List of works by Mikael Sigvardsson

A dose-dependent role for EBF1 in repressing non-B-cell-specific genes.

scientific article

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

scientific article

A human early B-cell factor-like protein participates in the regulation of the human CD19 promoter.

scientific article published on October 1999

ARID1a Associates with Lymphoid-Restricted Transcription Factors and Has an Essential Role in T Cell Development

scientific article published on 03 August 2020

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

scientific article

Analysis of Oct2-isoform expression in lipopolysaccharide-stimulated B lymphocytes.

scientific article published on June 1994

B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells

scientific article published on 21 May 2008

CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism

scientific article (publication date: 16 January 2004)

Characterization of the joining chain (J-chain) promoter

scientific article published on November 1993

Cited2 is an essential regulator of adult hematopoietic stem cells

scientific article

Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis

scientific article published on 10 November 2003

Context-dependent regulation of hematopoietic lineage choice by HEBAlt

scientific article published on 8 September 2010

Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors

scientific article published on 31 May 2007

Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.

scientific article published on 13 June 2018

Distinct roles of mesenchymal stem and progenitor cells during the development of acute myeloid leukemia in mice

scientific article published on 01 June 2018

E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.

scientific article published on 7 January 2013

EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes

scientific article published on July 1997

Early B-cell factor (O/E-1) is a promoter of adipogenesis and involved in control of genes important for terminal adipocyte differentiation.

scientific article published on November 2002

Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner

scientific article published on 27 September 2013

Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes

scientific article published on 11 January 2007

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.

scientific article

Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells

scientific article published on 3 November 2009

Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development.

scientific article published on 15 November 2013

Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression

scientific article published on 11 August 2008

Expression of integrin α2 receptor in human cord blood CD34+CD38-CD90+ stem cells engrafting long-term in NOD/SCID-IL2Rγ(c) null mice

scientific article published on 01 February 2013

Ezh2 Represses Transcription of Innate Lymphoid Genes in B Lymphocyte Progenitors and Maintains the B-2 Cell Fate

scientific article published on 24 February 2020

Fetal hepatic expression of 5-lipoxygenase activating protein is confined to colonizing hematopoietic cells

scientific article

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

scientific article

Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics

scientific article

Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication.

scientific article

HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development

scientific article published on 18 January 2007

IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.

scientific article published on 7 June 2011

Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.

scientific article published in April 2005

Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.

scientific article

Immune status and inflammatory response differ locally and systemically in severe acute pancreatitis.

scientific article published on April 2006

Induction ofID2Expression by Hypoxia-inducible Factor-1

scientific article published on 13 July 2004

Inhibition of p300/CBP by early B-cell factor

scientific article

Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells.

scientific article published on 9 September 2010

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

scientific article published on 20 December 2005

Lin28b controls a neonatal to adult switch in B cell positive selection

scientific article published on 01 September 2019

Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial cells

scientific article published on 7 August 2012

Load and lock: the molecular mechanisms of B-lymphocyte commitment.

scientific article

Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis.

scientific article published on May 2007

Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon.

scientific article published on 08 December 2006

Mice with an inactivated joining chain locus have perturbed IgM secretion

scientific article published on 01 August 1998

Molecular characterization of prospectively isolated multipotent mesenchymal progenitors provides new insight into the cellular identity of mesenchymal stem cells in mouse bone marrow.

scientific article published on 26 November 2012

Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors

scientific article published on 12 April 2007

Molecular profiling reveals distinct functional attributes of CD1d-restricted natural killer (NK) T cell subsets

scientific article

Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors.

scientific article published on 08 September 2011

Neuroblastoma and pre-B lymphoma cells share expression of key transcription factors but display tissue restricted target gene expression

scientific article

New light on the biology and developmental potential of haematopoietic stem cells and progenitor cells.

scientific article published on October 2009

Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia

scientific article

Oct proteins are qualitative rather than quantitative regulators of kappa transcription

scientific article published on 01 October 1997

Olf/EBF proteins are expressed in neuroblastoma cells: potential regulators of the Chromogranin A and SCG10 promoters

scientific article

PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia

scientific article published on 05 August 2019

Pearson correlation analysis of microarray data allows for the identification of genetic targets for early B-cell factor.

scientific article

Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development

scientific article published on 26 November 2007

Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)

article

Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate

scientific article

Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals

scientific article

Primary mesenchymal stem and progenitor cells from bone marrow lack expression of CD44 protein

scientific article published on 31 May 2012

Probabilistic estimation of microarray data reliability and underlying gene expression

scientific article

RNA analysis of B cell lines arrested at defined stages of differentiation allows for an approximation of gene expression patterns during B cell development.

scientific article

Real-time analysis of Oct protein-octamer interaction and transcription complex assembly

scientific article published on 01 December 1995

Shaping up a lineage--lessons from B lymphopoesis.

scientific article published on 06 March 2010

Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.

scientific article

Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.

scientific article published on 8 December 2009

Splenic B cells from Hymenolepis diminuta-infected mice ameliorate colitis independent of T cells and via cooperation with macrophages.

scientific article published on December 2014

Stimulation of kappa transcription by a decamer-dependent, synergistic mechanism.

scientific article published on January 1995

Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif

scientific article

The CD53 and CEACAM-1 genes are genetic targets for early B cell factor.

scientific article published on May 2007

The Cxcl12, periostin, and Ccl9 genes are direct targets for early B-cell factor in OP-9 stroma cells.

scientific article

The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers.

scientific article

The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells

scientific article

The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes

scientific article published on 06 July 2007

The pT alpha promoter and enhancer are direct targets for transactivation by E box-binding proteins

scientific article published on 01 March 2002

The roles of transcription factors in B lymphocyte commitment, development, and transformation

scientific article (publication date: June 2004)

The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor

scientific article

Transcription factor dose links development to disease

scientific article published on 01 November 2012

deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm

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