List of works - Laura Bravo

A Cell Culture Model for the Assessment of the Chemopreventive Potential of Dietary Compounds

article

A Comprehensive Characterisation of Rosemary tea Obtained from Rosmarinus officinalis L. Collected in a sub-Humid Area of Tunisia.

scientific article published on 12 September 2017

A diet rich in cocoa attenuates N-nitrosodiethylamine-induced liver injury in rats.

scientific article published on 12 July 2009

A diet rich in dietary fiber from cocoa improves lipid profile and reduces malondialdehyde in hypercholesterolemic rats

scientific article

A phenolic extract from grape by-products and its main hydroxybenzoic acids protect Caco-2 cells against pro-oxidant induced toxicity.

scientific article published on 17 December 2015

Absorption and metabolism of yerba mate phenolic compounds in humans

scientific article published on 02 August 2017

An aqueous pomegranate seed extract ameliorates oxidative stress of human hepatoma HepG2 cells.

scientific article published on 3 December 2013

An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples.

scientific article published on October 2010

Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers.

scientific article published on 21 October 2015

Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells

scientific article published on 20 March 2013

Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/antioxidant power assay.

scientific article

Antiproliferative and cytotoxic effects of green coffee and yerba mate extracts, their main hydroxycinnamic acids, methylxanthine and metabolites in different human cell lines.

scientific article

Bioavailability and Metabolism of Rosemary Infusion Polyphenols Using CACO-2 and HEPG2 Cell Model Systems.

scientific article

Bioavailability of hydroxycinnamates in an instant green/roasted coffee blend in humans. Identification of novel colonic metabolites.

scientific article published on 27 November 2017

Biscuit Melanoidins of Different Molecular Masses Protect Human HepG2 Cells against Oxidative Stress

scientific article published on 01 August 2009

Chemical characterization and chemo-protective activity of cranberry phenolic powders in a model cell culture. Response of the antioxidant defenses and regulation of signaling pathways

article

Chemo-protective activity and characterization of phenolic extracts from Corema album

Chromatographic and electrophoretic methods for the analysis of biomarkers of oxidative damage to macromolecules (DNA, lipids, and proteins).

scientific article published on February 2007

Cocoa flavanols show beneficial effects in cultured pancreatic beta cells and liver cells to prevent the onset of type 2 diabetes

Cocoa flavonoid epicatechin protects pancreatic beta cell viability and function against oxidative stress

scientific article published in October 2013

Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells

scientific article published on 4 March 2013

Cocoa flavonoids up-regulate antioxidant enzyme activity via the ERK1/2 pathway to protect against oxidative stress-induced apoptosis in HepG2 cells

scientific article published on 5 February 2009

Cocoa phenolic extract protects pancreatic beta cells against oxidative stress.

scientific article published on 31 July 2013

Cocoa polyphenols prevent inflammation in the colon of azoxymethane-treated rats and in TNF-α-stimulated Caco-2 cells

scientific article published on 28 November 2012

Cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosis

scientific article

Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cells

scientificarticle

Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2).

scientific article published on February 2005

Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats

scientific article published on 01 July 2014

Composition and antioxidant capacity of low-salt meat emulsion model systems containing edible seaweeds

scientific article published on 21 June 2009

Degradation of polyphenols (catechin and tannic acid) in the rat intestinal tract. Effect on coloic fermentation and faecal output

scientific article published on 01 June 1994

Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress. Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antio

scientific article published on 11 July 2005

Determination of malondialdehyde by liquid chromatography as the 2,4-dinitrophenylhydrazone derivative: a marker for oxidative stress in cell cultures of human hepatoma HepG2.

scientific article published on June 2004

Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells.

scientific article published on 16 September 2011

Dietary modulation of bacterial fermentative capacity by edible seaweeds in rats

scientific article published in May 2001

Digestive stability of hydroxytyrosol, hydroxytyrosyl acetate and alkyl hydroxytyrosyl ethers

scientific article published on 24 January 2012

Dihydrocaffeic acid, a major microbial metabolite of chlorogenic acids, shows similar protective effect than a yerba mate phenolic extract against oxidative stress in HepG2 cells

scientific article published on 17 June 2016

Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals and Humans

scientific article

Effect of coffee melanoidin on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide.

scientific article published on May 2007

Effect of phlorotannin-rich extracts of Ascophyllum nodosum and Himanthalia elongata (Phaeophyceae) on cellular oxidative markers in human HepG2 cells

Effects of bioactive constituents in functional cocoa products on cardiovascular health in humans.

