List of works - Brian J. Smith

1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP.

scientific article

A Critical Region in the Mineralocorticoid Receptor for Aldosterone Binding and Activation by Cortisol: Evidence for a Common Mechanism Governing Ligand Binding Specificity in Steroid Hormone Receptors

article

A common cross-species function for the double epidermal growth factor-like modules of the highly divergent plasmodium surface proteins MSP-1 and MSP-8.

scientific article published on 19 February 2004

A constricted opening in Kir channels does not impede potassium conduction

scientific article published on 15 June 2020

A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).

scientific article

A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion

scientific article (publication date: 13 March 2008)

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

scientific article

A newly discovered protein export machine in malaria parasites

scientific article

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

scientific article published on 01 June 2020

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

scientific article published on 18 November 2015

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum

scientific article (publication date: 2009)

Anticonvulsant Met-enkephalin analogues containing backbone spacers reveal alternative non-opioid signaling in the brain

scientific article

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

scientific article

Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.

scientific article

Author Correction: A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

scientific article published on 12 June 2020

BAK core dimers bind lipids and can be bridged by them

scientific article published on 14 September 2020

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

scientific article published on 6 March 2015

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

scientific article

BioPPSy: An Open-Source Platform for QSAR/QSPR Analysis

scientific article

Can thioglycosides imitate the oxonium intermediate in glycosyl hydrolases?

scientific article published in November 2003

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

scientific article published on 16 June 2011

Catalytic mechanisms and reaction intermediates along the hydrolytic pathway of a plant beta-D-glucan glucohydrolase

scientific article

Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange

scientific article

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

scientific article

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

scientific article

Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity

scientific article published in April 2007

Consequences of two different amino-acid substitutions at the same codon in KRT14 indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis

scientific article published on 19 May 2011

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

scientific article published in November 2017

Cortisol resistance in the New World revisited

scientific article published in September 2004

Crystal structure and immunological properties of the first annexin from Schistosoma mansoni: insights into the structural integrity of the schistosomal tegument

scientific article

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

scientific article

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

scientific article

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

scientific article

De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization

scientific article

Determinants of spironolactone binding specificity in the mineralocorticoid receptor

scientific article

Development of recombinant protein-based influenza vaccine. Expression and affinity purification of H1N1 influenza virus neuraminidase

scientific article

Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor

scientific article published in October 2004

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

scientific article

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

scientific article

Discovery of inhibitors of lupin diadenosine 5',5'''-P(1),P(4)-tetraphosphate hydrolase by virtual screening.

scientific article

Diverse Reactions of PhI(OTf)2 with Common 2-Electron Ligands: Complex Formation, Oxidation, and Oxidative Coupling

scientific article published on 13 November 2012

Diversity in the intrinsic apoptosis pathway of nematodes

scientific article published on 28 August 2020

Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels

scientific article

Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking

scientific article published on 03 August 2013

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

scientific article

Evolution of the thyroid hormone distributor protein transthyretin in microbes, C. elegans, and vertebrates

scientific article published in April 2005

Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.

scientific article published on 14 November 2016

Further Insights into the Effects of Pre-organizing the BimBH3 Helix

scientific article published on 18 February 2014

Gaussian-theory predictions of proton transfer to water of phenol and 3-chlorophenol: resolution of an apparent difficulty

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

scientific article

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

scientific article

How insulin engages its primary binding site on the insulin receptor

scientific article

Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening

scientific article

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

scientific article (publication date: July 2014)

Insight into the self-association of key enzymes from pathogenic species.

scientific article

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

scientific article

Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor

scientific article

Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease

scientific article published on 8 January 2013

Ion currents through Kir potassium channels are gated by anionic lipids

scientific article published on 25 January 2022

Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA

scientific article published on 12 October 2011

Leishmania major CorA-like magnesium transporters play a critical role in parasite development and virulence

scientific article published on 24 December 2008

Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation.

scientific article published on 30 November 2016

Modelling the structure of the fusion protein from human respiratory syncytial virus

scientific article published in May 2002

Modulation of voltage-gated K+ channels by the sodium channel β1 subunit

scientific article

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

scientific article published on 23 April 2015

Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels

scientific article published in May 2005

PS – a program for the analysis of helix geometry ⬇️

scientific article published on December 6, 2011

Physiological restraint of Bak by Bcl-xL is essential for cell survival

scientific article published on 19 May 2016

Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum

scientific article published on 09 February 2009

Predicting the Enthalpy and Gibbs Energy of Sublimation by QSPR Modeling.

