List of works - Vassilis I Zannis

A DNA insertion in the apolipoprotein A-I gene of patients with premature atherosclerosis

scientific article published in Nature

A hormone response element in the human apolipoprotein CIII (ApoCIII) enhancer is essential for intestinal expression of the ApoA-I and ApoCIII genes and contributes to the hepatic expression of the two linked genes in transgenic mice

scientific article published on 01 September 2000

A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different bi

scientific article published on February 1998

A2b adenosine receptor regulates hyperlipidemia and atherosclerosis

scientific article published on 5 December 2011

ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux.

scientific article published on 16 November 2003

Activation of CAAT enhancer-binding protein delta (C/EBPdelta) by interleukin-1 negatively influences apolipoprotein C-III expression.

scientific article published on September 1997

Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles.

scientific article published on 23 November 2012

Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL.

scientific article

An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines ⬇️

scientific article published on March 14, 2012

An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression.

scientific article published on December 1993

An inherited polymorphism in the human apolipoprotein A-I gene locus related to the development of atherosclerosis

scientific article published in Nature

Apolipoprotein A-I Exerts Bactericidal Activity against Yersinia enterocolitica Serotype O:3 ⬇️

scientific article published on September 6, 2011

Binding of high density lipoprotein (HDL) and discoidal reconstituted HDL to the HDL receptor scavenger receptor class B type I. Effect of lipid association and APOA-I mutations on receptor binding

scientific article published on 01 July 2000

Binding specificity and modulation of the ApoA-I promoter activity by homo- and heterodimers of nuclear receptors.

scientific article

Binding specificity and modulation of the human ApoCIII promoter activity by heterodimers of ligand-dependent nuclear receptors

scientific article published on 01 January 1999

Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia ⬇️

scientific article published on January 1, 2011

Carboxyl Terminus of Apolipoprotein A-I (ApoA-I) Is Necessary for the Transport of Lipid-free ApoA-I but Not Prelipidated ApoA-I Particles through Aortic Endothelial Cells ⬇️

scientific article published on January 5, 2011

Characterization of the major apolipoproteins secreted by two human hepatoma cell lines

scientific article published on 01 December 1981

Characterization of the subunits of purine nucleoside phosphorylase from cultured normal human fibroblasts ⬇️

scientific article published on August 1, 1979

Cloning and expression of a rat brain alpha 2B-adrenergic receptor ⬇️

scientific article published on February 1, 1991

Complementary DNA derived structure of the amino-terminal domain of human apolipoprotein B and size of its messenger RNA transcript.

scholarly article

Complex Interactions between SP1 Bound to Multiple Distal Regulatory Sites and HNF-4 Bound to the Proximal Promoter Lead to Transcriptional Activation of Liver-Specific Human APOCIII Gene

article

Contribution of the hormone-response elements of the proximal ApoA-I promoter, ApoCIII enhancer, and C/EBP binding site of the proximal ApoA-I promoter to the hepatic and intestinal expression of the ApoA-I and ApoCIII genes in transgenic mice.

scientific article published on May 2004

Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide

scientific article published on 21 April 2004

DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter

scientific article

Deletions of helices 2 and 3 of human apoA-I are associated with severe dyslipidemia following adenovirus-mediated gene transfer in apoA-I-deficient mice.

scientific article published on March 2005

Detailed molecular model of apolipoprotein A-I on the surface of high-density lipoproteins and its functional implications.

scientific article

Direct physical interactions between HNF-4 and Sp1 mediate synergistic transactivation of the apolipoprotein CIII promoter.

scientific article

Distal apolipoprotein C-III regulatory elements F to J act as a general modular enhancer for proximal promoters that contain hormone response elements. Synergism between hepatic nuclear factor-4 molecules bound to the proximal promoter and distal en

scientific article published on January 1997

Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain

scientific article

Domains of apoE4 required for the biogenesis of apoE-containing HDL.

