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List of works by Manuela Iezzi

A DNA vaccine against ERBB2 impairs chemical carcinogenesis in random-bred hamsters

scientific article published in July 2011

A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth

scientific article

A better immune reaction to Erbb-2 tumors is elicited in mice by DNA vaccines encoding rat/human chimeric proteins

scientific article published on 23 March 2010

A dietary tomato supplement prevents prostate cancer in TRAMP mice.

scientific article

A limited autoimmunity to p185neu elicited by DNA and allogeneic cell vaccine hampers the progression of preneoplastic lesions in HER-2/NEU transgenic mice.

scientific article

A multi-DNA preventive vaccine for p53/Neu-driven cancer syndrome

scientific article published in May 2009

A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors ⬇️

scientific article published on March 17, 2012

ALK Protein Analysis by IHC Staining after Recent Regulatory Changes: A Comparison of Two Widely Used Approaches, Revision of the Literature, and a New Testing Algorithm

scientific article

Activated d16HER2 homodimers and SRC kinase mediate optimal efficacy for trastuzumab

scientific article published on 27 August 2014

An integrated approach of immunogenomics and bioinformatics to identify new Tumor Associated Antigens (TAA) for mammary cancer immunological prevention

scientific article published in December 2005

Antimetastatic Activity of a Preventive Cancer Vaccine

scientific article (publication date: 15 November 2007)

Antitumor immunization of mothers delays tumor development in cancer-prone offspring.

scientific article published on 3 February 2015

Author Correction: The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries.

scientific article

Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes.

scientific article

AvidinOX for highly efficient tissue-pretargeted radionuclide therapy

scientific article published in April 2010

Biofilm formation by the emerging fungal pathogen Trichosporon asahii: development, architecture, and antifungal resistance

scientific article published in October 2006

Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers

scientific article

Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression.

scientific article published on 26 February 2016

Claudin-4 SPECT Imaging Allows Detection of Aplastic Lesions in a Mouse Model of Breast Cancer.

scientific article

Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds

scientific article published on 16 August 2016

Concordant morphologic and gene expression data show that a vaccine halts HER-2/neu preneoplastic lesions ⬇️

scientific article

Concordant morphologic and gene expression data show that a vaccine halts HER-2/neu preneoplastic lesions

article

Correction to: The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma

scientific article published on 01 April 2020

Cure of Mammary Carcinomas in Her-2 Transgenic Mice through Sequential Stimulation of Innate (Neoadjuvant Interleukin-12) and Adaptive (DNA Vaccine Electroporation) Immunity

scientific article published in March 2005

Cutting Edge: TRAIL Deficiency Accelerates Hematological Malignancies

scientific article published on 01 November 2005

DNA vaccination against oncoantigens: A promise

scientific article published on May 2012

Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice

article

Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells

scientific article published on 05 April 2018

Dramatic response to crizotinib in ROS1 fluorescent in situ hybridization- and immunohistochemistry-positive lung adenocarcinoma: a case series.

scientific article

EV20-Sap, a novel anti-HER-3 antibody-drug conjugate, displays promising antitumor activity in melanoma.

scientific article published on 8 September 2017

EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma.

scientific article published on 14 March 2018

Early activation of vascular endothelial cells and platelets in obese children

scientific article

Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice.

scientific article published on 12 September 2013

Effect of acute and chronic cobalt administration on carotid body chemoreceptors responses

article

Effect of maternal exposure to endocrine disrupting chemicals on reproduction and mammary gland development in female Sprague-Dawley rats

scientific article

Effects of castration on the development of prostate adenocarcinoma from its precursor HGPIN and on the occurrence of androgen-independent, poorly differentiated carcinoma in TRAMP mice

article

Electroporated DNA vaccine clears away multifocal mammary carcinomas in her-2/neu transgenic mice.

scientific article

Erbb2 DNA vaccine combined with regulatory T cell deletion enhances antibody response and reveals latent low-avidity T cells: potential and limits of its therapeutic efficacy

scientific article published on 30 April 2010

Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.

