List of works - Jeremy C. Simpson

A High-Throughput Automated Confocal Microscopy Platform for Quantitative Phenotyping of Nanoparticle Uptake and Transport in Spheroids

scientific article published on 23 July 2019

A method for improved clustering and classification of microscopy images using quantitative co-localization coefficients ⬇️

scientific article published on June 8, 2012

A microscope-based screening platform for large-scale functional protein analysis in intact cells

scientific article published in November 2003

A novel automated image analysis pipeline for quantifying morphological changes to the endoplasmic reticulum in cultured human cells

scientific article published on 08 September 2021

A novel laser nanosurgery approach supports de novo Golgi biogenesis in mammalian cells

scientific article

A real-time impedance based method to assess Rhodococcus equi virulence

scientific article

A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex

scientific article

A role for the small GTPase Rab21 in the early endocytic pathway

scientific article

A systematic High-Content Screening microscopy approach reveals key roles for Rab33b, OATL1 and Myo6 in nanoparticle trafficking in HeLa cells

scientific article published on 04 July 2016

Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni

scientific article published on 03 December 2019

An RNAi screening platform to identify secretion machinery in mammalian cells

Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome

scientific article

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)

scientific article

Association of CD2AP with dynamic actin on vesicles in podocytes

scientific article published on 14 June 2005

Automated recognition system to classify subcellular protein localizations in images of different cell lines acquired by different imaging systems.

scientific article published on April 2008

Biogenesis of tubular ER-to-Golgi transport intermediates

scientific article

Boosting multiclass learning with repeating codes and weak detectors for protein subcellular localization.

scientific article

CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum

scientific article

Catalytic and cytotoxic activities of recombinant ricin A chain mutants with charged residues added at the carboxyl terminus

scientific article published on 01 October 1995

Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line

scientific article published on 15 December 2010

Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement

scientific article published in December 2004

Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes

scientific article published on 05 March 2020

Characterization of carboxylate nanoparticle adhesion with the fungal pathogen Candida albicans

scientific article

Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A

scientific article

Comprehensive Proteomics Analysis of Polyhydroxyalkanoate (PHA) Biology in Pseudomonas putida KT2440: The Outer Membrane Lipoprotein OprL is a Newly Identified Phasin

scientific article published in 2024

Computational and experimental analysis of bioactive peptide linear motifs in the integrin adhesome

scientific article published in PLoS ONE

Dual channel rank-based intensity weighting for quantitative co-localization of microscopy images.

scientific article

Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance

scientific article

Expression of mutant dynamin protects cells against diphtheria toxin but not against ricin

scientific article published on 01 March 1998

Factor VIII-eGFP fusion proteins with preserved functional activity for the analysis of the early secretory pathway of factor VIII.

scientific article published in November 2009

Free ricin A chain reaches an early compartment of the secretory pathway before it enters the cytosol

scientific article published on 01 December 1996

Functional characterisation of the YIPF protein family in mammalian cells

scientific article published on 20 December 2016

Functional profiling: from microarrays via cell-based assays to novel tumor relevant modulators of the cell cycle

scientific article

Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking

scientific article

Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway

HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways.

scientific article

High-content microscopy identifies new neurite outgrowth regulators

scientific article

High-content screening and analysis of the Golgi complex

scientific article published on 01 January 2013

High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic

scientific article

High-speed imaging of Rab family small GTPases reveals rare events in nanoparticle trafficking in living cells

scientific article published in February 2012

Human diseases associated with form and function of the Golgi complex

scientific article published on 10 September 2013

Imaging Platforms for Measurement of Membrane Trafficking

Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells

article

Impact of live cell imaging on coated vesicle research.

scientific article published on 7 July 2007

Implementation of the Rank-Weighted Co-localization (RWC) algorithm in multiple image analysis platforms for quantitative analysis of microscopy images

scientific article published on 16 February 2016

Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum

scientific article published on September 2006

Intracellular traffic and fate of protein transduction domains HIV-1 TAT peptide and octaarginine. Implications for their utilization as drug delivery vectors

scientific article published on January 2006

Localizing the proteome

scientific article

Malectin: A Novel Carbohydrate-binding Protein of the Endoplasmic Reticulum and a Candidate Player in the Early Steps of Protein N-Glycosylation

scientific article

Maturation of the mammalian secretome

scientific article published in January 2007

Modification of the Mammalian Endomembrane System in Healthy and Diseased Cells

scientific article published on 20 March 2020

Multitasking Rab Proteins in Autophagy and Membrane Trafficking: A Focus on Rab33b

scientific article published on 12 August 2019

Navigating the secretory pathway: conference on exocytosis membrane structure and dynamics

scientific article published on September 2002

Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation

scientific article

Point mutations in the hydrophobic C-terminal region of ricin A chain indicate that Pro250 plays a key role in membrane translocation

scientific article published on 01 September 1995

Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells

scientific article

Quantitative image analysis approaches for probing Rab GTPase localization and function in mammalian cells ⬇️

scientific article published on December 1, 2012

Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.

scientific article

RNA Bacteriophage Capsid-Mediated Drug Delivery and Epitope Presentation

scientific article published on 01 January 2002

RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells

scientific article published on 28 April 2020

RNAi-mediated inhibition of apoptosis fails to prevent cationic nanoparticle-induced cell death in cultured cells

scientific article published on 20 December 2013

Rab18 and Rab43 have key roles in ER-Golgi trafficking

scientific article

Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology

scientific article

Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast

scientific article published on 01 October 1999

Ricin cytotoxicity is sensitive to recycling between the endoplasmic reticulum and the Golgi complex.

