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List of works by Simon W. Hayward

A Preliminary Study of JM-27: A Serum Marker That Can Specifically Identify Men With Symptomatic Benign Prostatic Hyperplasia

article

A comprehensive approach toward novel serum biomarkers for benign prostatic hyperplasia: the MPSA Consortium

scientific article

A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells

scientific article published on 06 April 2013

A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells

scientific article

ALCAM/CD166 is a TGF-β-responsive marker and functional regulator of prostate cancer metastasis to bone

scientific article

Altered TGF-α/β signaling drives cooperation between breast cancer cell populations.

scientific article published on 6 July 2016

Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis.

scientific article published on 8 February 2011

An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line.

scientific article published on November 2005

Androgen hormone action in prostatic carcinogenesis: stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis.

scientific article

Androgen receptor differentially regulates the proliferation of prostatic epithelial cells in vitro and in vivo

scientific article published on 07 September 2016

Androgen regulated genes in human prostate xenografts in mice: relation to BPH and prostate cancer

scientific article

Androgen-dependent prostate epithelial cell selection by targeting ARR(2)PBneo to the LPB-Tag model of prostate cancer

scientific article published on 07 August 2006

Approaches to understanding the importance and clinical implications of peroxisome proliferator-activated receptor gamma (PPARgamma) signaling in prostate cancer.

scientific article published on February 2004

Bladder stromal loss of transforming growth factor receptor II decreases fibrosis after bladder obstruction

scientific article published on 18 August 2009

Bladder tissue formation from cultured bladder urothelium.

scientific article published on October 2006

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin.

scientific article published on 11 October 2017

Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium.

scientific article

Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations

scientific article published on 11 January 2016

Chronic cyclic bladder over distention up-regulates hypoxia dependent pathways

scientific article

Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells.

scientific article

Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium.

scientific article published in May 2007

DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130

scientific article published on 28 February 2019

Development and characterization of efficient xenograft models for benign and malignant human prostate tissue

scientific article published on July 2005

Development of a three-dimensional culture model of prostatic epithelial cells and its use for the study of epithelial-mesenchymal transition and inhibition of PI3K pathway in prostate cancer

scientific article

Directed differentiation of bone marrow derived mesenchymal stem cells into bladder urothelium

scientific article

Directed differentiation of embryonic stem cells into bladder tissue

scientific article

Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy.

scientific article

Disruption of Rb/E2F pathway results in increased cyclooxygenase-2 expression and activity in prostate epithelial cells

scientific article

E2f binding-deficientRb1protein suppresses prostate tumor progression in vivo ⬇️

scientific article published on December 27, 2010

Endodermal origin of bladder trigone inferred from mesenchymal-epithelial interaction

scientific article

Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1.

scientific article published on January 1995

Evidence that the prostate-specific antigen (PSA)/Zn2+ axis may play a role in human prostate cancer cell invasion

scientific article published on April 2004

Expression of hepatocyte nuclear factor-3α in rat prostate, seminal vesicle, and bladder ⬇️

scientific article published on February 1, 1998

Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia

scientific article

Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression

scientific article

F2-isoprostanes as a biomarker of oxidative stress in the mouse bladder

scientific article

FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype

scientific article published on 19 May 2014

Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation

scientific journal article

Functional remodeling of benign human prostatic tissues in vivo by spontaneously immortalized progenitor and intermediate cells

scientific article

Genome-wide analysis of AR binding and comparison with transcript expression in primary human fetal prostate fibroblasts and cancer associated fibroblasts.

scientific article

Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression

scientific article

Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse

scientific article published on 18 April 2019

Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.

scientific article

Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer

scientific article

Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate ⬇️

scientific article published on March 1, 2012

Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration

scientific article

Immunotherapeutic Response in Tumors Is Affected by Microenvironmental ROS

scientific article published on 01 May 2020

Inhibition of NF-kappa B signaling restores responsiveness of castrate-resistant prostate cancer cells to anti-androgen treatment by decreasing androgen receptor-variant expression

scientific article

Interactions between adult human prostatic epithelium and rat urogenital sinus mesenchyme in a tissue recombination model

scientific article published on July 1998

Investigating prostate cancer tumour–stroma interactions: clinical and biological insights from an evolutionary game ⬇️

scientific article published on January 3, 2012

Isolation and analysis of discreet human prostate cellular populations

scientific article published on 3 November 2015

Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF

scientific article published on 13 August 2019

Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks

scientific article

Loss of TGF-β Responsiveness in Prostate Stromal Cells Alters Chemokine Levels and Facilitates the Development of Mixed Osteoblastic/Osteolytic Bone Lesions ⬇️

scientific article published on January 30, 2012

Methodologies in assaying prostate cancer stem cells.