scientific article

Effects of substituents on the rates of deacylation of substituted benzoyl papains. Role of a carboxylate residue in the catalytic mechanism ⬇️

scientific article published on June 27, 1978

Factors participating in the liver-specific expression of the human apolipoprotein A-II gene and their significance for transcription

scientific article published on 01 September 1993

Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor alpha/thyroid receptor beta heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor beta a

scientific article published on December 2003

Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells.

scientific article published in July 2002

High level of expression of functional human platelet alpha 2-adrenergic receptors in a stable mouse C127 cell line.

scientific article published on May 1990

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

scientific article published on 01 February 1981

Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain.

scientific article published on 16 October 2002

Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity

scientific article published on 08 December 2007

In vivo studies of HDL assembly and metabolism using adenovirus-mediated transfer of ApoA-I mutants in ApoA-I-deficient mice

scientific article published on 13 November 2001

Inflammatory signaling pathways regulating ApoE gene expression in macrophages.

scientific article published on 6 June 2007

Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction.

scientific article

Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.

scientific article published on August 1997

Intracellular and extracellular processing of human apolipoprotein A-I: secreted apolipoprotein A-I isoprotein 2 is a propeptide.

scientific article published on May 1983

Intracellular early and late modifications of human apolipoprotein A-II. Effect of glutamine- +1 to leucine substitution.

scientific article

Intracellular modification of human apolipoprotein AII (apoAII) and sites of apoAII mRNA synthesis: comparison of apoAII with apoCII and apoCIII isoproteins

scientific article published on 01 January 1990

Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family ⬇️

scientific article published on May 1, 1988

Isolation and characterization of cDNA clones for human apolipoprotein A-I ⬇️

scientific article published on November 1, 1982

Isolation and characterization of the human apolipoprotein A-I gene.

scientific article published on October 1983

LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN.

scientific article published on 21 August 2007

Linkage of human apolipoproteins A-I and C-III genes ⬇️

scientific article published on August 28, 1983

Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4

scientific article

Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich core

scientific article

Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels

scientific article published on 03 May 2011

Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT.

scientific article published on August 2007

Old and new players in the lipoprotein system

scientific article published on 01 April 2000

Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.

scientific article published on April 2007

Pharmacodynamic and pharmacokinetic analysis of apoE4 [L261A, W264A, F265A, L268A, V269A], a recombinant apolipoprotein E variant with improved biological properties.

scientific article published on 14 September 2012

Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency

scientific journal article

Probing the lipid-free structure and stability of apolipoprotein A-I by mutation

scientific article published on 01 December 2000

Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer.

scientific article published on April 2004

Purification and characterization of nuclear factors binding to the negative regulatory element D of human apolipoprotein A-II promoter: a negative regulatory effect is reversed by GABP, an Ets-related protein.

scientific article

Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding.

scientific article published on 22 February 2002

Regulation of human apolipoprotein m gene expression by orphan and ligand-dependent nuclear receptors.

scientific article published on 26 July 2010

Regulatory gene mutations affecting apolipoprotein gene expression: functions and regulatory behavior of known genes may guide future pharmacogenomic approaches to therapy.

scientific article published on April 2003

Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.

scientific article published on 27 July 2007

Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL.

scientific article

SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4

scientific article published on 01 December 2000

SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE. Structural mutations in SR-BI diminish cholesterol efflux

scientific article published on October 2005

Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro

scientific article published on 27 July 2006

Specificity of Lipid Incorporation Is Determined by Sequences in the N-Terminal 37 of ApoB†

scientific article published on 01 August 2000

Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids

scientific article

The -700/-310 fragment of the apolipoprotein A-IV gene combined with the -890/-500 apolipoprotein C-III enhancer is sufficient to direct a pattern of gene expression similar to that for the endogenous apolipoprotein A-IV gene

scientific article published on 01 February 1999

The amino-terminal 1-185 domain of apoE promotes the clearance of lipoprotein remnants in vivo. The carboxy-terminal domain is required for induction of hyperlipidemia in normal and apoE-deficient mice.

