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List of works by Michael O Hottiger

A Novel Spectral Annotation Strategy Streamlines Reporting of Mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ

scientific article published on 28 September 2021

A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function

scientific article published on 4 September 2014

A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation

scientific article published on 21 March 2019

A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions ⬇️

scientific article

A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation

scientific article published on July 2000

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

scientific article

A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation

scientific article published on 01 July 1999

ADP-ribosylation of histones by ARTD1: an additional module of the histone code?

scientific article published on 21 March 2011

ARTD1 Suppresses Interleukin 6 Expression by Repressing MLL1-Dependent Histone H3 Trimethylation.

scientific article

ARTD1 deletion causes increased hepatic lipid accumulation in mice fed a high-fat diet and impairs adipocyte function and differentiation

scientific article published on 16 March 2012

ARTD1 in Myeloid Cells Controls the IL-12/18-IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer

scientific article published on 23 January 2019

ARTD1 regulates cyclin E expression and consequently cell-cycle re-entry and G1/S progression in T24 bladder carcinoma cells.

scientific article published on 13 June 2016

ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange

scientific article

ARTD2 activity is stimulated by RNA.

scientific article published on 08 February 2014

Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation

scientific article

Absent in Melanoma 2 (AIM2) limits pro-inflammatory cytokine transcription in cardiomyocytes by inhibiting STAT1 phosphorylation

scientific article published on 2 May 2016

Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression

scientific article

Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription

scientific article

Acetylation regulates the DNA end-trimming activity of DNA polymerase beta

scientific article published on November 2002

Analysis of Chromatin ADP-Ribosylation at the Genome-wide Level and at Specific Loci by ADPr-ChAP.

scientific article published on 27 January 2016

Arginine methylation regulates DNA polymerase beta

scientific article

Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation

scientific article

CARM1 but not its enzymatic activity is required for transcriptional coactivation of NF-kappaB-dependent gene expression

scientific article published on 19 September 2009

Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

scientific article

Chemoselective Dimerization of Phosphates

scientific article published on 16 June 2016

Combining Higher-Energy Collision Dissociation and Electron-Transfer/Higher-Energy Collision Dissociation Fragmentation in a Product-Dependent Manner Confidently Assigns Proteomewide ADP-Ribose Acceptor Sites

scientific article published on 28 December 2016

Comprehensive ADP-ribosylome analysis identifies tyrosine as an ADP-ribose acceptor site

scientific article published on 28 June 2018

Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4 ⬇️

scientific article published on January 5, 2013

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

scientific article

Differential discrimination of DNA polymerase for variants of the non-standard nucleobase pair between xanthosine and 2,4-diaminopyrimidine, two components of an expanded genetic alphabet.

scientific article

Discovery of Compounds Inhibiting the ADP-Ribosyltransferase Activity of Pertussis Toxin

scientific article published on 13 January 2020

Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia

scientific article published on 28 November 2017

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

scientific article published on 15 October 2020

Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field

scientific article

Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage

scientific article published on 02 February 2017

Epstein-Barr virus nuclear antigen 3C and prothymosin alpha interact with the p300 transcriptional coactivator at the CH1 and CH3/HAT domains and cooperate in regulation of transcription and histone acetylation.

scientific article

Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling

scientific article

Functional genomics in HIV-1 virus replication: protein-protein interactions as a basis for recruiting the host cell machinery for viral propagation.

scientific article

Gas-Phase Fragmentation of ADP-Ribosylated Peptides: Arginine-Specific Side-Chain Losses and Their Implication in Database Searches

scientific article published on 03 November 2020

Gene expression in synovial membrane cells after intraarticular delivery of plasmid-linked superparamagnetic iron oxide particles--a preliminary study in sheep

scientific article published in September 2006

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells

scientific article published on 01 November 2018

HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

scientific article

HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator

scientific article

HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other

scientific article published on 01 October 2001

Histone ADP-ribosylation in DNA repair, replication and transcription.

scientific article published on 07 July 2011

Hyaluronic acid fragments enhance the inflammatory and catabolic response in human intervertebral disc cells through modulation of toll-like receptor 2 signalling pathways

scientific article published on 22 August 2013

Identification of distinct amino acids as ADP-ribose acceptor sites by mass spectrometry

scientific article published on 01 January 2011

Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation.