scientific article

Expression of CREB in primary pterygium and correlation with cyclin D1, ki-67, MMP7, p53, p63, Survivin and Vimentin

scientific article published on 3 July 2013

Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis

scientific article published on 13 September 2021

Feasibility of Telomerase-Specific Adoptive T-cell Therapy for B-cell Chronic Lymphocytic Leukemia and Solid Malignancies.

scientific article published on May 2016

Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions

scientific article published on April 2006

Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6) in breast cancer

scientific article

Gene expression analysis of immune-mediated arrest of tumorigenesis in a transgenic mouse model of HER-2/neu-positive basal-like mammary carcinoma

scientific article

Generation of multiparametric MRI maps by using Gd-labelled- RBCs reveals phenotypes and stages of murine prostate cancer.

scientific article published on 12 July 2018

HCG Hastens Both the Development of Mammary Carcinoma and the Metastatization of HCG/LH and ERBB-2 Receptor-Positive Cells in Mice ⬇️

scientific article published on July 1, 2011

HER-2/neu mediates oncogenic transformation via altered CREB expression and function.

scientific article published on 11 September 2013

HER2 isoforms co-expression differently tunes mammary tumor phenotypes affecting onset, vasculature and therapeutic response

scientific article published on 13 April 2017

Host perforin reduces tumor number but does not increase survival in oncogene-driven mammary adenocarcinoma

scientific article published in June 2007

Human responses against HER-2-positive cancer cells in human immune system-engrafted mice

scientific article published on 28 August 2012

Imaging DNA damage allows detection of preneoplasia in the BALB-neuT model of breast cancer.

scientific article published on 13 November 2014

Immune prevention of mammary carcinogenesis in HER-2/neu transgenic mice: a microarray scenario

scientific article

Immunoprevention of HER-2/neu transgenic mammary carcinoma through an interleukin 12-engineered allogeneic cell vaccine

scientific article published in June 2004

Immunoprevention of mammary carcinoma in HER-2/neu transgenic mice is IFN-gamma and B cell dependent

scientific article

Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance

scientific article published on August 2006

Induction of immunosuppressive functions and NF-κB by FLIP in monocytes

scientific article published in Nature Communications

Inhibition of mammary carcinoma development in HER-2/neu transgenic mice through induction of autoimmunity by xenogeneic DNA vaccination.

scientific article

Inhibition of prostate carcinogenesis by combined active immunoprophylaxis

scientific article published on July 2007

Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects

scientific article published on September 2005

Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis.

scientific article published on 22 May 2015

Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2/neu Tumor.

scientific article published on 13 July 2015

In vitro and in vivo studies of gold(I) azolate/phosphane complexes for the treatment of basal like breast cancer

scientific article published on 02 June 2018

Irreversible inhibition of Δ16HER2 is necessary to suppress Δ16HER2-positive breast carcinomas resistant to Lapatinib

scientific article published on 27 July 2016

LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice.

scientific article

Lack of Expression of Galectin-3 Is Associated With a Poor Outcome in Node-Negative Patients With Laryngeal Squamous-Cell Carcinoma

scientific article published on 01 September 2002

Mesenchymal/stromal gene expression signature relates to basal-like breast cancers, identifies bone metastasis and predicts resistance to therapies

scientific article

MiR-205-5p inhibition by locked nucleic acids impairs metastatic potential of breast cancer cells

scientific article published on 26 July 2018

Monomeric Allergoid Intragastric Administration Induces Local and Systemic Tolerogenic Response Involving IL-10-Producing CD4+CD25+ T Regulatory Cells in Mice

scientific article published on 01 October 2010

Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor

scientific article (publication date: 2012)

Multiple roles of perforin in hampering ERBB-2 (Her-2/neu) carcinogenesis in transgenic male mice

scientific article published on 30 April 2014

Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination

scientific article

Optical imaging detection of microscopic mammary cancer in ErbB-2 transgenic mice through the DA364 probe binding αv β3 integrins.

