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List of works by Gregory P. Downey

A novel model system for characterization of phagosomal maturation, acidification, and intracellular collagen degradation in fibroblasts

scientific article published on 01 November 2000

A simplified model for en bloc double lung xenotransplantation from hamster to rat

scientific article published on 01 February 2002

A ternary complex comprising FAK, PTPα and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts.

scientific article published on 26 November 2015

Abnormalities in the pulmonary innate immune system in cystic fibrosis

scientific article published on 17 November 2005

Accommodation after lung xenografting from hamster to rat.

scientific article published in March 2003

Actin assembly in electropermeabilized neutrophils: role of G-proteins

scientific article published on 01 October 1989

Actin filaments facilitate insulin activation of the src and collagen homologous/mitogen-activated protein kinase pathway leading to DNA synthesis and c-fos expression

scientific article published on 01 October 1998

Activation of Na+-permeant cation channel by stretch and cyclic AMP-dependent phosphorylation in renal epithelial A6 cells

scientific article published on September 1997

Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis.

scientific article

Air travel in women with lymphangioleiomyomatosis.

scientific article

Airway inflammation and infection in congenital bilateral absence of the vas deferens

scientific article published on 9 October 2003

An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals

scientific article published on 01 May 2011

Anti-synthetase syndrome in ANA and anti-Jo-1 negative patients presenting with idiopathic interstitial pneumonia.

scientific article

Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42

scientific article published on 15 November 2011

CD44 is a phagocytic receptor

scientific article published on 2 February 2006

Chasing the Lymph: New Clues for the Management of Idiopathic Plastic Bronchitis

scientific article published on October 2016

Conventional mechanical ventilation is associated with bronchoalveolar lavage-induced activation of polymorphonuclear leukocytes: a possible mechanism to explain the systemic consequences of ventilator-induced lung injury in patients with ARDS.

scientific article published in December 2002

Current techniques in cell and molecular biology.

scientific article published on September 1995

Cyclic nucleotides modulate genioglossus and hypoglossal responses to excitatory inputs in rats

scientific article published in December 2005

Cystic fibrosis mouse models

scientific article published on 3 August 2006

Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase

scientific article published on 8 October 2004

Death of the septic monocyte: is more better?

scientific article published on 2 June 2006

Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury.

scientific article

Divergent functions of Toll-like receptors during bacterial lung infections

scientific article

Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences.

scientific article published on 24 July 2009

Factors affecting attainment of paid employment after lung transplantation

scientific article published in April 2004

Focal adhesions and Ras are functionally and spatially integrated to mediate IL-1 activation of ERK.

scientific article

Human epidermal growth factor receptor signaling in acute lung injury

scientific article

Human neutrophil peptides and phagocytic deficiency in bronchiectatic lungs.

scientific article published on 30 April 2009

Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway

scientific article

IL-1β enhances cell adhesion to degraded fibronectin.

scientific article

Immune function in patients with Shwachman-Diamond syndrome

scientific article published in September 2001

Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expression

scientific article

Inactivation of macrophage Rab7 by Burkholderia cenocepacia.

scientific article

Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells

scientific article published on 08 January 2021

Inhibition of neutrophil oxidative burst and granule secretion by wortmannin: potential role of MAP kinase and renaturable kinases

scientific article published on 01 July 1997

Insulin, insulin-like growth factor-I, and platelet-derived growth factor activate extracellular signal-regulated kinase by distinct pathways in muscle cells

scientific article

Integrated genomics approaches identify transcriptional mediators and epigenetic responses to Afghan desert particulate matter in small airway epithelial cells

scientific article published in 2022

Interactions of the protein-tyrosine phosphatase-α with the focal adhesion targeting domain of focal adhesion kinase are involved in interleukin-1 signaling in fibroblasts.

scientific article

Intracellular signaling in neutrophil priming and activation

scientific article

Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung

scientific article published on March 2015

Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lung infection

scientific article

It's much more than just pretty pictures

scientific article published on 01 May 2010

L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration

scientific article published on 27 February 2003

Leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and Akt.

scientific article

Localised pulmonary resection for bronchiectasis in hypogammaglobulinaemic patients

scientific article published on May 1994

Lung inflammation as a therapeutic target in cystic fibrosis.

scientific article published in October 2004

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

scientific article

Matrix metalloproteinases and protein tyrosine kinases: potential novel targets in acute lung injury and ARDS

scientific article

Mechanisms of leukocyte motility and chemotaxis

scientific article published on February 1994

Mitochondrial function is a critical determinant of IL-1-induced ERK activation

scientific article

Molecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans

scientific article

Monocyte-induced endothelial calcium signaling mediates early xenogeneic endothelial activation.

