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List of works by Maria Vilanova Brugués

(1)H, (13)C and (15)N resonance assignments of the Onconase FL-G zymogen

scientific article published on 4 March 2012

A Cytotoxic Ribonuclease Variant with a Discontinuous Nuclear Localization Signal Constituted by Basic Residues Scattered Over Three Areas of the Molecule

scientific article published on 05 June 2006

A Nuclear-Directed Ribonuclease Variant Targets Cancer Stem Cells and Inhibits Migration and Invasion of Breast Cancer Cells

scientific article published on 30 August 2021

A family of manganese complexes containing heterocyclic-based ligands with cytotoxic properties.

scientific article published on 10 February 2018

A nuclear localization sequence endows human pancreatic ribonuclease with cytotoxic activity.

scientific article published in March 2004

A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells.

scientific article published on 22 February 2016

A truncated apoptin protein variant selectively kills cancer cells

scientific article published on 24 January 2017

Analysis of the thermal unfolding of porcine procarboxypeptidase A and its functional pieces by differential scnning calorimetry

scientific article published on 01 September 1988

Apoptin, a Versatile Protein with Selective Antitumor Activity

scientific article

Asymmetric kinetics of protein structural changes.

scientific article

Bactericidal Activity Engineered on Human Pancreatic Ribonuclease and Onconase

scientific article published on 01 March 2009

Carbodiimide EDC induces cross-links that stabilize RNase A C-dimer against dissociation: EDC adducts can affect protein net charge, conformation, and activity.

scientific article published on 16 July 2009

Characterization of the dimerization process of a domain-swapped dimeric variant of human pancreatic ribonuclease.

scientific article published in March 2006

Conformational predictive studies on the activation seoment of pancreatic procarboxypeptidases

scientific article published on 01 December 1987

Construction of Highly Stable Cytotoxic Nuclear-Directed Ribonucleases

scientific article published on 11 December 2018

Contribution of the C30/C75 disulfide bond to the biological properties of onconase.

scientific article

Crowding agents and osmolytes provide insight into the formation and dissociation of RNase A oligomers

scientific article published on 19 November 2010

Destabilizing mutations alter the hydrogen exchange mechanism in ribonuclease A.

scientific article published on 11 January 2008

Distinct unfolding and refolding pathways of ribonuclease a revealed by heating and cooling temperature jumps.

scientific article published on 30 January 2008

Formation, Structure, and Dissociation of the Ribonuclease S Three-dimensional Domain-swapped Dimer

scientific article published in Journal of Biological Chemistry

Generation of New Cytotoxic Human Ribonuclease Variants Directed to the Nucleus ⬇️

scientific article published on September 20, 2012

Human pancreatic ribonuclease presents higher endonucleolytic activity than ribonuclease A.

scientific article published on January 2008

Insights into the mechanism of Apoptin's exquisitely selective anti-tumor action from atomic level characterization of its conformation and dynamics.

scientific article published on 27 December 2016

Interactions crucial for three-dimensional domain swapping in the HP-RNase variant PM8.

scientific article

Intracellular pathway of Onconase that enables its delivery to the cytosol

scientific article published on 20 March 2007

Investigating the effects of double mutation C30A/C75A on onconase structure: Studies at atomic resolution

scientific article

Mapping the stability clusters in bovine pancreatic ribonuclease A.

scientific article published in December 2009

NMR spectroscopy reveals that RNase A is chiefly denatured in 40% acetic acid: implications for oligomer formation by 3D domain swapping.

scientific article

Pressure versus heat-induced unfolding of ribonuclease A: the case of hydrophobic interactions within a chain-folding initiation site

scientific article published in November 1999

Pressure versus temperature unfolding of ribonuclease A: an FTIR spectroscopic characterization of 10 variants at the carboxy-terminal site

scientific article

Pressure- and temperature-induced unfolding studies: thermodynamics of core hydrophobicity and packing of ribonuclease A

scientific article published on 01 March 2006

Pressure-jump-induced kinetics reveals a hydration dependent folding/unfolding mechanism of ribonuclease A

scientific article published on 23 June 2006

Production of Engineered Human Pancreatic Ribonucleases, Solving Expression and Purification Problems, and Enhancing Thermostability

scientific article published on 01 October 1999

Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation process of onconase.

scientific article published in March 2004

Stabilization of human pancreatic ribonuclease through mutation at its N-terminal edge

scientific article published on 01 November 2002

Structural Insights into Subunits Assembly and the Oxyester Splicing Mechanism of Neq pol Split Intein

scientific article published on 10 May 2018

The activation segment of procarboxypeptidase A from porcine pancreas constitutes a folded structural domain

article

The contribution of noncatalytic phosphate-binding subsites to the mechanism of bovine pancreatic ribonuclease A

scientific article published on 01 August 1998

The contribution of the residues from the main hydrophobic core of ribonuclease A to its pressure-folding transition state.

scientific article published on 5 April 2006

The nuclear transport capacity of a human-pancreatic ribonuclease variant is critical for its cytotoxicity.

scientific article

The structural determinants that lead to the formation of particular oligomeric structures in the pancreatic-type ribonuclease family.

scientific article published on August 2008

The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization

scientific article

The use of pressure-jump relaxation kinetics to study protein folding landscapes

scientific article published on 26 January 2006

Thermal unfolding of eosinophil cationic protein/ribonuclease 3: a nonreversible process.

scientific article published on 6 November 2006

Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases

scientific article

Towards tricking a pathogen's protease into fighting infection: the 3D structure of a stable circularly permuted onconase variant cleavedby HIV-1 protease

scientific article

Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance

scientific article

Urea-gradient gel electrophoresis studies on the association of procarboxypeptidases A and B, proproteinase E, and their tryptic activation products

scientific article published on 01 October 1985

Valine 108, a Chain-Folding Initiation Site-Belonging Residue, Crucial for the Ribonuclease A Stability

scientific article published on 01 November 1999

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