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List of works by Geoffrey Wells

3-(2-oxoethylidene)indolin-2-one derivatives activate Nrf2 and inhibit NF-κB: potential candidates for chemoprevention

scientific article published on 12 May 2014

4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines

scientific article

A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3)

scientific article published on 24 August 2018

An extended pyrrolobenzodiazepine-polyamide conjugate with selectivity for a DNA sequence containing the ICB2 transcription factor binding site.

scientific article

Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines

scientific article published on January 2006

Antitumor quinol PMX464 is a cytocidal anti-trypanosomal inhibitor targeting trypanothione metabolism

scientific article published on 6 January 2011

Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives

scientific article published on 01 March 2000

Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').

scientific article published on October 2006

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction

scientific article published on 8 September 2015

Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction

scientific article published on December 2013

Development of novel apoferritin formulations for antitumour benzothiazoles

scientific article published on 16 January 2019

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.

scientific article

Elucidation of thioredoxin as a molecular target for antitumor quinols.

scientific article

Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: synthesis, DNA interaction, cytotoxicity and differential cellular localization

scientific article

Heteroaromatic 4-arylquinols are novel inducers of nuclear factor-erythroid 2-related factor 2 (Nrf2).

scientific article published on 30 June 2010

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

scientific article (publication date: 28 June 2016)

Induction of tumor cell death through targeting tubulin and evoking dysregulation of cell cycle regulatory proteins by multifunctional cinnamaldehydes

scientific article

Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78.

scientific article published on May 2008

Integrated Target-Based and Phenotypic Screening Approaches for the Identification of Anti-Tubercular Agents That Bind to the Mycobacterial Adenylating Enzyme MbtA

scientific article published on 23 September 2019

Modelling the active SARS-CoV-2 helicase complex as a basis for structure-based inhibitor design

scientific article published on 06 September 2021

Modified Peptide Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction Incorporating Unnatural Amino Acids

scientific article published on 18 July 2018

Novel C8-linked pyrrolobenzodiazepine (PBD)–heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box

scientific article published on 20 April 2011

PMI: a ΔΨm independent pharmacological regulator of mitophagy

scientific article

Peptide and small molecule inhibitors of the Keap1-Nrf2 protein-protein interaction.

scientific article published on 3 August 2015

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity

scientific article published on 24 April 2013

Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode

scientific article published on 12 May 2022

Protein Encapsulation of Experimental Anticancer Agents 5F 203 and Phortress: Towards Precision Drug Delivery

scientific article published on 05 December 2019

Protocol for a Steady-State FRET Assay in Cancer Chemoprevention

scientific article published in January 2016

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy.

scientific article published on 4 September 2017

Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents

scientific article

Supramolecular domains in mixed peptide self-assembled monolayers on gold nanoparticles

scientific article published in September 2008

Synthesis and biological properties of benzothiazole, benzoxazole, and chromen-4-one analogues of the potent antitumor agent 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (PMX 610, NSC 721648).

scientific article

The mycosporine-like amino acids porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding

scientific article published on 30 July 2018

The pharmacological regulation of cellular mitophagy.

scientific article published on January 2017

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

scientific article published on 01 April 2019

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