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List of works by Mikko Metsä-Ketelä

A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation

scientific article published on 22 November 2007

A pharmaceutical model for the molecular evolution of microbial natural products

scientific article published on 22 November 2019

Activation of microbial secondary metabolic pathways: Avenues and challenges

scientific article published on 12 September 2018

Artificial Reconstruction of Two Cryptic Angucycline Antibiotic Biosynthetic Pathways

scientific article published on 01 September 2007

Biosynthesis of pyranonaphthoquinone polyketides reveals diverse strategies for enzymatic carbon-carbon bond formation

scientific article published on 22 July 2013

Biosynthetic conclusions from the functional dissection of oxygenases for biosynthesis of actinorhodin and related Streptomyces antibiotics.

scientific article published on April 2013

Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage

scientific article published on 2 April 2012

Characterization and overproduction of cell-associated cholesterol oxidase ChoD from Streptomyces lavendulae YAKB-15

scientific article published on 14 August 2019

Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin ⬇️

scientific article published on 20 June 2019

Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.

scientific article published in October 2008

Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis

scientific article

Chemoenzymatic synthesis of novel C-ribosylated naphthoquinones

scientific article published on 19 September 2013

Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater ⬇️

scientific article

Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis

scientific article

Discovery of a two-component monooxygenase SnoaW/SnoaL2 involved in nogalamycin biosynthesis

scientific article published on 01 May 2012

Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics

scientific article published on 18 April 2017

Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis

scientific article

Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway

scientific article (publication date: 10 May 2016)

Effective Antibiofilm Polyketides against Staphylococcus aureus from the Pyranonaphthoquinone Biosynthetic Pathways of Streptomyces Species ⬇️

scientific article published on 20 July 2015

Engineering Anthracycline Biosynthesis toward Angucyclines

scientific article published in 2003

Engineering anthracycline biosynthesis toward angucyclines

scientific article

Enzymatic Synthesis of the C-Glycosidic Moiety of Nogalamycin R

scientific article published on 20 August 2018

Evolution inspired engineering of antibiotic biosynthesis enzymes.

scientific article published on 27 April 2017

Evolution-guided engineering of non-heme iron enzymes involved in nogalamycin biosynthesis

scientific article published on 26 December 2019

Evolution-inspired engineering of anthracycline methyltransferases

Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases

scientific article published on 23 April 2019

Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis

scientific article published on 27 May 2011

Formation of 5-Hydroxy-3-methoxy-1,4-naphthoquinone and 8-Hydroxy-4-methoxy-1,2-naphthoquinone from Juglone

scientific article published on 23 September 2012

Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway

scientific article published on 25 August 2020

Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated Halophilic Streptomonospora sp. PA3 ⬇️

scientific article published on 09 June 2020

Identification of Late-Stage Glycosylation Steps in the Biosynthetic Pathway of the Anthracycline Nogalamycin

scientific article published on 25 November 2011

Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE.

scientific article published on 27 January 2016

Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.

scientific article

Laboratory course on Streptomyces genetics and secondary metabolism

scientific article published on 18 May 2016

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

scientific article published on 9 December 2024

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species

scientific article

Molecular evolution of the bacterial pseudouridine-5'-phosphate glycosidase protein family

scientific article published on 25 August 2014

Oxazinomycin arrests RNA polymerase at the polythymidine sequences

scientific article published on 01 November 2019

Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.

scientific article published on August 2004

Pathway engineering of anthracyclines: Blazing trails in natural product glycodiversification

scientific article published on 16 September 2020

Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products

scientific article

Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C.

scientific article

Single cell mutant selection for metabolic engineering of actinomycetes

scholarly article

Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis

scientific article

Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway

scientific article

Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis

scientific article published on 29 July 2020

Structure-based engineering of angucyclinone 6-ketoreductases

scientific article

Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities

scientific article

Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.

scientific article

Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection

scientific article published on 29 December 2014

The Rieske Oxygenase SnoT Catalyzes 2''-Hydroxylation of l-Rhodosamine in Nogalamycin Biosynthesis

scientific article published on 17 June 2020

The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases

scientific article published on 04 February 2021

Tracing the evolution of angucyclinone monooxygenases: structural determinants for C-12b hydroxylation and substrate inhibition in PgaE

scientific article

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