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List of works by Carole Yauk

A Return to the Origin of the EMGS: Rejuvenating the Quest for Human Germ Cell Mutagens and Determining the Risk to Future Generations

scientific article published on 10 October 2019

A cross-sector call to improve carcinogenicity risk assessment through use of genomic methodologies

scientific article published on 11 November 2019

A generic Transcriptomics Reporting Framework (TRF) for 'omics data processing and analysis.

scientific article published on 4 November 2017

A global toxicogenomic analysis investigating the mechanistic differences between tobacco and marijuana smoke condensates in vitro.

scientific article published on 28 March 2013

A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells.

scientific article published on 21 July 2005

A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells

scientific article

A single-molecule PCR approach to the measurement of induced expanded simple tandem repeat instability in vitro.

scientific article published on 28 November 2005

Adipogenic Effects and Gene Expression Profiling of Firemaster® 550 Components in Human Primary Preadipocytes

scientific article published on 14 September 2017

Adipogenic Mesenchymal Stromal Cells from Bone Marrow and Their Hematopoietic Supportive Role: Towards Understanding the Permissive Marrow Microenvironment in Acute Myeloid Leukemia

scientific article published on 01 April 2016

Air pollution induces heritable DNA mutations

scientific article

Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity

scientific article

Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9

scientific article

Application of the adverse outcome pathway framework to genotoxic modes of action

scientific article published on 31 October 2019

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.

scientific article published on 25 September 2017

Approaches for identifying germ cell mutagens: Report of the 2013 IWGT workshop on germ cell assays(☆).

scientific article published on 24 January 2015

Assessment of subclinical, toxicant-induced hepatic gene expression profiles after low-dose, short-term exposures in mice.

scientific article published on 15 February 2011

Assessment of the performance of the TGx-DDI biomarker to detect DNA damage-inducing agents using quantitative RT-PCR in TK6 cells

scientific article published on 29 November 2018

BMDExpress 2: Enhanced transcriptomic dose-response analysis workflow

scientific article published on 01 May 2019

BMDExpress Data Viewer - a visualization tool to analyze BMDExpress datasets

scientific article (publication date: August 2016)

Barhl1 is directly regulated by thyroid hormone in the developing cerebellum of mice.

scientific article

Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia.

scientific article published on 13 May 2016

Bisphenol A and Bisphenol S Induce Distinct Transcriptional Profiles in Differentiating Human Primary Preadipocytes.

scientific article

Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver

scientific article published on 6 June 2014

Building on the past, shaping the future: The environmental mutagenesis and genomics society ⬇️

scientific article published on February 26, 2013

Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver ⬇️

scientific article published on February 2, 2012

Carbon black nanoparticle intratracheal installation results in large and sustained changes in the expression of miR-135b in mouse lung.

scientific article published on 29 June 2012

Carbon black nanoparticle intratracheal instillation does not alter cardiac gene expression

scientific article published in December 2013

Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan

scientific article published on 29 October 2013

Celebrating 50 Years of EMGS: A Visionary Idea Continues

scientific article published on 12 December 2019

Changes in cholesterol homeostasis and acute phase response link pulmonary exposure to multi-walled carbon nanotubes to risk of cardiovascular disease

scientific article published on 22 January 2015

Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing.

scientific article

Chemically induced mutations in a MutaMouse reporter gene inform mechanisms underlying human cancer mutational signatures

scientific article published on 14 August 2020

Comparative transcriptomic analyses to scrutinize the assumption that genotoxic PAHs exert effects via a common mode of action

scientific article

Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water

scientific article

Comprehensive comparison of six microarray technologies

scientific article

Consensus recommendations to promote and advance predictive systems toxicology and toxicogenomics

scientific article published on June 2007

Corrigendum to "Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell Gene mutation assays) and integration with somatic cell testing." [Mutat. Res. 832-833 (2018) 7-18]

scientific article published on 07 June 2019

Corrigendum to "MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs" [Toxicol. Appl. Pharmacol., 284 (2015) 16-32]

scientific article published on 13 June 2018

Corrigendum to "Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488" [Mutat. Res. 832-833 (2018) 19-28]

scientific article published on 12 June 2019

Cross-platform analysis of global microRNA expression technologies

scientific article

Demodifying RNA for Transcriptomic Analyses of Archival Formalin-Fixed Paraffin-Embedded Samples.

scientific article published on 7 December 2017

Detection of induced male germline mutation: correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays.

scientific article

Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

scientific article published on 4 December 2017

Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells

scientific article published on 2 March 2015

Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement.

scientific article published on 22 May 2015

Dietary folic acid protects against genotoxicity in the red blood cells of mice

scientific article published on 29 June 2015

Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice exposed to the carcinogen furan.