scientific article

Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana

scientific article

Protective hinge in insulin opens to enable its receptor engagement

scientific article

Pseudohypoaldosteronism type 1: the index case revisited

scientific article published on 01 March 2011

Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex

scientific article

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

scientific article

Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

scientific article published on 7 November 2017

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change

scientific article published on 14 October 2009

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity

scientific article

Structural Basis for Broad Substrate Specificity in Higher Plant beta-D-Glucan Glucohydrolases

scientific article

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

scientific article

Structural analysis of bioinspired nano materials with synchrotron far IR spectroscopy

scientific article published on 8 April 2016

Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels

scientific article published in March 2006

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

scientific article

Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1

scientific article published on 09 January 2019

Structural insights into the degradation of Mcl-1 induced by BH3 domains

scientific article

Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine

scientific article

Structural rationale for low-nanomolar binding of transition state mimics to a family GH3 beta-D-glucan glucohydrolase from barley

scientific article

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

scientific article

Structural studies of the resistance of influenza virus neuramindase to inhibitors

scientific article

Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase

scientific article

Structure of Leishmania mexicana Phosphomannomutase Highlights Similarities with Human Isoforms

scientific article published on 12 August 2006

Structure of a calcium-deficient form of influenza virus neuraminidase: implications for substrate binding

scientific article published on 19 August 2006

Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum

scientific article published on 16 August 2005

Structure of the Plasmodium falciparum PfSERA5 pseudo-zymogen

scientific article published on 21 September 2020

Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion

scientific article

Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins

scientific article

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

scientific article

Structure-guided design of a novel class of benzyl-sulfonate inhibitors for influenza virus neuraminidase

scientific article

Structure-guided design of a selective BCL-X(L) inhibitor

scientific article

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

scientific article published on 27 August 2007

Substrate-Assisted Catalysis in Sialic Acid Aldolase

scientific article published on 01 February 1999

Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.

scientific article published on 13 July 2018

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production

scholarly article

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation

scientific article

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues

scientific article published on 20 December 2005

The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion

scientific article

The trypanosomal trans-sialidase: two catalytic functions associated with one catalytic site

scientific article

Three-dimensional structure of the barley beta-D-glucan glucohydrolase in complex with a transition state mimic

scientific article

Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.

scientific article

Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax

scientific article published on 11 September 2014

Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion.

scientific article published on 02 December 2016

Two Essential Light Chains Regulate the MyoA Lever Arm To Promote Toxoplasma Gliding Motility

scientific article

α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells

scientific article published on 28 August 2015

List of works by Brian J. Smith

1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP.

A Critical Region in the Mineralocorticoid Receptor for Aldosterone Binding and Activation by Cortisol: Evidence for a Common Mechanism Governing Ligand Binding Specificity in Steroid Hormone Receptors

A common cross-species function for the double epidermal growth factor-like modules of the highly divergent plasmodium surface proteins MSP-1 and MSP-8.

A constricted opening in Kir channels does not impede potassium conduction

A family of leukemia inhibitory factor-binding peptides that can act as antagonists when conjugated to poly(ethylene glycol).

A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

A newly discovered protein export machine in malaria parasites

A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum

Anticonvulsant Met-enkephalin analogues containing backbone spacers reveal alternative non-opioid signaling in the brain

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.

Author Correction: A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

BAK core dimers bind lipids and can be bridged by them

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

BioPPSy: An Open-Source Platform for QSAR/QSPR Analysis

Can thioglycosides imitate the oxonium intermediate in glycosyl hydrolases?

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

Catalytic mechanisms and reaction intermediates along the hydrolytic pathway of a plant beta-D-glucan glucohydrolase

Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity

Consequences of two different amino-acid substitutions at the same codon in KRT14 indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Cortisol resistance in the New World revisited

Crystal structure and immunological properties of the first annexin from Schistosoma mansoni: insights into the structural integrity of the schistosomal tegument

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins

De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization

Determinants of spironolactone binding specificity in the mineralocorticoid receptor

Development of recombinant protein-based influenza vaccine. Expression and affinity purification of H1N1 influenza virus neuraminidase

Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

Discovery of inhibitors of lupin diadenosine 5',5'''-P(1),P(4)-tetraphosphate hydrolase by virtual screening.

Diverse Reactions of PhI(OTf)2 with Common 2-Electron Ligands: Complex Formation, Oxidation, and Oxidative Coupling

Diversity in the intrinsic apoptosis pathway of nematodes

Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels

Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

Evolution of the thyroid hormone distributor protein transthyretin in microbes, C. elegans, and vertebrates

Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.

Further Insights into the Effects of Pre-organizing the BimBH3 Helix

Gaussian-theory predictions of proton transfer to water of phenol and 3-chlorophenol: resolution of an apparent difficulty

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain

How insulin engages its primary binding site on the insulin receptor

Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

Insight into the self-association of key enzymes from pathogenic species.

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor

Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease

Ion currents through Kir potassium channels are gated by anionic lipids

Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA

Leishmania major CorA-like magnesium transporters play a critical role in parasite development and virulence

Membrane Core-Specific Antimicrobial Action of Cathelicidin LL-37 Peptide Switches Between Pore and Nanofibre Formation.

Modelling the structure of the fusion protein from human respiratory syncytial virus

Modulation of voltage-gated K+ channels by the sodium channel β1 subunit

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels

PS – a program for the analysis of helix geometry ⬇️

Physiological restraint of Bak by Bcl-xL is essential for cell survival

Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum

Predicting the Enthalpy and Gibbs Energy of Sublimation by QSPR Modeling.

Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana

Protective hinge in insulin opens to enable its receptor engagement

Pseudohypoaldosteronism type 1: the index case revisited

Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity

Structural Basis for Broad Substrate Specificity in Higher Plant beta-D-Glucan Glucohydrolases