scientific article published on January 2009

Modulation of the hypoxic response following partial bladder outlet obstruction

scientific article published on 19 August 2012

Molecular, cellular and developmental biology of urothelium as a basis of bladder regeneration.

scientific article

NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice.

scientific article

NF-κB and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance.

scientific article published on 16 May 2016

NF-κB and androgen receptor variant expression correlate with human BPH progression

scientific article published on 28 December 2015

Nfib Regulates Transcriptional Networks That Control the Development of Prostatic Hyperplasia

scientific article published on 17 December 2015

PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation.

scientific article

PPARγ: a molecular link between systemic metabolic disease and benign prostate hyperplasia.

scientific article

Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ

scientific article (publication date: 15 May 2017)

Plasticity of the urothelial phenotype: effects of gastro-intestinal mesenchyme/stroma and implications for urinary tract reconstruction

scientific article

Propagation of human prostate tissue from induced pluripotent stem cells

scientific article published on 14 March 2020

Quantitation of apoptotic activity following castration in human prostatic tissue in vivo

scientific article published in February 2003

Recruitment of CD34(+) fibroblasts in tumor-associated reactive stroma: the reactive microvasculature hypothesis.

scientific article

Reduced Contractility and Motility of Prostatic Cancer-Associated Fibroblasts after Inhibition of Heat Shock Protein 90

scientific article published on 24 August 2016

Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis

scientific article published on 20 August 2002

Review of Prostate Anatomy and Embryology and the Etiology of Benign Prostatic Hyperplasia

scientific article

Role for stromal heterogeneity in prostate tumorigenesis

scientific article published on 28 March 2011

Role of mesenchymal-epithelial interactions in normal bladder development

scientific article published in November 1996

Role of stroma in carcinogenesis of the prostate.

scientific article

SOX2 expression in the developing, adult, as well as, diseased prostate

scientific article published on 5 August 2014

SPARCL1 suppresses metastasis in prostate cancer.

scientific article published on 20 July 2013

Species-specific detection of growth factor gene expression in developing murine prostatic tissue

scientific article published in July 1998

Steroid hormones stimulate human prostate cancer progression and metastasis

scientific article published on May 2006

Stretching fibroblasts remodels fibronectin and alters cancer cell migration

scientific article

Stromal androgen receptor in prostate development and cancer

scientific article

Stromal reactivity differentially drives tumour cell evolution and prostate cancer progression

scientific article published on 11 May 2020

Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity

scientific article

Surgical intervention for symptomatic benign prostatic hyperplasia is correlated with expression of the AP-1 transcription factor network

scientific article

TGF-β1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse

scientific article

TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease

scientific article published on 19 April 2022

Targeting the tumor stroma as a novel therapeutic approach for prostate cancer.

scientific article published on January 2012

Temporal-spatial protein expression in bladder tissue derived from embryonic stem cells

scientific article published on 21 August 2008

The Stress Response Mediator ATF3 Represses Androgen Signaling by Binding the Androgen Receptor ⬇️

scientific article published on June 4, 2012

Tissue-specific consequences of cyclin D1 overexpression in prostate cancer progression.

scientific article published on September 2007

Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease

scientific article

Transforming growth factor-beta promotes invasion in tumorigenic but not in nontumorigenic human prostatic epithelial cells.

scientific article published on August 2006

Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion

scientific article

Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype

scientific article published in June 2005

Urothelial inhibition of transforming growth factor-beta in a bladder tissue recombination model.

scientific article published on 16 August 2007

Urothelial transdifferentiation to prostate epithelia is mediated by paracrine TGF-beta signaling.

scientific article published on 25 October 2008

Use of tissue recombination to predict phenotypes of transgenic mouse models of prostate carcinoma

scientific article published on 01 September 2005

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