scientific article published on 12 July 2013

Discovering human germ cell mutagens with whole genome sequencing: Insights from power calculations reveal the importance of controlling for between-family variability

scientific article published on 20 April 2018

Dose-response mutation and spectrum analyses reveal similar responses at two microsatellite loci in benzo(a)pyrene-exposed mouse spermatogonia.

scientific article published on 30 May 2017

Effects of cross-fostering and developmental exposure to mixtures of environmental contaminants on hepatic gene expression in prepubertal 21 days old and adult male Sprague-Dawley rats

scientific article published on 11 February 2019

Enhanced Quality Metrics for Assessing RNA Derived From Archival Formalin-Fixed Paraffin-Embedded Tissue Samples

scientific article published on 01 August 2019

Exposure of pregnant mice to carbon black by intratracheal instillation: toxicogenomic effects in dams and offspring

scientific article published on 6 October 2011

Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation.

scientific article published on October 2013

Framework for the quality assurance of 'omics technologies considering GLP requirements.

scientific article

From sperm to offspring: Assessing the heritable genetic consequences of paternal smoking and potential public health impacts.

scientific article published on 12 April 2017

Functional analysis of the TRIB1 associated locus linked to plasma triglycerides and coronary artery disease.

scientific article

Gene Expression Analysis to Identify Molecular Correlates of Pre- and Post-conditioning Derived Neuroprotection ⬇️

scientific article published on April 1, 2012

Gene expression analysis of livers from female B6C3F1 mice exposed to carcinogenic and non-carcinogenic doses of furan, with or without bromodeoxyuridine (BrdU) treatment

scientific article

Gene expression profiling in rat cerebellum following in utero and lactational exposure to mixtures of methylmercury, polychlorinated biphenyls and organochlorine pesticides.

scientific article published on 14 September 2007

Gene expression profiling of the fathead minnow (Pimephales promelas) neuroendocrine brain in response to pulp and paper mill effluents.

scientific article published on 4 June 2010

Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure

scientific article published on 09 November 2012

Genetic toxicology and toxicogenomic analysis of three cigarette smoke condensates in vitro reveals few differences among full‐flavor, blonde, and light products ⬇️

scientific article published on March 19, 2012

Germ cell mutagens: risk assessment challenges in the 21st century.

scientific article published on October 2010

Germline mutation rates in mice following in utero exposure to diesel exhaust particles by maternal inhalation

Global transcriptional characterization of a mouse pulmonary epithelial cell line for use in genetic toxicology.

scientific article published on 3 May 2009

HPLC Measurement of the DNA Oxidation Biomarker, 8-oxo-7,8-dihydro-2'-deoxyguanosine, in Cultured Cells and Animal Tissues.

scientific article published on August 2015

Harnessing genomics to identify environmental determinants of heritable disease

journal article published in 2013

Hepatic gene expression changes in hypothyroid juvenile mice: characterization of a novel negative thyroid-responsive element.

scientific article published on 26 April 2007

Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene

scientific article

Hepatic miRNA profiles and thyroid hormone homeostasis in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS).

scientific article published on 21 December 2015

Hepatic transcriptional dose-response analysis of male and female Fischer rats exposed to hexabromocyclododecane

scientific article published on 27 December 2018

Hexabromocyclododecane (HBCD): A case study applying tiered testing for human health risk assessment

scientific article published on 13 June 2019

High information content assays for genetic toxicology testing: A report of the International Workshops on Genotoxicity Testing (IWGT)

scientific article published on 21 February 2019

High-resolution sperm typing of meiotic recombination in the mouse MHC Ebeta gene.

scientific article

Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling.

scientific article published on 22 July 2014

Identification of p53 Activators in a Human Microarray Compendium

scientific article published on 03 September 2019

Identification of thyroid hormone receptor binding sites and target genes using ChIP-on-chip in developing mouse cerebellum.

scientific article

Identification of thyroid hormone receptor binding sites in developing mouse cerebellum.

scientific article

Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing

scientific article published on 29 May 2018

Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD)

scientific article

Impact of cigarette smoke on the human and mouse lungs: a gene-expression comparison study

scientific article

Impact of nose-only exposure system on pulmonary gene expression

article

In Utero Exposure to Benzo[a]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice

scientific article published on 22 July 2016

In Utero Exposure to Benzo[a]pyrene Induces Ovarian Mutations at Doses that Deplete Ovarian Follicles in Mice

scientific article published on 21 December 2018

In utero Exposure to Genotoxicants Leading to Genetic Mosaicism: An Overlooked Window of Susceptibility in Genetic Toxicology Testing?