scientific article published in July 2013

PLC-gamma-1 phosphorylation status is prognostic of metastatic risk in patients with early-stage Luminal-A and -B breast cancer subtypes

scientific article published on 30 July 2019

Pathobiological implications of the d16HER2 splice variant for stemness and aggressiveness of HER2-positive breast cancer

scientific article

Pathological changes of the anatomical structure and markers of the limbal stem cell niche due to inflammation.

scientific article published on 26 February 2013

Phospholipase Cgamma1 is required for metastasis development and progression

scientific article

Preclinical therapy of disseminated HER-2⁺ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus.

scientific article

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma

scientific article published on 05 September 2019

Prevention of HER-2/neu transgenic mammary carcinoma by tamoxifen plus interleukin 12.

scientific article published in June 2003

Preventive vaccination with telomerase controls tumor growth in genetically engineered and carcinogen-induced mouse models of cancer

scientific article published in December 2008

Protective immunity against neu-positive carcinomas elicited by electroporation of plasmids encoding decreasing fragments of rat neu extracellular domain.

scientific article published on March 2008

Pyrvinium pamoate induces death of triple-negative breast cancer stem-like cells and reduces metastases through effects on lipid anabolism

scientific article published on 23 July 2020

Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection.

scientific article published on 19 April 2017

Resveratrol fuels HER2 and ERα-positive breast cancer behaving as proteasome inhibitor.

scientific article published on 26 February 2017

Resveratrol has anti-thyroid effects both in vitro and in vivo

scientific article

Salivary carcinoma in HER-2/neu transgenic male mice: an angiogenic switch is not required for tumor onset and progression

scientific article published in November 2000

Sanguinarine suppresses basal-like breast cancer growth through dihydrofolate reductase inhibition.

scientific article

Sorafenib's inhibition of prostate cancer growth in transgenic adenocarcinoma mouse prostate mice and its differential effects on endothelial and pericyte growth during tumor angiogenesis

scientific article published on 01 June 2010

Tamoxifen combined to anti-HER-2/neu cell vaccine does not hamper cancer immunopreventive efficacy.

scientific article published on 31 January 2009

Targeting Vesicular LGALS3BP by an Antibody-Drug Conjugate as Novel Therapeutic Strategy for Neuroblastoma

scientific article published on 15 October 2020

The Disabled homolog 2 controls pro-metastatic activity of tumor-associated macrophages

scientific article published on 10 July 2020

The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma

scientific article published on 08 July 2019

The adjuvant activity of BAT antibody enables DNA vaccination to inhibit the progression of established autochthonous Her-2/neu carcinomas in BALB/c mice.

scientific article published on May 2005

The expression of LEC/CCL16, a powerful inflammatory chemokine, is upregulated in ulcerative colitis.

scientific article published on May 2004

The human splice variant Δ16HER2 induces rapid tumor onset in a reporter transgenic mouse.

scientific article

The non-inflammatory role of C1q during Her2/neu-driven mammary carcinogenesis.

scientific article published on 8 November 2016

The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

scientific article published on 16 March 2017

The water soluble ruthenium(II) organometallic compound [Ru(p-cymene)(bis(3,5 dimethylpyrazol-1-yl)methane)Cl]Cl suppresses triple negative breast cancer growth by inhibiting tumor infiltration of regulatory T cells.

scientific article published on 30 March 2016

Timely DNA vaccine combined with systemic IL-12 prevents parotid carcinomas before a dominant-negative p53 makes their growth independent of HER-2/neu expression.

scientific article published on June 2006

Triggering CD40 on endothelial cells contributes to tumor growth

scientific article

Vaccines against human HER2 prevent mammary carcinoma in mice transgenic for human HER2.

scientific article published on 23 January 2014

Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway.

scientific article published on December 2010

[Neoplastic pathology of the breast: perspectives]

scientific article published on 01 August 2005

p130Cas is an essential transducer element in ErbB2 transformation

scientific article

p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells

scientific article

rBet v 1 immunotherapy of sensitized mice with Streptococcus thermophilus as vehicle and adjuvant.

scientific article published on 6 March 2014

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