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List of works by Spiros Efthimiopoulos

A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years

scientific article published in January 1998

Abeta(1-40)-induced secretion of matrix metalloproteinase-9 results in sAPPalpha release by association with cell surface APP.

scientific article published on 24 July 2007

Ageing research in Greece

scientific article published on June 2002

Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix

scientific article published in July 1997

BRI2 Interacts with BACE1 and Regulates Its Cellular Levels by Promoting its Degradation and Reducing Its mRNA Levels ⬇️

scientific article published on June 1, 2013

BRI2 homodimerizes with the involvement of intermolecular disulfide bonds.

scientific article published on 28 April 2008

Calcium regulates the interaction of amyloid precursor protein with Homer3 protein

scientific article published on 27 March 2014

Cell-line specific protection by berry polyphenols against hydrogen peroxide challenge and lack of effect on metabolism of amyloid precursor protein.

scientific article

Cellular processing and proteoglycan nature of amyloid precursor proteins

scientific article published on September 1993

Characterization of appican, the chondroitin sulfate proteoglycan form of the Alzheimer amyloid precursor protein

scientific article published on December 1996

Discovery of novel phenoxazinone derivatives as DKK1/LRP6 interaction inhibitors: Synthesis, biological evaluation and structure-activity relationships.

scientific article published on 16 January 2016

Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively

scientific article published on 01 April 1999

Downregulation of AβPP Enhances Both Calcium Content of Endoplasmic Reticulum and Acidic Stores and the Dynamics of Store Operated Calcium Channel Activity ⬇️

scientific article published on January 1, 2013

Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles

scientific article published in December 1998

Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization

scientific article published on April 1995

Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11alpha.

scientific article published on 3 February 2006

Familial Alzheimer disease: changes in Abeta production may indicate a disturbance in protein transport or function caused by pleiotropic effects of FAD mutations

scientific article published in January 1999

Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.

scientific article

Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins

scientific article published on 01 June 1995

Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production

scientific article

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

scientific article published on August 1996

Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations

scientific article published in May 1999

Inhibitory activity on amyloid-beta aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents

scientific article

Intracellular cyclic AMP inhibits constitutive and phorbol ester-stimulated secretory cleavage of amyloid precursor protein

scientific article published on 01 August 1996

Kinetics of dopamine and noradrenaline transport in synaptosomes from cerebellum, striatum and frontal cortex of normal and reeler mice ⬇️

scientific article published on August 1, 1991

Mechanism of amyloid beta-peptide (1-42) toxicity in PC12 cells

scientific article published on 01 November 1996

Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide.

scientific article

Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection ⬇️

scientific article published on January 14, 2011

Notch 1 interacts with the amyloid precursor protein in a Numb-independent manner

scientific article published on October 2005

Novel processing of Notch 1 within its intracellular domain by a cysteine protease.

scientific article

Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription

scientific article published in January 2004

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

scientific article

Presenilin-1: a component of synaptic and endothelial adherens junctions.

scientific article

Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes

scientific article published on 01 February 1998

Serum Starvation Induces BACE1 Processing and Secretion.

scientific article

Structural and regulatory elements of the interaction between amyloid-β protein precursor and Homer3

scientific article published on 01 January 2015

Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies

scientific article published on 22 November 2015

The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles

scientific article published in January 1999

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