List of works by Stefan Wirtz

A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2-mediated inflammation

scientific article published on 19 September 2019

A key pathogenic role for the STAT1/T-bet signaling pathway in T-cell-mediated liver inflammation

scientific article published on 01 December 2003

A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.

scientific article published on 14 February 2014

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice

scientific article

A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis

scientific article published on January 2002

A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling.

scientific article published on 11 February 2012

Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease

scientific article published on 22 March 2017

Activation of intestinal epithelial Stat3 orchestrates tissue defense during gastrointestinal infection

scientific article

Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities

scientific article

Assessment of tumor development and wound healing using endoscopic techniques in mice.

scientific article published on 16 October 2010

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis.

scientific article

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

article

Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus

scientific article published on 10 February 2013

Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis

scientific article

Chemically induced mouse models of acute and chronic intestinal inflammation

scientific article published in June 2017

Chemically induced mouse models of intestinal inflammation

scientific article

Confocal laser endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice.

scientific article

Crohn's-like colitis in a patient with immunodeficiency associated with a defect in expression of inducible costimulator.

scientific article

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

scientific article

Friend or Foe? The Ambiguous Role of Innate Lymphoid Cells in Cancer Development

scientific article published on 31 October 2016

Gene transfer approaches for the treatment of inflammatory bowel disease ⬇️

scientific article published on May 1, 2003

IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

scientific article published on 01 July 2007

IL-27 suppresses type 2 immune responses in vivo via direct effects on group 2 innate lymphoid cells

scientific article published on 16 March 2016

IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-bet.

scientific article published on 21 October 2006

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

scientific article

IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo

scientific article published on 18 January 2016

ILC2s in infectious diseases and organ-specific fibrosis.

scientific article

IRF4 regulates IL-17A promoter activity and controls RORγt-dependent Th17 colitis in vivo.

scientific article

Illuminating the role of type I IFNs in colitis

scientific article published on March 2005

Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major

scientific article

In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy.

scientific article published on July 2005

Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation

scientific article published on 16 November 2018

Interferon Gamma Counteracts the Angiogenic Switch and Induces Vascular Permeability in Dextran Sulfate Sodium Colitis in Mice.

scientific article published on 9 July 2015

Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.

scientific article published on 17 October 2007

Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis

scientific article published on 15 August 2013

Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis.

scientific article published on 4 August 2011

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche.

scientific article published on 16 September 2015

Mouse models of inflammatory bowel disease

scientific article published on 16 August 2007

Mycobacterial Cord Factor Reprograms the Macrophage Response to IFN-γ towards Enhanced Inflammation yet Impaired Antigen Presentation and Expression of GBP1

scientific article published on 12 August 2020

Overexpression of STAT-1 by adenoviral gene transfer does not inhibit hepatitis B virus replication.

scientific article published on February 2006

PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury

scientific article

Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer.

scientific article published in April 2010

Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection

scientific article published on 11 May 2016

Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27.

scientific article published on 31 July 2006

RELMα-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection

scientific article published on 01 May 2019

Rac1-regulated endothelial radiation response stimulates extravasation and metastasis that can be blocked by HMG-CoA reductase inhibitors

scientific article (publication date: 2011)

Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells

scientific article

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation

scientific article

STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis

scientific article published on 04 November 2019

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

scientific article published on 29 June 2009

Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production

scientific article published on 13 July 2015

Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo

scientific article published in March 2004

Stepwise regulation of TH1 responses in autoimmunity: IL-12-related cytokines and their receptors.

scientific article

Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain

scientific article published on 30 June 2016

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

scientific article published in October 2004

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

article by Katharina Gerlach et al published 8 June 2014 in Nature Immunology

The Intestinal Microbiota in Inflammatory Bowel Disease

scientific article (publication date: 2015)

The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling

scientific article

The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer

scientific article

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

scientific article published on 18 October 2016

The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6.

scientific article published on July 2008

Tissue Non-specific Alkaline Phosphatase Expression is Needed for the Full Stimulation of T Cells and T Cell-Dependent Colitis

scientific article published on 01 July 2017

Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production.

scientific article published on 16 March 2016

VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer

scientific article

VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis.

scientific article published on 19 March 2015

Wnt inhibitory factor 1 deficiency uncouples cartilage and bone destruction in tumor necrosis factor α-mediated experimental arthritis

scientific article published in September 2013

Paulina is supported by:

About Paulina

Help