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List of works by Nicos A. Nicola

A (selective) history of Australian involvement in cytokine biology ⬇️

scientific article published on March 30, 2013

A fusion protein system for the recombinant production of short disulfide-containing peptides.

scientific article

A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia

scientific article

Affinity conversion of receptors for colony stimulating factors: properties of solubilized receptors

scientific article published on January 1992

Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.

scientific article

Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development

scientific journal article

An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor

scientific article

Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation

scientific article

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene

scientific article published on 21 January 2005

Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A G1H) mouse model of familial amyotrophic lateral sclerosis

scientific article published in August 2003

Binding, internalization, and degradation of 125I-multipotential colony-stimulating factor (interleukin-3) by FDCP-1 cells

scientific article

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

scientific article

Blocking Endogenous Leukemia Inhibitory Factor During Placental Development in Mice Leads to Abnormal Placentation and Pregnancy Loss

scientific article

Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy.

scholarly article

Cellular Processing of Murine Colony-Stimulating Factor (Multi-CSF, GM-CSF, G-CSF) Receptors by Normal Hemopoietic Cells and Cell Lines

scientific article published on 01 January 1988

Clearance and fate of leukemia-inhibitory factor (LIF) after injection into mice

scientific article published on 01 September 1991

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor

scientific article

Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

scientific article published on 8 May 2015

Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling

scientific article

Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes

scientific article

DEC-205 is a cell surface receptor for CpG oligonucleotides

scientific article

Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice

scientific article

Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation

scientific article

Development of hydrocephalus in mice lacking SOCS7.

scholarly article

Differential expression of lectin receptors during hemopoietic differentiation: enrichment for granulocyte-macrophage progenitor cells

scientific article published in May 1980

Differentiation commitment in normal hemopoiesis and leukemic transformation

scientific article published on November 1997

Distinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transduction

scientific article (publication date: 8 August 1997)

Donald Metcalf (1929–2014)

scientific article published on 01 January 2015

Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops

scientific article

Enhancement of human blood eosinophil cytotoxicity by semi-purified eosinophil colony-stimulating factor(s)

scientific article

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

scientific article published on 01 November 2019

Expression of BCR – ABL in M1 myeloid leukemia cells induces differentiation without arresting proliferation

scientific article published on 01 January 1999

Functional analysis of Asb-1 using genetic modification in mice

scientific article

Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia

scientific article

Growth Factor-Induced Phosphorylation of c-rasp21 in Normal Hemopoietic Progenitor Cells

scientific article published on 01 January 1989

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)

scientific article (publication date: June 2002)

Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

scientific article published on January 1998

Hemopoietic growth factor receptor abnormalities in leukemia

scientific article published on 01 December 1998

Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.

scientific article

IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.

scientific article

Identification and Characterization of Two Distinct Truncated Forms of gp130 and a Soluble Form of Leukemia Inhibitory Factor Receptor α-Chain in Normal Human Urine and Plasma

scientific article published in Journal of Biological Chemistry

Immuno-haematology and blood bank inventory and issue management

scientific article

Inhibition of IL-6 family cytokines by SOCS3.

scientific article published on 10 January 2014

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.

scientific article published on December 1996

Letter to the Editor: Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2)

scientific article published in January 2005

Leukemia Inhibitory Factor Is an Autocrine Survival Factor for Schwann Cells

scientific article published on 01 July 1999

Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors.

scientific article

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

scientific article published on November 1998

Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region.

scientific article

Macrophage cell lines transformed by the malignant histiocytosis sarcoma virus: increase of CSF receptors suggests a model for transformation

scientific article

Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFα

scientific article published on 01 October 2007

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

scientific article

Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor

scientific article published in June 1984

NMR studies of a murine-human chimera of leukaemia inhibitory factor (LIF). Comparison with human LIF.

scientific article

Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.

scientific article published on June 2003

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

scientific article

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice

scientific journal article

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).

scientific article

Polyethylene glycated leukemia inhibitory factor antagonist inhibits human blastocyst implantation and triggers apoptosis by down-regulating embryonic AKT.

scientific article published on 19 July 2013

Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1

scientific article

Purification of a ligand for the EPH-like receptor HEK using a biosensor-based affinity detection approach

scientific article published on March 1996

Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates

scientific article

Regulation of Janus kinases by SOCS proteins

scientific article published on August 2013

Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2.

scientific article

SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities

scientific article

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

scientific article

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine

scientific article published in September 1999

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

scientific article

SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis

scientific article published in February 2004

SOCS3 negatively regulates IL-6 signaling in vivo

scientific article

SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

scientific article published on July 2004

Solution Structure of Leukemia Inhibitory Factor ⬇️

scientific article published on May 29, 1998

Specific binding of leukemia inhibitory factor to murine myoblasts in culture

article

Structural aspects of cytokine/receptor interactions

scientific article published on September 1995

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

scientific article published on January 2013

Suckling defect in mice lacking the soluble haemopoietin receptor NR6.

scientific article published in June 1999

Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity

scientific article published in February 2012

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

scientific article

Suppressor of Cytokine Signaling-1 Attenuates the Duration of Interferon γ Signal Transductionin Vitroandin Vivo

scientific article published on 16 April 2001

Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other γc-dependent Cytokines in Peripheral T Cells

scientific article published on 28 March 2003

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

scientific journal article

Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.

scientific article

Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection

scientific article

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

scientific article published on June 2000

Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

scientific article

The Disulfide Bond Arrangement of Leukemia Inhibitory Factor: Homology to Oncostatin M and Structural Implications

scientific article published on 01 January 1993

The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase

scientific article

The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression

scientific article published on March 2009

The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo

scientific article

The SOCS box: a tale of destruction and degradation

scientific article (publication date: May 2002)

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues

scientific article published on 20 December 2005

The Unusual Species Cross-reactivity of the Leukemia Inhibitory Factor Receptor α-Chain Is Determined Primarily by the Immunoglobulin-like Domain

scientific article published on 01 September 1997

The biological consequences of excess GM-CSF levels in transgenic mice also lacking high-affinity receptors for GM-CSF

scientific article published on 01 March 1998

The biology and mechanism of action of suppressor of cytokine signaling 3

scientific article

The box-1 region of the leukemia inhibitory factor receptor alpha-chain cytoplasmic domain is sufficient for hemopoietic cell proliferation and differentiation.

scientific article published on December 1998

The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling

scientific article published on 10 February 2006

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments

scientific article

The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor

scientific article

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

scientific article

The role of leukemia inhibitory factor in tubal ectopic pregnancy.

scientific article published on 13 September 2013

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

scientific article published on April 2006

The suppressors of cytokine signaling (SOCS) proteins: important feedback inhibitors of cytokine action.

scientific article

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

scientific article

Towards a Four-Dimensional View of Neutrophils ⬇️

scientific article published on January 1, 2012

Twenty proteins containing a C-terminal SOCS box form five structural classes

scientific article published in January 1998

Two forms of murine epidermal growth factor: rapid separation by using reverse-phase HPLC

scientific article

Vaginally administered PEGylated LIF antagonist blocked embryo implantation and eliminated non-target effects on bone in mice

scientific article

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