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List of works by Guy Lippens

15N-NMR-Based Approach for Amino Acids-Based 13C-Metabolic Flux Analysis of Metabolism

scientific article

1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptides

scientific article

A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein

scientific article published on 16 April 2015

A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication

scientific article published on 17 June 2015

A constant-time 13C−1H HSQC with uniform excitation over the complete 13C chemical shift range

scientific article published on 01 January 1995

A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge

scientific article published in 2014

A new strategy for sequential assignment of intrinsically unstructured proteins based on 15N single isotope labelling

scientific article published on 23 July 2013

A small CDC25 dual-specificity tyrosine-phosphatase isoform in Arabidopsis thaliana

scientific article

A β-Turn Motif in the Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52.

scientific article published on 19 September 2016

Accepting its Random Coil Nature Allows a Partial NMR Assignment of the Neuronal Tau Protein

scholarly article by Caroline Smet published in November 2004

Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules

scientific article published on 12 December 2008

An Improved Homonuclear TOCSY Experiment with Minimal Water Saturation

scientific article published on 01 May 1996

An alternative scheme for the multiplexed acquisition of 1D and 2D NMR spectra

scientific article published on 9 June 2010

Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A.

scientific article published on 12 May 2006

Assignment of the 1H, 13C and 15N resonances and secondary structure of the monomeric p13suc1 protein of Saccharomyces pombe

scientific article published on 01 June 2002

Capsular polysaccharide produced by the thermophilic cyanobacterium Mastigocladus laminosus. Structural study of an undecasaccharide obtained by lithium degradation

scientific article published in December 1999

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

scientific article

Cell signaling, post-translational protein modifications and NMR spectroscopy

scientific article

Cell-associated glucans of Burkholderia solanacearum and Xanthomonas campestris pv. citri: a new family of periplasmic glucans.

scientific article published on April 1996

Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase

scientific article published on 8 February 2016

Characterization of a new family of toxin‐like peptides from the venom of the scorpion Leiurus quinquestriatus hebraeus‐NMR structure of leiuropeptide II ⬇️

scientific article (publication date: June 1997)

Characterization of the AT180 epitope of phosphorylated Tau protein by a combined nuclear magnetic resonance and fluorescence spectroscopy approach

scientific article

Characterization of the Arabidopsis thaliana Arath;CDC25 dual-specificity tyrosine phosphatase.

scientific article published in September 2004

Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels

scientific article

Comparative analysis of Erk phosphorylation suggests a mixed strategy for measuring phospho-form distributions ⬇️

scientific article published on April 2011

Contribution of rotational diffusion to pulsed field gradient diffusion measurements

Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides

scientific article published on July 2005

Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication

scientific article published on 17 July 2019

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A

scientific article (publication date: 27 October 2010)

Detection by 1H-NMR spectroscopy of chloroquine in urine from acutely poisoned patient

scientific article published on 01 April 1997

Detection of Localized Water Clusters in a Charged Peptidyl Resin ⬇️

scientific article published on December 5, 2001

Development of a high-resolution magic-angle spinning nuclear magnetic resonance identity assay of the capsular polysaccharide from Haemophilus influenzae type b present in cetavlon precipitate

scientific article published in March 2005

Diagnosis of a case of acute chloroquine poisoning using 1H NMR spectroscopy: characterisation of drug metabolites in urine

scientific article published on September 1997

Differential contribution of the repeats to heparin binding of HBHA, a major adhesin of Mycobacterium tuberculosis

scientific article

Dissociation kinetics of a binary complex in solution by protein displacement

scientific article published on 7 October 2013

Divalent Cations Differentially Regulate Integrin αIIbCytoplasmic Tail Binding to β3and to Calcium- and Integrin-binding Protein

scientific article published in Journal of Biological Chemistry

Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.

