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List of works by Trond Ulven

1,2-Dihydrospiro[carbazole-3(4H),2′-[1,3]dioxolane] ⬇️

scientific article published on February 21, 2009

4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

scientific article published in October 2004

4-Fluoro-N-methyl-N-(1,2,3,4-tetra-hydro-carbazol-3-yl)benzene-sulfonamide

scientific article

6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists: structure-activity exploration of eastern and western parts

scientific article

6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode

scientific article published in September 2005

A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor

scientific article

A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.

scientific article published on 27 May 2012

A multistep continuous-flow system for rapid on-demand synthesis of receptor ligands

scientific article published on 01 November 2009

A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst

scientific article published on 21 August 2007

A physicogenetic method to assign ligand-binding relationships between 7TM receptors

scientific article published in August 2005

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

scientific article published on 01 January 2016

A rapid and efficient Sonogashira protocol and improved synthesis of free fatty acid 1 (FFA1) receptor agonists

scientific article published in February 2010

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

scientific article

Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

scientific article published on 28 April 2015

An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights

scientific article published on 27 November 2019

Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation

scientific article published on 28 February 2007

Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival

scientific article published on 11 May 2019

Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.

scientific article

Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.

scientific article

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.

scientific article published on 23 August 2012

Complex Pharmacology of Free Fatty Acid Receptors.

scientific article published on 14 June 2016

Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands

scientific article

Comprehensive and quantitative profiling of lipid species in human milk, cow milk and a phospholipid-enriched milk formula by GC and MS/MS(ALL).

scientific article published on 24 February 2015

Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4

scientific article published on 9 May 2014

Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40.

scientific article published on 21 February 2011

Continuous flow nucleophilic aromatic substitution with dimethylamine generated in situ by decomposition of DMF.

scientific article published on 2 April 2013

Controlled generation and use of CO in flow

scientific article published in 2016

Design, synthesis and evaluation of 4,7-diamino-1,10-phenanthroline G-quadruplex ligands

scientific article published on 4 November 2009

Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43).

scientific article

Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer.

scientific article published on 13 April 2016

Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120.

scientific article published on July 2015

Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum.

scientific article published on 10 July 2018

Direct N9-arylation of purines with aryl halides

scientific article published on 01 May 2014

Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.

scientific article published on March 2016

Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties

scientific article published on 12 October 2018

Discovery of a potent and selective GPR120 agonist.

scientific article published on 2 May 2012

Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.

scientific article published on 22 January 2013

Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.

scientific article published on November 2008

Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120.

scientific article published on 12 February 2016

Efficient synthesis of 4,7-diamino substituted 1,10-phenanthroline-2,9-dicarboxamides

scientific article published on 09 June 2011

Ethyl 2-(1,2,3,4-tetrahydro-spiro-[carba-zole-3,2'-[1,3]dioxolan]-9-yl)acetate

scientific article

Extracellular disulfide bridges serve different purposes in two homologous chemokine receptors, CCR1 and CCR5.

scientific article published on 13 June 2013

Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.

scientific article published on 12 October 2012

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance

scientific article

Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties

scientific article published on 13 July 2012

G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets

scientific article published on 2 January 2014

Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.

scientific article

Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2.

scientific article published on 3 May 2005

Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist

scientific article published in February 2005

Modulation in Selectivity and Allosteric Properties of Small-Molecule Ligands for CC-Chemokine Receptors

Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5).

scientific article published on 10 November 2016

Mucus can change the permeation rank order of drug candidates

scientific article

Multistep continuous-flow synthesis in medicinal chemistry: discovery and preliminary structure-activity relationships of CCR8 ligands

scientific article published on 28 May 2013

Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity

scientific article published on 29 August 2016

Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands.

scientific article published on 29 October 2015

Novel CRTH2 antagonists: a review of patents from 2006 to 2009.

scientific article published on 15 October 2010

Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice

scientific article published on 05 December 2019

Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits

scientific article published on 01 November 2006

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1.

scientific article

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2.

scientific article

On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

scientific article

Oxalyl chloride as a practical carbon monoxide source for carbonylation reactions

scientific article published on 22 May 2015

PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2

scientific article (publication date: 2012)

Pathophysiological regulation of lung function by the free fatty acid receptor FFA4

scientific article published on 01 August 2020

Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120).

scientific article published on 3 November 2016

Phenanthroline-2,9-bistriazoles as selective G-quadruplex ligands

scientific article published on 05 December 2013

Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

scientific article published on 26 April 2017

Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

scientific article published on 17 June 2008

Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4.

scientific article

Reevaluation of fatty acid receptor 1 as a drug target for the stimulation of insulin secretion in humans

scientific article published on February 2013

Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1

scientific article published on 13 November 2019

Selective extraction of G-quadruplex ligands from a rationally designed scaffold-based dynamic combinatorial library

scientific article

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

scientific article

Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators

scientific article published on 19 March 2020

Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.

scientific article published on 2 July 2010

Structure-activity relationships and identification of optmized CC-chemokine receptor CCR1, 5, and 8 metal-ion chelators

scientific article published on 22 October 2013

Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84.

scientific article published on 12 May 2017

Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2

scientific article published on 22 August 2007

Tetrasubstituted phenanthrolines as highly potent, water-soluble, and selective G-quadruplex ligands

scientific article published on 17 July 2012

The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat.

scientific article published on 17 January 2018

The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment

scientific article published on 8 August 2016

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

scientific article published on 21 September 2011

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120).

scientific article published on 24 May 2014

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism

scientific article published on 26 August 2013

The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs.

scientific article published on January 2013

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84.

scientific article published on 20 December 2017

Treatment of type 2 diabetes by free Fatty Acid receptor agonists

scientific article published on 28 August 2014

Treatment with TUG891, a free fatty acid receptor 4 agonist, restores adipose tissue metabolic dysfunction following chronic sleep fragmentation in mice.

scientific article published on 16 March 2016

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