scientific article published on 7 November 2014

Effects of consuming diets containing Agave tequilana dietary fibre and jamaica calyces on body weight gain and redox status in hypercholesterolemic rats

scientific article published on 9 October 2013

Effects of dietary fibre and tannins from apple pulp on the composition of faeces in rats

article

Effects of in vitro digestion and storage on the phenolic content and antioxidant capacity of a red grape pomace.

scientific article published on 9 September 2016

Effects of regularly consuming dietary fibre rich soluble cocoa products on bowel habits in healthy subjects: a free-living, two-stage, randomized, crossover, single-blind intervention

scientific article

Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells.

scientific article published on January 2013

Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in He

scientific article published on January 2010

Evaluation of novel nutraceuticals based on the combination of oat beta-glucans and a green coffee phenolic extract to combat obesity and its comorbidities. A randomized, dose–response, parallel trial

scientific article published in 2022

Exhaustive Qualitative LC-DAD-MSn Analysis of Arabica Green Coffee Beans: Cinnamoyl-glycosides and Cinnamoylshikimic Acids as New Polyphenols in Green Coffee.

scientific article

Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells.

scientific article published in July 2010

Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol.

scientific article published on 5 December 2012

Hypocholesterolaemic and antioxidant effects of yerba mate (Ilex paraguariensis) in high-cholesterol fed rats

scientific article

Hypolipidemic effect in cholesterol-fed rats of a soluble fiber-rich product obtained from cocoa husks

scientific article published on 12 July 2008

Hypotensive, hypoglycaemic and antioxidant effects of consuming a cocoa product in moderately hypercholesterolemic humans

scientific article published on 12 June 2012

Improved LC-MSn characterization of hydroxycinnamic acid derivatives and flavonols in different commercial mate (Ilex paraguariensis) brands. Quantification of polyphenols, methylxanthines, and antioxidant activity

scientific article published on 26 August 2017

In Vitro Determination of the Indigestible Fraction in Foods: An Alternative to Dietary Fiber Analysis

scientific article published on 01 August 2000

Influence of different types and proportions of added edible seaweeds on characteristics of low-salt gel/emulsion meat systems.

scientific article published on 23 November 2007

Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2).

scientific article

Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways.

scientific article published on 31 January 2014

Molecular mechanisms involved in the protective effect of selenocystine against methylmercury-induced cell death in human HepG2 cells

scientific article published on 6 July 2013

Molecular mechanisms of (-)-epicatechin and chlorogenic acid on the regulation of the apoptotic and survival/proliferation pathways in a human hepatoma cell line.

scientific article published on 8 February 2007

Molecular mechanisms of methylmercury-induced cell death in human HepG2 cells.

scientific article published on 10 March 2010

Nitroderivatives of olive oil phenols protect HepG2 cells against oxidative stress

scientific article published on 27 July 2012

Nutritional and antioxidant properties of different brown and red Spanish edible seaweeds.

scientific article published on 10 September 2010

Olive oil hydroxytyrosol reduces toxicity evoked by acrylamide in human Caco-2 cells by preventing oxidative stress

scientific article published on 12 July 2011

Phloroglucinol: antioxidant properties and effects on cellular oxidative markers in human HepG2 cell line

scientific article published on 19 May 2012

Polyphenol content, in vitro bioaccessibility and antioxidant capacity of widely consumed beverages

scientific article

Polyphenols as dietary fiber associated compounds. Comparative study on in vivo and in vitro properties

Preparation and antioxidant activity of tyrosyl and homovanillyl ethers

scientific article published on 26 May 2011

Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway

scientific article published on 21 February 2011

Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress

scientific article published in November 2011

Protection of human HepG2 cells against oxidative stress by cocoa phenolic extract

scientific article

Protection of human HepG2 cells against oxidative stress by the flavonoid epicatechin.

scientific article published in April 2010

Quercetin attenuates TNF-induced inflammation in hepatic cells by inhibiting the NF-κB pathway

scientific article

Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death in human hepatoma cells.

scientific article published on January 2010

Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.

scientific article published on 16 December 2011

Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide

scientific article published on 29 August 2005

Realistic intake of a flavanol-rich soluble cocoa product increases HDL-cholesterol without inducing anthropometric changes in healthy and moderately hypercholesterolemic subjects

scientific article published on 01 February 2014

Regular consumption of a cocoa product improves the cardiometabolic profile in healthy and moderately hypercholesterolaemic adults

scientific article published on 4 July 2013

Regularly consuming a green/roasted coffee blend reduces the risk of metabolic syndrome

scientific article published on 13 October 2016

Response of the antioxidant defense system to tert-butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2).