scientific article

Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth

scientific article

Screening the secretion machinery: High throughput imaging approaches to elucidate the secretory pathway

scientific article published on 4 August 2009

Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death

scientific article

Spatiotemporal dynamics of the COPI vesicle machinery

scientific article published on 19 September 2003

Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing

article published in 2009

The Spir actin organizers are involved in vesicle transport processes

scientific journal article

The subcellular localization of the mammalian proteome comes a fraction closer

scientific article published on January 2006

The systematic functional characterisation of Xq28 genes prioritises candidate disease genes

scientific article published on 17 February 2006

The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport.

scientific article

Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles

scientific article published on 9 October 2013

Trajectory-based co-localization measures for nanoparticle-cell interaction studies

scientific article published on 15 December 2014

ojoplano-mediated basal constriction is essential for optic cup morphogenesis.

scientific article published on July 2009

List of works by Jeremy C. Simpson

A High-Throughput Automated Confocal Microscopy Platform for Quantitative Phenotyping of Nanoparticle Uptake and Transport in Spheroids

A method for improved clustering and classification of microscopy images using quantitative co-localization coefficients ⬇️

A microscope-based screening platform for large-scale functional protein analysis in intact cells

A novel automated image analysis pipeline for quantifying morphological changes to the endoplasmic reticulum in cultured human cells

A novel laser nanosurgery approach supports de novo Golgi biogenesis in mammalian cells

A real-time impedance based method to assess Rhodococcus equi virulence

A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex

A role for the small GTPase Rab21 in the early endocytic pathway

A systematic High-Content Screening microscopy approach reveals key roles for Rab33b, OATL1 and Myo6 in nanoparticle trafficking in HeLa cells

Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni

An RNAi screening platform to identify secretion machinery in mammalian cells

Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)

Association of CD2AP with dynamic actin on vesicles in podocytes

Automated recognition system to classify subcellular protein localizations in images of different cell lines acquired by different imaging systems.

Biogenesis of tubular ER-to-Golgi transport intermediates

Boosting multiclass learning with repeating codes and weak detectors for protein subcellular localization.

CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum

Catalytic and cytotoxic activities of recombinant ricin A chain mutants with charged residues added at the carboxyl terminus

Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line

Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement

Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes

Characterization of carboxylate nanoparticle adhesion with the fungal pathogen Candida albicans

Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A

Comprehensive Proteomics Analysis of Polyhydroxyalkanoate (PHA) Biology in Pseudomonas putida KT2440: The Outer Membrane Lipoprotein OprL is a Newly Identified Phasin

Computational and experimental analysis of bioactive peptide linear motifs in the integrin adhesome

Dual channel rank-based intensity weighting for quantitative co-localization of microscopy images.

Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance

Expression of mutant dynamin protects cells against diphtheria toxin but not against ricin

Factor VIII-eGFP fusion proteins with preserved functional activity for the analysis of the early secretory pathway of factor VIII.

Free ricin A chain reaches an early compartment of the secretory pathway before it enters the cytosol

Functional characterisation of the YIPF protein family in mammalian cells

Functional profiling: from microarrays via cell-based assays to novel tumor relevant modulators of the cell cycle

Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking

Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway

HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways.

High-content microscopy identifies new neurite outgrowth regulators

High-content screening and analysis of the Golgi complex

High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic

High-speed imaging of Rab family small GTPases reveals rare events in nanoparticle trafficking in living cells

Human diseases associated with form and function of the Golgi complex

Imaging Platforms for Measurement of Membrane Trafficking

Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells

Impact of live cell imaging on coated vesicle research.

Implementation of the Rank-Weighted Co-localization (RWC) algorithm in multiple image analysis platforms for quantitative analysis of microscopy images

Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum

Intracellular traffic and fate of protein transduction domains HIV-1 TAT peptide and octaarginine. Implications for their utilization as drug delivery vectors

Localizing the proteome

Malectin: A Novel Carbohydrate-binding Protein of the Endoplasmic Reticulum and a Candidate Player in the Early Steps of Protein N-Glycosylation

Maturation of the mammalian secretome

Modification of the Mammalian Endomembrane System in Healthy and Diseased Cells

Multitasking Rab Proteins in Autophagy and Membrane Trafficking: A Focus on Rab33b

Navigating the secretory pathway: conference on exocytosis membrane structure and dynamics

Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation

Point mutations in the hydrophobic C-terminal region of ricin A chain indicate that Pro250 plays a key role in membrane translocation

Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells

Quantitative image analysis approaches for probing Rab GTPase localization and function in mammalian cells ⬇️

Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.

RNA Bacteriophage Capsid-Mediated Drug Delivery and Epitope Presentation

RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells

RNAi-mediated inhibition of apoptosis fails to prevent cationic nanoparticle-induced cell death in cultured cells

Rab18 and Rab43 have key roles in ER-Golgi trafficking

Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology

Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast

Ricin cytotoxicity is sensitive to recycling between the endoplasmic reticulum and the Golgi complex.

Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth

Screening the secretion machinery: High throughput imaging approaches to elucidate the secretory pathway

Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death

Spatiotemporal dynamics of the COPI vesicle machinery

Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing

The Spir actin organizers are involved in vesicle transport processes

The subcellular localization of the mammalian proteome comes a fraction closer

The systematic functional characterisation of Xq28 genes prioritises candidate disease genes

The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport.

Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles

Trajectory-based co-localization measures for nanoparticle-cell interaction studies

ojoplano-mediated basal constriction is essential for optic cup morphogenesis.