List of works - Timofei Zatsepin

1-Phenylethynylpyrene (PEPy) as a novel blue-emitting dye for qPCR assay

scientific article published on 7 January 2016

A new fluorometric assay for the study of DNA-binding and 3'-processing activities of retroviral integrases and its use for screening of HIV-1 integrase inhibitors.

scientific article

A study on endonuclease BspD6I and its stimulus-responsive switching by modified oligonucleotides

scientific article published in PLoS ONE

Analysis of DNA-protein interactions in complexes of transcription factor NF-kappaB with DNA.

scientific article

Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads

scientific article published in 2021

Application of sorting and next generation sequencing to study 5΄-UTR influence on translation efficiency in Escherichia coli

scientific article

Automated Solid-Phase Click Synthesis of Oligonucleotide Conjugates: From Small Molecules to Diverse N-Acetylgalactosamine Clusters.

scientific article published on 18 September 2017

Biodegradable Polymeric Multilayer Capsules for Therapy of Lung Cancer

scientific article published on 27 January 2020

Characterization of HIV-1 integrase interaction with human Ku70 protein and initial implications for drug targeting.

scientific article

Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly.

scientific article published on 31 July 2014

Clustered DNA Lesions Containing 5-Formyluracil and AP Site: Repair via the BER System ⬇️

scientific article published on August 6, 2013

DNA -Motifs With Guanidino--Clamp Residues: The Counterplay Between Kinetics and Thermodynamics and Implications for the Design of pH Sensors

scientific article published on 13 April 2019

DNA-methyltransferase SsoII as a bifunctional protein: features of the interaction with the promoter region of SsoII restriction-modification genes

scientific article published on 01 December 2006

Dynamics of human telomerase RNA structure revealed by antisense oligonucleotide technique.

scientific article

Fine Tuning of Pyrene Excimer Fluorescence in Molecular Beacons by Alteration of the Monomer Structure.

scientific article published on 31 August 2017

Focused ultrasound-mediated fluorescence of composite microcapsules loaded with magnetite nanoparticles: In vitro and in vivo study

scientific article published on 14 June 2019

Human Ku70 protein binds hairpin RNA and double stranded DNA through two different sites.

scientific article published on 4 November 2016

Improved Electroactivity of Redox Probes onto Electropolymerized Azidomethyl-PEDOT: Enabling Click Chemistry for Advanced (Bio)Sensors

scientific article published in 2021

Integrator is a key component of human telomerase RNA biogenesis

scientific article published in Scientific Reports

Interaction of nucleotide excision repair factors XPC-HR23B, XPA, and RPA with damaged DNA.

scientific article

In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation

scientific article published on 18 November 2019

Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside

scientific article

Metal ion CHElate-aSSisted LIGAtion (CHESS LIGA) for SNP detection on microarrays.

scientific article published on 13 June 2009

Method for site-specific detection of m6A nucleoside presence in RNA based on high-resolution melting (HRM) analysis.

scientific article published on 21 November 2013

Modification of Adenosine196 by Mettl3 Methyltransferase in the 5'-External Transcribed Spacer of 47S Pre-rRNA Affects rRNA Maturation

scientific article published on 24 April 2020

Modulation of HIV-1 integrase activity by single-stranded oligonucleotides and their conjugates with eosin.

scientific article

Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro

scientific article published on 05 August 2020

NHEJ pathway is involved in post-integrational DNA repair due to Ku70 binding to HIV-1 integrase

scientific article published on 06 November 2019

Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo

scientific article published on 02 July 2018

Novel homo Yin-Yang probes improve sensitivity in RT-qPCR detection of low copy HIV RNA

scientific article published on 16 October 2018

Oligonucleotide Primers with G8AE-Clamp Modifications for RT-qPCR Detection of the Low-Copy dsRNA

scientific article published on 01 January 2019

Oligonucleotide inhibitors of telomerase: prospects for anticancer therapy and diagnostics.