scientific article published in March 2005

Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced by tert-butyl hydroperoxide

scientific article published on 19 October 2007

Signal Transduction Pathways Involved in the Chemo-Preventive Effect of Dietary Antioxidants: Study in HepG2 as a Cell Culture Model

article

Stability and bioactivity of a Bowman–Birk inhibitor in orange juice during processing and storage ⬇️

scientific article published on March 28, 2013

Synthesis and Antioxidant Activity of Alkyl Nitroderivatives of Hydroxytyrosol.

scientific article published on 18 May 2016

Synthesis and Antioxidant Activity of Nitrohydroxytyrosol and Its Acyl Derivatives

scientific article published on 14 October 2014

Synthesis and Bioactivity Profile of 5-S-Lipoylhydroxytyrosol-Based Multidefense Antioxidants with a Sizeable (Poly)sulfide Chain

scientific article published on 03 January 2013

Synthesis and antioxidant evaluation of isochroman-derivatives of hydroxytyrosol: structure-activity relationship

scientific article published on 16 October 2014

The colonic metabolites dihydrocaffeic acid and dihydroferulic acid are more effective inhibitors of in vitro platelet activation than their phenolic precursors.

scientific article published on 23 February 2017

Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells

scientific article

Time-course regulation of survival pathways by epicatechin on HepG2 cells

scientific article

Transepithelial transport and metabolism of new lipophilic ether derivatives of hydroxytyrosol by enterocyte-like Caco-2/TC7 cells

scientific article published on 7 October 2010

Uptake and metabolism of hydroxycinnamic acids (chlorogenic, caffeic, and ferulic acids) by HepG2 cells as a model of the human liver.

scientific article published on November 2006

Uptake and metabolism of new synthetic lipophilic derivatives, hydroxytyrosyl ethers, by human hepatoma HepG2 cells

scientific article published in January 2010

List of works by Laura Bravo

A Cell Culture Model for the Assessment of the Chemopreventive Potential of Dietary Compounds

A Comprehensive Characterisation of Rosemary tea Obtained from Rosmarinus officinalis L. Collected in a sub-Humid Area of Tunisia.

A diet rich in cocoa attenuates N-nitrosodiethylamine-induced liver injury in rats.

A diet rich in dietary fiber from cocoa improves lipid profile and reduces malondialdehyde in hypercholesterolemic rats

A phenolic extract from grape by-products and its main hydroxybenzoic acids protect Caco-2 cells against pro-oxidant induced toxicity.

Absorption and metabolism of yerba mate phenolic compounds in humans

An aqueous pomegranate seed extract ameliorates oxidative stress of human hepatoma HepG2 cells.

An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples.

Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers.

Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells

Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/antioxidant power assay.

Antiproliferative and cytotoxic effects of green coffee and yerba mate extracts, their main hydroxycinnamic acids, methylxanthine and metabolites in different human cell lines.

Bioavailability and Metabolism of Rosemary Infusion Polyphenols Using CACO-2 and HEPG2 Cell Model Systems.

Bioavailability of hydroxycinnamates in an instant green/roasted coffee blend in humans. Identification of novel colonic metabolites.

Biscuit Melanoidins of Different Molecular Masses Protect Human HepG2 Cells against Oxidative Stress

Chemical characterization and chemo-protective activity of cranberry phenolic powders in a model cell culture. Response of the antioxidant defenses and regulation of signaling pathways

Chemo-protective activity and characterization of phenolic extracts from Corema album

Chromatographic and electrophoretic methods for the analysis of biomarkers of oxidative damage to macromolecules (DNA, lipids, and proteins).

Cocoa flavanols show beneficial effects in cultured pancreatic beta cells and liver cells to prevent the onset of type 2 diabetes

Cocoa flavonoid epicatechin protects pancreatic beta cell viability and function against oxidative stress

Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells

Cocoa flavonoids up-regulate antioxidant enzyme activity via the ERK1/2 pathway to protect against oxidative stress-induced apoptosis in HepG2 cells

Cocoa phenolic extract protects pancreatic beta cells against oxidative stress.

Cocoa polyphenols prevent inflammation in the colon of azoxymethane-treated rats and in TNF-α-stimulated Caco-2 cells

Cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosis

Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cells

Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2).

Comparative evaluation of the metabolic effects of hydroxytyrosol and its lipophilic derivatives (hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether) in hypercholesterolemic rats

Composition and antioxidant capacity of low-salt meat emulsion model systems containing edible seaweeds

Degradation of polyphenols (catechin and tannic acid) in the rat intestinal tract. Effect on coloic fermentation and faecal output

Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress. Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antio

Determination of malondialdehyde by liquid chromatography as the 2,4-dinitrophenylhydrazone derivative: a marker for oxidative stress in cell cultures of human hepatoma HepG2.

Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells.

Dietary modulation of bacterial fermentative capacity by edible seaweeds in rats

Digestive stability of hydroxytyrosol, hydroxytyrosyl acetate and alkyl hydroxytyrosyl ethers

Dihydrocaffeic acid, a major microbial metabolite of chlorogenic acids, shows similar protective effect than a yerba mate phenolic extract against oxidative stress in HepG2 cells

Effect of Cocoa and Its Flavonoids on Biomarkers of Inflammation: Studies of Cell Culture, Animals and Humans

Effect of coffee melanoidin on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide.

Effect of phlorotannin-rich extracts of Ascophyllum nodosum and Himanthalia elongata (Phaeophyceae) on cellular oxidative markers in human HepG2 cells

Effects of bioactive constituents in functional cocoa products on cardiovascular health in humans.

Effects of consuming diets containing Agave tequilana dietary fibre and jamaica calyces on body weight gain and redox status in hypercholesterolemic rats

Effects of dietary fibre and tannins from apple pulp on the composition of faeces in rats

Effects of in vitro digestion and storage on the phenolic content and antioxidant capacity of a red grape pomace.

Effects of regularly consuming dietary fibre rich soluble cocoa products on bowel habits in healthy subjects: a free-living, two-stage, randomized, crossover, single-blind intervention

Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells.

Epicatechin induces NF-kappaB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in He

Evaluation of novel nutraceuticals based on the combination of oat beta-glucans and a green coffee phenolic extract to combat obesity and its comorbidities. A randomized, dose–response, parallel trial

Exhaustive Qualitative LC-DAD-MSn Analysis of Arabica Green Coffee Beans: Cinnamoyl-glycosides and Cinnamoylshikimic Acids as New Polyphenols in Green Coffee.

Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells.

Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol.

Hypocholesterolaemic and antioxidant effects of yerba mate (Ilex paraguariensis) in high-cholesterol fed rats

Hypolipidemic effect in cholesterol-fed rats of a soluble fiber-rich product obtained from cocoa husks

Hypotensive, hypoglycaemic and antioxidant effects of consuming a cocoa product in moderately hypercholesterolemic humans

Improved LC-MSn characterization of hydroxycinnamic acid derivatives and flavonols in different commercial mate (Ilex paraguariensis) brands. Quantification of polyphenols, methylxanthines, and antioxidant activity

In Vitro Determination of the Indigestible Fraction in Foods: An Alternative to Dietary Fiber Analysis

Influence of different types and proportions of added edible seaweeds on characteristics of low-salt gel/emulsion meat systems.

Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2).

Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways.

Molecular mechanisms involved in the protective effect of selenocystine against methylmercury-induced cell death in human HepG2 cells

Molecular mechanisms of (-)-epicatechin and chlorogenic acid on the regulation of the apoptotic and survival/proliferation pathways in a human hepatoma cell line.

Molecular mechanisms of methylmercury-induced cell death in human HepG2 cells.

Nitroderivatives of olive oil phenols protect HepG2 cells against oxidative stress

Nutritional and antioxidant properties of different brown and red Spanish edible seaweeds.

Olive oil hydroxytyrosol reduces toxicity evoked by acrylamide in human Caco-2 cells by preventing oxidative stress

Phloroglucinol: antioxidant properties and effects on cellular oxidative markers in human HepG2 cell line

Polyphenol content, in vitro bioaccessibility and antioxidant capacity of widely consumed beverages

Polyphenols as dietary fiber associated compounds. Comparative study on in vivo and in vitro properties

Preparation and antioxidant activity of tyrosyl and homovanillyl ethers

Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway

Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress

Protection of human HepG2 cells against oxidative stress by cocoa phenolic extract

Protection of human HepG2 cells against oxidative stress by the flavonoid epicatechin.

Quercetin attenuates TNF-induced inflammation in hepatic cells by inhibiting the NF-κB pathway

Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death in human hepatoma cells.

Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.

Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide

Realistic intake of a flavanol-rich soluble cocoa product increases HDL-cholesterol without inducing anthropometric changes in healthy and moderately hypercholesterolemic subjects

Regular consumption of a cocoa product improves the cardiometabolic profile in healthy and moderately hypercholesterolaemic adults

Regularly consuming a green/roasted coffee blend reduces the risk of metabolic syndrome