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List of works by Richard J. Lewis

'Messy' Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency

scientific article published on 14 March 2019

2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin

scientific article published on 24 June 2014

A Second Extracellular Site Is Required for Norepinephrine Transport by the Human Norepinephrine Transporter

scientific article published on 08 August 2012

A Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3C

scientific article published on 01 October 1999

A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202

scientific article

A crinotoxin from the skin tubercle glands of a stonefish (Synanceia trachynis).

scientific article published in January 1981

AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

scientific article

Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators

scientific article published on 13 September 2005

Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals.

scientific article published on 10 January 2018

Action of ciguatoxin on human atrial trabeculae

scientific article published in August 1992

Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia

scientific article published on 30 July 2015

Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors

scientific article

Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA.

scientific article

Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.

scientific article

Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors

scientific article published in November 2003

Alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes

scientific article

Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition

scientific article published on 01 October 2013

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways

scientific article published on 24 May 2013

An efficient transcriptome analysis pipeline to accelerate venom peptide discovery and characterisation

scientific article published on 13 September 2015

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain.

scientific article published on 17 March 2016

Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin.

scientific article published on 8 April 2014

Analgesic treatment of ciguatoxin-induced cold allodynia.

scientific article published on 15 June 2013

Analysis of Caribbean ciguatoxin-1 effects on frog myelinated axons and the neuromuscular junction.

scientific article published on 29 July 2009

Analysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West Indies

scientific article (publication date: November 2002)

Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

scientific article

Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor

scientific article

Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators

scientific article published on 21 September 2020

Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells

scientific article published on July 2004

Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor

scientific article published in June 2005

Block of voltage-gated potassium channels by Pacific ciguatoxin-1 contributes to increased neuronal excitability in rat sensory neurons

scientific article published in April 2005

Brain mechanisms of abnormal temperature perception in cold allodynia induced by ciguatoxin.

scientific article published on 20 December 2016

Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells

scientific article

Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment.

scientific article published on 23 September 2017

Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells

scientific article

Characterisation of d-Conotoxin TxVIA as a Mammalian T-Type Calcium Channel Modulator

scientific article published on 30 June 2020

Characterisation of multiple Caribbean ciguatoxins and congeners in individual specimens of horse-eye jack (Caranx latus) by high-performance liquid chromatography/mass spectrometry

scientific article

Characterization of ciguatoxins and ciguatoxin congeners present in ciguateric fish by gradient reverse-phase high-performance liquid chromatography/mass spectrometry

scientific article published on 01 February 1997

Characterization of endogenous calcium responses in neuronal cell lines

scientific article published on 31 October 2009

Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone.

scientific article published in February 2004

Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1

scientific article

Chemical synthesis and structure of the prokineticin Bv8

scientific article

Ciguatera fish poisoning in the Pacific Islands (1998 to 2008).

scientific article

Ciguatera: Australian perspectives on a global problem

scientific article published on 14 July 2006

Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones

scientific article published in August 1998

Ciguatoxin from the flesh and viscera of the barracuda, Sphyraena jello

scientific article published on 01 January 1984

Ciguatoxin-2 is a diastereomer of ciguatoxin-3

scientific article published on 01 May 1993

Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: mechanism of action and reversible inhibition by brevenal

scientific article published on 11 August 2009

Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons

scientific article published in July 2002

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1.

scientific article published on 30 August 2017

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

scientific article

Ciguatoxins are potent ichthyotoxins

scientific article published on February 1, 1992

Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function

scientific article

Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids

scientific article published on 4 August 2006

Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus.

scientific article published on 31 August 2015

Comparative action of three major ciguatoxins on guinea-pig atria and ilea

scientific article published in April 1993

Computational approaches to understand alpha-conotoxin interactions at neuronal nicotinic receptors

scientific article published on June 2004

Cone snail venomics: from novel biology to novel therapeutics

scientific article

Conopeptide  -TIA Defines a New Allosteric Site on the Extracellular Surface of the  1B-Adrenoceptor

scientific article

Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties.

scientific article published on 9 February 2016

Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides

scientific article published on 2 January 2008

Conotoxin engineering: dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability

scientific article published on 11 May 2012

Conotoxin venom peptide therapeutics

scientific article published on January 2009

Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity

scientific article published on 5 October 2017

Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters

scientific article published on February 2004

Conotoxins: Chemistry and Biology

scientific article published on 21 October 2019

Conotoxins: molecular and therapeutic targets

scientific article published on January 2009

Conus Venom Peptide Pharmacology ⬇️

scientific article published on March 8, 2012

Cooliatoxin, the first toxin from Coolia monotis (Dinophyceae).