scientific article published on 05 December 2019

In utero exposure to nanosized carbon black (Printex90) does not induce tandem repeat mutations in female murine germ cells

scientific article

In vitro microarray analysis identifies genes in acute-phase response pathways that are down-regulated in the liver of chicken embryos exposed in ovo to PFUdA.

scientific article published on 16 April 2013

Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

scientific article

Induced minisatellite germline mutations in herring gulls (Larus argentatus) living near steel mills.

scientific article published on September 2000

Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke

scientific article published on 21 August 2009

Integrated In Vivo Genotoxicity Assessment of Procarbazine Hydrochloride Demonstrates Induction of Pig-a and LacZ Mutations, and Micronuclei, in MutaMouse Hematopoietic Cells

scientific article published on 18 January 2019

Integrated in silico and in vitro genotoxicity assessment of thirteen data-poor substances

scientific article published on 20 July 2019

Integrating toxicogenomics into human health risk assessment: lessons learned from the benzo[a]pyrene case study.

scientific article

Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells.

scientific article published on 2 March 2015

Integration of sperm DNA damage assessment into OECD test guidelines for genotoxicity testing using the MutaMouse model

scientific article published on 27 August 2018

Integration of the TGx-28.65 genomic biomarker with the flow cytometry micronucleus test to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human TK6 cells.

scientific article published on 13 September 2017

Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice

scientific article

Investigating the effects of dietary folic acid on sperm count, DNA damage and mutation in Balb/c mice

scientific article published on 20 July 2012

Is there a role for the adverse outcome pathway framework to support radiation protection?

scientific article published on 29 October 2018

Lack of acute phase response in the livers of mice exposed to diesel exhaust particles or carbon black by inhalation

scientific article published on 20 April 2009

Lack of change in microRNA expression in adult mouse liver following treatment with benzo(a)pyrene despite robust mRNA transcriptional response.

scientific article published on 25 February 2010

MWCNTs of different physicochemical properties cause similar inflammatory responses, but differences in transcriptional and histological markers of fibrosis in mouse lungs

scientific article published on 29 December 2014

Maternal inhalation of surface-coated nanosized titanium dioxide (UV-Titan) in C57BL/6 mice: effects in prenatally exposed offspring on hepatic DNA damage and gene expression

scientific article published on 28 November 2011

Methoxyacetic acid-induced spermatocyte death is associated with histone hyperacetylation in rats

scientific article

Mice exposed in situ to urban air pollution exhibit pulmonary alterations in gene expression in the lipid droplet synthesis pathways.

scientific article

Mining the Archives: A Cross-Platform Analysis of Gene Expression Profiles in Archival Formalin-Fixed Paraffin-Embedded Tissues.

scientific article published on 10 September 2015

Molecular insight into the effects of hypothyroidism on the developing cerebellum.

scientific article

Monitoring for induced heritable mutations in natural populations: application of minisatellite DNA screening.

scientific article published on August 1998

NanoTIO(2) (UV-Titan) does not induce ESTR mutations in the germline of prenatally exposed female mice.

scientific article

Neurotoxicity may be an overlooked consequence of benzo[a]pyrene exposure that is relevant to human health risk assessment

scientific article published on 21 March 2015

Next generation sequencing of benzo(a)pyrene-induced lacZ mutants identifies a germ cell-specific mutation spectrum.

scientific article published on 10 November 2016

Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.

scientific article published on 21 September 2016

No evidence for transgenerational genomic instability in the F1 or F2 descendants of Muta™Mouse males exposed to N-ethyl-N-nitrosourea.

scientific article published in January 2013

Novel design and controls for focused DNA microarrays: applications in quality assurance/control and normalization for the Health Canada ToxArray

scientific article published on 19 October 2006

Overexpression of tumor necrosis factor-α in the lungs alters immune response, matrix remodeling, and repair and maintenance pathways.

scientific article published on 7 February 2012

Particle-induced pulmonary acute phase response may be the causal link between particle inhalation and cardiovascular disease

scientific article

Paternal exposure to benzo(a)pyrene induces genome-wide mutations in mouse offspring.

scientific article

Paternal lifestyle as a potential source of germline mutations transmitted to offspring.

scientific article

Pulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage ⬇️

scientific article published on April 30, 2011

Pulmonary instillation of low doses of titanium dioxide nanoparticles in mice leads to particle retention and gene expression changes in the absence of inflammation

scientific article published on April 2013

Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: a toxicogenomic study

scientific article

Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment.

