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List of works by Brian D Hudson

A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor

scientific article

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

scientific article

Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

scientific article published on 28 April 2015

Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4.

scientific article

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs.

scientific article published on 23 August 2012

Chemogenetics defines receptor-mediated functions of short chain free fatty acids

scientific article published on 15 April 2019

Comparison of immunomodulator mRNA and protein expression in the lungs of Stachybotrys chartarum spore-exposed mice

scientific article

Comparison of inflammatory and cytotoxic lung responses in mice after intratracheal exposure to spores of two different Stachybotrys chartarum strains

scientific article

Complex Pharmacology of Free Fatty Acid Receptors.

scientific article published on 14 June 2016

Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands

scientific article

Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4

scientific article published on 9 May 2014

Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

scientific article

Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43).

scientific article

Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer.

scientific article published on 13 April 2016

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes ⬇️

scientific article published on April 8, 2013

Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.

scientific article published on March 2016

Discovery of a potent and selective GPR120 agonist.

scientific article published on 2 May 2012

Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.

scientific article published on 22 January 2013

Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120.

scientific article published on 12 February 2016

Drugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRs

scientific article published on October 2013

Experimental challenges to targeting poorly characterized GPCRs: uncovering the therapeutic potential for free fatty acid receptors.

scientific article published on January 2011

Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.

scientific article published on 12 October 2012

Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator

scientific article

FFA4/GPR120: Pharmacology and Therapeutic Opportunities.

scientific article

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance

scientific article

Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties

scientific article published on 13 July 2012

G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets

scientific article published on 2 January 2014

Identification of novel competing β2AR phospho-extracellular signal regulated kinase 1/2 signaling pathways in human trabecular meshwork cells

scientific article

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

scientific article

Indirect sympatholytic actions at β-adrenoceptors account for the ocular hypotensive actions of cannabinoid receptor agonists

scientific article published on 01 September 2011

Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice

scientific article

Ligand- and heterodimer-directed signaling of the CB(1) cannabinoid receptor.

scientific article published on 16 October 2009

Mechanism and function of Drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor

scientific article (publication date: 2012)

Minireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.

scientific article published on 17 May 2013

Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity

scientific article published on 29 August 2016

Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands.

scientific article published on 29 October 2015

Physical and functional interaction between CB1 cannabinoid receptors and beta2-adrenoceptors

scientific article

Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4.

scientific article

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

scientific article

The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35

scientific article published on 10 October 2013

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120).

scientific article published on 24 May 2014

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism

scientific article published on 26 August 2013

The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs.

scientific article published on January 2013

Treatment of type 2 diabetes by free Fatty Acid receptor agonists

scientific article published on 28 August 2014

Using Biosensors to Study Free Fatty Acid Receptor Pharmacology and Function

scientific article published on 19 October 2016

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