scientific article

The carboxy-terminal region of apoA-I is required for the ABCA1-dependent formation of alpha-HDL but not prebeta-HDL particles in vivo.

scientific article published on 21 April 2007

The carboxyl-terminal hydrophobic residues of apolipoprotein A-I affect its rate of phospholipid binding and its association with high density lipoprotein

scientific article published on 01 July 1997

The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo.

scientific article published on 17 December 2002

Transactivation of the human apolipoprotein CII promoter by orphan and ligand-dependent nuclear receptors. The regulatory element CIIC is a thyroid hormone response element.

scientific article

Transcriptional regulation of the genes involved in lipoprotein transport. The role of proximal promoters and long-range regulatory elements and factors in apolipoprotein gene regulation.

scientific article published on April 1996

Ultraspiracle, a Drosophila retinoic X receptor alpha homologue, can mobilize the human thyroid hormone receptor to transactivate a human promoter.

scientific article published in July 1997

Which, and How Limited Number of Polymorphisms Should Be Selected per Disease, Risk Assessment, Health Profile or Biological System?

article

List of works by Vassilis I Zannis

A DNA insertion in the apolipoprotein A-I gene of patients with premature atherosclerosis

A hormone response element in the human apolipoprotein CIII (ApoCIII) enhancer is essential for intestinal expression of the ApoA-I and ApoCIII genes and contributes to the hepatic expression of the two linked genes in transgenic mice

A short proximal promoter and the distal hepatic control region-1 (HCR-1) contribute to the liver specificity of the human apolipoprotein C-II gene. Hepatic enhancement by HCR-1 requires two proximal hormone response elements which have different bi

A2b adenosine receptor regulates hyperlipidemia and atherosclerosis

ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux.

Activation of CAAT enhancer-binding protein delta (C/EBPdelta) by interleukin-1 negatively influences apolipoprotein C-III expression.

Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles.

Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL.

An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines ⬇️

An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression.

An inherited polymorphism in the human apolipoprotein A-I gene locus related to the development of atherosclerosis

Apolipoprotein A-I Exerts Bactericidal Activity against Yersinia enterocolitica Serotype O:3 ⬇️

Binding of high density lipoprotein (HDL) and discoidal reconstituted HDL to the HDL receptor scavenger receptor class B type I. Effect of lipid association and APOA-I mutations on receptor binding

Binding specificity and modulation of the ApoA-I promoter activity by homo- and heterodimers of nuclear receptors.

Binding specificity and modulation of the human ApoCIII promoter activity by heterodimers of ligand-dependent nuclear receptors

Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia ⬇️

Carboxyl Terminus of Apolipoprotein A-I (ApoA-I) Is Necessary for the Transport of Lipid-free ApoA-I but Not Prelipidated ApoA-I Particles through Aortic Endothelial Cells ⬇️

Characterization of the major apolipoproteins secreted by two human hepatoma cell lines

Characterization of the subunits of purine nucleoside phosphorylase from cultured normal human fibroblasts ⬇️

Cloning and expression of a rat brain alpha 2B-adrenergic receptor ⬇️

Complementary DNA derived structure of the amino-terminal domain of human apolipoprotein B and size of its messenger RNA transcript.

Complex Interactions between SP1 Bound to Multiple Distal Regulatory Sites and HNF-4 Bound to the Proximal Promoter Lead to Transcriptional Activation of Liver-Specific Human APOCIII Gene

Contribution of the hormone-response elements of the proximal ApoA-I promoter, ApoCIII enhancer, and C/EBP binding site of the proximal ApoA-I promoter to the hepatic and intestinal expression of the ApoA-I and ApoCIII genes in transgenic mice.

Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide

DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter

Deletions of helices 2 and 3 of human apoA-I are associated with severe dyslipidemia following adenovirus-mediated gene transfer in apoA-I-deficient mice.