scientific article

Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded

scientific article published on 26 February 2009

Dual anomeric specificity and dual anomerase activity of phosphoglucoisomerase quantified by two-dimensional phase-sensitive 13C EXSY NMR ⬇️

scientific article published in Journal of Biological Chemistry

ELISE NMR: experimental liquid sealing of NMR samples

scientific article

Elucidating Tau function and dysfunction in the era of cryo-EM.

scientific article published on 14 May 2019

Exploring the molecular function of PIN1 by nuclear magnetic resonance

scientific article published on June 2006

Fine-tuned characterization at the solid/solution interface of organotin compounds grafted onto cross-linked polystyrene by using high-resolution MAS NMR spectroscopy

scientific article published in August 2002

Fluorescent BODIPY-based Zn(II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of Alzheimer's disease patients

scientific article

Futile Encounter Engineering of the DSR-M Dextransucrase Modifies the Resulting Polymer Length

scientific article published on 07 June 2019

Glycan Determinants of Heparin-Tau Interaction

scientific article

Glycerol and glycerol carbonate as ultraviscous solvents for mixture analysis by NMR.

scientific article

Graphical interpretation of Boolean operators for protein NMR assignments

scientific article published on 2 September 2008

HRMAS NMR observation of beta-sheet secondary structure on a water swollen solid support

scientific article

Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B

scientific article

Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A

scientific article

High-resolution magic angle spinning NMR of the neuronal tau protein integrated in Alzheimer's-like paired helical fragments

scientific article published on 01 July 2005

Homo- and heteronuclear two-dimensional NMR studies of the globular domain of histone H1: Sequential assignment and secondary structure

scientific article (publication date: October 1993)

Homo- and heteronuclear two-dimensional NMR studies of the globular domain of histone H1: full assignment, tertiary structure, and comparison with the globular domain of histone H5

scientific article

Identification and characterization of andalusicin: N-terminally dimethylated class III lantibiotic from Bacillus thuringiensis sv. andalousiensis ⬇️

scientific article published on 29 April 2021

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation

scientific article

Identification of the Tau phosphorylation pattern that drives its aggregation

scientific article published on 7 August 2017

Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

scientific article

Improved Isotopic Profiling by Pure Shift Heteronuclear 2D J-Resolved NMR Spectroscopy

scientific article published on 06 March 2018

Improved NMR Detection of Phospho-Metabolites in a Complex Mixture

scientific article published in 2021

In vivo detection of the cyclic osmoregulated periplasmic glucan of Ralstonia solanacearum by high-resolution magic angle spinning NMR.

scientific article

In-cell NMR: from metabolites to macromolecules

scientific article published on 15 January 2018

Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice

scientific article (publication date: 2013)

Increasing field strength versus advanced isotope labeling for NMR-based fluxomics

scientific article published on 16 January 2020

Integrated pH Measurement during Reaction Monitoring with Dual-Reception 1H-31P NMR Spectroscopy

scientific article published on 27 February 2019

Interact: Automated analysis of protein-ligand interactions by 1D and 2D NMR

article published in 2018

Interaction study between HCV NS5A-D2 and NS5B using 19F NMR.

scientific article published on 7 December 2017

Intermolecular interaction studies using small volumes

scientific article published on 29 November 2010

Isomerization and Oligomerization of Truncated and Mutated Tau Forms by FKBP52 are Independent Processes

scientific article

MAS as a tool for suppressing dipolar field effects in high-resolution liquid NMR

scientific article published on 01 August 2000

Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements.

scientific article

Measurement of three-bond coupling constants in the osmoregulated periplasmic glucan of Burkholderia solanacearum.

scientific article published on October 1996

Mechanism of Tau-Promoted Microtubule Assembly As Probed by NMR Spectroscopy

scientific article published in 2014

Metabolic phenotyping of human plasma by 1 H-NMR at high and medium magnetic field strengths: a case study for lung cancer

scientific article published on 6 January 2017

Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta

scientific article

Microinjection of recombinant O-GlcNAc transferase potentiates Xenopus oocytes M-phase entry.