scientific article

Phenotypic Alteration of BMDM In Vitro Using Small Interfering RNA

scientific article published in 2022

RT-qPCR Detection of Low-Copy HIV RNA with Yin-Yang Probes

scientific article published on 01 January 2020

Red light-triggered photoreduction on a nucleic acid template

scientific article published on 30 July 2020

Restriction Endonuclease SsoII with Photoregulated Activity—a “Molecular Gate” Approach ⬇️

scientific article published on July 20, 2011

Short Duplex Module Coupled to G-Quadruplexes Increases Fluorescence of Synthetic GFP Chromophore Analogues

scientific article published on 09 February 2020

Silver(I)-mediated base pairing in parallel-stranded DNA involving the luminescent cytosine analog 1,3-diaza-2-oxophenoxazine

scientific article published on 01 July 2019

Solid- and solution-phase synthesis and application of R6G dual-labeled oligonucleotide probes

scientific article published on September 2015

Specificity of SNP detection with molecular beacons is improved by stem and loop separation with spacers

scientific article published on 21 February 2017

Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase.

scientific article published on 23 December 2017

Structure-Activity Relationship Studies of HIV-1 Integrase Oligonucleotide Inhibitors.

scientific article published on 19 April 2011

Structure-based cross-linking of NF-kappaB p50 homodimer and decoy bearing a novel 2'-disulfide trapping site

scientific article published on 01 November 2006

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.

scientific article published on 13 November 2017

Suicide inactivation of covalent peroxidase-mimicking DNAzyme with hydrogen peroxide and its protection by a reductant substrate.

scientific article published on 19 April 2016

Synthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates.

scientific article published on 12 December 2017

Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates

scientific article published on 14 December 2017

Synthesis of (2'S)- and (2'R)-2'-deoxy-2'-[(2-methoxyethoxy)amino] pyrimidine nucleosides and oligonucleotides

scientific article published on 01 October 2004

Synthesis of 2'-modified oligonucleotides containing aldehyde or ethylenediamine groups.

scientific article published in May 2003

Synthesis of oligonucleotides containing novel G-clamp analogue with C8-tethered group in phenoxazine ring: Implication to qPCR detection of the low-copy Kemerovo virus dsRNA.

scientific article

TERRA mimicking ssRNAs prevail over the DNA substrate for telomerase in vitro due to interactions with the alternative binding site

scientific article published on 16 December 2015

The Arg/N-Degron Pathway-A Potential Running Back in Fine-Tuning the Inflammatory Response?

scientific article published on 14 June 2020

Toehold-Mediated Selective Assembly of Compact Discrete DNA Nanostructures

scientific article published on 02 December 2020

Use of carbonyl group addition--elimination reactions for synthesis of nucleic acid conjugates.

scientific article

[Modification of nucleic acids using [3+2] dipolar cycloaddition of azides and alkynes]

scientific article published on 01 July 2010

eIF4G2 balances its own mRNA translation via a PCBP2-based feedback loop

scientific article published on 22 April 2019

i-Clamp phenoxazine for the fine tuning of DNA i-motif stability

scientific article published on 21 February 2018

lncRNA in the liver: Prospects for fundamental research and therapy by RNA interference

scientific article

mRNA-Based Therapeutics - Advances and Perspectives

scientific article

List of works by Timofei Zatsepin

1-Phenylethynylpyrene (PEPy) as a novel blue-emitting dye for qPCR assay

A new fluorometric assay for the study of DNA-binding and 3'-processing activities of retroviral integrases and its use for screening of HIV-1 integrase inhibitors.

A study on endonuclease BspD6I and its stimulus-responsive switching by modified oligonucleotides

Analysis of DNA-protein interactions in complexes of transcription factor NF-kappaB with DNA.

Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads

Application of sorting and next generation sequencing to study 5΄-UTR influence on translation efficiency in Escherichia coli

Automated Solid-Phase Click Synthesis of Oligonucleotide Conjugates: From Small Molecules to Diverse N-Acetylgalactosamine Clusters.

Biodegradable Polymeric Multilayer Capsules for Therapy of Lung Cancer

Characterization of HIV-1 integrase interaction with human Ku70 protein and initial implications for drug targeting.

Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly.

Clustered DNA Lesions Containing 5-Formyluracil and AP Site: Repair via the BER System ⬇️

DNA -Motifs With Guanidino--Clamp Residues: The Counterplay Between Kinetics and Thermodynamics and Implications for the Design of pH Sensors

DNA-methyltransferase SsoII as a bifunctional protein: features of the interaction with the promoter region of SsoII restriction-modification genes

Dynamics of human telomerase RNA structure revealed by antisense oligonucleotide technique.