Detailed molecular model of apolipoprotein A-I on the surface of high-density lipoproteins and its functional implications.

Direct physical interactions between HNF-4 and Sp1 mediate synergistic transactivation of the apolipoprotein CIII promoter.

Distal apolipoprotein C-III regulatory elements F to J act as a general modular enhancer for proximal promoters that contain hormone response elements. Synergism between hepatic nuclear factor-4 molecules bound to the proximal promoter and distal en

Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain

Domains of apoE4 required for the biogenesis of apoE-containing HDL.

Effects of substituents on the rates of deacylation of substituted benzoyl papains. Role of a carboxylate residue in the catalytic mechanism ⬇️

Factors participating in the liver-specific expression of the human apolipoprotein A-II gene and their significance for transcription

Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor alpha/thyroid receptor beta heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor beta a

Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells.

High level of expression of functional human platelet alpha 2-adrenergic receptors in a stable mouse C127 cell line.

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain.

Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity

In vivo studies of HDL assembly and metabolism using adenovirus-mediated transfer of ApoA-I mutants in ApoA-I-deficient mice

Inflammatory signaling pathways regulating ApoE gene expression in macrophages.

Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction.

Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.

Intracellular and extracellular processing of human apolipoprotein A-I: secreted apolipoprotein A-I isoprotein 2 is a propeptide.

Intracellular early and late modifications of human apolipoprotein A-II. Effect of glutamine- +1 to leucine substitution.

Intracellular modification of human apolipoprotein AII (apoAII) and sites of apoAII mRNA synthesis: comparison of apoAII with apoCII and apoCIII isoproteins

Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family ⬇️

Isolation and characterization of cDNA clones for human apolipoprotein A-I ⬇️

Isolation and characterization of the human apolipoprotein A-I gene.

LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN.

Linkage of human apolipoproteins A-I and C-III genes ⬇️

Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4

Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich core

Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels

Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT.

Old and new players in the lipoprotein system

Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.

Pharmacodynamic and pharmacokinetic analysis of apoE4 [L261A, W264A, F265A, L268A, V269A], a recombinant apolipoprotein E variant with improved biological properties.

Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency

Probing the lipid-free structure and stability of apolipoprotein A-I by mutation

Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer.

Purification and characterization of nuclear factors binding to the negative regulatory element D of human apolipoprotein A-II promoter: a negative regulatory effect is reversed by GABP, an Ets-related protein.

Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding.

Regulation of human apolipoprotein m gene expression by orphan and ligand-dependent nuclear receptors.

Regulatory gene mutations affecting apolipoprotein gene expression: functions and regulatory behavior of known genes may guide future pharmacogenomic approaches to therapy.

Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.

Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL.

SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4

SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE. Structural mutations in SR-BI diminish cholesterol efflux

Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro

Specificity of Lipid Incorporation Is Determined by Sequences in the N-Terminal 37 of ApoB†

Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids

The -700/-310 fragment of the apolipoprotein A-IV gene combined with the -890/-500 apolipoprotein C-III enhancer is sufficient to direct a pattern of gene expression similar to that for the endogenous apolipoprotein A-IV gene

The amino-terminal 1-185 domain of apoE promotes the clearance of lipoprotein remnants in vivo. The carboxy-terminal domain is required for induction of hyperlipidemia in normal and apoE-deficient mice.

The carboxy-terminal region of apoA-I is required for the ABCA1-dependent formation of alpha-HDL but not prebeta-HDL particles in vivo.

The carboxyl-terminal hydrophobic residues of apolipoprotein A-I affect its rate of phospholipid binding and its association with high density lipoprotein

The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo.

Transactivation of the human apolipoprotein CII promoter by orphan and ligand-dependent nuclear receptors. The regulatory element CIIC is a thyroid hormone response element.

Transcriptional regulation of the genes involved in lipoprotein transport. The role of proximal promoters and long-range regulatory elements and factors in apolipoprotein gene regulation.