scientific article

Identification of novel and cell type enriched cofactors of the transcription activation domain of RelA (p65 NF-kappaB).

scientific article

Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

scientific article published on 21 July 2008

Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes

scientific article published on 29 March 2012

Inheritance of silent rDNA chromatin is mediated by PARP1 via noncoding RNA.

scientific article published on 8 March 2012

Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia.

scientific article published on July 2010

Isolation, establishment, and characterization of ex vivo equine melanoma cell cultures

scientific article published on 5 December 2008

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo

scientific article published on 18 August 2017

Liposome-mediated gene transfer into human basal cell carcinoma

scientific article published on December 1999

Localized insulin-like growth factor I delivery to enhance new bone formation

scientific article published in October 2003

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

scientific article

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.

scientific article published on 10 March 2013

Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300.

scientific article published on June 1998

NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells

scientific article published in September 2005

New Quantitative Mass Spectrometry Approaches Reveal Different ADP-ribosylation Phases Dependent On the Levels of Oxidative Stress.

scientific article

New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis, and therapy

scientific article published on 24 November 2020

Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics.

scientific article

Optimization of LTQ-Orbitrap Mass Spectrometer Parameters for the Identification of ADP-Ribosylation Sites

scientific article

PARP-1 and gene regulation: progress and puzzles.

scientific article published on 26 January 2013

PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase

scientific article

PARP1 ADP-ribosylates lysine residues of the core histone tails

scientific article

PARP1 is required for adhesion molecule expression in atherogenesis

scientific article

PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts

scientific article published on 14 February 2013

PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation

scientific article published on 19 May 2016

Peroxynitrite induces gene expression in intervertebral disc cells

scientific article published in May 2009

Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

scientific journal article

Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression

scientific article published on 01 February 2008

Poly(ADP-ribose) polymerase inhibitor therapeutic effect: are we just scratching the surface?

scientific article published on 27 July 2015

Poly(ADP-ribose) polymerase-1 protects from oxidative stress induced endothelial dysfunction

scientific article published in November 2011

Poly(ADP-ribosyl)ation of Methyl CpG Binding Domain Protein 2 Regulates Chromatin Structure.

scientific article published on 15 January 2016

Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation

scientific article published on 24 March 2016

Progress in the function and regulation of ADP-Ribosylation

scientific article published on 24 May 2011

Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1.

scientific article

Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses

scientific article published on 19 September 2013

Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue.

scientific article published on 30 September 2016

Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase

scientific article published on 12 December 2017

Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation

scientific article published on 21 April 2016

Regulation of beta -catenin transformation by the p300 transcriptional coactivator.

scientific article published in November 2000

SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress

scientific article

SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance

scientific article published on 08 July 2011

SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1

scientific article

SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310

scientific article

Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission

scientific article published on 7 November 2016

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1

scientific article published on 21 January 2020

SnapShot: ADP-Ribosylation Signaling

scientific article published on 01 June 2015

Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

scientific article published on October 2008

Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function.

scientific article published on 21 July 2009

Systemic distribution and elimination of plain and with Cy3.5 functionalized poly(vinyl alcohol) coated superparamagnetic maghemite nanoparticles after intraarticular injection in sheep in vivo

scientific article published on 01 September 2006

Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death

scientific article published on 11 May 2022

The Peroxisome Proliferator-activated Receptor γ Coactivator 1α/β (PGC-1) Coactivators Repress the Transcriptional Activity of NF-κB in Skeletal Muscle Cells ⬇️

scientific article published on December 8, 2012

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

scientific article

The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.

scientific article published on 19 October 2012

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

scientific article published on January 2008

The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity

scientific article published on 27 September 2005

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

scientific article published on 26 January 2010

Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis

scientific article (publication date: 15 March 2001)

Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1.

scientific article published on 5 September 2003

Uptake and biocompatibility of functionalized poly(vinylalcohol) coated superparamagnetic maghemite nanoparticles by synoviocytes in vitro.

scientific article published on September 2006

WNT/β-catenin signaling inhibits CBP-mediated RelA acetylation and expression of proinflammatory NF-κB target genes.

scientific article published on 28 May 2015

p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization.

scientific article

p65 controls NF-κB activity by regulating cellular localization of IκBβ

scientific article published on 01 March 2011

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