scientific article published on January 1995

Corrigendum to: α-Conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors (FEBS 27779)

scholarly article published in FEBS Letters

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

scientific article published on 26 May 2017

Corrigendum: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter

scientific article published on 01 May 2018

Critical Review and Conceptual and Quantitative Models for the Transfer and Depuration of Ciguatoxins in Fishes

scientific article published on 23 July 2021

Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia.

scientific article published on 18 July 2016

Crystal structure of a cellulosomal family 3 carbohydrate esterase from Clostridium thermocellum provides insights into the mechanism of substrate recognition

scientific article

Crystallization and preliminary X-ray analysis of RsbS from Moorella thermoacetica at 2.5 A resolution.

scientific article published on 23 February 2008

Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom

scientific article

Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands

scientific article published on 8 December 2014

Determination of alpha-conotoxin binding modes on neuronal nicotinic acetylcholine receptors.

scientific article

Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy

scientific article

Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

scientific article published on 29 March 2016

Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel

scientific article published in January 2004

Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta.

scientific article published on 12 January 2005

Differential evolution and neofunctionalization of snake venom metalloprotease domains

scientific article published on 12 December 2012

Differential expression of calcium channels in sympathetic and parasympathetic preganglionic inputs to neurons in paracervical ganglia of guinea-pigs

scientific article

Differential involvement of N-type calcium channels in transmitter release from vasoconstrictor and vasodilator neurons

scientific article

Direct and indirect effects of ciguatoxin on guinea-pig atria and papillary muscles

scientific article published in November 1986

Discovery and development of the χ-conopeptide class of analgesic peptides ⬇️

scientific article published on 03 August 2011

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

scientific article published on 7 September 2017

Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor

scientific article published on 02 October 2020

Discovery, synthesis, and structure-activity relationships of conotoxins.

scientific article published on 10 April 2014

Ecology of the ciguatera causing dinoflagellates from the Northern Great Barrier Reef: changes in community distribution and coastal eutrophication

scientific article published on 7 November 2013

Editorial: Toxins in seafood

scientific article published on 01 August 2010

Effects of Chirality at Tyr13 on the Structure−Activity Relationships of ω-Conotoxins fromConus magus†

scientific article published on 01 May 1999

Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID

scientific article published on 01 January 2012

Efficient chemical synthesis of human complement protein C3a

scientific article

Emerging opportunities for allosteric modulation of G-protein coupled receptors

scientific article published on 11 September 2012

Emerging structure-function relationships defining monoamine NSS transporter substrate and ligand affinity

scientific article

Emerging tropical diseases in Australia. Part 2. Ciguatera fish poisoning ⬇️

scientific article published on October 1, 2010

Engineering of a Spider Peptide <i>via</i> Conserved Structure-Function Traits Optimizes Sodium Channel Inhibition <i>In Vitro</i> and Anti-Nociception <i>In Vivo</i>

scientific article published on 21 September 2021

Environmental Poisoning: Presentation and Management

scientific article published on 01 October 1998

Escherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs)

scientific article

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails

scientific article

Expression and pharmacology of endogenous Cav channels in SH-SY5Y human neuroblastoma cells

scientific article

Extracellular surface residues of the α1B-adrenoceptor critical for G protein-coupled receptor function

scientific article published on 28 October 2014

Flow cytometric-membrane potential detection of sodium channel active marine toxins: application to ciguatoxins in fish muscle and feasibility of automating saxitoxin detection

scientific article published on March 2014

Functional Modulation of the Human Voltage-Gated Sodium Channel Na<sub>V</sub>1.8 by Auxiliary β Subunits

scientific article published on 14 December 2020

Functional and Structural Characterization of RsbU, a Stress Signaling Protein Phosphatase 2C

scientific article published in Journal of Biological Chemistry

HPLC/Tandem Electrospray Mass Spectrometry for the Determination of Sub-ppb Levels of Pacific and Caribbean Ciguatoxins in Crude Extracts of Fish

scientific article published on 01 January 1999

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain

scientific article

High-voltage-activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury

scientific article published on 10 December 2014

Human fatality associated with Pacific ciguatoxin contaminated fish

scientific article

Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors

scientific article published on 5 August 2014

Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens

scientific article

Identification of Caribbean ciguatoxins as the cause of an outbreak of fish poisoning among U.S. soldiers in Haiti

scientific article published in May 1997

Identification of a Novel Class of Nicotinic Receptor Antagonists

scientific article published in Journal of Biological Chemistry

Identification of slow and fast-acting toxins in a highly ciguatoxic barracuda (Sphyraena barracuda) by HPLC/MS and radiolabelled ligand binding

scientific article published in November 2003

In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile

scientific article published on 25 January 2020

Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives

scientific article

Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1.