scientific article

Review of the literature examining the correlation among DNA microarray technologies

scientific article

Sidestream tobacco smoke is a male germ cell mutagen ⬇️

scientific article published on July 18, 2011

Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488

scientific article published on 01 June 2018

Single-molecule PCR analysis of an unstable microsatellite for detecting mutations in sperm of mice exposed to chemical mutagens

scientific article

Subchronic oral exposure to benzo(a)pyrene leads to distinct transcriptomic changes in the lungs that are related to carcinogenesis

scientific article published on 18 May 2012

Sublinear response in lacZ mutant frequency of Muta™ Mouse spermatogonial stem cells after low dose subchronic exposure to N-ethyl-N-nitrosourea.

scientific article published on 17 January 2015

Supplemental dietary folic acid has no effect on chromosome damage in erythrocyte progenitor cells of mice.

scientific article published on 21 March 2012

Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action

scientific article published in January 2008

Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals.

scientific article published on 2 May 2015

Technical-grade perfluorooctane sulfonate alters the expression of more transcripts in cultured chicken embryonic hepatocytes than linear perfluorooctane sulfonate

scientific article published on 01 December 2011

Testing for mean and correlation changes in microarray experiments: an application for pathway analysis.

scientific article

The adverse outcome pathway (AOP) for chemical binding to tubulin in oocytes leading to aneuploid offspring.

scientific article

The application of transcriptional benchmark dose modeling for deriving thresholds of effects associated with solar-simulated ultraviolet radiation exposure

scientific article published on 15 May 2018

The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook.

scientific article published on 16 September 2017

The development of adverse outcome pathways for mutagenic effects for the organization for economic co-operation and development

article

The use of In vitro Transcriptional data to Identify Thresholds of Effects in a Human Lens Epithelial Cell-line Exposed to Ionizing Radiation

scientific article published on 29 November 2018

Thyroid Hormone May Regulate mRNA Abundance in Liver by Acting on MicroRNAs ⬇️

scientific article published on August 13, 2010

Thyroid hormone response element half-site organization and its effect on thyroid hormone mediated transcription

scientific article

Thyroid hormone-regulated gene expression in juvenile mouse liver: identification of thyroid response elements using microarray profiling and in silico analyses ⬇️

scientific article published on December 29, 2011

Time-dependent subcellular distribution and effects of carbon nanotubes in lungs of mice

scientific article

Toxicogenomic analysis of mainstream tobacco smoke-exposed mice reveals repression of plasminogen activator inhibitor-1 gene in heart

article

Toxicogenomic analysis of susceptibility to inhaled urban particulate matter in mice with chronic lung inflammation.

scientific article published on 11 March 2009

Toxicogenomic assessment of liver responses following subchronic exposure to furan in Fischer F344 rats

scientific article (publication date: June 2016)

Transcriptional Profiles in the Cerebral Hemisphere of Chicken Embryos Following In Ovo Perfluorohexane Sulfonate Exposure ⬇️

scientific article published on July 12, 2012

Transcriptional Profiling of Dibenzo[def,p]chrysene-induced Spleen Atrophy Provides Mechanistic Insights into its Immunotoxicity in MutaMouse.

scientific article published on 24 October 2015

Transcriptional benchmark dose modeling: Exploring how advances in chemical risk assessment may be applied to the radiation field

scientific article published on 07 September 2016

Transcriptional profiling identifies physicochemical properties of nanomaterials that are determinants of the in vivo pulmonary response

scientific article published on 11 December 2014

Transcriptional profiling of male CD-1 mouse lungs and Harderian glands supports the involvement of calcium signaling in acrylamide-induced tumors.

scientific article published on 21 February 2018

Transcriptional profiling of male F344 rats suggests the involvement of calcium signaling in the mode of action of acrylamide-induced thyroid cancer.

scientific article published on 09 June 2017

Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene.

scientific article published on 19 May 2016

Transcriptomic analysis reveals novel mechanistic insight into murine biological responses to multi-walled carbon nanotubes in lungs and cultured lung epithelial cells

scientific article

Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish Danio rerio.

scientific article published on 10 December 2018

Transgenic rodent assay for quantifying male germ cell mutant frequency.

scientific article

Transient Maternal Hypothyroxinemia Potentiates the Transcriptional Response to Exogenous Thyroid Hormone in the Fetal Cerebral Cortex Before the Onset of Fetal Thyroid Function: A Messenger and MicroRNA Profiling Study

scientific article published on 15 January 2014

Tris(1,3-dichloro-2-propyl) phosphate perturbs the expression of genes involved in immune response and lipid and steroid metabolism in chicken embryos

scientific article published on 7 January 2014

Using a gene expression biomarker to identify DNA damage-inducing agents in microarray profiles

article

Whole Genome Sequencing of the Mutamouse Model Reveals Strain- and Colony-Level Variation, and Genomic Features of the Transgene Integration Site

scientific article published on 24 September 2019

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