scientific article

Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice.

scientific article

Na+/H+ exchange activity during phagocytosis in human neutrophils: role of Fcgamma receptors and tyrosine kinases

scientific article published on March 1996

Neuroleptic malignant syndrome. Patient with unique clinical and physiologic features

scientific article published on 01 August 1984

Neutrophil activation and acute lung injury.

scientific article

Neutrophil cell signaling in infection: role of phosphatidylinositide 3-kinase ⬇️

scientific article published on November 1, 2003

Neutrophil products and alterations in epithelial junctional proteins: prevention of artifactual degradation.

scientific article published in May 2000

Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling.

scientific article

Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management

scientific article published in September 2016

On, around, and through: neutrophil-endothelial interactions in innate immunity

scientific article

Oxidative Stress and Acute Lung Injury ⬇️

scientific article published on October 1, 2003

Patients' perceptions versus medical testing of function in women with lymphangioleiomyomatosis (LAM).

scientific article published on 25 January 2005

Phagosomal Maturation, Acidification, and Inhibition of Bacterial Growth in Nonphagocytic Cells Transfected with FcγRIIA Receptors

scientific article published in Journal of Biological Chemistry

Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signaling.

scientific article published on 11 August 2006

Protease-activated receptor (Par)1 alters bioelectric properties of distal lung epithelia without compromising barrier function.

scientific article published in March 2009

Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness.

scientific article published on 17 March 2014

Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides.

scientific article

Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling.

scientific article published on 03 June 2009

Protein-tyrosine phosphatase-α and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling

scientific article published in September 2009

Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

scientific article

Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression

scientific article published on February 2013

Receptor-mediated actin assembly in electropermeabilized neutrophils: role of intracellular pH.

scientific article published on April 1989

Regenerative medicine and the developing world

scientific article

Regulation of Src homology 2-containing tyrosine phosphatase 1 during activation of human neutrophils. Role of protein kinase C

scientific article published on 01 January 1997

Remote ischemic preconditioning decreases adhesion and selectively modifies functional responses of human neutrophils.

scientific article

Reply: defining lung injury in animals

scientific article published on 01 February 2013

Resolving the Scar of Pulmonary Fibrosis

scientific article published on 01 September 2011

Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report

scientific article published on 01 August 2019

Role of PAR2 in murine pulmonary pseudomonal infection.

scientific article published on 14 December 2007

Role of PTPα in the destruction of periodontal connective tissues

scientific article

Role of caveolin-1 in regulation of inflammation: different strokes for different folks

scientific article published on 30 November 2007

SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1.

scientific article published on 24 November 2004

Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial

scientific article

Signaling functions of L-selectin. Enhancement of tyrosine phosphorylation and activation of MAP kinase

scientific article published on June 1995

Stimulation of glucose transport in L6 muscle cells by long-term intermittent stretch-relaxation

scientific article published on April 1992

Subglottic stenosis complicating Wegener's granulomatosis: surgical repair as a viable treatment option

scientific article published on 01 May 1996

Taking It Off: New Insights into the Role of Tyrosine Phosphorylation-dependent Pathways in the Pathogenesis of Pulmonary Fibrosis

scientific article published in February 2017

Targeting transgene expression for cystic fibrosis gene therapy

scientific article published in July 2001

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

scientific article

The immunoglobulin light chain related protein lambda 5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule

scientific article published on November 1991

The importance of matrix metalloproteinase-3 in respiratory disorders

scientific article published on 29 May 2014

The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts

scientific article published on 29 April 2003

The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans

article

The role of actin-binding protein 280 in integrin-dependent mechanoprotection

scientific article

The yin and yang of cystic fibrosis transmembrane conductance regulator function: implications for chronic lung disease

scientific article published in January 2013

Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury

scientific article published on 31 October 2008

Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease

scientific article published on 21 January 2016

Translocation of the tetraspanin CD63 in association with human eosinophil mediator release

scientific article

Tumor necrosis factor-α accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages

scientific article

Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function

scientific article

Tyrosine phosphatase PTPalpha regulates focal adhesion remodeling through Rac1 activation

scientific article

Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions

scientific article published on April 2006

Tyrosine phosphorylation is essential for microfilament assembly in B lymphocytes

scientific article published on 01 May 1991

Underlying chronic granulomatous disease in a patient with bronchocentric granulomatosis

scientific article published on December 2003

Up-regulation of functional CXCR4 expression on human lymphocytes in sepsis.

scientific article published in December 2006

Use of fluorescent probes to detect lipid signaling intermediates in macrophages

scientific article

Volume regulation in leukocytes: requirement for an intact cytoskeleton

scientific article published on April 1995

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