scientific article published on 13 June 2017

Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues

scientific article

Inhibition of somatosensory mechanotransduction by annexin A6

scientific article published on 19 June 2018

Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship

scientific article published on 28 July 2003

Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers

scientific article published on 22 February 2016

Insight into T-type calcium channel structure, function and modulation

scientific article published on 01 October 2018

Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose.

scientific article published on 7 October 2014

Intraspecific variations in Conus purpurascens injected venom using LC/MALDI-TOF-MS and LC-ESI-TripleTOF-MS.

scientific article published on 6 June 2015

Ionic mechanisms of spinal neuronal cold hypersensitivity in ciguatera

scientific article

Isolation and characterisation of Caribbean ciguatoxins from the horse-eye jack (Caranx latus) ⬇️

scientific article published on June 1, 1997

Isolation and characterisation of Indian Ocean ciguatoxin

scientific article published in June 2002

Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail.

scientific article published on 16 June 2006

Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily

scientific article

Isolation and characterization of conopeptides by high-performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry

scientific article published on 01 January 1996

Isolation and characterization of peptides from Momordica cochinchinensis seeds

scientific article

Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors

scientific article published on 4 August 2013

Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom

scientific article

Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels

scientific article published in December 2006

Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

scientific article published on 16 May 2012

Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence

scientific article

Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors

scientific article published on 08 April 2017

Lonspray mass spectrometry of ciguatoxin-1, maitotoxin-2 and -3, and related marine polyether toxins

scientific article published on 01 January 1994

Lophozozymus pictor toxin: a fluorescent structural isomer of palytoxin

scientific article published on October 1995

Low molecular weight non-peptide mimics of omega-conotoxin GVIA.

scientific article published on 28 March 2009

Mechanisms involved in the swelling of erythrocytes caused by Pacific and Caribbean ciguatoxins

scientific article published on 20 December 2005

Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail

scientific article

Modulating oxytocin activity and plasma stability by disulfide bond engineering

scientific article published on 30 November 2010

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.

scientific article

Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function

scientific article published in September 2008

MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors

scientific article published on 30 December 2013

Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins

scientific article

Multiple ciguatoxins in the flesh of fish

scientific article published on 01 August 1992

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1.

scientific article

Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors

scientific article published on 12 March 2019

N- and c-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels

scientific article published on 10 February 2012

NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-G.

scientific article

Natural Product Ligands of TRP Channels ⬇️

scientific article published on January 1, 2011

Negative inotropic and arrhythmic effects of high doses of ciguatoxin on guinea-pig atria and papillary muscles

scientific article published in January 1988

Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails.

scientific article published on 13 June 2018

Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels

scientific article published on 3 June 2008

Neuropharmacology of venom peptides.

scientific article published on 14 November 2017

Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: a comparison with other osmotic agents and free radical scavengers

scientific article published in October 2005

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

scientific article published on 04 May 2018

Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain

scientific article published in 2024

Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily

scientific article published in May 2009

Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides

scientific article published in Scientific Reports

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels

scientific article published on 24 April 2019

Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration.

scientific article published on 20 October 2013

Occurrence of a ciguatoxin-like substance in the Spanish mackerel (Scomberomorus commersoni).

scientific article published in January 1983

Omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels

scientific article published in January 2007

Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals

scientific article

Omega-conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine

scientific article published on 30 July 2009

Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue

scientific article

Origin of Ciguateric Fish: Quantitative Modelling of the Flow of Ciguatoxin through a Marine Food Chain

scientific article published in 2022

Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation

scientific article

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

scientific article

Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors

scientific article

Pharmacology of predatory and defensive venom peptides in cone snails

scientific article published in November 2017

Phorbasins G-K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp.

scientific article published on 28 August 2008

Purification and characterisation of large and small maitotoxins from cultured gambierdiscus toxicus

scientific article published on 01 January 1994

Purification and characterization of ciguatoxins from moray eel (Lycodontis javanicus, Muraenidae) ⬇️

scientific article published on January 1, 1991

Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional Bioassay

scientific article

Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins in ciguateric fish flesh

scientific article published on 19 March 2009

Re-engineering the μ-conotoxin SIIIA scaffold.

scientific article published in April 2014

Release of neuropeptides from a neuro-cutaneous co-culture model: A novel in vitro model for studying sensory effects of ciguatoxins

scientific article published on 10 November 2015

Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS

scientific article published on 08 April 2009

Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain.

scientific article published on 21 December 2017

Role of voltage-gated calcium channels in ascending pain pathways

scientific article

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

scientific article published in Nature Communications

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach

scientific article published on 4 March 2015

Sodium channels and pain: from toxins to therapies

scientific article published on 27 July 2017

Solution structure and proposed binding mechanism of a novel potassium channel toxin κ-conotoxin PVIIA ⬇️

scientific article published on December 15, 1997

Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter

scientific article

Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels

scientific article

Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists.

