

scientific article published on 17 August 2009

Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease

scientific article published in October 2004

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

scientific article published on 15 February 2017

High-Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo

scientific article published on 3 August 2016

Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration

scientific article

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

scientific article

Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1.

scientific article published in January 2002

Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology

scientific article published on 8 January 2014

Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice

scientific article published on 28 September 2012

Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.

scientific article published on 13 July 2005

Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology

scientific article

Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease

scientific article (publication date: June 1999)

Modulation of tau pathology in tau transgenic models

scientific article published on August 2010

Motor deficit in a tauopathy model is induced by disturbances of axonal transport leading to dying-back degeneration and denervation of neuromuscular junctions

scientific article published on 10 August 2015

Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth.

scientific article published on December 2003

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

scientific article published on 01 March 1999

Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury

article

Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice

scientific article published in January 2015

The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease

scientific article published on 29 November 2001

The function of the microtubule-associated protein tau is variably modulated by graded changes in glycogen synthase kinase-3β activity

scientific article published on 01 January 2000

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

scientific article published on July 2005

Vaccination with Sarkosyl insoluble PHF-tau decrease neurofibrillary tangles formation in aged tau transgenic mouse model: a pilot study.

scientific article

List of works by Karelle Leroy

A neuronal aging pattern unique to humans and common chimpanzees

Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits

Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model

Analysis of Peripapillary Intrachoroidal Cavitation and Myopic Peripapillary Distortions in Polar Regions by Optical Coherence Tomography

Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells

Cell surface targeting of VPAC1 receptors: evidence for implication of a quality control system and the proteasome

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model

Developmental expression and localization of glycogen synthase kinase-3beta in rat brain

Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice

Epigenetic control of aquaporin 1 expression by the amyloid precursor protein

Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

High-Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo

Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1.

Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology

Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice

Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.

Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology

Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease

Modulation of tau pathology in tau transgenic models

Motor deficit in a tauopathy model is induced by disturbances of axonal transport leading to dying-back degeneration and denervation of neuromuscular junctions

Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth.

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury

Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice

The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease

The function of the microtubule-associated protein tau is variably modulated by graded changes in glycogen synthase kinase-3β activity

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

Vaccination with Sarkosyl insoluble PHF-tau decrease neurofibrillary tangles formation in aged tau transgenic mouse model: a pilot study.