scientific article

Microtubule and MAPs: thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR.

scientific article published on January 2010

Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2

scientific article

Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.

scientific article

Molecular mechanisms of the phospho-dependent prolyl cis/trans isomerase Pin1.

scientific article published on 24 September 2007

Monitoring of solid-phase organic synthesis on macroscopic supports by high-resolution magic angle spinning NMR.

scientific article published in November 2001

Monitoring of the ethionamide pro-drug activation in mycobacteria by (1)H high resolution magic angle spinning NMR.

scientific article published in June 2005

NMR Meets Tau: Insights into Its Function and Pathology

scientific article

NMR analysis of a Tau phosphorylation pattern

scientific article published in March 2006

NMR investigation of the interaction between the neuronal protein tau and the microtubules

scientific article published on 21 February 2007

NMR observation of Tau in Xenopus oocytes.

scientific article published on 14 March 2008

NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.

scientific article published on 14 September 2017

NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels

scientific article

NMR spectroscopy of the neuronal tau protein: normal function and implication in Alzheimer's disease

scientific article published on August 2010

Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to neuronal apoptosis?

scientific article

New DEFT sequences for the acquisition of one-dimensional carbon NMR spectra of small unlabelled molecules

Nuclear Magnetic Resonance Analysis of the Acetylation Pattern of the Neuronal Tau Protein

article

Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins

scientific article published on 27 December 2016

Nuclear magnetic resonance spectroscopy characterization of interaction of Tau with DNA and its regulation by phosphorylation

scientific article published on 09 February 2015

Osmoregulated periplasmic glucans of the free-living photosynthetic bacterium Rhodobacter sphaeroides

scientific article

Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2.

scientific article

Pin1 allows for differential Tau dephosphorylation in neuronal cells

scientific article published on 11 May 2006

Pin1: a therapeutic target in Alzheimer neurodegeneration

scientific article published on December 2002

Post‐translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding ⬇️

scientific article published on August 15, 2012

Practical aspects of shimming a high resolution magic angle spinning probe

scientific article

Proline Conformation in a Functional Tau Fragment

scientific article published on 2 December 2015

Proline-directed random-coil chemical shift values as a tool for the NMR assignment of the tau phosphorylation sites

scientific article published in January 2004

Quantitative monitoring of solid phase organic reactions by high-resolution magic angle spinning NMR spectroscopy

article

Ranking high affinity ligands of low solubility by NMR spectroscopy

scientific article

Recombinant Production of the p10CKS1AtProtein fromArabidopsis thalianaand13C and15N Double-Isotopic Enrichment for NMR Studies

article

Regions of tau implicated in the paired helical fragment core as defined by NMR.

scientific article

Regulation of Pin1 peptidyl-prolylcis/transisomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein

scholarly article by Caroline Smet published in July 2005

Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain

scientific article published on 29 July 2017

Resin dynamics contributes to the NMR line broadening of organic molecules grafted onto a polystyrene resin

scientific article published on 01 June 2002

Restricted linear least square treatment processing of heteronuclear spectra of biomolecules using the ANAFOR strategy

scientific article published in April 2003

Rotor synchronization of radiofrequency and gradient pulses in high-resolution magic angle spinning NMR

Sandwich-ELISE NMR: reducing the sample volume of NMR samples

scientific article

Selective backbone labelling of ILV methyl labelled proteins

scientific article published on 14 March 2009

Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria

scientific article published on 8 August 2006

Solid-phase enolate chemistry investigated using HR-MAS NMR spectroscopy

scientific article published in January 2002

Solution NMR study of the monomeric form of p13suc1 protein sheds light on the hinge region determining the affinity for a phosphorylated substrate

scientific article published on 25 January 2002

Solution structure of R-elafin, a specific inhibitor of elastase

scientific article

Solution structure of the main alpha-amylase inhibitor from amaranth seeds

scientific article

Solution structure of the single-domain prolyl cis/trans isomerase PIN1At from Arabidopsis thaliana

scientific article

Spectroscopic studies of GSK3{beta} phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E.