Fine Tuning of Pyrene Excimer Fluorescence in Molecular Beacons by Alteration of the Monomer Structure.

Focused ultrasound-mediated fluorescence of composite microcapsules loaded with magnetite nanoparticles: In vitro and in vivo study

Human Ku70 protein binds hairpin RNA and double stranded DNA through two different sites.

Improved Electroactivity of Redox Probes onto Electropolymerized Azidomethyl-PEDOT: Enabling Click Chemistry for Advanced (Bio)Sensors

Integrator is a key component of human telomerase RNA biogenesis

Interaction of nucleotide excision repair factors XPC-HR23B, XPA, and RPA with damaged DNA.

In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation

Lipid nanoparticles for targeted siRNA delivery - going from bench to bedside

Metal ion CHElate-aSSisted LIGAtion (CHESS LIGA) for SNP detection on microarrays.

Method for site-specific detection of m6A nucleoside presence in RNA based on high-resolution melting (HRM) analysis.

Modification of Adenosine196 by Mettl3 Methyltransferase in the 5'-External Transcribed Spacer of 47S Pre-rRNA Affects rRNA Maturation

Modulation of HIV-1 integrase activity by single-stranded oligonucleotides and their conjugates with eosin.

Murine Long Noncoding RNA Morrbid Contributes in the Regulation of NRAS Splicing in Hepatocytes In Vitro

NHEJ pathway is involved in post-integrational DNA repair due to Ku70 binding to HIV-1 integrase

Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo

Novel homo Yin-Yang probes improve sensitivity in RT-qPCR detection of low copy HIV RNA

Oligonucleotide Primers with G8AE-Clamp Modifications for RT-qPCR Detection of the Low-Copy dsRNA

Oligonucleotide inhibitors of telomerase: prospects for anticancer therapy and diagnostics.

Phenotypic Alteration of BMDM In Vitro Using Small Interfering RNA

RT-qPCR Detection of Low-Copy HIV RNA with Yin-Yang Probes

Red light-triggered photoreduction on a nucleic acid template

Restriction Endonuclease SsoII with Photoregulated Activity—a “Molecular Gate” Approach ⬇️

Short Duplex Module Coupled to G-Quadruplexes Increases Fluorescence of Synthetic GFP Chromophore Analogues

Silver(I)-mediated base pairing in parallel-stranded DNA involving the luminescent cytosine analog 1,3-diaza-2-oxophenoxazine

Solid- and solution-phase synthesis and application of R6G dual-labeled oligonucleotide probes

Specificity of SNP detection with molecular beacons is improved by stem and loop separation with spacers

Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase.

Structure-Activity Relationship Studies of HIV-1 Integrase Oligonucleotide Inhibitors.

Structure-based cross-linking of NF-kappaB p50 homodimer and decoy bearing a novel 2'-disulfide trapping site

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.

Suicide inactivation of covalent peroxidase-mimicking DNAzyme with hydrogen peroxide and its protection by a reductant substrate.

Synthesis and biological evaluation of novel doxorubicin-containing ASGP-R-targeted drug-conjugates.

Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates

Synthesis of (2'S)- and (2'R)-2'-deoxy-2'-[(2-methoxyethoxy)amino] pyrimidine nucleosides and oligonucleotides

Synthesis of 2'-modified oligonucleotides containing aldehyde or ethylenediamine groups.

Synthesis of oligonucleotides containing novel G-clamp analogue with C8-tethered group in phenoxazine ring: Implication to qPCR detection of the low-copy Kemerovo virus dsRNA.

TERRA mimicking ssRNAs prevail over the DNA substrate for telomerase in vitro due to interactions with the alternative binding site

The Arg/N-Degron Pathway-A Potential Running Back in Fine-Tuning the Inflammatory Response?

Toehold-Mediated Selective Assembly of Compact Discrete DNA Nanostructures

Use of carbonyl group addition--elimination reactions for synthesis of nucleic acid conjugates.

[Modification of nucleic acids using [3+2] dipolar cycloaddition of azides and alkynes]

eIF4G2 balances its own mRNA translation via a PCBP2-based feedback loop

i-Clamp phenoxazine for the fine tuning of DNA i-motif stability

lncRNA in the liver: Prospects for fundamental research and therapy by RNA interference

mRNA-Based Therapeutics - Advances and Perspectives