scientific article published in March 2010

Spermine modulation of the glutamate(NMDA) receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex

scientific article

Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways

scientific article published on 29 October 2019

Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model.

scientific article published on September 2013

Stabilization of the cysteine-rich conotoxin MrIA by using a 1,2,3-triazole as a disulfide bond mimetic

scientific article published on 5 December 2014

Stress responses of bacteria.

scientific article published on 24 October 2007

Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor.

scientific article published on 31 March 2017

Structure-Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels

scientific article published on 11 April 2019

Structure-activity studies of conantokins as human N-methyl-D-aspartate receptor modulators

scientific article published in February 1999

Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons.

scientific article

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

scientific article

Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA.

scientific article

Synthesis and biological evaluation of nonpeptide mimetics of omega-conotoxin GVIA.

scientific article published in August 2004

Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels

scientific article published on 19 March 2018

Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers

scientific article published on 28 November 2018

Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from Conus miliaris

scientific article published on 06 March 2020

Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII.

scientific article published in March 2003

Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies

scientific article

The 1.1 Å Resolution Crystal Structure of [Tyr15]EpI, a Novel α-Conotoxin fromConus episcopatus, Solved by Direct Methods ⬇️

scientific article published on August 18, 1998

The Toxicological Intersection between Allergen and Toxin: A Structural Comparison of the Cat Dander Allergenic Protein Fel d1 and the Slow Loris Brachial Gland Secretion Protein

scientific article published on 28 January 2020

The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels

scientific article

The antispasmogenic action on guinea-pig ileum of a fraction obtained from the toxic skin secretion of the stonefish, Synanceia trachynis

article

The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor

scientific article published in January 2005

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices

scientific article

The role of defensive ecological interactions in the evolution of conotoxins.

scientific article published on 28 November 2015

The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer's disease

scientific article

The structure of bacterial RNA polymerase in complex with the essential transcription elongation factor NusA

scientific article

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

scientific article

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

scientific article

The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms

scientific article published on January 2009

The α1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa

scientific article published on 28 November 2019

Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides) ⬇️

scientific article published on January 1, 2012

Therapeutic opportunities for targeting cold pain pathways

scientific article

Therapeutic potential of venom peptides

scientific article (publication date: October 2003)

Towards an integrated venomics approach for accelerated conopeptide discovery

scientific article published on 28 April 2012

Toxic material from the crab Atergatis floridus

article

Toxicity of Australian and French Polynesian strains of Gambierdiscus Toxicus (Dinophyceae) grown in culture: Characterization of a new type of maitotoxin

article

Toxicology of Gambierdiscus spp. (Dinophyceae) from Tropical and Temperate Australian Waters.

scientific article

Toxin insights into nicotinic acetylcholine receptors

scientific article

Toxins in pain.

scientific article published on 12 February 2018

Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom.

scientific article published on 28 October 2015

Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target

scientific article published on 28 August 2016

Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity

scientific article published on 16 September 2013

Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail,

scientific article published on 19 March 2019

Unique Pharmacological Properties of α-Conotoxin OmIA at α7 nAChRs

scientific article published on 08 December 2021

Use of venom peptides to probe ion channel structure and function

scientific article

Venom Peptide Modulators of the Immune System ⬇️

scientific article published on October 1, 2011

Venom duct origins of prey capture and defensive conotoxins in piscivorous Conus striatus

scientific article published on 24 June 2021

Venom peptides as a rich source of cav2.2 channel blockers

scientific article published on 4 February 2013

Venomics Reveals Venom Complexity of the Piscivorous Cone Snail,

scientific article published on 21 January 2019

Venomics-Accelerated Cone Snail Venom Peptide Discovery

scientific article published on 9 March 2018

Venomics: a new paradigm for natural products-based drug discovery.

scientific article published on 24 February 2010

Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter

scientific article published on 24 September 2013

Voltage-Gated Sodium Channel Modulation by a New Spider Toxin Ssp1a Isolated From an Australian Theraphosid

scientific article published on 24 December 2021

alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors

scientific article published in June 1998

chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter

scientific article published in July 2003

chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

scientific article published in November 2009

muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits

scholarly article

α-Conotoxin ImI Incorporating Stable Cystathionine Bridges Maintains Full Potency and Identical Three-Dimensional Structure

scientific article published on 15 September 2011

α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors.

scientific article

α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors.

scientific article

δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails

scientific article (publication date: 22 July 2015)

χ-Conotoxin and Tricyclic Antidepressant Interactions at the Norepinephrine Transporter Define a New Transporter Model

scientific article published in Journal of Biological Chemistry

ω-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca(v)2.2 ion channels

scientific article

ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential

scientific article published on 6 April 2006

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