scientific article published on 2 August 2010

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

scientific article

Structural analysis of Escherichia coli OpgG, a protein required for the biosynthesis of osmoregulated periplasmic glucans.

scientific article

Structural and functional characterization of the interaction between cyclophilin B and a heparin-derived oligosaccharide

scientific article published on 12 September 2007

Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025.

scientific article published in June 2010

Structural characterization by nuclear magnetic resonance of the impact of phosphorylation in the proline-rich region of the disordered Tau protein.

scientific article published on 9 November 2011

Structural impact of heparin binding to full-length Tau as studied by NMR spectroscopy

scientific article published on 01 October 2006

Studying Intrinsically Disordered Proteins under True In Vivo Conditions by Combined Cross-Polarization and Carbonyl-Detection NMR Spectroscopy

article by Juan Lopez et al published 9 May 2016 in Angewandte Chemie

Studying Intrinsically Disordered Proteins under True In Vivo Conditions by Combined Cross-Polarization and Carbonyl-Detection NMR Spectroscopy

scientific article

Studying Posttranslational Modifications by In-Cell NMR

scientific article published on 01 April 2008

Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy

scientific article

Substrate recognition by the POTRA domains of TpsB transporter FhaC.

scientific article

Synthesis, Three-Dimensional Structure, and Specific 15N-Labelling of the Streptococcal Protein G B1-Domain

scientific article published in 1995

Synthesis, folding, and structure of the beta-turn mimic modified B1 domain of streptococcal protein G.

scientific article published on December 1999

Synthesis, three-dimensional structure, and specific 15N-labelling of the streptococcal protein G B1-domain

scientific article published on 01 July 1995

Systematic identification of tubulin-interacting fragments of the microtubule-associated protein Tau leads to a highly efficient promoter of microtubule assembly

scientific article published on 12 July 2011

Tau aggregation in Alzheimer's disease: what role for phosphorylation?

scientific article published on 23 January 2007

Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics

scientific article

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker

scientific article published on 25 August 2012

Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain

scientific article published on 23 September 2015

The Chemical Shift Index method applied to resin-bound peptides

scientific article published on 01 December 2000

The FK506-binding protein FKBP52 in vitro induces aggregation of truncated Tau forms with prion-like behavior

scientific article

The Neuronal Tau Protein Blocks in Vitro Fibrillation of the Amyloid-β (Aβ) Peptide at the Oligomeric Stage

scientific article published on 22 May 2018

The Study of Posttranslational Modifications of Tau Protein by Nuclear Magnetic Resonance Spectroscopy: Phosphorylation of Tau Protein by ERK2 Recombinant Kinase and Rat Brain Extract, and Acetylation by Recombinant Creb-Binding Protein

scientific article published in January 2017

The domain 2 of the HCV NS5A protein is intrinsically unstructured

scientific article published in August 2010

The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau.

scientific article published in February 2004

The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges

scientific article

TheArabidopsis thaliana PIN1AtGene Encodes a Single-domain Phosphorylation-dependent Peptidyl Prolylcis/transIsomerase

scientific article published in Journal of Biological Chemistry

Towards understanding the phosphorylation code of tau.

scientific article published on August 2012

Transfer nuclear Overhauser effect study of the conformation of oxytocin bound to bovine neurophysin I.

scientific article

Unraveling a phosphorylation event in a folded protein by NMR spectroscopy: phosphorylation of the Pin1 WW domain by PKA.

scientific article published on 2 March 2013

Use of a water flip-back pulse in the homonuclear NOESY experiment

scientific article

p13(SUC1) and the WW domain of PIN1 bind to the same phosphothreonine-proline epitope

scientific article published in January 2001

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